Karen Horsburgh

Affiliations: 
Neuroscience University of Edinburgh, Edinburgh, Scotland, United Kingdom 
Area:
Cerebral metabolism, pathology
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"Karen Horsburgh"
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Publications

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Askew KE, Beverley J, Sigfridsson E, et al. (2023) Inhibiting CSF1R alleviates cerebrovascular white matter disease and cognitive impairment. Glia
Alfieri A, Koudelka J, Li M, et al. (2022) Nox2 underpins microvascular inflammation and vascular contributions to cognitive decline. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X221077766
Sigfridsson E, Marangoni M, Hardingham GE, et al. (2020) Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment. Journal of Neuroinflammation. 17: 367
Stevenson W, Hase Y, Wilson E, et al. (2020) Long-term effects of experimental carotid stenosis on hippocampal infarct pathology, neurons and glia and amelioration by environmental enrichment. Brain Research Bulletin
Hase Y, Polvikoski TM, Firbank MJ, et al. (2019) Small Vessel Disease Pathological Changes in Neurodegenerative and Vascular Dementias concomitant with Autonomic Dysfunction. Brain Pathology (Zurich, Switzerland)
Sigfridsson E, Marangoni M, Johnson JA, et al. (2018) Astrocyte-specific overexpression of Nrf2 protects against optic tract damage and behavioural alterations in a mouse model of cerebral hypoperfusion. Scientific Reports. 8: 12552
Horsburgh K, Wardlaw JM, van Agtmael T, et al. (2018) Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. Clinical Science (London, England : 1979). 132: 851-868
Hase Y, Horsburgh K, Ihara M, et al. (2017) White Matter Degeneration in Vascular and Other Ageing-Related Dementias. Journal of Neurochemistry
Duncombe J, Kitamura A, Hase Y, et al. (2017) Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia. Clinical Science (London, England : 1979). 131: 2451-2468
Manso Y, Holland PR, Kitamura A, et al. (2017) Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease. Glia
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