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Joseph Ramcharan, Ph.D.

Affiliations: 
Pennsylvania State University, State College, PA, United States 
Area:
Bioanalytical Chemistry
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"Joseph Ramcharan"
Mean distance: 17.61 (cluster 6)
 		SNBCP
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Parents

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Stephen J. Benkovic grad student 2001 Penn State (Chemistry Tree)
 (De novo purine biosynthesis: Interaction and inhibition studies of AICAR transformylase.)
Andrew G. Ewing grad student 2001 Penn State
 (De novo purine biosynthesis: Interaction and inhibition studies of AICAR transformylase.)

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BETA: Related publications

Publications

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Marsilje TH, Labroli MA, Hedrick MP, et al. (2002) 10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway. Bioorganic & Medicinal Chemistry. 10: 2739-49
Gooljarsingh LT, Ramcharan J, Gilroy S, et al. (2001) Localization of GAR transformylase in Escherichia coli and mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 6565-70
Greasley SE, Horton P, Ramcharan J, et al. (2001) Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis. Nature Structural Biology. 8: 402-6
Benkovic SJ, Gooljarsingh L, Ramcharan J, et al. (2000) The Transformylase Enzymes in de Novo Purine Biosynthesis Biochemical Society Transactions. 28: A122-A122
Boger DL, Kochanny MJ, Cai H, et al. (1998) Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors. Bioorganic & Medicinal Chemistry. 6: 643-59
Boger DL, Haynes NE, Warren MS, et al. (1997) Multisubstrate analogue based on 5,8,10-trideazafolate. Bioorganic & Medicinal Chemistry. 5: 1853-7
Boger DL, Haynes NE, Warren MS, et al. (1997) Abenzyl 10-formyl-trideazafolic acid (abenzyl 10-formyl-TDAF): an effective inhibitor of glycinamide ribonucleotide transformylase. Bioorganic & Medicinal Chemistry. 5: 1847-52
Boger DL, Haynes NE, Warren MS, et al. (1997) Functionalized analogues of 5,8,10-trideazafolate: development of an enzyme-assembled tight binding inhibitor of GAR Tfase and a potential irreversible inhibitor of AICAR Tfase. Bioorganic & Medicinal Chemistry. 5: 1839-46
Boger DL, Haynes NE, Warren MS, et al. (1997) Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase. Bioorganic & Medicinal Chemistry. 5: 1831-8
Boger DL, Haynes NE, Kitos PA, et al. (1997) 10-Formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): a potent inhibitor of glycinamide ribonucleotide transformylase. Bioorganic & Medicinal Chemistry. 5: 1817-30
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