James D. Orth
Affiliations: | University of Colorado, Boulder, Boulder, CO, United States |
Area:
cell biology, dynamin, actin, anti-mitotic drugs, mitosis, cell migrationGoogle:
"James Orth"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Mark A. McNiven | grad student | 1999-2005 | |
| Timothy J. Mitchison | post-doc | 2005-2012 | (Cell Biology Tree) |
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Publications
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| Burke RT, Marcus JM, Orth JD. (2017) Inhibition of exportin-1 function results in rapid cell cycle-associated DNA damage in cancer cells. Oncotarget |
| Burke RT, Orth JD. (2016) Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics. Journal of Visualized Experiments : Jove |
| Marcus JM, Burke RT, DeSisto JA, et al. (2015) Longitudinal tracking of single live cancer cells to understand cell cycle effects of the nuclear export inhibitor, selinexor. Scientific Reports. 5: 14391 |
| Chittajallu DR, Florian S, Kohler RH, et al. (2015) In vivo cell-cycle profiling in xenograft tumors by quantitative intravital microscopy. Nature Methods. 12: 577-85 |
| Laughney AM, Kim E, Sprachman MM, et al. (2014) Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin. Science Translational Medicine. 6: 261ra152 |
| Orth JD, Loewer A, Lahav G, et al. (2012) Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction. Molecular Biology of the Cell. 23: 567-76 |
| Tang Y, Orth JD, Xie T, et al. (2011) Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells. Cancer Letters. 310: 15-24 |
| Orth JD, Kohler RH, Foijer F, et al. (2011) Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. Cancer Research. 71: 4608-16 |
| Huang HC, Shi J, Orth JD, et al. (2010) Cell death when the SAC is out of commission. Cell Cycle (Georgetown, Tex.). 9: 2049-50 |
| Tsui M, Xie T, Orth JD, et al. (2009) An intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitor. Plos One. 4: e7339 |