Paul M. Lea, Ph.D.

Affiliations: 
Uniformed Services University of the Health Sciences, Bethesda, MD 
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"Paul Lea"
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John M. Sarvey grad student 2000 Uniformed Services University
 (Modulation of long -term potentiation and epileptiform activity in the rat dentate gyrus by the group II metabotropic glutamate receptor subtype mGluR3.)
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Publications

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Lea PM, Faden AI. (2006) Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP. Cns Drug Reviews. 12: 149-66
Lea PM, Movsesyan VA, Faden AI. (2005) Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors. British Journal of Pharmacology. 145: 527-34
Movsesyan VA, Stoica BA, Yakovlev AG, et al. (2004) Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways. Cell Death and Differentiation. 11: 1121-32
Cernak I, Vink R, Natale J, et al. (2004) The "dark side" of endocannabinoids: a neurotoxic role for anandamide. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 24: 564-78
Lea PM, Faden AI. (2003) Modulation of metabotropic glutamate receptors as potential treatment for acute and chronic neurodegenerative disorders. Drug News & Perspectives. 16: 513-22
Lea PM, Custer SJ, Stoica BA, et al. (2003) Modulation of stretch-induced enhancement of neuronal NMDA receptor current by mGluR1 depends upon presence of glia. Journal of Neurotrauma. 20: 1233-49
Lea PM, Sarvey JM. (2003) Modulation of epileptiform burst frequency by the metabotropic glutamate receptor subtype mGluR3. Epilepsy Research. 53: 207-15
Lea PM, Custer SJ, Vicini S, et al. (2002) Neuronal and glial mGluR5 modulation prevents stretch-induced enhancement of NMDA receptor current. Pharmacology, Biochemistry, and Behavior. 73: 287-98
Lea PM, Faden AI. (2001) Traumatic brain injury: developmental differences in glutamate receptor response and the impact on treatment. Mental Retardation and Developmental Disabilities Research Reviews. 7: 235-48
Lea PM, Wroblewska B, Sarvey JM, et al. (2001) beta-NAAG rescues LTP from blockade by NAAG in rat dentate gyrus via the type 3 metabotropic glutamate receptor. Journal of Neurophysiology. 85: 1097-106
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