David Spanswick

Affiliations: 
University of Warwick, Coventry, England, United Kingdom 
Area:
Neuronal electrophysiology
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"David Spanswick"
Bio:

Main areas of research interests are broadly three-fold and relate to: Neuronal electrical synapses in health and disease. Central autonomic control of organ, body and cardiovascular homeostasis in health and disease at the level of the hypothalamus. These interests are related in that electrotonic coupling is an important feature of autonomic sympathetic preganglionic neurones (SPN) and the SPN are the model for health and disease that research within the group has previously focused on. Future research aims are to build upon and develop already on-going projects relating to these general themes. The work involves combined electrophysiological, anatomical and molecular approaches in collaboration with colleagues both overseas and within the UK.

Mean distance: 35622 (cluster 6)
 
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Publications

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Patra PH, Tench B, Hitrec T, et al. (2022) Pro-opiomelanocortin neurons in the nucleus of the solitary tract mediate endorphinergic endogenous analgesia in mice. Pain
Sykes MJ, Kekesi OS, Wong YT, et al. (2021) Neuron-specific responses to acetylcholine within the spinal dorsal horn circuits of rodent and primate. Neuropharmacology. 198: 108755
Haynes VR, Michael NJ, van den Top M, et al. (2020) A Neural basis for Octanoic acid regulation of energy balance. Molecular Metabolism. 34: 54-71
Dodd GT, Michael NJ, Lee-Young RS, et al. (2018) Insulin regulates POMC neuronal plasticity to control glucose metabolism. Elife. 7
Dodd GT, Michael NJ, Lee-Young RS, et al. (2018) Author response: Insulin regulates POMC neuronal plasticity to control glucose metabolism Elife
Michael NJ, Simonds SE, van den Top M, et al. (2017) Mitochondrial uncoupling in the melanocortin system differentially regulates NPY and POMC neurons to promote weight-loss. Molecular Metabolism. 6: 1103-1112
Dodd GT, Andrews ZB, Simonds SE, et al. (2017) A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding. Cell Metabolism. 26: 375-393.e7
Jones MG, Andreou AP, McMahon SB, et al. (2016) Pharmacology of reflex blinks in the rat: a novel model for headache research. The Journal of Headache and Pain. 17: 96
Andreetta F, Carboni L, Grafton G, et al. (2016) Hippocampal 5-HT7 receptors signal phosphorylation of the GluA1 subunit to facilitate AMPA receptor mediated-neurotransmission in vitro and in vivo. British Journal of Pharmacology
Barrett P, Van Den Top M, Wilson D, et al. (2014) Short photoperiod-induced decrease of histamine H3 receptors facilitates activation of hypothalamic neurons in the Siberian hamster (Endocrinology (2009) 150, (3655-3663) DOI: 10.1210/en.2008-1620) Endocrinology. 155: 1566
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