Christopher E. Dempsey, Ph.D.

Affiliations: 
Biochemistry University of Bristol, Bristol, England, United Kingdom 
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"Christopher Dempsey"
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Cross-listing: Chemistry Tree

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Publications

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Zhang Y, Grimwood AL, Hancox JC, et al. (2022) Evolutionary coupling analysis guides identification of mistrafficking-sensitive variants in cardiac K channels: Validation with hERG. Frontiers in Pharmacology. 13: 1010119
Al-Moubarak E, Shiels HA, Zhang Y, et al. (2021) Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant. Cellular and Molecular Life Sciences : Cmls
Zhang Y, Dempsey CE, Hancox JC. (2020) Electrophysiological characterization of the modified hERG potassium channel used to obtain the first cryo-EM hERG structure. Physiological Reports. 8: e14568
Al-Moubarak E, Zhang Y, Dempsey CE, et al. (2020) Serine mutation of a conserved threonine in the hERG K channel S6-pore region leads to loss-of-function through trafficking impairment. Biochemical and Biophysical Research Communications
El Harchi A, Butler AS, Zhang Y, et al. (2020) The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine. Physiological Reports. 8: e14385
Al-Moubarak E, Shiels H, Zhang Y, et al. (2020) Inhibition of hERG Potassium Channels by the Polycylic Aromatic Hydrocarbon Phenanthrene Biophysical Journal. 118: 109a
Butler A, Helliwell MV, Zhang Y, et al. (2019) An Update on the Structure of hERG. Frontiers in Pharmacology. 10: 1572
Wilson SL, Dempsey CE, Hancox JC, et al. (2019) Identification of a proton sensor that regulates conductance and open time of single hERG channels. Scientific Reports. 9: 19825
Cheng H, Du C, Zhang Y, et al. (2019) Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome. Journal of Molecular and Cellular Cardiology
Butler A, Zhang Y, Stuart AG, et al. (2019) Functional and pharmacological characterization of an S5 domain hERG mutation associated with short QT syndrome. Heliyon. 5: e01429
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