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Paul J. Lombroso, MD

Affiliations: 
Child Study Center and Departments of Neurobiology and Psychiatry Yale University, New Haven, CT 
Area:
molecular psychiatry
Website:
http://medicine.yale.edu/labs/lombroso/
Google:
"Paul Lombroso"
Bio:

I have a somewhat unusual career trajectory that brings me to my current interest in translational neuroscience. I was a board-certified psychiatrist with an active clinical practice in Boston (Harvard Medical School) when I decided that molecular biology was a critical but neglected area in psychiatry. This was in the early 1980s when several genes for neuropsychiatric disorders were just being mapped onto specific chromosomes (e.g. Huntington's chorea). I was very excited by the idea that we could map genes and then find mutations within those genes that cause specific disorders. I decided to get retooled in molecular biology, as this discipline held the greatest promise to uncover the underlying molecular basis for neuropsychiatric disorders. Molecular biology would both advance our understanding for these disorders as well as suggest novel therapeutic interventions.

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Mean distance: 13.4 (cluster 6)
 		SNBCP
Cross-listing: PsychTree

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Parents

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Paul Greengard post-doc 1986-1987 Yale

Children

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Sara E. Royston research assistant Yale
Pradeep Kotapurathu Kurup grad student Yale
Deepa V. Venkitaramani post-doc 2005-2008 Yale School of Medicine

Collaborators

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Janice R. Naegele collaborator Yale School of Medicine
Benjamin Siemsen collaborator Yale
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Publications

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Chatterjee M, Singh P, Xu J, et al. (2020) Inhibition of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) Activity Reverses Behavioral Deficits in a Rodent Model of Autism. Behavioural Brain Research. 112713
Mallozzi C, Pepponi R, Visentin S, et al. (2019) The activity of the STriatal-Enriched protein tyrosine Phosphatase (STEP) in neuronal cells is modulated by adenosine A receptor. Journal of Neurochemistry
Dedek A, Xu J, Kandegedara CM, et al. (2019) Loss of STEP61 couples disinhibition to N-methyl-d-aspartate receptor potentiation in rodent and human spinal pain processing. Brain : a Journal of Neurology. 142: 1535-1546
Castonguay D, Dufort-Gervais J, Ménard C, et al. (2018) The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline. Current Biology : Cb
Bosco F, Valente P, Milanese M, et al. (2018) Altered Intracellular Calcium Homeostasis Underlying Enhanced Glutamatergic Transmission in Striatal-Enriched Tyrosine Phosphatase (STEP) Knockout Mice. Molecular Neurobiology
Tjin CC, Otley KD, Baguley TD, et al. (2017) Glutathione-Responsive Selenosulfide Prodrugs as a Platform Strategy for Potent and Selective Mechanism-Based Inhibition of Protein Tyrosine Phosphatases. Acs Central Science. 3: 1322-1328
Witten MR, Wissler L, Snow M, et al. (2017) X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors. Journal of Medicinal Chemistry
Chatterjee M, Kurup PK, Lundbye CJ, et al. (2017) STEP inhibition reverses behavioral, electrophysiologic, and synaptic abnormalities in Fmr1 KO mice. Neuropharmacology
Xu J, Kurup P, Nairn AC, et al. (2017) Synaptic NMDA Receptor Activation Induces Ubiquitination and Degradation of STEP61. Molecular Neurobiology
Siemsen BM, Lombroso PJ, McGinty JF. (2017) Intra-prelimbic cortical inhibition of striatal-enriched tyrosine phosphatase suppresses cocaine seeking in rats. Addiction Biology
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