Shikhar Sharma, Ph.D.
Affiliations: | 2010 | Genetic, Molecular, and Cell Biology | University of Southern California, Los Angeles, CA, United States |
Area:
DNA methylation, cancer, epigeneticsGoogle:
"Shikhar Sharma"Mean distance: 14248.8
Parents
Sign in to add mentor| Peter A. Jones | grad student | 2010 | USC | |
| (Role of DNA methyltransferases 3A and 3B in inheritance of DNA methylation patterns.) | ||||
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Publications
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| Qiu J, Sharma S, Rollins RA, et al. (2020) The complex role of EZH2 in the tumor microenvironment: opportunities and challenges for immunotherapy combinations. Future Medicinal Chemistry |
| Rugo HS, Jacobs I, Sharma S, et al. (2020) The Promise for Histone Methyltransferase Inhibitors for Epigenetic Therapy in Clinical Oncology: A Narrative Review. Advances in Therapy |
| Kung PP, Bingham P, Brooun A, et al. (2017) Optimization of orally bioavailable enhancer of zeste homolog 2 (EZH2) inhibitors using ligand and property-based design strategies: Identification of development candidate (R)-5,8-dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497). Journal of Medicinal Chemistry |
| Vangamudi B, Paul TA, Shah PK, et al. (2015) The SMARCA2/4 ATPase domain surpasses the bromodomain as a drug target in SWI/SNF mutant cancers: Insights from cDNA rescue and PFI-3 inhibitor studies. Cancer Research |
| Vangamudi B, Paul T, Shah PK, et al. (2015) Abstract 3528: The SMARCA2/4 catalytic activity, but not the bromodomain, is a drug target in SWI/SNF mutant cancers Cancer Research. 75: 3528-3528 |
| Paul TA, Sharma S, Hallin J, et al. (2015) Abstract 3518: Growth inhibition of SCLC cell lines by treatment with LSD1 inhibitors is associated with modulation of neuroendocrine pathways Cancer Research. 75: 3518-3518 |
| De Carvalho DD, Sharma S, You JS, et al. (2012) DNA methylation screening identifies driver epigenetic events of cancer cell survival. Cancer Cell. 21: 655-67 |
| Sharma S, Gerke DS, Han HF, et al. (2012) Lysine methyltransferase G9a is not required for DNMT3A/3B anchoring to methylated nucleosomes and maintenance of DNA methylation in somatic cells. Epigenetics & Chromatin. 5: 3 |
| Sharma S, De Carvalho DD, Jeong S, et al. (2011) Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance. Plos Genetics. 7: e1001286 |
| Wolff EM, Byun HM, Han HF, et al. (2010) Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer. Plos Genetics. 6: e1000917 |