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Lori Isom

Affiliations: 
University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Sodium Channels
Google:
"Lori Isom"
Mean distance: 15.45 (cluster 11)
 		SNBCP
Cross-listing: MichiganTree

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Parents

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William A. Catterall post-doc 1988-1993 University of Washington

Children

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Larisa C. Kruger grad student 2010- University of Michigan
Dyke P. McEwen grad student 2004 University of Michigan
Tigwa H. Davis grad student 1999-2006 University of Michigan
Amanda J. Fein grad student 2007 University of Michigan
Heather A. O'Malley grad student 2009 University of Michigan
Gustavo A. Patino grad student 2010 University of Michigan
Jeffrey D. Calhoun grad student 2013 University of Michigan

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Publications

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Chen C, Ziobro J, Robinson-Cooper L, et al. (2023) Epilepsy and sudden unexpected death in epilepsy in a mouse model of human -linked developmental and epileptic encephalopathy. Brain Communications. 5: fcad283
Yuan Y, Lopez-Santiago L, Denomme N, et al. (2023) ASO restores excitability, GABA signalling and sodium current density in a model of Dravet syndrome. Brain : a Journal of Neurology
Hull JM, Denomme N, Yuan Y, et al. (2023) Heterogeneity of voltage gated sodium current density between neurons decorrelates spiking and suppresses network synchronization in Scn1b null mouse models. Scientific Reports. 13: 8887
Hodges SL, Bouza AA, Isom LL. (2022) Therapeutic Potential of Targeting Regulated Intramembrane Proteolysis Mechanisms of Voltage-Gated Ion Channel Subunits and Cell Adhesion Molecules. Pharmacological Reviews. 74: 1028-1048
Haworth AS, Hodges SL, Capatina AL, et al. (2022) Subcellular dynamics and functional activity of the cleaved intracellular domain of the Na channel β1 subunit. The Journal of Biological Chemistry. 102174
Zhu W, Wang W, Angsutararux P, et al. (2021) Modulation of the effects of Class-Ib antiarrhythmics on cardiac NaV1.5-encoded channels by accessory NaVβ subunits. Jci Insight
Bouza AA, Edokobi N, Hodges SL, et al. (2021) Sodium channel β1 subunits participate in regulated intramembrane proteolysis-excitation coupling. Jci Insight
Hull JM, O'Malley HA, Chen C, et al. (2020) Excitatory and inhibitory neuron defects in a mouse model of Scn1b-linked EIEE52. Annals of Clinical and Translational Neurology
Han Z, Chen C, Christiansen A, et al. (2020) Antisense oligonucleotides increase expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome. Science Translational Medicine. 12
Bouza AA, Philippe JM, Edokobi N, et al. (2020) Sodium channel β1 subunits are post-translationally modified by tyrosine phosphorylation, S-palmitoylation, and regulated intramembrane proteolysis. The Journal of Biological Chemistry
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