Robert J. Lefkowitz
Affiliations: | Duke University, Durham, NC |
Area:
G protein-coupled receptorsWebsite:
http://cardiology.medicine.duke.edu/faculty/details/0096962Google:
"Robert Lefkowitz"Bio:
The Nobel Prize in Chemistry 2012 was awarded jointly to Robert J. Lefkowitz and Brian K. Kobilka "for studies of G-protein-coupled receptors."
Mean distance: 13.4 (cluster 11) | S | N | B | C | P |
Cross-listing: Chemistry Tree - Cell Biology Tree
Parents
Sign in to add mentor| Ira Pastan | post-doc | 1968-1970 | NIH |
| Jesse Roth | post-doc | 1968-1970 | NIH |
| Edgar Haber | post-doc | 1970-1973 | Harvard Medical School |
Children
Sign in to add traineeCollaborators
Sign in to add collaborator| Abraham White | collaborator | 1975-1981 | Duke (Chemistry Tree) |
| Bruno Giros | collaborator | 1992-1994 | Duke University Medical Center |
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Publications
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| Casiraghi M, Wang H, Brennan P, et al. (2024) Molecular insights into G protein specificity and biased agonism at the β -adrenergic receptor. Biorxiv : the Preprint Server For Biology |
| Rockman HA, Lefkowitz RJ. (2024) G protein-coupled receptors: from radioligand binding to cellular signaling. The Journal of Clinical Investigation. 134 |
| Lefkowitz RJ, Rockman HA, Shim PJ, et al. (2023) How carvedilol does not activate β-adrenoceptors. Nature Communications. 14: 7866 |
| Kahsai AW, Shah KS, Shim PJ, et al. (2023) Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin. Proceedings of the National Academy of Sciences of the United States of America. 120: e2303794120 |
| Ahn S, Maarsingh H, Walker JK, et al. (2023) Allosteric modulator potentiates β2AR agonist-promoted bronchoprotection in asthma models. The Journal of Clinical Investigation |
| Li A, Liu S, Huang R, et al. (2023) Loss of biased signaling at a G protein-coupled receptor in overexpressed systems. Plos One. 18: e0283477 |
| Asher WB, Terry DS, Gregorio GGA, et al. (2022) GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision. Cell |
| Utz PJ, Jain MK, Cheung VG, et al. (2022) Translating science to medicine: The case for physician-scientists. Science Translational Medicine. 14: eabg7852 |
| Zang Y, Kahsai AW, Pakharukova N, et al. (2021) The GPCR-β-arrestin complex allosterically activates C-Raf by binding its amino-terminus. The Journal of Biological Chemistry. 101369 |
| Pani B, Ahn S, Rambarat PK, et al. (2021) . Molecular Pharmacology |