Ken A. Witt, Ph.D.

Affiliations: 
University of Arizona, Tucson, AZ 
Area:
blood-brain barrier, drug delivery
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"Ken Witt"
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Thomas P. Davis grad student 2001 University of Arizona
 (Modification of opioid peptides to enhance permeability into the brain.)
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Publications

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Reeb C, Sandoval K, Wooten J, et al. (2020) Dietary Dependent Alteration of Blood‐Brain Barrier Tight Junctional Protein Expression The Faseb Journal. 34: 1-1
Sandoval K, Umbaugh D, House A, et al. (2019) Somatostatin Receptor Subtype-4 Regulates mRNA Expression of Amyloid-Beta Degrading Enzymes and Microglia Mediators of Phagocytosis in Brains of 3xTg-AD Mice. Neurochemical Research
Witt KA, Sandoval KE. (2014) Steroids and the blood-brain barrier: therapeutic implications. Advances in Pharmacology (San Diego, Calif.). 71: 361-90
Sandoval KE, Farr SA, Banks WA, et al. (2013) Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ(42) oligomers via a metalloproteinase-dependent mechanism. Brain Research. 1520: 145-56
Egleton RD, Witt KA, Davis TP. (2013) Opioid Peptides Handbook of Biologically Active Peptides. 1696-1701
Sandoval KE, Farr SA, Banks WA, et al. (2012) Somatostatin receptor subtype-4 agonist NNC 26-9100 decreases extracellular and intracellular Aβ₁₋₄₂ trimers. European Journal of Pharmacology. 683: 116-24
Sandoval KE, Witt KA. (2011) Age and 17β-estradiol effects on blood-brain barrier tight junction and estrogen receptor proteins in ovariectomized rats. Microvascular Research. 81: 198-205
Sandoval KE, Farr SA, Banks WA, et al. (2011) Chronic peripheral administration of somatostatin receptor subtype-4 agonist NNC 26-9100 enhances learning and memory in SAMP8 mice. European Journal of Pharmacology. 654: 53-9
Witt KA, Ronaldson PT, Sandoval KE, et al. (2010) CNS delivery of peptides across the bbb using the dual-artery in situ brain perfusion model Neuromethods. 45: 233-247
Sandoval KE, Witt KA. (2008) Blood-brain barrier tight junction permeability and ischemic stroke. Neurobiology of Disease. 32: 200-19
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