| Year |
Citation |
Score |
| 2022 |
Rom JS, Le Breton Y, Islam E, Belew AT, El-Sayed NM, McIver KS. Loss of Encoding the δ-Factor of RNA Polymerase Impacts Pathophysiology of the M1T1 Strain 5448. Microorganisms. 10. PMID 36014103 DOI: 10.3390/microorganisms10081686 |
0.417 |
|
| 2022 |
Burcham LR, Akbari MS, Alhajjar N, Keogh RA, Radin JN, Kehl-Fie TE, Belew AT, El-Sayed NM, McIver KS, Doran KS. Genomic Analyses Identify Manganese Homeostasis as a Driver of Group B Streptococcal Vaginal Colonization. Mbio. e0098522. PMID 35658538 DOI: 10.1128/mbio.00985-22 |
0.336 |
|
| 2021 |
Woo JKK, McIver KS, Federle MJ. Carbon catabolite repression on the Rgg2/3 quorum sensing system in Streptococcus pyogenes is mediated by PTS and Mga. Molecular Microbiology. PMID 34923680 DOI: 10.1111/mmi.14866 |
0.457 |
|
| 2021 |
Rom JS, Hart MT, McIver KS. PRD-Containing Virulence Regulators (PCVRs) in Pathogenic Bacteria. Frontiers in Cellular and Infection Microbiology. 11: 772874. PMID 34737980 DOI: 10.3389/fcimb.2021.772874 |
0.403 |
|
| 2020 |
Burcham LR, Le Breton Y, Radin JN, Spencer BL, Deng L, Hiron A, Ransom MR, Mendonça JDC, Belew AT, El-Sayed NM, McIver KS, Kehl-Fie TE, Doran KS. Identification of Zinc-Dependent Mechanisms Used by Group B To Overcome Calprotectin-Mediated Stress. Mbio. 11. PMID 33173000 DOI: 10.1128/mBio.02302-20 |
0.335 |
|
| 2020 |
Braza RE, Silver AB, Sundar GS, Davis SE, Razi A, Islam E, Hart M, Zhu J, Le Breton Y, McIver KS. PTS Uptake and Metabolism of the ß-Glucoside Salicin Impacts Group A Streptococcal Bloodstream Survival and Soft Tissue Infection. Infection and Immunity. PMID 32719156 DOI: 10.1128/IAI.00346-20 |
0.412 |
|
| 2020 |
Le Breton Y, Belew AT, McIver KS. Protocols for Tn-seq Analyses in the Group A Streptococcus. Methods in Molecular Biology (Clifton, N.J.). 2136: 33-57. PMID 32430812 DOI: 10.1007/978-1-0716-0467-0_4 |
0.307 |
|
| 2019 |
Braza RE, Le Breton Y, McIver K. The Operon Encodes a Predicted ABC Importer Required for Fitness and Virulence During Group A Streptococcal Invasive Infection. Infection and Immunity. PMID 31591169 DOI: 10.1128/IAI.00613-19 |
0.396 |
|
| 2018 |
van Hensbergen VP, Movert E, de Maat V, Lüchtenborg C, Le Breton Y, Lambeau G, Payré C, Henningham A, Nizet V, van Strijp JAG, Brügger B, Carlsson F, McIver KS, van Sorge NM. Streptococcal Lancefield polysaccharides are critical cell wall determinants for human Group IIA secreted phospholipase A2 to exert its bactericidal effects. Plos Pathogens. 14: e1007348. PMID 30321240 DOI: 10.1371/Journal.Ppat.1007348 |
0.405 |
|
| 2018 |
Valdes KM, Sundar GS, Belew AT, Islam E, El-Sayed NM, Le Breton Y, McIver KS. Glucose Levels Alter the Mga Virulence Regulon in the Group A Streptococcus. Scientific Reports. 8: 4971. PMID 29563558 DOI: 10.1038/S41598-018-23366-7 |
0.388 |
|
| 2018 |
Brouwer S, Cork AJ, Ong CY, Barnett TC, West NP, McIver KS, Walker MJ. The endopeptidase PepO regulates the SpeB cysteine protease and is essential for the virulence of invasive M1T1 Streptococcus pyogenes. Journal of Bacteriology. PMID 29378883 DOI: 10.1128/JB.00654-17 |
0.471 |
|
| 2017 |
Le Breton Y, Belew AT, Freiberg JA, Sundar GS, Islam E, Lieberman J, Shirtliff ME, Tettelin H, El-Sayed NM, McIver KS. Genome-wide discovery of novel M1T1 group A streptococcal determinants important for fitness and virulence during soft-tissue infection. Plos Pathogens. 13: e1006584. PMID 28832676 DOI: 10.1371/Journal.Ppat.1006584 |
0.398 |
|
| 2016 |
Vega LA, Valdes KM, Sundar GS, Belew AT, Islam E, Berge J, Curry P, Chen S, El-Sayed NM, Breton YL, McIver KS. The transcriptional regulator CpsY is important for innate immune evasion in Streptococcus pyogenes. Infection and Immunity. PMID 27993974 DOI: 10.1128/Iai.00925-16 |
0.458 |
|
| 2016 |
Freiberg JA, Le Breton Y, Tran BQ, Scott AJ, Harro JM, Ernst RK, Goo YA, Mongodin EF, Goodlett DR, McIver KS, Shirtliff ME. Global Analysis and Comparison of the Transcriptomes and Proteomes of Group A Streptococcus Biofilms. Msystems. 1. PMID 27933318 DOI: 10.1128/mSystems.00149-16 |
0.363 |
|
| 2016 |
Sundar GS, Islam E, Gera K, Le Breton Y, McIver KS. A PTS EII mutant library in Group A Streptococcus identifies a promiscuous Man-family PTS transporter influencing SLS-mediated hemolysis. Molecular Microbiology. PMID 27862457 DOI: 10.1111/mmi.13573 |
0.382 |
|
| 2016 |
Valdes KM, Sundar GS, Vega LA, Belew AT, Islam E, Binet R, El-Sayed NM, Le Breton Y, McIver KS. The fruRBA operon is necessary for Group A Streptococcal growth in fructose and for resistance to neutrophil killing during growth in whole human blood. Infection and Immunity. PMID 26787724 DOI: 10.1128/Iai.01296-15 |
0.34 |
|
| 2015 |
van der Beek SL, Le Breton Y, Ferenbach AT, Chapman RN, van Aalten DM, Navratilova I, Boons GJ, McIver K, van Sorge NM, Dorfmueller HC. GacA is Essential for Group A Streptococcus and Defines a New Class of Monomeric dTDP-4-dehydrorhamnose Reductases (RmlD). Molecular Microbiology. PMID 26278404 DOI: 10.1111/mmi.13169 |
0.389 |
|
| 2015 |
Le Breton Y, Belew AT, Valdes KM, Islam E, Curry P, Tettelin H, Shirtliff ME, El-Sayed NM, McIver KS. Essential Genes in the Core Genome of the Human Pathogen Streptococcus pyogenes. Scientific Reports. 5: 9838. PMID 25996237 DOI: 10.1038/Srep09838 |
0.42 |
|
| 2014 |
Sachla AJ, Le Breton Y, Akhter F, McIver KS, Eichenbaum Z. The crimson conundrum: heme toxicity and tolerance in GAS. Frontiers in Cellular and Infection Microbiology. 4: 159. PMID 25414836 DOI: 10.3389/Fcimb.2014.00159 |
0.411 |
|
| 2014 |
Freiberg JA, McIver KS, Shirtliff ME. In vivo expression of Streptococcus pyogenes immunogenic proteins during tibial foreign body infection. Infection and Immunity. 82: 3891-9. PMID 25001603 DOI: 10.1128/IAI.01831-14 |
0.311 |
|
| 2014 |
Baruch M, Belotserkovsky I, Hertzog BB, Ravins M, Dov E, McIver KS, Le Breton YS, Zhou Y, Cheng CY, Chen CY, Hanski E. An extracellular bacterial pathogen modulates host metabolism to regulate its own sensing and proliferation. Cell. 156: 97-108. PMID 24439371 DOI: 10.1016/j.cell.2013.12.007 |
0.417 |
|
| 2014 |
Gera K, Le T, Jamin R, Eichenbaum Z, McIver KS. The phosphoenolpyruvate phosphotransferase system in group A Streptococcus acts to reduce streptolysin S activity and lesion severity during soft tissue infection. Infection and Immunity. 82: 1192-204. PMID 24379283 DOI: 10.1128/Iai.01271-13 |
0.372 |
|
| 2013 |
Hondorp ER, Hou SC, Hause LL, Gera K, Lee CE, McIver KS. PTS phosphorylation of Mga modulates regulon expression and virulence in the group A streptococcus. Molecular Microbiology. 88: 1176-93. PMID 23651410 DOI: 10.1111/Mmi.12250 |
0.682 |
|
| 2013 |
Le Breton Y, Mistry P, Valdes KM, Quigley J, Kumar N, Tettelin H, McIver KS. Genome-wide identification of genes required for fitness of group A Streptococcus in human blood. Infection and Immunity. 81: 862-75. PMID 23297387 DOI: 10.1128/IAI.00837-12 |
0.484 |
|
| 2012 |
Hause LL, McIver KS. Nucleotides critical for the interaction of the Streptococcus pyogenes Mga virulence regulator with Mga-regulated promoter sequences. Journal of Bacteriology. 194: 4904-19. PMID 22773785 DOI: 10.1128/Jb.00809-12 |
0.643 |
|
| 2012 |
Hondorp ER, Hou SC, Hempstead AD, Hause LL, Beckett DM, McIver KS. Characterization of the Group A Streptococcus Mga virulence regulator reveals a role for the C-terminal region in oligomerization and transcriptional activation. Molecular Microbiology. 83: 953-67. PMID 22468267 DOI: 10.1111/J.1365-2958.2012.07980.X |
0.704 |
|
| 2010 |
Toukoki C, Gold KM, McIver KS, Eichenbaum Z. MtsR is a dual regulator that controls virulence genes and metabolic functions in addition to metal homeostasis in the group A streptococcus. Molecular Microbiology. 76: 971-89. PMID 20398221 DOI: 10.1111/J.1365-2958.2010.07157.X |
0.653 |
|
| 2009 |
McIver KS. Stand-alone response regulators controlling global virulence networks in streptococcus pyogenes. Contributions to Microbiology. 16: 103-19. PMID 19494581 DOI: 10.1159/000219375 |
0.498 |
|
| 2009 |
Nakata M, Köller T, Moritz K, Ribardo D, Jonas L, McIver KS, Sumitomo T, Terao Y, Kawabata S, Podbielski A, Kreikemeyer B. Mode of expression and functional characterization of FCT-3 pilus region-encoded proteins in Streptococcus pyogenes serotype M49. Infection and Immunity. 77: 32-44. PMID 18852238 DOI: 10.1128/IAI.00772-08 |
0.424 |
|
| 2008 |
Fisher M, Huang YS, Li X, McIver KS, Toukoki C, Eichenbaum Z. Shr is a broad-spectrum surface receptor that contributes to adherence and virulence in group A streptococcus. Infection and Immunity. 76: 5006-15. PMID 18710861 DOI: 10.1128/Iai.00300-08 |
0.402 |
|
| 2008 |
Leday TV, Gold KM, Kinkel TL, Roberts SA, Scott JR, McIver KS. TrxR, a new CovR-repressed response regulator that activates the Mga virulence regulon in group A Streptococcus. Infection and Immunity. 76: 4659-68. PMID 18678666 DOI: 10.1128/Iai.00597-08 |
0.656 |
|
| 2008 |
Kinkel TL, McIver KS. CcpA-mediated repression of streptolysin S expression and virulence in the group A streptococcus. Infection and Immunity. 76: 3451-63. PMID 18490461 DOI: 10.1128/IAI.00343-08 |
0.532 |
|
| 2007 |
Hondorp ER, McIver KS. The Mga virulence regulon: infection where the grass is greener. Molecular Microbiology. 66: 1056-65. PMID 18001346 DOI: 10.1111/j.1365-2958.2007.06006.x |
0.518 |
|
| 2007 |
Almengor AC, Kinkel TL, Day SJ, McIver KS. The catabolite control protein CcpA binds to Pmga and influences expression of the virulence regulator Mga in the Group A streptococcus. Journal of Bacteriology. 189: 8405-16. PMID 17905980 DOI: 10.1128/JB.01038-07 |
0.541 |
|
| 2006 |
Ribardo DA, McIver KS. Defining the Mga regulon: Comparative transcriptome analysis reveals both direct and indirect regulation by Mga in the group A streptococcus. Molecular Microbiology. 62: 491-508. PMID 16965517 DOI: 10.1111/j.1365-2958.2006.05381.x |
0.423 |
|
| 2006 |
Almengor AC, Walters MS, McIver KS. Mga is sufficient to activate transcription in vitro of sof-sfbX and other Mga-regulated virulence genes in the group A Streptococcus. Journal of Bacteriology. 188: 2038-47. PMID 16513733 DOI: 10.1128/JB.188.6.2038-2047.2006 |
0.609 |
|
| 2006 |
Vahling CM, McIver KS. Domains required for transcriptional activation show conservation in the mga family of virulence gene regulators. Journal of Bacteriology. 188: 863-73. PMID 16428389 DOI: 10.1128/JB.188.3.863-873.2006 |
0.509 |
|
| 2005 |
Vahling CM, McIver KS. Identification of residues responsible for the defective virulence gene regulator Mga produced by a natural mutant of Streptococcus pyogenes. Journal of Bacteriology. 187: 5955-66. PMID 16109937 DOI: 10.1128/JB.187.17.5955-5966.2005 |
0.362 |
|
| 2004 |
McIver KS, Kessler E, Ohman DE. Identification of residues in the Pseudomonas aeruginosa elastase propeptide required for chaperone and secretion activities. Microbiology (Reading, England). 150: 3969-77. PMID 15583150 DOI: 10.1099/Mic.0.27340-0 |
0.332 |
|
| 2004 |
Almengor AC, McIver KS. Transcriptional activation of sclA by Mga requires a distal binding site in Streptococcus pyogenes. Journal of Bacteriology. 186: 7847-57. PMID 15547255 DOI: 10.1128/JB.186.23.7847-7857.2004 |
0.52 |
|
| 2004 |
Ribardo DA, Lambert TJ, McIver KS. Role of Streptococcus pyogenes two-component response regulators in the temporal control of Mga and the Mga-regulated virulence gene emm. Infection and Immunity. 72: 3668-73. PMID 15155682 DOI: 10.1128/IAI.72.6.3668-3673.2004 |
0.43 |
|
| 2003 |
Ribardo DA, McIver KS. amrA encodes a putative membrane protein necessary for maximal exponential phase expression of the Mga virulence regulon in Streptococcus pyogenes. Molecular Microbiology. 50: 673-85. PMID 14617188 DOI: 10.1046/j.1365-2958.2003.03726.x |
0.517 |
|
| 2003 |
Kreikemeyer B, McIver KS, Podbielski A. Virulence factor regulation and regulatory networks in Streptococcus pyogenes and their impact on pathogen-host interactions. Trends in Microbiology. 11: 224-32. PMID 12781526 DOI: 10.1016/S0966-842X(03)00098-2 |
0.41 |
|
| 2002 |
McIver KS, Myles RL. Two DNA-binding domains of Mga are required for virulence gene activation in the group A streptococcus. Molecular Microbiology. 43: 1591-601. PMID 11952907 DOI: 10.1046/j.1365-2958.2002.02849.x |
0.5 |
|
| 2001 |
Limbago B, McIver KS, Penumalli V, Weinrick B, Scott JR. Restoration of Mga function to a Streptococcus pyogenes strain (M type 50) that is virulent in mice Infection and Immunity. 69: 1215-1220. PMID 11160026 DOI: 10.1128/Iai.69.2.1215-1220.2001 |
0.34 |
|
| 1999 |
Yung DL, Mciver KS, Scott JR, Hollingshead SK. Attenuated expression of the mga virulence regulon in an M serotype 50 mouse-virulent group A streptococcal strain Infection and Immunity. 67: 6691-6694. PMID 10569793 |
0.374 |
|
| 1999 |
McIver KS, Thurman AS, Scott JR. Regulation of mga transcription in the group A streptococcus: specific binding of mga within its own promoter and evidence for a negative regulator. Journal of Bacteriology. 181: 5373-83. PMID 10464209 DOI: 10.1128/Jb.181.17.5373-5383.1999 |
0.469 |
|
| 1999 |
Federle MJ, McIver KS, Scott JR. A response regulator that represses transcription of several virulence operons in the group A streptococcus. Journal of Bacteriology. 181: 3649-57. PMID 10368137 DOI: 10.1128/Jb.181.12.3649-3657.1999 |
0.545 |
|
| 1997 |
McIver KS, Scott JR. Role of mga in growth phase regulation of virulence genes of the group A streptococcus Journal of Bacteriology. 179: 5178-5187. PMID 9260962 DOI: 10.1128/Jb.179.16.5178-5187.1997 |
0.428 |
|
| 1996 |
Andersson G, McIver K, Hedén LO, Scott JR. Complementation of divergent mga genes in group A Streptococcus Gene. 175: 77-81. PMID 8917079 DOI: 10.1016/0378-1119(96)00124-2 |
0.402 |
|
| 1996 |
McIver KS, Subbarao S, Kellner EM, Heath AS, Scott JR. Identification of isp, a locus encoding an immunogenic secreted protein conserved among group a Streptococci Infection and Immunity. 64: 2548-2555. PMID 8698478 DOI: 10.1128/Iai.64.7.2548-2555.1996 |
0.458 |
|
| 1995 |
McIver KS, Heath AS, Green BD, Scott JR. Specific binding of the activator Mga to promoter sequences of the emm and scpA genes in the group A Streptococcus Journal of Bacteriology. 177: 6619-6624. PMID 7592441 DOI: 10.1128/Jb.177.22.6619-6624.1995 |
0.511 |
|
| 1995 |
McIver KS, Heath AS, Scott JR. Regulation of virulence by environmental signals in group A streptococci: Influence of osmolarity, temperature, gas exchange, and iron limitation on emm transcription Infection and Immunity. 63: 4540-4542. PMID 7591100 DOI: 10.1128/Iai.63.11.4540-4542.1995 |
0.334 |
|
| 1991 |
McIver K, Kessler E, Ohman DE. Substitution of active-site His-223 in Pseudomonas aeruginosa elastase and expression of the mutated lasB alleles in Escherichia coli show evidence for autoproteolytic processing of proelastase Journal of Bacteriology. 173: 7781-7789. PMID 1744034 DOI: 10.1128/Jb.173.24.7781-7789.1991 |
0.395 |
|
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