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Chris D. Pacheco

Affiliations: 
2002-2008 University of Michigan, Ann Arbor, Ann Arbor, MI 
 2008-2010 Whitehead Institute for Biomedical Research (MIT) 
Area:
Neurodegeneration
Google:
"Chris Pacheco"
Mean distance: 18.17 (cluster 24)
 		SNBCP
Cross-listing: MichiganTree

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Parents

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Andrew P. Lieberman grad student 2008 University of Michigan
 (Autophagy and tau in Niemann-Pick type C disease.)
Susan L. Lindquist post-doc 2008-2010 Whitehead Institute for Biomedical Research (MIT) (FlyTree)

Children

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Publications

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Krishnan R, Goodman JL, Mukhopadhyay S, et al. (2012) Conserved features of intermediates in amyloid assembly determine their benign or toxic states. Proceedings of the National Academy of Sciences of the United States of America. 109: 11172-7
Dumitriu A, Pacheco CD, Wilk JB, et al. (2011) Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study. Human Molecular Genetics. 20: 1478-87
Elrick MJ, Pacheco CD, Yu T, et al. (2010) Conditional Niemann-Pick C mice demonstrate cell autonomous Purkinje cell neurodegeneration. Human Molecular Genetics. 19: 837-47
Pacheco CD, Elrick MJ, Lieberman AP. (2009) Tau normal function influences Niemann-Pick type C disease pathogenesis in mice and modulates autophagy in NPC1-deficient cells. Autophagy. 5: 548-50
Pacheco CD, Elrick MJ, Lieberman AP. (2009) Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis. Human Molecular Genetics. 18: 956-65
Pacheco CD, Lieberman AP. (2008) The pathogenesis of Niemann-Pick type C disease: a role for autophagy? Expert Reviews in Molecular Medicine. 10: e26
Hughes ED, Qu YY, Genik SJ, et al. (2007) Genetic variation in C57BL/6 ES cell lines and genetic instability in the Bruce4 C57BL/6 ES cell line. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 18: 549-58
Pacheco CD, Lieberman AP. (2007) Lipid trafficking defects increase Beclin-1 and activate autophagy in Niemann-Pick type C disease. Autophagy. 3: 487-9
Pacheco CD, Kunkel R, Lieberman AP. (2007) Autophagy in Niemann-Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects. Human Molecular Genetics. 16: 1495-503
Schauber CA, Tuerk MJ, Pacheco CD, et al. (2004) Lentiviral vectors pseudotyped with baculovirus gp64 efficiently transduce mouse cells in vivo and show tropism restriction against hematopoietic cell types in vitro. Gene Therapy. 11: 266-75
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