James Doherty
Affiliations: | 1994-2001 | Pharmacology | Emory University, Atlanta, GA |
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| Beckley JT, Aman TK, Ackley MA, et al. (2023) Pharmacological characterization of SAGE-718, a novel NMDA receptor positive allosteric modulator. British Journal of Pharmacology |
| Tang W, Beckley JT, Zhang J, et al. (2023) Novel neuroactive steroids as positive allosteric modulators of NMDA receptors: mechanism, site of action, and rescue pharmacology on GRIN variants associated with neurological conditions. Cellular and Molecular Life Sciences : Cmls. 80: 42 |
| Althaus AL, Ackley MA, Belfort GM, et al. (2020) Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABA receptor positive allosteric modulator. Neuropharmacology. 108333 |
| Mannara F, Radosevic M, Planagumà J, et al. (2020) Allosteric modulation of NMDA receptors prevents the antibody effects of patients with anti-NMDAR encephalitis. Brain : a Journal of Neurology |
| La DS, Salituro FG, Martinez Botella G, et al. (2019) Neuroactive Steroid N-Methyl-D-aspartate Receptor (NMDAR) Positive Allosteric Modulators: Synthesis, SAR and Pharmacological Activity. Journal of Medicinal Chemistry |
| Warikoo N, Brunwasser SJ, Benz A, et al. (2018) Positive allosteric modulation as a potential therapeutic strategy in anti-NMDA receptor encephalitis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience |
| Althaus AL, McCarren HS, Alqazzaz A, et al. (2017) The synthetic neuroactive steroid SGE-516 reduces status epilepticus and neuronal cell death in a rat model of soman intoxication. Epilepsy & Behavior : E&B. 68: 22-30 |
| Martin BS, Martinez-Botella G, Loya CM, et al. (2015) Rescue of deficient amygdala tonic γ-aminobutyric acidergic currents in the Fmr(-/y) mouse model of fragile X syndrome by a novel γ-aminobutyric acid type A receptor-positive allosteric modulator. Journal of Neuroscience Research |
| Linsenbardt AJ, Taylor A, Emnett CM, et al. (2014) Different oxysterols have opposing actions at N-methyl-D-aspartate receptors. Neuropharmacology. 85: 232-42 |
| Martinez-Botella G, Ackley MA, Salituro FG, et al. (2014) Natural and synthetic neuroactive steroid modulators of GABAA and NMDA receptors Annual Reports in Medicinal Chemistry. 49: 27-42 |