Krista Spiller
Affiliations: | 2006-2009 | NIH/NIDA, Rockville, MD, United States | |
| 2009-2013 | Neurobiology and Behavior | Columbia University, New York, NY | |
| 2014- | University of Pennsylvania, Philadelphia, PA, United States |
Area:
motor neuron diversity, neurodegeneration, glia, neuroregenerationGoogle:
"Krista Spiller"Bio:
https://www.linkedin.com/in/krista-spiller-558ba46a
https://scholar.google.com/citations?user=Ec0sbQwAAAAJ&hl=en
Mean distance: 15.56 (cluster 11) | S | N | B | C | P |
Parents
Sign in to add mentor| Eliot L. Gardner | research assistant | 2006-2009 | NIH/NIDA | |
| Christopher E. Henderson | grad student | 2014 | Columbia | |
| (Using the natural resistance of motor neuron subpopulations to identify therapeutic targets in amyotrophic lateral sclerosis.) | ||||
| Virginia Man-Yee Lee | post-doc | 2014- | ||
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Publications
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| Hur SK, Hunter M, Dominique MA, et al. (2022) Slow motor neurons resist pathological TDP-43 and mediate motor recovery in the rNLS8 model of amyotrophic lateral sclerosis. Acta Neuropathologica Communications. 10: 75 |
| Hunter M, Spiller KJ, Dominique MA, et al. (2021) Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery. Acta Neuropathologica Communications. 9: 140 |
| Spiller KJ, Bi GH, He Y, et al. (2019) Cannabinoid CB and CB receptor mechanisms underlie cannabis reward and aversion in rats. British Journal of Pharmacology |
| Spiller KJ, Khan T, Dominique MA, et al. (2018) Reduction of matrix metalloproteinase 9 (MMP-9) protects motor neurons from TDP-43-triggered death in rNLS8 mice. Neurobiology of Disease |
| Thams S, Lowry ER, Larraufie MH, et al. (2018) A Stem Cell-Based Screening Platform Identifies Compounds that Desensitize Motor Neurons to Endoplasmic Reticulum Stress. Molecular Therapy : the Journal of the American Society of Gene Therapy |
| Spiller KJ, Restrepo CR, Khan T, et al. (2018) Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy. Nature Neuroscience |
| Spiller KJ, Restrepo CR, Khan T, et al. (2016) Progression of motor neuron disease is accelerated and the ability to recover is compromised with advanced age in rNLS8 mice. Acta Neuropathologica Communications. 4: 105 |
| Spiller KJ, Cheung CJ, Restrepo CR, et al. (2016) Selective Motor Neuron Resistance and Recovery in a New Inducible Mouse Model of TDP-43 Proteinopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 7707-17 |
| Walker AK, Spiller KJ, Ge G, et al. (2015) Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43. Acta Neuropathologica |
| Kaplan A, Spiller KJ, Towne C, et al. (2014) Neuronal matrix metalloproteinase-9 is a determinant of selective neurodegeneration. Neuron. 81: 333-48 |