David Hackos
Affiliations: | 1998-2001 | Neuroscience | Genentech, Inc., San Francisco, CA, United States |
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| Kschonsak M, Jao CC, Arthur CP, et al. (2023) Cryo-EM reveals an unprecedented binding site for Na1.7 inhibitors enabling rational design of potent hybrid inhibitors. Elife. 12 |
| Liu C, Reese R, Vu S, et al. (2020) A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel. Neuron |
| Chernov-Rogan T, Gianti E, Liu C, et al. (2019) TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism. Proceedings of the National Academy of Sciences of the United States of America |
| Xu H, Li T, Rohou A, et al. (2019) Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin. Cell. 176: 1238-1239 |
| Clairfeuille T, Cloake A, Infield DT, et al. (2019) Structural basis of α-scorpion toxin action on Nav channels. Science (New York, N.Y.) |
| Xu H, Li T, Rohou A, et al. (2019) Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin. Cell |
| Payandeh J, Hackos DH. (2018) Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7. Handbook of Experimental Pharmacology. 246: 271-306 |
| Chernov-Rogan T, Li T, Lu G, et al. (2018) Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors. Proceedings of the National Academy of Sciences of the United States of America |
| Wang TM, Brown BM, Deng L, et al. (2017) A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain. Neuropharmacology |
| Ahuja S, Mukund S, Deng L, et al. (2015) Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist. Science (New York, N.Y.). 350: aac5464 |