Denise C. Liotta

Affiliations: 
Emory University, Atlanta, GA 
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"Denise Liotta"
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Epplin M, Mohan A, Harris L, et al. (2020) The Discovery of Dihydropyrrolo[1,2-a]pyrazin-3(4H)-one-Based Second-Generation GluN2C- and GluN2D-Selective Positive Allosteric Modulators (PAMs) of the N-Methyl-D-Aspartate (NMDA) Receptor. Journal of Medicinal Chemistry
McDaniel MJ, Ogden KK, Kell SA, et al. (2020) NMDA receptor channel gating control by the pre-M1 helix. The Journal of General Physiology. 152
Perszyk RE, Swanger SA, Shelley C, et al. (2020) Biased modulators of NMDA receptors control channel opening and ion selectivity. Nature Chemical Biology
Summer SL, Kell SA, Zhu Z, et al. (2019) Di-aryl Sulfonamide Motif Adds π-Stacking Bulk in Negative Allosteric Modulators of the NMDA Receptor. Acs Medicinal Chemistry Letters. 10: 248-254
Regan MC, Zhu Z, Yuan H, et al. (2019) Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors. Nature Communications. 10: 321
Katzman BM, Cox BD, Prosser AR, et al. (2019) Tetrahydroisoquinoline CXCR4 Antagonists Adopt a Hybrid Binding Mode within the Peptide Subpocket of the CXCR4 Receptor. Acs Medicinal Chemistry Letters. 10: 67-73
Wells G, Yuan H, McDaniel MJ, et al. (2018) The GluN2B-Glu413Gly NMDA receptor variant arising from a de novo GRIN2B mutation promotes ligand-unbinding and domain opening. Proteins
Gibb A, Ogden KK, McDaniel MJ, et al. (2018) A structurally-derived model of subunit-dependent NMDA receptor function. The Journal of Physiology
Perszyk R, Katzman BM, Kusumoto H, et al. (2018) An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups. Elife. 7
Swanger SA, Vance KM, Acker TM, et al. (2017) A novel negative allosteric modulator selective for GluN2C/2D-containing NMDA receptors inhibits synaptic transmission in hippocampal interneurons. Acs Chemical Neuroscience
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