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Stephen V. Desiderio

Affiliations: 
Molecular Biology and Genetics Johns Hopkins University School of Medicine, Baltimore, MD, United States 
Area:
Development of Immune System
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"Stephen Desiderio"
Mean distance: 15.37 (cluster 6)
 		SNBCP
Cross-listing: Chemistry Tree

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Parents

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David Baltimore post-doc MIT (Chemistry Tree)

Children

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Susan M. Dymecki grad student Johns Hopkins Medical School
Yun Liu grad student 2003-2009 (GenetiTree)

Collaborators

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Scheherazade Sadegh-Nasseri collaborator (Chemistry Tree)
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Publications

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May MR, Bettridge JT, Desiderio S. (2020) Binding and allosteric transmission of histone H3 Lys-4 trimethylation to the recombinase RAG-1 are separable functions of the RAG-2 plant homeodomain finger. The Journal of Biological Chemistry. 295: 9052-9060
Ahmed R, Omidian Z, Giwa A, et al. (2019) A Public BCR Present in a Unique Dual-Receptor-Expressing Lymphocyte from Type 1 Diabetes Patients Encodes a Potent T Cell Autoantigen. Cell. 177: 1583-1599.e16
Wagner CL, Hanumanthu VS, Talbot CC, et al. (2018) Short telomere syndromes cause a primary T cell immunodeficiency. The Journal of Clinical Investigation
Ward A, Kumari G, Sen R, et al. (2018) The RAG-2 Inhibitory Domain Gates Accessibility Of The V(D)J Recombinase To Chromatin. Molecular and Cellular Biology
May M, Desiderio S, Bettridge JT. (2018) An Allosteric Mechanism for Epigenetic Activation of the V(D)J Recombinase Blood. 132: 512-512
Lu W, Dordai D, Huso D, et al. (2017) Smoothened signaling in the mouse osteoblastoid lineage is required for efficient B lymphopoiesis. Blood
Bettridge J, Na CH, Pandey A, et al. (2017) H3K4me3 induces allosteric conformational changes in the DNA-binding and catalytic regions of the V(D)J recombinase. Proceedings of the National Academy of Sciences of the United States of America
Desiderio S. (2016) Pumping the breaks on B cell development. The Journal of Experimental Medicine. 213: 140
Bettridge JT, Na C, Pandey A, et al. (2016) Allosteric Regulation of V(D)J Recombination By Active Chromatin Blood. 128: 3707-3707
Lu C, Ward A, Bettridge J, et al. (2015) An autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation. Cell Reports. 10: 29-38
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