Rosa A. DeFilippis, Ph.D.

Affiliations: 
Yale University, New Haven, CT 
Area:
Molecular Biology of Tumor Viruses
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"Rosa DeFilippis"
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Daniel C. DiMaio grad student 2002 Yale
 (Biochemical and phenotypic analysis of HeLa cervical carcinoma cells following specific repression of E6 or E7 oncogene expression.)
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Publications

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Mali RS, Zhang Q, DeFilippis R, et al. (2020) Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models. Haematologica
DeFilippis RA, Fordyce C, Patten K, et al. (2014) Stress signaling from human mammary epithelial cells contributes to phenotypes of mammographic density. Cancer Research. 74: 5032-44
Dumont N, Liu B, Defilippis RA, et al. (2013) Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics. Neoplasia (New York, N.Y.). 15: 249-62
Fordyce CA, Patten KT, Fessenden TB, et al. (2012) Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes. Breast Cancer Research : Bcr. 14: R155
Psyrri A, DeFilippis RA, Edwards AP, et al. (2004) Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cells. Cancer Research. 64: 3079-86
Horner SM, DeFilippis RA, Manuelidis L, et al. (2004) Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells. Journal of Virology. 78: 4063-73
DeFilippis RA, Goodwin EC, Wu L, et al. (2003) Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence, and apoptosis in HeLa cervical carcinoma cells. Journal of Virology. 77: 1551-63
Naeger LK, Goodwin EC, Hwang ES, et al. (1999) Bovine papillomavirus E2 protein activates a complex growth-inhibitory program in p53-negative HT-3 cervical carcinoma cells that includes repression of cyclin A and cdc25A phosphatase genes and accumulation of hypophosphorylated retinoblastoma protein. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 10: 413-22
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