2004 — 2008 |
Sakai, Joseph T |
K08Activity Code Description: To provide the opportunity for promising medical scientists with demonstrated aptitude to develop into independent investigators, or for faculty members to pursue research aspects of categorical areas applicable to the awarding unit, and aid in filling the academic faculty gap in these shortage areas within health profession's institutions of the country. |
Asian Teens, Substance Dependence and Conduct Disorder @ University of Colorado Denver
DESCRIPTION (provided by applicant): This application proposes five years of support to investigate the relationship between substance dependence, conduct disorder and certain genetic polymorphisms among Asian American adolescents. There is little research characterizing conduct disordered Asian American adolescents. General population estimates and the applicant's preliminary data suggest conduct disordered Asian American adolescents are a high-risk population for comorbid substance use disorders. Asians also have high prevalence of alleles that are known to affect alcohol and nicotine metabolism. Therefore, conduct disordered Asian American adolescents likely represent a genetically informative population regarding adolescent substance use disorders. The applicant proposes to collect a sample of Asian American adolescents with conduct disorder (n=100), Asian adolescent controls (n=200), and first-degree relatives of conduct disordered probands (n=162). The aims include 1) examining the relationship between conduct disorder and substance use disorders among Asian American adolescents, 2) testing whether substance dependence and conduct disorder are familial in Asian American families, and 3) testing whether ALDH and CYP2A6 genotypes are associated with alcohol and nicotine dependence. The proposed training includes 1) completion of formal coursework and workshops dealing with twin studies, genetic association and linkage studies, 2) mentored analyses of data already collected (DA11015), focusing on within and between family genetic association studies of adolescent substance use disorders, 3) mentored analyses of national data bases examining risk factors for substance dependence among Asian Americans, and 4) attendance at national meetings.
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0.948 |
2012 — 2015 |
Sakai, Joseph T |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Adolescents With Substance and Conduct Problems: Imaging Callous-Unemotionality @ University of Colorado Denver
DESCRIPTION (provided by applicant): This proposal, submitted by an early stage investigator, seeks four years of R01 support to conduct an MRI study of adolescent patients with serious substance and conduct problems and adolescent controls. This proposal seeks to identify the neural correlates (both functional and structural) of callous-unemotionality (CU). CU is identifiable in childhood and adolescence, is a relatively stable trait into adulthood, and is linked with persistent antisocial behavior problems and substance dependence; individuals with CU, antisocial behavior problems and substance use disorders appear more resistant to treatment. This proposal will also allow searching for neural correlates of subtypes of adolescent-onset substance dependence. We will recruit, complete extensive diagnostic interviews and image subjects while they play the AlAn's game. That game, which was designed for use in the MRI environment, has demonstrated a strong relationship with CU trait scores in our out-of-magnet pilot testing. PUBLIC HEALTH RELEVANCE: Substance use disorders and antisocial behavior are major public health problems, are linked to serious morbidity and high mortality and have a partial genetic etiology. Callous-unemotional traits are identifiable in childhood and adolescents, are relatively stable into young adulthood and predict future and persistent antisocial behavior and substance problems. The current study proposes a search for neurobiological correlates callous-unemotionality and subtypes of adolescent-onset substance dependence. Better understanding the biological etiology of these disorders may lead to better prevention or treatment approaches.
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0.948 |
2012 — 2017 |
Hopfer, Christian J [⬀] Sakai, Joseph T |
R25Activity Code Description: For support to develop and/or implement a program as it relates to a category in one or more of the areas of education, information, training, technical assistance, coordination, or evaluation. |
Substance Use Disorder Research Training For Medical Students @ University of Colorado Denver
DESCRIPTION (provided by applicant): The number of US citizens with substance use disorders or where substance use contributes to other health disorders is expected to continue to be high over the next several decades. Programs are needed to provide trainees with the skills to conduct research that helps prevent and treat substance use disorders. Physician scientists bring a unique perspective to substance use research and are a critical component of future advances in this area. This program will focus on recruiting and training medical students, preparing them for careers as substance use researchers. The program includes both core and individualized curricular components. Core curricular components include a seminar on substance use and disease, an ongoing work-in-progress seminar with both faculty and trainee involvement, and a seminar related to the Responsible Conduct of Research. The individualized curricular components include both class work and direct project experience, including dissemination, mentored by an experienced substance use researcher. Both short-term intensive and longitudinal training components are included; students will enter the program as first-year medical students and be involved in the program over all 4 years of medical school. Two new students per year will be recruited for a total of four students in the program at any one time. There will be ongoing evaluation of the program including both student feedback and outcome assessment. This will include short (e.g student satisfaction), intermediate (early publication and attitude changes), and long-term (long-term publication rates and success at receiving research grants) outcomes. A Senior Advisory Board will provide oversight for the program and ensure use of the outcome data for ongoing quality improvement of the program. PUBLIC HEALTH RELEVANCE: Substance use continues to be a major contributor to decreased health. Physician scientists add a unique and critical perspective to research that helps prevent and treat substance use disorders and the sequela of those disorders. This program will recruit and train medical students for careers as leaders in substance use research.
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0.948 |