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Kevin T Bush, Ph.D.

Affiliations: 
1999- UCSD School of Medicine, San Diego, CA, United States 
Area:
kidney development, drug transporters, organic anion transporter
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Parents

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Hsin-Yi Lee grad student 1985-1990 Rutgers Camden
Sanjay K. Nigam post-doc 1992- (BME Tree)
Robert G. Nagele post-doc 1990-1992 Univ. of Medicine & Dentistry of New Jersey

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Publications

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Granados JC, Nigam AK, Bush KT, et al. (2021) A key role for the transporter OAT1 in systemic lipid metabolism. The Journal of Biological Chemistry. 100603
Bush KT, Singh P, Nigam SK. (2020) Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease. Jci Insight. 5
Nigam SK, Bush KT, Bhatnagar V, et al. (2020) The Systems Biology of Drug Metabolizing Enzymes and Transporters: Relevance to Quantitative Systems Pharmacology. Clinical Pharmacology and Therapeutics
Nigam AK, Li JG, Lall K, et al. (2020) Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning. The Journal of Biological Chemistry
Rosenthal SB, Bush KT, Nigam SK. (2019) A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis. Scientific Reports. 9: 11879
Nigam SK, Bush KT. (2019) Uraemic syndrome of chronic kidney disease: altered remote sensing and signalling. Nature Reviews. Nephrology
Ye M, Xu L, Fu M, et al. (2018) Gene-targeted deletion in mice of the Ets-1 transcription factor, a candidate gene in the Jacobsen syndrome kidney "critical region," causes abnormal kidney development. American Journal of Medical Genetics. Part A
Bush KT, Wu W, Lun C, et al. (2017) The drug transporter OAT3 (SLC22A8) regulates endogenous metabolite flow through the gut-liver-kidney axis. The Journal of Biological Chemistry
Wu W, Bush KT, Nigam SK. (2017) Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes. Scientific Reports. 7: 4939
Liu HC, Goldenberg A, Chen Y, et al. (2016) Analysis of Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach. The Journal of Pharmacology and Experimental Therapeutics
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