Al La Spada, MD PhD
Affiliations: | 1993-2009 | University of Washington, Seattle, Seattle, WA | |
| 2009- | Pediatrics | University of California, San Diego, La Jolla, CA |
Area:
Polyglutamine disease mechanismsWebsite:
https://profiles.ucsd.edu/albert.laspadaGoogle:
"Al La Spada"Bio:
https://medschool.ucsd.edu/education/neurograd/faculty/Pages/albert-spada.aspx
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Mean distance: 16.6 (cluster 11) | S | N | B | C | P |
Children
Sign in to add trainee| Scott A. Wilke | research assistant | UCSD | |
| Stephan J. Guyenet | grad student | 2009 | University of Washington |
| Jamie Ann Johansen | post-doc | 2008-2010 | UCSD |
| Stevan N. Djakovic | post-doc | 2010-2011 | UCSD |
BETA: Related publications
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Publications
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| Bennett CL, Dastidar S, Arnold FJ, et al. (2023) Senataxin helicase, the causal gene defect in ALS4, is a significant modifier of C9orf72 ALS G4C2 and arginine-containing dipeptide repeat toxicity. Acta Neuropathologica Communications. 11: 164 |
| Gromova A, Cha B, Robinson EM, et al. (2023) X-linked SBMA model mice display relevant non-neurological phenotypes and their expression of mutant androgen receptor protein in motor neurons is not required for neuromuscular disease. Acta Neuropathologica Communications. 11: 90 |
| Lim WF, Forouhan M, Roberts TC, et al. (2021) Gene therapy with AR isoform 2 rescues spinal and bulbar muscular atrophy phenotype by modulating AR transcriptional activity. Science Advances. 7 |
| Zhu Q, Jiang J, Gendron TF, et al. (2020) Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72. Nature Neuroscience |
| Gray AL, Annan L, Dick JRT, et al. (2020) Deterioration of muscle force and contractile characteristics are early pathological events in spinal and bulbar muscular atrophy mice. Disease Models & Mechanisms |
| Malik B, Devine H, Patani R, et al. (2019) Gene expression analysis reveals early dysregulation of disease pathways and links Chmp7 to pathogenesis of spinal and bulbar muscular atrophy. Scientific Reports. 9: 3539 |
| Wenzel HJ, Murray KD, Haify SN, et al. (2019) Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pathology. Acta Neuropathologica Communications. 7: 27 |
| Cortes CJ, La Spada AR. (2018) TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities. Neurobiology of Disease |
| Bennett CL, Dastidar SG, Ling SC, et al. (2018) Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients. Acta Neuropathologica |
| Badders NM, Korff A, Miranda HC, et al. (2018) Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy. Nature Medicine |