Adam J. Wieschhaus, Ph.D.

Affiliations: 
2013 Pharmacology University of Illinois at Chicago, Chicago, IL, United States 
Area:
Pharmacology, Cell Biology, Neuroscience Biology
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"Adam Wieschhaus"
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Athar Chishti grad student 2013 University of Illinois, Chicago
 (Dematin regulates Calcium mobilization and signaling in platelets.)
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Publications

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Lu Y, Hanada T, Fujiwara Y, et al. (2016) Gene disruption of dematin causes precipitous loss of erythrocyte membrane stability and severe hemolytic anemia. Blood
Wu Z, Chen X, Liu F, et al. (2014) Calpain-1 contributes to IgE-mediated mast cell activation Journal of Immunology. 192: 5130-5139
Mattheij NJ, Gilio K, van Kruchten R, et al. (2013) Dual mechanism of integrin αIIbβ3 closure in procoagulant platelets. The Journal of Biological Chemistry. 288: 13325-36
De Franceschi L, Franco RS, Bertoldi M, et al. (2013) Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 750-9
Wieschhaus AJ, Le Breton GC, Chishti AH. (2012) Headpiece domain of dematin regulates calcium mobilization and signaling in platelets. The Journal of Biological Chemistry. 287: 41218-31
Wieschhaus A, Khan A, Zaidi A, et al. (2012) Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology. The Biochemical Journal. 448: 141-52
Kuchay SM, Wieschhaus AJ, Marinkovic M, et al. (2012) Targeted gene inactivation reveals a functional role of calpain-1 in platelet spreading. Journal of Thrombosis and Haemostasis : Jth. 10: 1120-32
Yamada KH, Kozlowski DA, Seidl SE, et al. (2012) Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress. The Journal of Biological Chemistry. 287: 13182-93
De Franceschi L, Mattè A, Brugnara C, et al. (2011) Pharmacological Inhibition of Calpain-1 Prevents Red Cell Dehydration and Reduces Gardos Channel Activity in a Mouse Model of Sickle Cell Disease. Identification of Druggable Protease Target Blood. 118: 852-852
Wieschhaus AJ, Breton GL, Chishti AH. (2011) Dematin Is Essential for Calcium Mobilization in Platelets Blood. 118: 365-365
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