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High-probability grants
According to our matching algorithm, Richard P. Bobbin is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1985 — 1988 |
Bobbin, Richard |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Cochlear Afferent Transmitter Search @ Louisiana State University Health Sciences Center |
0.915 |
1991 — 1997 |
Bobbin, Richard P |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Pharmacology of Isolated Outer Hair Cells @ Louisiana State Univ Hsc New Orleans
The long-term objective of this research is to shed light on how the cochlea analyzes sound. Others have demonstrated that single outer hair cells isolated in vitro change their longitudinal lengths in response to chemical or electrical stimuli. This and other data suggests that the outer hair cells play a role in the high sensitivity transduction process of the cochlea in response to sound and this has been included in several models. Our goal is to determine how chemicals such as neurotransmitters, modulators, and other chemicals present in the cochlea interact with the outer hair cells and alter their role in the transduction process. The hypothesis to be tested is that chemicals proposed as efferent neurotransmitters and neuromodulators and other chemicals in the cochlea react with receptors on the outer hair cells to produce one or more of the following changes in the outer hair cells: 1) length, and/or 2) ion channel activity, and/or 2) guanine nucleotide binding (G) protein activity. We will examine the mechanisms of any changes found by testing antagonists in addition to monitoring the effects of the chemicals on ion channel activity in the isolated hair cells. This information should aid researchers and physicians in identifying disease states which might involve malfunction of the outer hair cells in the processing of sound and in proposing drug intervention therapy.
|
0.96 |
1999 — 2002 |
Bobbin, Richard Chen, Chu (co-PI) [⬀] Parker, Margarett |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Functional Characteristics of Three P2x2 Splice Variants of the Atp Receptor @ Louisiana State University Health Sciences Center
Bobbin, Richard P. 987165 Lay summary
Proteins are the building blocks of cells in animal tissue. Our laboratory has been focusing its research on proteins involved in communicating messages from one cell to another in nervous tissue, i.e., the receivers/translators of the message. This proposal will concentrate on the role of the protein called P2X2 that receives messages from the messenger known as adenosine triphosphate (ATP). We have recently discovered a new form of the protein called P2X2-3. We have determined that this new protein has a very unusual structure. Based on this unusual structure, we surmise that P2X2-3 may have a special role in cells. This role may be to translate a special type of message to the cell when the messenger, ATP, is received. Therefore, this proposal will investigate the function of P2X2-3 in cells. We will determine how it is functionally different from other related proteins. These goals will be accomplished by first studying the proteins by placing them into special cells where their function can be defined without any other proteins interfering with the study. Then we will determine what cells in tissue already make the protein to be studied and we will study the protein in these cells. Finally, the results obtained in isolation will be compared to results obtained from cells obtained from the tissue. We predict that the properties of the proteins in the cells from the tissue will be determined by the properties of the proteins observed in isolation. In this manner, we will define the role of P2X2-3 in cells. These results will also allow us to predict the role of similar proteins in nervous tissue
|
0.915 |
2001 — 2002 |
Bobbin, Richard P |
R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
Drug Manipulation of Noise-Induced Hearing Loss @ Louisiana State Univ Hsc New Orleans
DESCRIPTION (provided by applicant): The long-term objective of this research is to develop drugs that will decrease the effects of intense sound on the cochlea. Recent results from our laboratory have shown that PPADS, an ATP antagonist, decreases the effect of intense sound on the cochlea as monitored with distortion product otoacoustic emissions (DPOAEs). Our working hypothesis is that PPADS is blocking the effects of endogenous ATP acting on receptors on the perilymph surface of Deiters' cells. Exogenously applied ATP depolarizes Deiters' cells and increases their intracellular free calcium levels. Deiters' cells are innervated by what appears to be branches of type II afferents to the outer hair cells (OHCs). This suggests that the source of the ATP acting on ATP receptors on the Deiters' cells may be the terminals of these nerve fibers. Anatomically, Deiters' cells are attached to the base and apex of OHCs, to the basilar membrane, and reticular lamina. Thus Deiters' cells may play a significant role in the transduction process carried out by the OHCs and their stereocilia. Deiters' cells may do this by altering their own stiffness. The hypothesis to be tested is that ATP, proposed as a neurotransmitter in the cochlea, reacts with receptors on the Deiters' cells to enhance the deleterious effects of intense sound on the cochlea. This hypothesis will be tested by experiments that: (1) determine if endogenous ATP enhances the deleterious effects of intense sound by testing ATP agonists and antagonists during intense sound exposure; (2) determine if the mechanism of action of ATP involves a movement of Deiters' cell or a stiffness change; and (3) determine if the receptor mechanism on Deiters' cells involves the metabotropic P2Y type of receptor.
|
0.96 |