Makoto R. Hara
Affiliations: | Novartis, Basel, Basel-Stadt, France |
Area:
Signal transduction, GPCRGoogle:
"Makoto Hara"Mean distance: 13.97 (cluster 11) | S | N | B | C | P |
Parents
Sign in to add mentor| Solomon H. Snyder | grad student | 2001-2006 | Johns Hopkins | |
| (S-nitrosylated glyceraldehyde -3 -phosphate dehydrogenase initiates apoptotic cell death by nuclear translocation following Siah1 binding.) | ||||
| Robert J. Lefkowitz | post-doc | 2006-2012 | Duke | |
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Publications
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| Nieto A, Hara MR, Quereda V, et al. (2019) βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1. Cell Death and Differentiation |
| Hara MR, Sachs BD, Caron MG, et al. (2013) Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model. Cell Cycle (Georgetown, Tex.). 12: 219-24 |
| Shenoy SK, Han S, Zhao YL, et al. (2012) β-arrestin1 mediates metastatic growth of breast cancer cells by facilitating HIF-1-dependent VEGF expression. Oncogene. 31: 282-92 |
| Xiao K, Sun J, Kim J, et al. (2012) Global phosphorylation analysis of β-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR) (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 34 (15299-15304) doi:10.1073/pnas.1008461107) Proceedings of the National Academy of Sciences of the United States of America. 109: 13464 |
| Nobles KN, Xiao K, Ahn S, et al. (2011) Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin. Science Signaling. 4: ra51 |
| Hara MR, Kovacs JJ, Whalen EJ, et al. (2011) A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. Nature. 477: 349-53 |
| Kornberg MD, Sen N, Hara MR, et al. (2010) GAPDH mediates nitrosylation of nuclear proteins. Nature Cell Biology. 12: 1094-100 |
| Xiao K, Sun J, Kim J, et al. (2010) Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proceedings of the National Academy of Sciences of the United States of America. 107: 15299-304 |
| Kovacs JJ, Hara MR, Davenport CL, et al. (2009) Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways. Developmental Cell. 17: 443-58 |
| Sen N, Hara MR, Ahmad AS, et al. (2009) GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Neuron. 63: 81-91 |