Juan P. Cueva, Ph.D.
Affiliations: | Medicinal Chemistry and Molecular Pharmacology | Purdue University, West Lafayette, IN, United States |
Area:
Dopamine and Serotonin AgonistsGoogle:
"Juan Cueva"Mean distance: 18.16 (cluster 11)
Parents
Sign in to add mentor| David E. Nichols | grad student | 2008 | Purdue | |
| (Inquiry into the structural and conformational requirements of beta-phenyldopamine-type ligands for selective dopamine D1 receptor activation.) | ||||
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Publications
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| Cueva JP, Roche C, Ostovar M, et al. (2015) C7β-Methyl Analogues of the Orvinols: The Discovery of Kappa Opioid Antagonists with Nociceptin/Orphanin FQ Peptide (NOP) Receptor Partial Agonism and Low, or Zero, Efficacy at Mu Opioid Receptors. Journal of Medicinal Chemistry. 58: 4242-9 |
| Kormos CM, Cueva JP, Gichinga MG, et al. (2014) Effect of the 3- and 4-methyl groups on the opioid receptor properties of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines. Journal of Medicinal Chemistry. 57: 3140-7 |
| Kormos CM, Jin C, Cueva JP, et al. (2013) Discovery of N-{4-[(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2-methylpropyl}-4-phenoxybenzamide analogues as selective kappa opioid receptor antagonists. Journal of Medicinal Chemistry. 56: 4551-67 |
| Juncosa JI, Hansen M, Bonner LA, et al. (2013) Extensive rigid analogue design maps the binding conformation of potent N-benzylphenethylamine 5-HT2A serotonin receptor agonist ligands. Acs Chemical Neuroscience. 4: 96-109 |
| Cueva JP, Chemel BR, Juncosa JI, et al. (2012) Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a]phenanthridines. European Journal of Medicinal Chemistry. 48: 97-107 |
| Cueva JP, Gallardo-Godoy A, Juncosa JI, et al. (2011) Probing the steric space at the floor of the D1 dopamine receptor orthosteric binding domain: 7α-, 7β-, 8α-, and 8β-methyl substituted dihydrexidine analogues. Journal of Medicinal Chemistry. 54: 5508-21 |
| Clark LH, Cueva JP, McCorvy JD, et al. (2011) C-Ring expanded analogs of doxanthrine: Conformation plays a critical role Arkivoc. 2010: 125-138 |
| Carroll FI, Cueva JP, Thomas JB, et al. (2010) 1-Substituted 4-(3-Hydroxyphenyl)piperazines Are Pure Opioid Receptor Antagonists. Acs Medicinal Chemistry Letters. 1: 365-369 |
| Cueva JP, Cai TB, Mascarella SW, et al. (2009) Synthesis and in vitro opioid receptor functional antagonism of methyl-substituted analogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). Journal of Medicinal Chemistry. 52: 7463-72 |
| Przybyla JA, Cueva JP, Chemel BR, et al. (2009) Comparison of the enantiomers of (+/-)-doxanthrine, a high efficacy full dopamine D(1) receptor agonist, and a reversal of enantioselectivity at D(1) versus alpha(2C) adrenergic receptors. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 19: 138-46 |