Area:
Dystrophen-glycoprotein complex
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High-probability grants
According to our matching algorithm, Kurt W. Prins is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2015 — 2016 |
Prins, Kurt W |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Investigating Microtubules in Duchenne Cardiomyopathy @ University of Minnesota
? DESCRIPTION (provided by applicant): The goals of this project are to further train Kurt Prins MD, PhD as a physician-scientist in cardiology and advance the field of Duchenne cardiomyopathy. Dr. Prins is currently a Cardiology fellow in the Physician- Scientist Training Program at the University of Minnesota, a combined research and clinical track which dedicates three years of protected time for research and two years to clinical cardiology training. Dr. Prins has elected to continue his research training in the laboratory of Dr. Joseph Metzger, a world leader in cardiac physiology and Duchenne cardiomyopathy. Dr. Prins' educational objectives include gaining expertise in cardiac physiology by working in a lab of an established investigator in cardiology and attending seminars to gain further exposure to outside investigators and build possible collaborations. The research project will investigate the role of disorganized microtubules in Duchenne cardiomyopathy. Dr. Prins authored the manuscript that first described the dystrophin-microtubule interaction and he now looks to build on these findings by probing the cardiac-specific physiological consequences of disorganized microtubules. This project will study the link between microtubule disorganization with t-tubule disruptions and calcium handling abnormalities, and will also test the hypothesis that targeting microtubules with colchicine will be a novel therapy for Duchenne cardiomyopathy. If results are positive, this project will identify colchicine, an already FDA-approved medication, as a therapy for Duchenne cardiomyopathy and thus allow for quick translation into a Duchenne-orientated clinical trial. The training of Dr. Prins as physician-scientist will advance the mission of the NIH by creating a scientist that will conduct clinically relevant research.
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1 |
2018 — 2021 |
Prins, Kurt W |
K08Activity Code Description: To provide the opportunity for promising medical scientists with demonstrated aptitude to develop into independent investigators, or for faculty members to pursue research aspects of categorical areas applicable to the awarding unit, and aid in filling the academic faculty gap in these shortage areas within health profession's institutions of the country. |
Mechanisms of Junctophilin-2 Misregulation That Contribute to Right Ventricular Dysfunction in Pulmonary Arterial Hypertension @ University of Minnesota
Project Summary The goals of this project are to train Kurt Prins MD, PhD as a physician-scientist in Cardiology and advance the understanding of right ventricular dysfunction in pulmonary arterial hypertension (PAH). Dr. Prins is currently a third year Cardiology fellow in the Physician-Scientist Training Program, a combined research and clinical track dedicated to training the next generation of physician-scientist at the University of Minnesota. Dr. Prins has elected to conduct his research training in the laboratory of Dr. Joseph Metzger, a leader in molecular cardiac physiology who has a long track record of obtaining NIH funding and experience training physician-scientists. Dr. Prins has chosen two experts in pulmonary arterial hypertension research: Drs. Stephen Archer and E. Kenneth Weir to be on his mentoring committee to further guide him in his early career. Dr. Prins? educational objectives include gaining expertise in cardiac physiology by working in a lab of an established investigator in cardiology and collaborating with an expert in PAH, attending seminars to gain further exposure to outside investigators and build collaborations, and taking courses to prepare for future grant applications. The research project will investigate two distinct mechanisms of junctophilin-2 misregulation that contribute to right ventricular dysfunction in PAH. Dr. Prins authored a manuscript that showed increased microtubule density was associated with junctophilin-2 misregulation resulting in t-tubule disruptions and calcium mishandling in Duchenne cardiomyopathy. Now he will define the role of junctophilin-2 in RV dysfunction in PAH, a disease that he has worked to specialize in clinically. Thus, this proposed training period will allow Dr. Prins to combine his basic science and clinical interests by studying the link between junctophilin-2 misregulation due to improper trafficking on a pathologically remodeled microtubule cytoskeleton and miR-24-mediated repression and RV dysfunction in PAH. The project will determine if misregulation of junctophilin-2 leads to altered t-tubule structure, calcium mishandling, and ultimately RV dysfunction in pulmonary arterial hypertension. Also, it will also test the hypothesis that normalizing junctophilin-2 with colchicine treatment and by inhibiting miR-24 could be novel therapeutic strategies to improve RV function in PAH.
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1 |