Ryan Strachan
Affiliations: | Duke University, Durham, NC |
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Publications
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Krumm BE, DiBerto JF, Olsen RHJ, et al. (2023) Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator. Biochemistry |
Levit Kaplan A, Strachan RT, Braz JM, et al. (2022) Structure-Based Design of a Chemical Probe Set for the 5-HT Serotonin Receptor. Journal of Medicinal Chemistry |
Olsen RHJ, DiBerto JF, English JG, et al. (2020) TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome. Nature Chemical Biology |
Foster SR, Hauser AS, Vedel L, et al. (2019) Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors. Cell. 179: 895-908.e21 |
Kenakin T, Strachan RT. (2018) PAM-Antagonists: A Better Way to Block Pathological Receptor Signaling? Trends in Pharmacological Sciences |
Che T, Majumdar S, Zaidi SA, et al. (2018) Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor. Cell |
Jean-Charles PY, Yu SM, Abraham D, et al. (2017) Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling. Jci Insight. 2 |
Ahn S, Kahsai AW, Pani B, et al. (2017) Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library. Proceedings of the National Academy of Sciences of the United States of America |
Thomsen AR, Plouffe B, Cahill TJ, et al. (2016) GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling. Cell |
Staus DP, Strachan RT, Manglik A, et al. (2016) Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature |