Christopher E. Dempsey, Ph.D.
Affiliations: | Biochemistry | University of Bristol, Bristol, England, United Kingdom |
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"Christopher Dempsey"Mean distance: 19.51 (cluster 32)
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Publications
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Zhang Y, Grimwood AL, Hancox JC, et al. (2022) Evolutionary coupling analysis guides identification of mistrafficking-sensitive variants in cardiac K channels: Validation with hERG. Frontiers in Pharmacology. 13: 1010119 |
Al-Moubarak E, Shiels HA, Zhang Y, et al. (2021) Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant. Cellular and Molecular Life Sciences : Cmls |
Zhang Y, Dempsey CE, Hancox JC. (2020) Electrophysiological characterization of the modified hERG potassium channel used to obtain the first cryo-EM hERG structure. Physiological Reports. 8: e14568 |
Al-Moubarak E, Zhang Y, Dempsey CE, et al. (2020) Serine mutation of a conserved threonine in the hERG K channel S6-pore region leads to loss-of-function through trafficking impairment. Biochemical and Biophysical Research Communications |
El Harchi A, Butler AS, Zhang Y, et al. (2020) The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine. Physiological Reports. 8: e14385 |
Al-Moubarak E, Shiels H, Zhang Y, et al. (2020) Inhibition of hERG Potassium Channels by the Polycylic Aromatic Hydrocarbon Phenanthrene Biophysical Journal. 118: 109a |
Butler A, Helliwell MV, Zhang Y, et al. (2019) An Update on the Structure of hERG. Frontiers in Pharmacology. 10: 1572 |
Wilson SL, Dempsey CE, Hancox JC, et al. (2019) Identification of a proton sensor that regulates conductance and open time of single hERG channels. Scientific Reports. 9: 19825 |
Cheng H, Du C, Zhang Y, et al. (2019) Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome. Journal of Molecular and Cellular Cardiology |
Butler A, Zhang Y, Stuart AG, et al. (2019) Functional and pharmacological characterization of an S5 domain hERG mutation associated with short QT syndrome. Heliyon. 5: e01429 |