Jennifer M. Spaethling, Ph.D.

Affiliations: 
2010 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Biomechanics, Traumatic Brain Injury
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"Jennifer Spaethling"
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David Meaney grad student 2010 Penn
 (Signaling leading to calcium-permeable AMPA receptors and their role in neuronal loss following mechanical injury.)
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Publications

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Spaethling JM, Na YJ, Lee J, et al. (2017) Primary Cell Culture of Live Neurosurgically Resected Aged Adult Human Brain Cells and Single Cell Transcriptomics. Cell Reports. 18: 791-803
Cavanaugh DJ, Geratowski JD, Wooltorton JR, et al. (2014) Identification of a circadian output circuit for rest:activity rhythms in Drosophila. Cell. 157: 689-701
Spaethling J, Le L, Meaney DF. (2012) NMDA receptor mediated phosphorylation of GluR1 subunits contributes to the appearance of calcium-permeable AMPA receptors after mechanical stretch injury. Neurobiology of Disease. 46: 646-54
Singh P, Doshi S, Spaethling JM, et al. (2012) N-methyl-D-aspartate receptor mechanosensitivity is governed by C terminus of NR2B subunit. The Journal of Biological Chemistry. 287: 4348-59
von Reyn CR, Spaethling JM, Mesfin MN, et al. (2009) Calpain mediates proteolysis of the voltage-gated sodium channel alpha-subunit. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 10350-6
Spaethling JM, Klein DM, Singh P, et al. (2008) Calcium-permeable AMPA receptors appear in cortical neurons after traumatic mechanical injury and contribute to neuronal fate. Journal of Neurotrauma. 25: 1207-16
Spaethling JM, Geddes-Klein DM, Miller WJ, et al. (2007) Linking impact to cellular and molecular sequelae of CNS injury: modeling in vivo complexity with in vitro simplicity. Progress in Brain Research. 161: 27-39
Spaethling J, Rozak E, Eberwine J. (2006) Molecular Neurobiology, Single‐Cell Reviews in Cell Biology and Molecular Medicine
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