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Shirin R. Modarai, Ph.D.

Affiliations: 
2014 Department of Biological Sciences University of Delaware, Newark, DE, United States 
Area:
Cell Biology, Oncology, Immunology
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"Shirin Modarai"
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Parents

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Bruce M. Boman grad student 2014 University of Delaware
 (Stem cell and neuroendocrine cell phenotypes in normal and malignant colonic cells.)
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Publications

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Boman BM, Dinh TN, Decker K, et al. (2023) Beyond the Genetic Code: Biorxiv : the Preprint Server For Biology
Zhang T, Ahn K, Emerick B, et al. (2020) APC mutations in human colon lead to decreased neuroendocrine maturation of ALDH+ stem cells that alters GLP-2 and SST feedback signaling: Clue to a link between WNT and retinoic acid signalling in colon cancer development. Plos One. 15: e0239601
Viswanathan V, Opdenaker L, Modarai S, et al. (2020) MicroRNA Expression Profiling of Normal and Malignant Human Colonic Stem Cells Identifies as a Regulator of the Stem Cell Gene. International Journal of Molecular Sciences. 21
Opdenaker LM, Kowash R, Masters G, et al. (2018) Increased Musashi-2 and Decreased NUMB Protein Levels Observed in Human Colorectal Cancer are reverted to Normal Levels by ATRA-Induced Cell Differentiation. International Journal of Cancer Research & Therapy. 3
Modarai SR, Gupta A, Opdenaker LM, et al. (2018) The anti-cancer effect of retinoic acid signaling in CRC occurs via decreased growth of ALDH+ colon cancer stem cells and increased differentiation of stem cells. Oncotarget. 9: 34658-34669
Boman BM, Zhang T, Modarai S, et al. (2018) Abstract 1136: Decrease in maturation of stem cells along the neuroendocrine lineage contributes to stem cell overpopulation that drives human CRC development Cancer Research. 78: 1136-1136
Viswanathan V, Damle S, Zhang T, et al. (2017) An miRNA expression signature for the human colonic stem cell niche distinguishes malignant from normal epithelia. Cancer Research
Modarai SR, Opdenaker LM, Gupta A, et al. (2017) Abstract 2878: Anti-cancer effects of retinoic acid in CRC occurs via decreased growth of ALDH+ cancer stem cells and increased differentiation of stem cells to neuroendocrine cells Cancer Research. 77: 2878-2878
Modarai SR, Opdenaker LM, Viswanathan V, et al. (2016) Somatostatin signaling via SSTR1 contributes to the quiescence of colon cancer stem cells. Bmc Cancer. 16: 941
Opdenaker LM, Modarai SR, Boman BM. (2015) The Proportion of ALDEFLUOR-Positive Cancer Stem Cells Changes with Cell Culture Density Due to the Expression of Different ALDH Isoforms. Cancer Studies and Molecular Medicine : Open Journal. 2: 87-95
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