Leah Caroline Thomas Byrne, Ph.D.
Affiliations: | School of Veterinary Medicine, Ophthalmology | University of Pennsylvania, Philadelphia, PA, United States |
Area:
Viral gene therapy, retinal degenerationWebsite:
http://www.cchem.berkeley.edu/schaffer/leah.htmlGoogle:
"Leah Byrne"Mean distance: 16.6 (cluster 6) | S | N | B | C | P |
Parents
Sign in to add mentor| John G. Flannery | grad student | 2011 | UC Berkeley | |
| (Engineered Adeno-Associated Viral Vectors for Gene Therapy in the Retina.) | ||||
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Publications
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| Aweidah H, Xi Z, Sahel JA, et al. (2023) PRPF31-retinitis pigmentosa: Challenges and opportunities for clinical translation. Vision Research. 213: 108315 |
| Zin EA, Ozturk BE, Dalkara D, et al. (2023) Developing New Vectors for Retinal Gene Therapy. Cold Spring Harbor Perspectives in Medicine |
| Xi Z, Vats A, Sahel JA, et al. (2022) Gene augmentation prevents retinal degeneration in a CRISPR/Cas9-based mouse model of PRPF31 retinitis pigmentosa. Nature Communications. 13: 7695 |
| Rodrigues A, Slembrouck-Brec A, Nanteau C, et al. (2022) Modeling PRPF31 retinitis pigmentosa using retinal pigment epithelium and organoids combined with gene augmentation rescue. Npj Regenerative Medicine. 7: 39 |
| Xi Z, Öztürk BE, Johnson ME, et al. (2022) Quantitative single-cell transcriptome-based ranking of engineered AAVs in human retinal explants. Molecular Therapy. Methods & Clinical Development. 25: 476-489 |
| Miyadera K, Santana E, Roszak K, et al. (2022) Targeting ON-bipolar cells by AAV gene therapy stably reverses -congenital stationary night blindness. Proceedings of the National Academy of Sciences of the United States of America. 119: e2117038119 |
| Öztürk BE, Johnson ME, Kleyman M, et al. (2021) scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution. Elife. 10 |
| Gemayel M, Byrne LC, Ciulla T, et al. (2021) Delivery of Genetic Information: Viral Vector and Nonviral Vector Gene Therapies. International Ophthalmology Clinics. 61: 35-57 |
| Liu X, Feng B, Vats A, et al. (2020) Pharmacological clearance of misfolded rhodopsin for the treatment of RHO-associated retinitis pigmentosa. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology |
| Byrne LC, Day TP, Visel M, et al. (2020) In vivo directed evolution of AAV in the primate retina. Jci Insight |