Christopher P. Ptak, Ph.D.

Affiliations: 
2005 University of Virginia, Charlottesville, VA 
Area:
General Biophysics
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"Christopher Ptak"
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Eduardo Perozo grad student 2005 UVA
 (Characterization of an archaeal potassium channel: Electrostatic interactions between the cytoplasmic domain and anionic lipids.)
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Publications

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Ptak CP, Peterson TA, Hopkins JB, et al. (2023) Homomeric interactions of the MPZ Ig domain and their relation to Charcot-Marie-Tooth disease. Brain : a Journal of Neurology
Yuan CL, Shi EY, Srinivasan J, et al. (2019) Modulation of AMPA Receptor Gating by the Anticonvulsant Drug, Perampanel. Acs Medicinal Chemistry Letters. 10: 237-242
Shi EY, Yuan CL, Sipple MT, et al. (2019) Noncompetitive antagonists induce cooperative AMPA receptor channel gating. The Journal of General Physiology
Ptak CP, Akif M, Hsieh CL, et al. (2018) Comparative screening of recombinant antigen thermostability for improved leptospirosis vaccine design. Biotechnology and Bioengineering
Goffin E, Drapier T, Larsen AP, et al. (2017) 7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency. Journal of Medicinal Chemistry
Hsieh CL, Ptak CP, Tseng A, et al. (2017) Extended low-resolution structure of a Leptospira antigen offers high bactericidal antibody accessibility amenable to vaccine design. Elife. 6
Hsieh CL, Chang E, Tseng A, et al. (2016) Leptospira Immunoglobulin-Like Protein B (LigB) Binds to Both the C-Terminal 23 Amino Acids of Fibrinogen αC Domain and Factor XIII: Insight into the Mechanism of LigB-Mediated Blockage of Fibrinogen α Chain Cross-Linking. Plos Neglected Tropical Diseases. 10: e0004974
Ptak CP, Ahmed AH, Oswald RE. (2016) Sensing Allosteric Modulator Binding to AMPA Receptors at the Glutamate-Binding Site Biophysical Journal. 110: 201a
Oswald RE, Ahmed AH, Ptak CP, et al. (2015) AMPA Receptor Structure, Function, and Dynamics Biophysical Journal. 108: 335a-336a
Ptak CP, Hsieh CL, Lin YP, et al. (2014) NMR solution structure of the terminal immunoglobulin-like domain from the leptospira host-interacting outer membrane protein, LigB. Biochemistry. 53: 5249-60
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