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Heather R. Brignull

Affiliations: 
University of Washington, Seattle, Seattle, WA 
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"Heather Brignull"
Mean distance: 15.79 (cluster 11)
 		SNBCP
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Parents

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Richard I. Morimoto grad student 2005 Northwestern
 (Modeling neurodegenerative disease in Caenorhabditis elegans.)
David W. Raible post-doc 2007-2015 University of Washington

Children

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Publications

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Teixeira-Castro A, Ailion M, Jalles A, et al. (2011) Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways. Human Molecular Genetics. 20: 2996-3009
Brignull HR, Raible DW, Stone JS. (2009) Feathers and fins: non-mammalian models for hair cell regeneration. Brain Research. 1277: 12-23
Brignull HR, Morley JF, Morimoto RI. (2007) The stress of misfolded proteins: C. elegans models for neurodegenerative disease and aging. Advances in Experimental Medicine and Biology. 594: 167-89
Brignull HR, Morley JF, Garcia SM, et al. (2006) Modeling polyglutamine pathogenesis in C. elegans. Methods in Enzymology. 412: 256-82
Brignull HR, Moore FE, Tang SJ, et al. (2006) Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 7597-606
Gidalevitz T, Ben-Zvi A, Ho KH, et al. (2006) Progressive disruption of cellular protein folding in models of polyglutamine diseases. Science (New York, N.Y.). 311: 1471-4
Morley JF, Brignull HR, Weyers JJ, et al. (2002) The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 99: 10417-22
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