Richard H. P. Porter, PhD
Affiliations: | Roche, Indianapolis, IN, United States |
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"Richard Porter"Mean distance: 17.21 (cluster 32) | S | N | B | C | P |
Parents
Sign in to add mentor| J. Timothy Greenamyre | post-doc | 1992-1993 | University of Rochester Medical Center |
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Publications
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| Lindemann L, Jaeschke G, Michalon A, et al. (2011) CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor. The Journal of Pharmacology and Experimental Therapeutics. 339: 474-86 |
| Kratochwil NA, Gatti-McArthur S, Hoener MC, et al. (2011) G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey. Current Topics in Medicinal Chemistry. 11: 1902-24 |
| Wallace TL, Porter R, Neveu E, et al. (2011) Effects of RG3487 at the α7β2 nicotinic acetylcholine receptor expressed in Xenopus oocytes Biochemical Pharmacology. 82: 1026-1027 |
| Malherbe P, Kratochwil N, Mühlemann A, et al. (2006) Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP. Journal of Neurochemistry. 98: 601-15 |
| Mühlemann A, Ward NA, Kratochwil N, et al. (2006) Determination of key amino acids implicated in the actions of allosteric modulation by 3,3'-difluorobenzaldazine on rat mGlu5 receptors. European Journal of Pharmacology. 529: 95-104 |
| Ballard TM, Woolley ML, Prinssen E, et al. (2005) The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: A comparison Psychopharmacology. 179: 218-229 |
| Malherbe P, Kratochwil N, Zenner MT, et al. (2003) Mutational analysis and molecular modeling of the binding pocket of the metabotropic glutamate 5 receptor negative modulator 2-methyl-6-(phenylethynyl)-pyridine. Molecular Pharmacology. 64: 823-32 |
| Quirk K, Lawrence A, Jones J, et al. (2001) Characterisation of agonist binding on human 5-HT2C receptor isoforms. European Journal of Pharmacology. 419: 107-12 |
| Betarbet R, Porter RH, Greenamyre JT. (2000) GluR1 glutamate receptor subunit is regulated differentially in the primate basal ganglia following nigrostriatal dopamine denervation. Journal of Neurochemistry. 74: 1166-74 |
| Porter RH, Benwell KR, Lamb H, et al. (1999) Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. British Journal of Pharmacology. 128: 13-20 |