Area:
growth come guidance
We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, James Zheng is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 2001 — 2006 |
Zheng, James |
N/AActivity Code Description:
No activity code was retrieved: click on the grant title for more information |
Ca2+-Signaling in Growth Cone Guidance @ Rutgers, the State University of New Jersey-Rbhs-Robert Wood
Each function of the adult nervous system, from a simple reflex response to a complex behavior, depends on the actions of distinct neuronal circuits. These circuits operate correctly because their component neurons are appropriately connected to each other. Precise wiring of these circuits requires guided growth of nerve fibers to reach the specific targets. Recent studies have identified a variety of molecular cues that provide the "road signs" for growing nerve fibers to navigate through their complex environment, with some of these cues attracting but others repelling growing nerve fibers. It is believed that the tiny, motile tip of each growing nerve fiber, known as the growth cone, is responsible for reading these "road signs" to steer the fiber in the appropriate direction (steering). Dr. Zheng's study aims to elucidate the mechanism by which motile growth cones accurately read direction from these extracellular cues. The research team will specifically focus on the role of intracellular calcium ions (Ca2+) in the growth cone's sensing of direction from diffusible cues. The hypothesis to be tested is that tempo-spatial Ca2+ signals in the growth cone provide the cellular mechanism for encoding of the directional information in the growth cone to initiate appropriate steering responses. Dr. Zheng's research team will use a combination of high-resolution digital imaging and manipulation techniques to examine the tempo-spatial pattern of intracellular Ca2+ signals associated with growth cone steering in response to different guidance cues. Furthermore, the research team will directly generate a similar tempo-spatial pattern of Ca2+ signals in the growth cone using a sophisticated laser-induced photoactivated release method to elucidate the precise role of these Ca2+ signals in guidance. The long-term goal of the study is to understand the molecular and cellular mechanisms that allow nerve growth cones to accurately sense direction in the complex extracellular space for the generation of highly ordered brain architecture.
|
0.922 |