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Lu Zhang

Affiliations: 
2014 Dentistry (Oral Biology) University of North Carolina, Chapel Hill, Chapel Hill, NC 
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"Lu Zhang"
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Jenny P-Y Ting grad student 2014 UNC Chapel Hill
 (NLRC3 is a negative regulator of DNA-induced immune response.)

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Publications

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Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 1-382
Deng M, Tam JW, Wang L, et al. (2020) TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination. Nature Communications. 11: 2193
Li X, Deng M, Petrucelli AS, et al. (2019) Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon. Immunity. 50: 591-599.e6
Guo H, König R, Deng M, et al. (2016) NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses. Cell Host & Microbe. 19: 515-528
Zhang L, Mo J, Swanson KV, et al. (2014) NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING. Immunity. 40: 329-41
Schneider M, Zimmermann AG, Roberts RA, et al. (2012) The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nature Immunology. 13: 823-31
Lei Y, Wen H, Yu Y, et al. (2012) The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity. 36: 933-46
Robbins GR, Truax AD, Davis BK, et al. (2012) Regulation of class I major histocompatibility complex (MHC) by nucleotide-binding domain, leucine-rich repeat-containing (NLR) proteins. The Journal of Biological Chemistry. 287: 24294-303
Wen H, Gris D, Lei Y, et al. (2011) Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nature Immunology. 12: 408-15
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