2010 |
Maidment, Andrew D.a. |
R03Activity Code Description: To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Radiologists'Performance in Digital Mammography and Breast Tomosynthesis @ University of Pennsylvania
DESCRIPTION (provided by applicant): Clinical Feasibility of Digital Breast Tomosynthesis: Analysis of Observer Performance Background: Digital breast tomosynthesis (DBT) is considered the latest and most promising development in breast cancer imaging. In clinical pilot studies DBT has demonstrated higher sensitivity and specificity over projection mammography, which is presently the breast cancer screening tool of choice. Importantly, DBT will be provided at a relatively modest premium compared to existing digital mammography (DM) systems. For these reasons it has been widely suggested that DBT will replace DM in the diagnosis of breast cancer;some further believe that DBT may replace mammography in screening breast cancer. A practical concern for implementation of DBT is the radiologists'review time because DBT generates approximately 50 times more images than mammography. An increase in review time might significantly impact the breast cancer screening capacity and thus access to screening. Objective: Our aim is to obtain insight into the likely success of DBT as the population breast cancer screening modality of choice by comparing the radiologists'performance to interpret DBT images with DM images for the detection of breast cancer using time-controlled viewing experiments. The time-controlled viewing conditions will provide an unbiased perceptual viewing situation to compare whether 3D DBT facilitates perceptual recognition of breast cancers compared to 2D DM. We will also record the eye positions of radiologists as they view DBT and DM cases. The eye position analyses will provide a rigorous metric that will enable the quantitative measurement of the radiologists'performance. These will help to understand the current status of review issues so that they can be better addressed in future studies. Specific Aims (SA): SA1: Develop a platform to display DBT and DM cases under time-controlled viewing conditions. SA2: Compare for DBT and DM the radiologists'breast cancers detection performance under time-controlled viewing conditions and analyze the eye positions. Study Design: SA1: Task 1: We will modify our existing display hardware and software to allow equally short presentation times (2 s and 4 s) for DBT and DM images. Task 2: We will design a graphical user interface for the radiologists to report their decisions after each time-controlled viewing. SA2: Task 1: An experienced MQSA-certified radiologist will select a set of paired DBT and DM images of 100 breasts. Task 2: Four experienced MQSA-certified radiologists will review the images during short time-controlled presentations while their eye positions are tracked. Task 3: We will process the eye-position data. Task 4: We will compare the radiologists'breast cancer detection performance and the analyses on the eye-position data between DBT and DM. PUBLIC HEALTH RELEVANCE: This proposal aims to investigate the potential of digital breast tomosynthesis (DBT) as a population screening modality. We will focus on comparing radiologists'performance to rapidly interpret DBT cross-sectional images in stack mode with DM projection images for the detection of breast cancer using short time-controlled viewing experiments.
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2011 — 2014 |
Maidment, Andrew D.a. |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Virtual Clinical Trials: Simulation of Digital Breast Tomosynthesis Screening @ University of Pennsylvania
DESCRIPTION (provided by applicant): Although shown to decrease breast cancer mortality, mammographic screening suffers from less than optimal sensitivity and specificity. This has led to the development of new breast screening technologies such as digital breast tomosynthesis (DBT) and dedicated breast CT. These new technologies have shown promise in early studies, but their innate complexity challenges optimization. Breast imaging represents a complex chain of image acquisition, display and interpretation that is best tested in a clinical trial. Conducting clinical trials comparing all potential configurations of DBT systems is simply not practical. In response, we propose an innovative system to perform virtual clinical trials (VCT) of breast imaging technologies. We envision VCTs being complementary to clinical trials, and having a critical role in preclinical testing of imaging devices, so that human clinical trials may be targeted to the most promising devices and appropriate clinical roles. This approach leverages unique expertise of the collaborators. The University of Pennsylvania has developed a 3D virtual breast phantom that is well suited for use in VCTs;it provides infinite anatomic variation and can simulate a multitude of breast lesions. The Barco MeVIC (Medical Virtual Imaging Chain) is among the most sophisticated observer modeling tools available, incorporating image acquisition, image processing, image reconstruction, image display, and the human visual and perceptual systems. We propose to integrate these technologies into a VCT system for digital mammography (DM) and DBT. The VCT system will be used to simulate an actual trial of DBT and DM being conducted by the ACRIN clinical trials network in order to compare relative performance in terms of sensitivity and specificity with an actual clinical trial. The richness of the VCT components will allow exploration of the broadest possible sampling of breast parenchyma, lesions, and observer performance. We propose the following. The existing voxel phantom and lesion models will be refined. The image simulation environment will be adapted to model the Hologic DM/DBT system. The existing MeVIC 2D channelized Hotelling observer (CHO) will be adapted to 3D (2D + time) by studying and then implementing the human spatio-temporal contrast sensitivity function. Various channeling mechanisms will be tested and perceptual factors such as degradation of memory with time will be included. 2D and 3D 2-AFC experiments will be conducted with human observers to estimate observer performance for each observer, modality and lesion type. The performance of the MeVIC observer models will be tested with real and synthetic DM and DBT images. The resultant validated 2D and 3D observer models will be used to conduct a VCT of DBT and DM screening. The results of the VCT will be compared to the results of the ongoing ACRIN PA clinical trial of DBT and DM screening. If successful, the VCT system can be utilized to test technology variations in breast cancer screening technology, accelerating development and clinical implementation of improved imaging systems in a more cost-efficient fashion. PUBLIC HEALTH RELEVANCE: Medical imaging is undergoing a rapid expansion both in terms of new devices and new methodologies;as the pace of medical device development increases, one is faced with the quandary of increasing the pace of clinical trials or finding effective and safe alternatives to some clinical trials. In response, we propose the development of an innovative system to perform virtual clinical trials (VCT) of breast cancer screening technology that builds on our prior work in developing a virtual breast phantom and complex observer model for 3D breast imaging. If successful, the VCT system can be utilized to test technology variations in breast cancer screening technology, accelerating development and clinical implementation of improved imaging systems in a more cost-efficient fashion.
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2014 |
Maidment, Andrew D.a. |
R13Activity Code Description: To support recipient sponsored and directed international, national or regional meetings, conferences and workshops. |
Iwdm-2014: the 12th International Workshop On Breast Imaging @ University of Pennsylvania
DESCRIPTION (provided by applicant): The 12th International Workshop on Breast Imaging (IWDM-2014) is the premiere international event for leading breast imaging research. The 12th IWDM will be held June 29 - July 2, 2014 in Gifu, Japan, hosted by Gifu University, with Dr. Hiroshi Fujita serving as the Chair of the Scientific Program Committee. The IWDM-2014 is designed as a platform to present the latest technological developments and clinical experiences of novel breast imaging technologies, including digital mammography, tomosynthesis, CT, MR, ultrasound, optical and molecular imaging. The International Workshop on Breast Imaging (formerly the International Workshop on Digital Mammography) brings together a diverse group of researchers, clinicians and representatives of industry, who are jointly committed to developing technology for the early detection and subsequent patient management of breast cancer. The workshops are designed to help advance the fields of breast cancer and medical imaging through the sharing of scientific discoveries, best clinical practices, and industrial innovations. The conference series was initiated at a 1993 meeting of the SPIE in San Jose, with subsequent meetings hosted every two years by researchers around the world. Subsequent meetings have been held in York (1994), Chicago (1996), Nijmegen (1998), Toronto (2000), Bremen (2002), Durham (2004), Manchester (2006), Tucson (2008), Girona (2010) and Philadelphia (2012). This R13 grant application is submitted in an effort to support the travel costs of graduate students and post-doctoral fellows who intend to present their original research at the IWDM-2014. An important consideration in the selection process is the diversification and participation of all traiees, including disadvantaged and under-represented individuals. Trainees need to be exposed to the broader international advances in their field - participation in the IWDM-2014 will help them gain this perspective.
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2014 — 2019 |
Davies, Peter Francis (co-PI) [⬀] Davies, Peter Francis (co-PI) [⬀] Gee, James C Maidment, Andrew D.a. |
T32Activity Code Description: To enable institutions to make National Research Service Awards to individuals selected by them for predoctoral and postdoctoral research training in specified shortage areas. |
Training Program in Biomedical Imaging and Informational Sciences @ University of Pennsylvania
DESCRIPTION (provided by applicant): The training of quantitative basic scientists in clinically-related imaging science is increasingly important. Excellent imaging sciences are well represented at Penn in multiple schools, but no formal integration of efforts in graduate training existed, nor was there a formal clinical component to the training until the creation of the Training Program in Biomedical Imaging and Informational Sciences. Established in 2006 under the auspices of the HHMI-NIBIB Interfaces Initiative, the program represents a partnership led by the Institute for Medicine and Engineering and the Department of Radiology in collaboration with many other Departments across multiple Schools. Our premise is that the most successful research and technologies in quantitative imaging science are those that integrate clinical relevance, mathematical rigor, and engineering finesse. Accordingly, the program embraces strong clinical exposure alongside analytical imaging science. The objective is to develop a new kind of interdisciplinary training by ensuring that students attain a level of integration that woud allow them to become the next generation of leaders in hypothesis-driven, clinically focused biomedical imaging research. Program outcomes to date are strong across all impact measures, indicating successful progress toward training objectives: publications (107); numerous research awards and distinctions; and recruitment of 6 URM and disadvantaged trainees. A formalized curriculum, the doctoral foundation, developed for the program provides 18 months of vertical integration of the core didactic elements of biomedicine and basic science education in biomedical imaging through 4 components, two of them Foundational, followed by Integrative and Professional components. In the first, Foundations in Biomedical Science (2 courses), students participate in modified modules 1 and 2 of the medical student curriculum that teaches the Core Principles of Medicine (including Gross Anatomy) and a 12- month sequence of organ systems medicine, Integrative Systems and Diseases. This is complemented by 4 courses in Foundations of Imaging Science: Molecular Imaging, Biomedical Image Analysis, Fundamental Techniques of Imaging, and Mathematics of Medical Imaging & Measurements. The third component is an Integrative Module: Advanced Biomedical Imaging Applications and Biomedical Image Sciences Seminars. The fourth component is Professional Training: Responsible Conduct of Research, Teaching Practicum, Patient-Oriented Research Training, Research 'Survival' Skills, and Career Development Skills. The core curriculum is complemented by many elective courses offered through the program faculty and tailored to Biomedical Imaging. Obligatory Laboratory Rotations will be offered through the laboratories of the participating faculty. To ensure that the thesis research is directed to translational medicine through the solution of discrete clinical problems, trainees will be co-advised by members of the clinical and basic science faculty.
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2016 |
Maidment, Andrew D.a. |
R13Activity Code Description: To support recipient sponsored and directed international, national or regional meetings, conferences and workshops. |
Iwdm-2016: the 13th International Workshop On Breast Imaging @ University of Pennsylvania
? DESCRIPTION (provided by applicant): The 13th International Workshop on Breast Imaging (IWDM?2016) is the premiere international event for leading breast imaging research. The 13th IWDM will be held June 19 - 22, 2016 in Malmö, Sweden, hosted by Malmö University Hospital, with Dr. Anders Tingberg serving as the Chair of the Scientific Program Committee. The IWDM?2016 is designed as a platform to present the latest technological developments and clinical experiences of novel breast imaging technologies, including digital mammography, tomosynthesis, CT, MR, ultrasound, optical and molecular imaging. The International Workshop on Breast Imaging (formerly the International Workshop on Digital Mammography) brings together a diverse group of researchers, clinicians and representatives of industry, who are jointly committed to developing technology for the early detection and subsequent patient management of breast cancer. The workshops are designed to help advance the fields of breast cancer and medical imaging through the sharing of scientific discoveries, best clinical practices, and indutrial innovations. The conference series was initiated at a 1993 meeting of the SPIE in San Jose, with subsequent meetings hosted every two years by researchers around the world. Subsequent meetings have been held in York (1994), Chicago (1996), Nijmegen (1998), Toronto (2000), Bremen (2002), Durham (2004), Manchester (2006), Tucson (2008), Girona (2010), Philadelphia (2012), and Gifu (2014). This R13 grant application is submitted in an effort to support the travel costs of graduate students and post?doctoral fellows who intend to present their original research at the IWDM?2016. An important consideration in the selection process is the diversification and participation of all trainees, including disadvantaged and under? represented individuals. Trainees need to be exposed to the broader international advances in their field - participation in the IWDM?2016 will help the gain this perspective.
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