| Year |
Citation |
Score |
| 2023 |
Vogler EC, Mahavongtrakul M, Sarkan K, Bohannan RC, Catuara-Solarz S, Busciglio J. Genetic removal of synaptic Zn impairs cognition, alters neurotrophic signaling and induces neuronal hyperactivity. Frontiers in Neurology. 13: 882635. PMID 36742045 DOI: 10.3389/fneur.2022.882635 |
0.33 |
|
| 2019 |
Hwang S, Williams JF, Kneissig M, Lioudyno M, Rivera I, Helguera P, Busciglio J, Storchova Z, King MC, Torres EM. Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells. Cell Reports. 29: 2473-2488.e5. PMID 31747614 DOI: 10.1016/J.Celrep.2019.10.059 |
0.304 |
|
| 2018 |
Zamponi E, Zamponi N, Coskun P, Quassollo G, Lorenzo A, Cannas SA, Pigino G, Chialvo D, Gardiner K, Busciglio J, Helguera P. Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells. Aging Cell. e12812. PMID 30028071 DOI: 10.1111/Acel.12812 |
0.312 |
|
| 2017 |
Torres MD, Garcia O, Tang C, Busciglio J. Dendritic spine pathology and thrombospondin-1 deficits in Down syndrome. Free Radical Biology & Medicine. PMID 28965914 DOI: 10.1016/J.Freeradbiomed.2017.09.025 |
0.607 |
|
| 2016 |
Delabar JM, Allinquant B, Bianchi D, Blumenthal T, Dekker A, Edgin J, O'Bryan J, Dierssen M, Potier MC, Wiseman F, Guedj F, Créau N, Reeves R, Gardiner K, Busciglio J. Changing Paradigms in Down Syndrome: The First International Conference of the Trisomy 21 Research Society. Molecular Syndromology. 7: 251-261. PMID 27867340 DOI: 10.1159/000449049 |
0.337 |
|
| 2016 |
Coskun P, Helguera P, Nemati Z, Bohannan RC, Thomas J, Samuel SE, Argueta J, Doran E, Wallace DC, Lott IT, Busciglio J. Metabolic and Growth Rate Alterations in Lymphoblastic Cell Lines Discriminate Between Down Syndrome and Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 27802222 DOI: 10.3233/Jad-160278 |
0.395 |
|
| 2014 |
Iulita MF, Do Carmo S, Ower AK, Fortress AM, Aguilar LF, Hanna M, Wisniewski T, Granholm AC, Buhusi M, Busciglio J, Cuello AC. Nerve growth factor metabolic dysfunction in Down's syndrome brains. Brain : a Journal of Neurology. 137: 860-72. PMID 24519975 DOI: 10.1093/Brain/Awt372 |
0.406 |
|
| 2014 |
Sosa LJ, Postma NL, Estrada-Bernal A, Hanna M, Guo R, Busciglio J, Pfenninger KH. Dosage of amyloid precursor protein affects axonal contact guidance in Down syndrome. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 195-205. PMID 24036883 DOI: 10.1096/Fj.13-232686 |
0.409 |
|
| 2014 |
Potier M, Janel N, Bottlaender M, Corlier F, Corne H, Souza LCd, Lamari F, Blehaut H, Hindie V, Rain JC, Arbones M, Paul JL, Coskun P, Lott I, Busciglio J, et al. Dyrk1A: A Novel Biomarker For Alzheimer'S Disease (Ad) Identified In Plasma And Lcls From Ad And Ds Alzheimers & Dementia. 10: 473. DOI: 10.1016/J.Jalz.2014.05.681 |
0.324 |
|
| 2013 |
Yeo M, Berglund K, Hanna M, Guo JU, Kittur J, Torres MD, Abramowitz J, Busciglio J, Gao Y, Birnbaumer L, Liedtke WB. Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. Proceedings of the National Academy of Sciences of the United States of America. 110: 4315-20. PMID 23440186 DOI: 10.1073/Pnas.1300959110 |
0.347 |
|
| 2013 |
Helguera P, Seiglie J, Rodriguez J, Hanna M, Helguera G, Busciglio J. Adaptive downregulation of mitochondrial function in down syndrome. Cell Metabolism. 17: 132-40. PMID 23312288 DOI: 10.1016/J.Cmet.2012.12.005 |
0.325 |
|
| 2012 |
Coskun PE, Busciglio J. Oxidative Stress and Mitochondrial Dysfunction in Down's Syndrome: Relevance to Aging and Dementia. Current Gerontology and Geriatrics Research. 2012: 383170. PMID 22611387 DOI: 10.1155/2012/383170 |
0.341 |
|
| 2012 |
Vogler E, Busciglio J. Investigating the role of synaptic zinc and seizure activity in Alzheimer's disease Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.1734 |
0.322 |
|
| 2011 |
Tiano L, Busciglio J. Mitochondrial dysfunction and Down's syndrome: is there a role for coenzyme Q(10) ? Biofactors (Oxford, England). 37: 386-92. PMID 22009852 DOI: 10.1002/Biof.184 |
0.326 |
|
| 2011 |
Torres M, Garcia O, Busciglio J. Spine pathology in down's syndrome and Alzheimer's disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.2052 |
0.582 |
|
| 2010 |
Garcia O, Torres M, Helguera P, Coskun P, Busciglio J. A role for thrombospondin-1 deficits in astrocyte-mediated spine and synaptic pathology in Down's syndrome. Plos One. 5: e14200. PMID 21152035 DOI: 10.1371/Journal.Pone.0014200 |
0.622 |
|
| 2010 |
Rahman AS, Parvinjah S, Hanna MA, Helguera PR, Busciglio J. Cryopreservation of cortical tissue blocks for the generation of highly enriched neuronal cultures. Journal of Visualized Experiments : Jove. PMID 21113113 DOI: 10.3791/2384 |
0.38 |
|
| 2009 |
Deshpande A, Kawai H, Metherate R, Glabe CG, Busciglio J. A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 4004-15. PMID 19339596 DOI: 10.1523/Jneurosci.5980-08.2009 |
0.327 |
|
| 2009 |
Pigino G, Morfini G, Atagi Y, Deshpande A, Yu C, Jungbauer L, LaDu M, Busciglio J, Brady S. Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta. Proceedings of the National Academy of Sciences of the United States of America. 106: 5907-12. PMID 19321417 DOI: 10.1073/Pnas.0901229106 |
0.398 |
|
| 2009 |
Busciglio J, Deshpande A. Alzheimer's Disease-Related Mechanisms of Neuronal Dysfunction and Degeneration: Studies in Human Cortical Neurons From Development to Degeneration and Regeneration of the Nervous System. DOI: 10.1093/acprof:oso/9780195369007.003.0010 |
0.323 |
|
| 2008 |
Resende R, Moreira PI, Proença T, Deshpande A, Busciglio J, Pereira C, Oliveira CR. Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease. Free Radical Biology & Medicine. 44: 2051-7. PMID 18423383 DOI: 10.1016/J.Freeradbiomed.2008.03.012 |
0.393 |
|
| 2008 |
Deshpande A, Win KM, Busciglio J. Tau isoform expression and regulation in human cortical neurons. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 2357-67. PMID 18263702 DOI: 10.1096/Fj.07-096909 |
0.408 |
|
| 2008 |
Pelsman A, Busciglio J. A role for the transcription factor ets-2 in Down's syndrome neuropathology Journal of Neurochemistry. 81: 60-63. DOI: 10.1046/J.1471-4159.81.S1.20_6.X |
0.397 |
|
| 2008 |
Deshpande A, Glabe C, Busciglio J. O2-02-07: Neuronal activity promotes oligomer formation and accumulation at excitatory synapses Alzheimer's & Dementia. 4: T134-T135. DOI: 10.1016/J.Jalz.2008.05.319 |
0.36 |
|
| 2007 |
Busciglio J, Pelsman A, Helguera P, Ashur-Fabian O, Pinhasov A, Brenneman DE, Gozes I. NAP and ADNF-9 protect normal and Down's syndrome cortical neurons from oxidative damage and apoptosis. Current Pharmaceutical Design. 13: 1091-8. PMID 17430172 DOI: 10.2174/138161207780618957 |
0.412 |
|
| 2006 |
Lott IT, Head E, Doran E, Busciglio J. Beta-amyloid, oxidative stress and down syndrome. Current Alzheimer Research. 3: 521-8. PMID 17168651 DOI: 10.2174/156720506779025305 |
0.406 |
|
| 2006 |
Heredia L, Helguera P, de Olmos S, Kedikian G, Solá Vigo F, LaFerla F, Staufenbiel M, de Olmos J, Busciglio J, Cáceres A, Lorenzo A. Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6533-42. PMID 16775141 DOI: 10.1523/Jneurosci.5567-05.2006 |
0.439 |
|
| 2006 |
Deshpande A, Mina E, Glabe C, Busciglio J. Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6011-8. PMID 16738244 DOI: 10.1523/Jneurosci.1189-06.2006 |
0.436 |
|
| 2006 |
Busciglio J, Pelsman A, Helguera P, Ashur-Fabian O, Pinhasov A, Brenneman DE, Gozes I. Analysis of ADNF-9 and NAP neuroprotection in human neurons: Relevance for Alzheimer disease and down syndrome therapies Neuropeptides. 40: 431. DOI: 10.1016/J.Npep.2006.09.020 |
0.408 |
|
| 2006 |
Deshpande A, Mina E, Glabe C, Busciglio J. P4-014: Divergent cytotoxic mechanisms of soluble and fibrillar forms of AAY in human cortical neurons Alzheimer's & Dementia. 2: S517-S518. DOI: 10.1016/J.Jalz.2006.05.1752 |
0.346 |
|
| 2005 |
Helguera P, Pelsman A, Pigino G, Wolvetang E, Head E, Busciglio J. ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2295-303. PMID 15745955 DOI: 10.1523/Jneurosci.5107-04.2005 |
0.441 |
|
| 2004 |
Heredia L, Lin R, Vigo FS, Kedikian G, Busciglio J, Lorenzo A. Deposition of amyloid fibrils promotes cell-surface accumulation of amyloid beta precursor protein. Neurobiology of Disease. 16: 617-29. PMID 15262274 DOI: 10.1016/J.Nbd.2004.04.015 |
0.422 |
|
| 2004 |
Gouras G, LaFerla F, Strobel G, Busciglio J, Almeida C, Geula C, Stenh C, Lee D, D'Andrea M, Nagele B, Takahashi R, Hartmann T, LeBlanc A, Dineley K, Koudinov A. Intraneuronal Aβ accumulation-more evidence, less controversy? Alzheimer research forum live discussion Journal of Alzheimer's Disease. 6: 443-449. DOI: 10.3233/Jad-2004-6413 |
0.331 |
|
| 2003 |
Wolvetang EJ, Bradfield OM, Hatzistavrou T, Crack PJ, Busciglio J, Kola I, Hertzog PJ. Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis. Neurobiology of Disease. 14: 349-56. PMID 14678752 DOI: 10.1016/S0969-9961(03)00107-4 |
0.386 |
|
| 2003 |
Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J. Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4499-508. PMID 12805290 DOI: 10.1523/Jneurosci.23-11-04499.2003 |
0.379 |
|
| 2003 |
Pelsman A, Hoyo-Vadillo C, Gudasheva TA, Seredenin SB, Ostrovskaya RU, Busciglio J. GVS-111 prevents oxidative damage and apoptosis in normal and Down's syndrome human cortical neurons. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 21: 117-24. PMID 12711349 DOI: 10.1016/S0736-5748(03)00031-5 |
0.398 |
|
| 2003 |
Grace EA, Busciglio J. Aberrant activation of focal adhesion proteins mediates fibrillar amyloid beta-induced neuronal dystrophy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 493-502. PMID 12533609 |
0.346 |
|
| 2003 |
Grace EA, Busciglio J. Aberrant Activation of Focal Adhesion Proteins Mediates Fibrillar Amyloid β-Induced Neuronal Dystrophy The Journal of Neuroscience. 23: 493-502. DOI: 10.1523/Jneurosci.23-02-00493.2003 |
0.446 |
|
| 2002 |
Morfini G, Pigino G, Beffert U, Busciglio J, Brady ST. Fast axonal transport misregulation and Alzheimer's disease. Neuromolecular Medicine. 2: 89-99. PMID 12428805 DOI: 10.1385/Nmm:2:2:089 |
0.399 |
|
| 2002 |
Grace EA, Rabiner CA, Busciglio J. Characterization of neuronal dystrophy induced by fibrillar amyloid beta: implications for Alzheimer's disease. Neuroscience. 114: 265-73. PMID 12207971 DOI: 10.1016/S0306-4522(02)00241-5 |
0.376 |
|
| 2002 |
Busciglio J, Pelsman A, Wong C, Pigino G, Yuan M, Mori H, Yankner BA. Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome. Neuron. 33: 677-88. PMID 11879646 DOI: 10.1016/S0896-6273(02)00604-9 |
0.475 |
|
| 2001 |
Pigino G, Pelsman A, Mori H, Busciglio J. Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 834-42. PMID 11157069 DOI: 10.1523/Jneurosci.21-03-00834.2001 |
0.415 |
|
| 2000 |
Pigino G, Mori H, Busciglio J. The association of PS1 with the neuronal cytoskeleton and its role in Notch signaling and the regulation of neurite outgrowth Neurobiology of Aging. 21: 117. DOI: 10.1016/S0197-4580(00)82325-8 |
0.346 |
|
| 1999 |
Kerkovich DM, Sapp D, Weidenheim K, Brosnan CF, Pfeiffer SE, Yeh HH, Busciglio J. Fetal human cortical neurons grown in culture: morphological differentiation, biochemical correlates and development of electrical activity. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 17: 347-56. PMID 10479069 DOI: 10.1016/S0736-5748(99)00036-2 |
0.346 |
|
| 1998 |
Shi B, Raina J, Lorenzo A, Busciglio J, Gabuzda D. Neuronal apoptosis induced by HIV-1 Tat protein and TNF-alpha: potentiation of neurotoxicity mediated by oxidative stress and implications for HIV-1 dementia. Journal of Neurovirology. 4: 281-90. PMID 9639071 DOI: 10.3109/13550289809114529 |
0.355 |
|
| 1997 |
Busciglio J, Hartmann H, Lorenzo A, Wong C, Baumann K, Sommer B, Staufenbiel M, Yankner BA. Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 5101-7. PMID 9185547 DOI: 10.1523/Jneurosci.17-13-05101.1997 |
0.441 |
|
| 1997 |
Hartmann H, Busciglio J, Baumann KH, Staufenbiel M, Yankner BA. Developmental regulation of presenilin-1 processing in the brain suggests a role in neuronal differentiation. The Journal of Biological Chemistry. 272: 14505-8. PMID 9169406 DOI: 10.1074/Jbc.272.23.14505 |
0.374 |
|
| 1996 |
Shi B, De Girolami U, He J, Wang S, Lorenzo A, Busciglio J, Gabuzda D. Apoptosis induced by HIV-1 infection of the central nervous system. The Journal of Clinical Investigation. 98: 1979-90. PMID 8903316 DOI: 10.1172/Jci119002 |
0.33 |
|
| 1995 |
Busciglio J, Yankner BA. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature. 378: 776-9. PMID 8524410 DOI: 10.1038/378776A0 |
0.431 |
|
| 1995 |
Busciglio J, Lorenzo A, Yeh J, Yankner BA. beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron. 14: 879-88. PMID 7718249 DOI: 10.1016/0896-6273(95)90232-5 |
0.411 |
|
| 1995 |
Martin BL, Schrader-Fischer G, Busciglio J, Duke M, Paganetti P, Yankner BA. Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein. The Journal of Biological Chemistry. 270: 26727-30. PMID 7592902 DOI: 10.1074/Jbc.270.45.26727 |
0.382 |
|
| 1993 |
Busciglio J, Gabuzda DH, Matsudaira P, Yankner BA. Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells. Proceedings of the National Academy of Sciences of the United States of America. 90: 2092-6. PMID 8446635 DOI: 10.1073/Pnas.90.5.2092 |
0.322 |
|
| 1993 |
Busciglio J, Yeh J, Yankner BA. beta-Amyloid neurotoxicity in human cortical culture is not mediated by excitotoxins. Journal of Neurochemistry. 61: 1565-8. PMID 8377009 DOI: 10.1111/J.1471-4159.1993.Tb13658.X |
0.368 |
|
| 1993 |
Gabuzda D, Busciglio J, Yankner BA. Inhibition of beta-amyloid production by activation of protein kinase C. Journal of Neurochemistry. 61: 2326-9. PMID 8245986 DOI: 10.1111/J.1471-4159.1993.Tb07479.X |
0.329 |
|
| 1992 |
Busciglio J, Lorenzo A, Yankner BA. Methodological variables in the assessment of beta amyloid neurotoxicity. Neurobiology of Aging. 13: 609-12. PMID 1461350 DOI: 10.1016/0197-4580(92)90065-6 |
0.395 |
|
| 1991 |
Kowall NW, Beal MF, Busciglio J, Duffy LK, Yankner BA. An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P. Proceedings of the National Academy of Sciences of the United States of America. 88: 7247-51. PMID 1714596 DOI: 10.1073/Pnas.88.16.7247 |
0.379 |
|
| 1990 |
Gravotta D, Ferreira A, Busciglio J, Caceres A, Landa CA, Maccioni HJ. Coexpression of lactosyl and gangliotetraosyl gangliosides in rat cerebellar radial glial cells in culture. Journal of Neuroscience Research. 25: 214-22. PMID 2319630 DOI: 10.1002/Jnr.490250209 |
0.338 |
|
| 1990 |
Ferreira A, Busciglio J, Landa C, Caceres A. Ganglioside-enhanced neurite growth: evidence for a selective induction of high-molecular-weight MAP-2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 293-302. PMID 2153774 DOI: 10.1523/Jneurosci.10-01-00293.1990 |
0.324 |
|
| 1989 |
Ferreira A, Busciglio J, Cáceres A. Microtubule formation and neurite growth in cerebellar macroneurons which develop in vitro: evidence for the involvement of the microtubule-associated proteins, MAP-1a, HMW-MAP2 and Tau. Brain Research. Developmental Brain Research. 49: 215-28. PMID 2509111 DOI: 10.1016/0165-3806(89)90023-0 |
0.31 |
|
| 1987 |
Busciglio J, Ferreira A, Steward O, Cáceres A. An immunocytochemical and biochemical study of the microtubule-associated protein Tau during post-lesion afferent reorganization in the hippocampus of adult rats. Brain Research. 419: 244-52. PMID 3119145 DOI: 10.1016/0006-8993(87)90590-7 |
0.322 |
|
| 1987 |
Ferreira A, Busciglio J, Cáceres A. An immunocytochemical analysis of the ontogeny of the microtubule-associated proteins MAP-2 and Tau in the nervous system of the rat. Brain Research. 431: 9-31. PMID 3113673 DOI: 10.1016/0165-3806(87)90191-X |
0.363 |
|
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