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Lisa K. Brents, Ph.D.

Affiliations: 
2013 Interdisciplinary Toxicology University of Arkansas for Medical Sciences, United States 
Area:
Pharmacology, Behavioral Psychology
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Paul L. Prather grad student 2013 UAMS
 (Active metabolites and drug-drug interactions of the synthetic cannabinoids JWH-018 and JWH-073 at the Cannabinoid 1 Receptor.)
William E. Fantegrossi research scientist 2016- UAMS

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Publications

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Janganati V, Salazar P, Parks BJ, et al. (2023) Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine and resists metabolism to the active metabolite norbuprenorphine in rats. Frontiers in Pharmacology. 14: 1123261
Brents LK, Kulbeth HJ. (2020) Automated Quantification of Opioid Withdrawal Severity in Neonatal Rat Pups Using Ethovision® XT Software The Faseb Journal. 34: 1-1
Griffin BA, Caperton CO, Russell LN, et al. (2019) exposure to norbuprenorphine, a major metabolite of buprenorphine, induces fetal opioid dependence and leads to neonatal opioid withdrawal syndrome. The Journal of Pharmacology and Experimental Therapeutics
Brents L, Griffin BA, Caperton C, et al. (2018) 2421 Development and validation of a translational rat model of neonatal abstinence syndrome Journal of Clinical and Translational Science. 2: 9-9
Tai S, Hyatt WS, Gu C, et al. (2015) Repeated administration of phytocannabinoid Δ(9)-THC or synthetic cannabinoids JWH-018 and JWH-073 induces tolerance to hypothermia but not locomotor suppression in mice, and reduces CB1 receptor expression and function in a brain region-specific manner. Pharmacological Research. 102: 22-32
Marshell R, Kearney-Ramos T, Brents LK, et al. (2014) In vivo effects of synthetic cannabinoids JWH-018 and JWH-073 and phytocannabinoid Δ9-THC in mice: inhalation versus intraperitoneal injection. Pharmacology, Biochemistry, and Behavior. 124: 40-7
Brents LK, Prather PL. (2014) The K2/Spice phenomenon: emergence, identification, legislation and metabolic characterization of synthetic cannabinoids in herbal incense products. Drug Metabolism Reviews. 46: 72-85
Brents LK, Zimmerman SM, Saffell AR, et al. (2013) Differential drug-drug interactions of the synthetic cannabinoids JWH-018 and JWH-073: Implications for drug abuse liability and pain therapys Journal of Pharmacology and Experimental Therapeutics. 346: 350-361
Rajasekaran M, Brents LK, Franks LN, et al. (2013) Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors. Toxicology and Applied Pharmacology. 269: 100-8
Madadi NR, Penthala NR, Brents LK, et al. (2013) Evaluation of (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)-quinuclidin-3-one analogues as novel, high affinity ligands for CB1 and CB2 cannabinoid receptors. Bioorganic & Medicinal Chemistry Letters. 23: 2019-21
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