| Year |
Citation |
Score |
| 2023 |
Capp JP, Thomas F, Marusyk A, M Dujon A, Tissot S, Gatenby R, Roche B, Ujvari B, DeGregori J, Brown JS, Nedelcu AM. The paradox of cooperation among selfish cancer cells. Evolutionary Applications. 16: 1239-1256. PMID 37492150 DOI: 10.1111/eva.13571 |
0.666 |
|
| 2022 |
Somarelli JA, DeGregori J, Gerlinger M, Heng HH, Marusyk A, Welch DR, Laukien FH. Questions to guide cancer evolution as a framework for furthering progress in cancer research and sustainable patient outcomes. Medical Oncology (Northwood, London, England). 39: 137. PMID 35781581 DOI: 10.1007/s12032-022-01721-z |
0.63 |
|
| 2021 |
Dujon AM, Aktipis A, Alix-Panabières C, Amend SR, Boddy AM, Brown JS, Capp JP, DeGregori J, Ewald P, Gatenby R, Gerlinger M, Giraudeau M, Hamede RK, Hansen E, Kareva I, et al. Identifying key questions in the ecology and evolution of cancer. Evolutionary Applications. 14: 877-892. PMID 33897809 DOI: 10.1111/eva.13190 |
0.62 |
|
| 2021 |
Capp JP, DeGregori J, Nedelcu AM, Dujon AM, Boutry J, Pujol P, Alix-Panabières C, Hamede R, Roche B, Ujvari B, Marusyk A, Gatenby R, Thomas F. Group phenotypic composition in cancer. Elife. 10. PMID 33784238 DOI: 10.7554/eLife.63518 |
0.622 |
|
| 2020 |
Jones CL, Stevens BM, Pollyea DA, Culp-Hill R, Reisz JA, Nemkov T, Gehrke S, Gamboni F, Krug A, Winters A, Pei S, Gustafson A, Ye H, Inguva A, Amaya M, ... ... DeGregori J, et al. Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells. Cell Stem Cell. PMID 32822582 DOI: 10.1016/J.Stem.2020.07.021 |
0.308 |
|
| 2020 |
DeGregori J. The special issue on cancer and evolution: Lessons learned. Evolutionary Applications. 13: 1784-1790. PMID 32821282 DOI: 10.1111/Eva.13040 |
0.305 |
|
| 2020 |
Rozhok AI, DeGregori J. The three dimensions of somatic evolution: Integrating the role of genetic damage, life-history traits, and aging in carcinogenesis. Evolutionary Applications. 13: 1569-1580. PMID 32821273 DOI: 10.1111/Eva.12947 |
0.337 |
|
| 2020 |
Rozhok AI, Silberman RE, Higa KC, Liggett LA, Amon A, DeGregori J. A somatic evolutionary model of the dynamics of aneuploid cells during hematopoietic reconstitution. Scientific Reports. 10: 12198. PMID 32699207 DOI: 10.1038/S41598-020-68729-1 |
0.354 |
|
| 2020 |
Laconi E, Marongiu F, DeGregori J. Cancer as a disease of old age: changing mutational and microenvironmental landscapes. British Journal of Cancer. 122: 943-952. PMID 32042067 DOI: 10.1038/S41416-019-0721-1 |
0.372 |
|
| 2019 |
Somarelli JA, Gardner H, Cannataro VL, Gunady EF, Boddy AM, Johnson NA, Fisk JN, Gaffney SG, Chuang JH, Li S, Ciccarelli FD, Panchenko AR, Megquier K, Kumar S, Dornburg A, ... DeGregori J, et al. Molecular biology and evolution of cancer: from discovery to action. Molecular Biology and Evolution. PMID 31642480 DOI: 10.1093/Molbev/Msz242 |
0.346 |
|
| 2019 |
Pham-Danis C, DeGregori J. Studying Cancer Evolution and Therapeutic Responses in Different Organs: The Pros and Cons of a Broad Focus. Cancer Research. 79: 4582-4584. PMID 31439547 DOI: 10.1158/0008-5472.Can-19-1303 |
0.337 |
|
| 2019 |
Liggett LA, Sharma A, De S, DeGregori J. FERMI: A Novel Method for Sensitive Detection of Rare Mutations in Somatic Tissue. G3 (Bethesda, Md.). PMID 31352405 DOI: 10.1534/G3.119.400438 |
0.32 |
|
| 2019 |
Guida JL, Ahles TA, Belsky D, Campisi J, Cohen HJ, DeGregori J, Fuldner R, Ferrucci L, Gallicchio L, Gavrilov L, Gavrilova N, Green PA, Jhappan C, Kohanski R, Krull K, et al. Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors. Journal of the National Cancer Institute. PMID 31321426 DOI: 10.1093/Jnci/Djz136 |
0.318 |
|
| 2019 |
Jones CL, Stevens BM, D'Alessandro A, Culp-Hill R, Reisz JA, Pei S, Gustafson A, Khan N, DeGregori J, Pollyea DA, Jordan CT. Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II. Blood. PMID 31101624 DOI: 10.1182/Blood.2019898114 |
0.361 |
|
| 2019 |
Rozhok A, DeGregori J. A generalized theory of age-dependent carcinogenesis. Elife. 8. PMID 31034356 DOI: 10.7554/Elife.39950 |
0.375 |
|
| 2019 |
Bilousova G, DeGregori J. Elimination of unfit cells in young and ageing skin. Nature. 568: 318-319. PMID 30980033 DOI: 10.1038/D41586-019-00825-3 |
0.665 |
|
| 2019 |
Gregory MA, Nemkov T, Park HJ, Zaberezhnvv V, Gehrke S, Adane B, Jordan CT, Hansen KC, D'Alessandro A, DeGregori J. Targeting glutamine metabolism and redox state for leukemia therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30940653 DOI: 10.1158/1078-0432.Ccr-18-3223 |
0.355 |
|
| 2019 |
Pham-Danis C, Gehrke S, Danis E, Rozhok AI, Daniels MW, Gao D, Collins C, Di Paola JT, D'Alessandro A, DeGregori J. Urea cycle sustains cellular energetics upon EGFR inhibition in EGFR mutant NSCLC. Molecular Cancer Research : McR. PMID 30808730 DOI: 10.1158/1541-7786.Mcr-18-1068 |
0.36 |
|
| 2019 |
Oliphant MUJ, Vincent MY, Galbraith MD, Pandey A, Zaberezhnyy V, Rudra P, Johnson KR, Costello JC, Ghosh D, DeGregori J, Espinosa JM, Ford HL. Six2 mediates late-stage metastasis via direct regulation of Sox2 and induction of a cancer stem cell program. Cancer Research. PMID 30606720 DOI: 10.1158/0008-5472.Can-18-1791 |
0.36 |
|
| 2019 |
Chavez J, Rabe JL, Higa K, Loeffler D, Nouraiz A, Mills T, Idler BM, Stevens BM, Fleenor C, Nerlov C, Nakajima H, Hagman J, Schroeder T, Kim HM, Jordan CT, ... DeGregori J, et al. PU.1 Enforces Hematopoietic Stem Cell Quiescence during Chronic Inflammation Blood. 134: 822-822. DOI: 10.1182/Blood-2019-129300 |
0.389 |
|
| 2019 |
Pietras E, Rabe J, Chavez J, Higa K, Loeffler D, Mills T, Nerlov C, Schroeder T, DeGregori J. INTERLEUKIN-1 RESTRICTS HSC PROLIFERATION VIA A PU.1-DEPENDENT MECHANISM Experimental Hematology. 76: S82. DOI: 10.1016/J.Exphem.2019.06.420 |
0.348 |
|
| 2018 |
Jones CL, Stevens BM, D'Alessandro A, Reisz JA, Culp-Hill R, Nemkov T, Pei S, Khan N, Adane B, Ye H, Krug A, Reinhold D, Smith C, DeGregori J, Pollyea DA, et al. Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells. Cancer Cell. 34: 724-740.e4. PMID 30423294 DOI: 10.1182/Blood-2018-99-111965 |
0.327 |
|
| 2018 |
Tippimanchai DD, Nolan K, Poczobutt J, Verzosa G, Li H, Scarborough H, Huang J, Young C, DeGregori J, Nemenoff RA, Malkoski SP. Adenoviral vectors transduce alveolar macrophages in lung cancer models. Oncoimmunology. 7: e1438105. PMID 29872579 DOI: 10.1016/J.Jtho.2017.06.056 |
0.319 |
|
| 2018 |
Pilling AB, Kim J, Estrada-Bernal A, Zhou Q, Le AT, Singleton KR, Heasley LE, Tan AC, DeGregori J, Doebele RC. ALK is a critical regulator of the MYC-signaling axis in ALK positive lung cancer. Oncotarget. 9: 8823-8835. PMID 29507657 DOI: 10.18632/Oncotarget.24260 |
0.389 |
|
| 2018 |
Jones CL, Stevens BM, D'Alessandro A, Culp-Hill R, Reisz J, Ye H, Khan N, Minhajuddin M, DeGregori J, Pollyea DA, Jordan CT. Cysteine and Cystine Depletion Targets Leukemia Stem Cells Blood. 132: 431-431. DOI: 10.1182/Blood-2018-99-113181 |
0.38 |
|
| 2017 |
Gregory MA, Nemkov T, Reisz JA, Zaberezhnyy V, Hansen KC, D'Alessandro A, DeGregori J. Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia. Experimental Hematology. PMID 28947392 DOI: 10.1016/J.Exphem.2017.09.007 |
0.422 |
|
| 2017 |
Henry CJ, Nemkov T, Casas-Selves M, Bilousova G, Zaberezhnyy V, Higa KC, Serkova NJ, Hansen KC, D' Alessandro A, DeGregori J. Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis. Haematologica. PMID 28883079 DOI: 10.3324/Haematol.2017.171074 |
0.687 |
|
| 2017 |
DeGregori J. Connecting cancer to its causes requires incorporation of effects on tissue microenvironments. Cancer Research. PMID 28754675 DOI: 10.1158/0008-5472.Can-17-1207 |
0.308 |
|
| 2017 |
Alexander Liggett L, DeGregori J. Changing Mutational and Adaptive Landscapes and the Genesis of Cancer. Biochimica Et Biophysica Acta. PMID 28167050 DOI: 10.1016/J.Bbcan.2017.01.005 |
0.419 |
|
| 2016 |
Rozhok AI, DeGregori J. The evolution of lifespan and age-dependent cancer risk. Trends in Cancer. 2: 552-560. PMID 28439564 DOI: 10.1016/J.Trecan.2016.09.004 |
0.337 |
|
| 2016 |
Zhang G, Scarborough H, Kim J, Rozhok AI, Chen YA, Zhang X, Song L, Bai Y, Fang B, Liu RZ, Koomen J, Tan AC, Degregori J, Haura EB. Coupling an EML4-ALK-centric interactome with RNA interference identifies sensitizers to ALK inhibitors. Science Signaling. 9: rs12. PMID 27811184 DOI: 10.1126/Scisignal.Aaf5011 |
0.347 |
|
| 2016 |
Gregory MA, D'Alessandro A, Alvarez-Calderon F, Kim J, Nemkov T, Adane B, Rozhok AI, Kumar A, Kumar V, Pollyea DA, Wempe MF, Jordan CT, Serkova NJ, Tan AC, Hansen KC, ... DeGregori J, et al. ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America. 113: E6669-E6678. PMID 27791036 DOI: 10.1073/Pnas.1603876113 |
0.791 |
|
| 2016 |
Scarborough HA, Helfrich BA, Casas-Selves M, Schuller A, Grosskurth SE, Kim J, Tan AC, Chan DC, Zhang Z, Zaberezhnyy V, Bunn PA, DeGregori J. AZ1366: An inhibitor of tankyrase and the canonical Wnt pathway that limits the persistence of non-small cell lung cancer cells following EGFR inhibition. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27663586 DOI: 10.1158/1078-0432.Ccr-16-1179 |
0.351 |
|
| 2016 |
Sullivan KD, Lewis HC, Hill AA, Pandey A, Jackson LP, Cabral JM, Smith KP, Liggett LA, Gomez EB, Galbraith MD, DeGregori J, Espinosa JM. Trisomy 21 consistently activates the interferon response. Elife. 5. PMID 27472900 DOI: 10.7554/Elife.16220 |
0.394 |
|
| 2016 |
Fernández-Cabezudo MJ, Faour I, Jones K, Champagne DP, Jaloudi MA, Mohamed YA, Bashir G, Almarzooqi S, Albawardi A, Hashim MJ, Roberts TS, El-Salhat H, El-Taji H, Kassis A, O'Sullivan DE, ... ... DeGregori J, et al. Deficiency of mitochondrial modulator MCJ promotes chemoresistance in breast cancer. Jci Insight. 1. PMID 27275014 DOI: 10.1172/Jci.Insight.86873 |
0.328 |
|
| 2016 |
Yadav VK, DeGregori J, De S. The landscape of somatic mutations in protein coding genes in apparently benign human tissues carries signatures of relaxed purifying selection. Nucleic Acids Research. PMID 26883632 DOI: 10.1093/Nar/Gkw086 |
0.328 |
|
| 2016 |
Rozhok AI, Salstrom JL, DeGregori J. Stochastic modeling reveals an evolutionary mechanism underlying elevated rates of childhood leukemia. Proceedings of the National Academy of Sciences of the United States of America. 113: 1050-5. PMID 26755588 DOI: 10.1073/Pnas.1509333113 |
0.32 |
|
| 2015 |
Henry CJ, Casás-Selves M, Kim J, Zaberezhnyy V, Aghili L, Daniel AE, Jimenez L, Azam T, McNamee EN, Clambey ET, Klawitter J, Serkova NJ, Tan AC, Dinarello CA, DeGregori J. Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors. The Journal of Clinical Investigation. PMID 26551682 DOI: 10.1172/Jci83024 |
0.38 |
|
| 2015 |
Fleenor CJ, Higa K, Weil MM, DeGregori J. Evolved Cellular Mechanisms to Respond to Genotoxic Insults: Implications for Radiation-Induced Hematologic Malignancies. Radiation Research. 184: 341-51. PMID 26414506 DOI: 10.1667/Rr14147.1 |
0.331 |
|
| 2015 |
Rozhok AI, DeGregori J. Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations. Proceedings of the National Academy of Sciences of the United States of America. 112: 8914-21. PMID 26195756 DOI: 10.1073/Pnas.1501713112 |
0.39 |
|
| 2015 |
Rozhok AI, Wahl GM, DeGregori J. A Critical Examination of the "Bad Luck" Explanation of Cancer Risk. Cancer Prevention Research (Philadelphia, Pa.). 8: 762-4. PMID 26122457 DOI: 10.1158/1940-6207.Capr-15-0229 |
0.318 |
|
| 2015 |
Alvarez-Calderon F, DeGregori J. Oncogenic drivers and mitochondrial dependency. Aging. 7: 148-9. PMID 25868642 |
0.724 |
|
| 2015 |
Avasarala S, Van Scoyk M, Karuppusamy Rathinam MK, Zerayesus S, Zhao X, Zhang W, Pergande MR, Borgia JA, DeGregori J, Port JD, Winn RA, Bikkavilli RK. PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer. The Journal of Biological Chemistry. 290: 13479-89. PMID 25847239 DOI: 10.1074/Jbc.M114.636050 |
0.341 |
|
| 2015 |
Alvarez-Calderon F, Gregory MA, Pham-Danis C, DeRyckere D, Stevens BM, Zaberezhnyy V, Hill AA, Gemta L, Kumar A, Kumar V, Wempe MF, Pollyea DA, Jordan CT, Serkova NJ, Graham DK, ... DeGregori J, et al. Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 1360-72. PMID 25547679 DOI: 10.1158/1078-0432.Ccr-14-2146 |
0.777 |
|
| 2015 |
Scarborough HA, Bunn PA, DeGregori J. Personalized one-two punches for lung cancer. Cell Research. 25: 269-70. PMID 25547118 DOI: 10.1038/Cr.2014.168 |
0.313 |
|
| 2015 |
Fleenor CJ, Rozhok AI, Zaberezhnyy V, Mathew D, Kim J, Tan AC, Bernstein ID, DeGregori J. Contrasting roles for C/EBPα and Notch in irradiation-induced multipotent hematopoietic progenitor cell defects. Stem Cells (Dayton, Ohio). 33: 1345-58. PMID 25546133 DOI: 10.1002/Stem.1936 |
0.385 |
|
| 2015 |
Gregory MA, D'Alessandro A, Alvarez-Calderon F, Kim J, Nemkov T, Tan AC, Hansen KC, DeGregori J. Abstract C78: ATM/G6PD-dependent metabolic pathways promote mitochondrial redox homeostasis and resistance to FLT3 inhibition in acute myeloid leukemia Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-C78 |
0.798 |
|
| 2014 |
Gardner LA, Klawitter J, Gregory MA, Zaberezhnyy V, Baturin D, Pollyea DA, Takebe N, Christians U, Gore L, DeGregori J, Porter CC. Inhibition of calcineurin combined with dasatinib has direct and indirect anti-leukemia effects against BCR-ABL1(+) leukemia. American Journal of Hematology. 89: 896-903. PMID 24891015 DOI: 10.1002/Ajh.23776 |
0.376 |
|
| 2014 |
Aghili L, Foo J, DeGregori J, De S. Patterns of somatically acquired amplifications and deletions in apparently normal tissues of ovarian cancer patients. Cell Reports. 7: 1310-9. PMID 24794429 DOI: 10.1016/J.Celrep.2014.03.071 |
0.331 |
|
| 2014 |
Ostrow SL, Barshir R, DeGregori J, Yeger-Lotem E, Hershberg R. Cancer evolution is associated with pervasive positive selection on globally expressed genes. Plos Genetics. 10: e1004239. PMID 24603726 DOI: 10.1371/Journal.Pgen.1004239 |
0.354 |
|
| 2014 |
Wie SM, Adwan TS, DeGregori J, Anderson SM, Reyland ME. Inhibiting tyrosine phosphorylation of protein kinase Cδ (PKCδ) protects the salivary gland from radiation damage. The Journal of Biological Chemistry. 289: 10900-8. PMID 24569990 DOI: 10.1074/Jbc.M114.551366 |
0.33 |
|
| 2013 |
Yang X, La Rosa FG, Genova EE, Huber K, Schaack J, Degregori J, Serkova NJ, Li Y, Su LJ, Kessler E, Flaig TW. Simultaneous activation of Kras and inactivation of p53 induces soft tissue sarcoma and bladder urothelial hyperplasia. Plos One. 8: e74809. PMID 24058630 DOI: 10.1371/Journal.Pone.0074809 |
0.318 |
|
| 2013 |
Spreafico A, Tentler JJ, Pitts TM, Tan AC, Gregory MA, Arcaroli JJ, Klauck PJ, McManus MC, Hansen RJ, Kim J, Micel LN, Selby HM, Newton TP, McPhillips KL, Gustafson DL, ... Degregori JV, et al. Rational combination of a MEK inhibitor, selumetinib, and the Wnt/calcium pathway modulator, cyclosporin A, in preclinical models of colorectal cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 4149-62. PMID 23757356 DOI: 10.1158/1078-0432.Ccr-12-3140 |
0.399 |
|
| 2013 |
Singleton KR, Kim J, Hinz TK, Marek LA, Casás-Selves M, Hatheway C, Tan AC, DeGregori J, Heasley LE. A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head and neck squamous carcinoma cell lines. Molecular Pharmacology. 83: 882-93. PMID 23371912 DOI: 10.1124/Mol.112.084111 |
0.359 |
|
| 2013 |
Alvarez-Calderon F, Gregory MA, DeGregori J. Using functional genomics to overcome therapeutic resistance in hematological malignancies. Immunologic Research. 55: 100-15. PMID 22941562 DOI: 10.1007/S12026-012-8353-Z |
0.78 |
|
| 2013 |
Degregori J. Challenging the axiom: Does the occurrence of oncogenic mutations truly limit cancer development with age Oncogene. 32: 1869-1875. PMID 22751134 DOI: 10.1038/Onc.2012.281 |
0.373 |
|
| 2012 |
Casás-Selves M, Kim J, Zhang Z, Helfrich BA, Gao D, Porter CC, Scarborough HA, Bunn PA, Chan DC, Tan AC, DeGregori J. Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition. Cancer Research. 72: 4154-64. PMID 22738915 DOI: 10.1158/0008-5472.Can-11-2848 |
0.37 |
|
| 2012 |
Sullivan KD, Padilla-Just N, Henry RE, Porter CC, Kim J, Tentler JJ, Eckhardt SG, Tan AC, DeGregori J, Espinosa JM. ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. Nature Chemical Biology. 8: 646-54. PMID 22660439 DOI: 10.1038/Nchembio.965 |
0.406 |
|
| 2012 |
Bahmed K, Henry C, Holliday M, Redzic J, Ciobanu M, Zhang F, Weekes C, Sclafani R, Degregori J, Eisenmesser E. Extracellular cyclophilin-A stimulates ERK1/2 phosphorylation in a cell-dependent manner but broadly stimulates nuclear factor kappa B. Cancer Cell International. 12: 19. PMID 22631225 DOI: 10.1186/1475-2867-12-19 |
0.334 |
|
| 2012 |
Porter CC, Kim J, Fosmire S, Gearheart CM, Van Linden A, Baturin D, Zaberezhnyy V, Patel PR, Gao D, Tan AC, Degregori J. Integrated genomic analyses identify WEE1 as a critical mediator of cell fate and a novel therapeutic target in acute myeloid leukemia Leukemia. 26: 1266-1276. PMID 22289989 DOI: 10.1038/Leu.2011.392 |
0.424 |
|
| 2012 |
Pilling AB, Le AT, Tan A, Kim J, Singleton KR, Heasley LE, Helfrich B, DeGregori J, Doebele RC. Abstract 5594: ALK-driven lung cancer: Potential therapeutic strategies for treatment and prevention of drug resistance Cancer Research. 72: 5594-5594. DOI: 10.1158/1538-7445.Am2012-5594 |
0.392 |
|
| 2012 |
Henry CJ, Marusyk A, Zaberezhnyy V, Casas M, Adane B, Merz A, Serkova N, DeGregori J. Abstract 4982: Aging-associated alterations in IL-7 receptor signaling and inflammation promote declining B-lymphopoiesis and increased leukemogenesis Cancer Research. 72: 4982-4982. DOI: 10.1158/1538-7445.Am2012-4982 |
0.758 |
|
| 2012 |
Alvarez-Calderon F, Zaberezhnyy V, Gemta L, Gregory MA, DeGregori JV. Abstract 1127: Bcr-Abl inhibition in leukemia cells creates metabolic addictions Cancer Research. 72: 1127-1127. DOI: 10.1158/1538-7445.Am2012-1127 |
0.799 |
|
| 2011 |
Casás-Selves M, Degregori J. How cancer shapes evolution, and how evolution shapes cancer. Evolution. 4: 624-634. PMID 23705033 DOI: 10.1007/S12052-011-0373-Y |
0.367 |
|
| 2011 |
Henry CJ, Marusyk A, DeGregori J. Aging-associated changes in hematopoiesis and leukemogenesis: what's the connection? Aging. 3: 643-56. PMID 21765201 |
0.633 |
|
| 2011 |
DeGregori J. Evolved tumor suppression: why are we so good at not getting cancer? Cancer Research. 71: 3739-44. PMID 21610109 DOI: 10.1158/0008-5472.Can-11-0342 |
0.406 |
|
| 2011 |
Degregori J. A new role for E2F1 in DNA repair: all for the greater good. Cell Cycle (Georgetown, Tex.). 10: 1716. PMID 21532333 DOI: 10.4161/Cc.10.11.15649 |
0.332 |
|
| 2011 |
Porter CC, Kim J, Fosmire S, Gearheart CM, van Linden A, Zaberezhnyy V, Gao D, Tan AC, DeGregori J. Genome-Wide shRNA Screen Identifies WEE1 As a Critical Mediator of Cell Fate and Novel Therapeutic Target in AML, Blood. 118: 3503-3503. DOI: 10.1182/Blood.V118.21.3503.3503 |
0.442 |
|
| 2011 |
Alvarez-Calderon F, Gregory MA, DeGregori J. Abstract 3796: Inhibition of mitochondrial respiration synergizes with tyrosine kinase inhibitors to eliminate Bcr-Abl+ leukemia Cancer Research. 71: 3796-3796. DOI: 10.1158/1538-7445.Am2011-3796 |
0.796 |
|
| 2010 |
Henry CJ, Marusyk A, Zaberezhnyy V, Adane B, DeGregori J. Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 21713-8. PMID 21098275 DOI: 10.1073/Pnas.1005486107 |
0.708 |
|
| 2010 |
Fleenor CJ, Marusyk A, DeGregori J. Ionizing radiation and hematopoietic malignancies: altering the adaptive landscape. Cell Cycle (Georgetown, Tex.). 9: 3005-11. PMID 20676038 DOI: 10.4161/Cc.9.15.12311 |
0.669 |
|
| 2010 |
Bui MR, Hodson V, King T, Leopold D, Dai S, Fiolkoski V, Oakes S, Duke R, Apelian D, Franzusoff A, DeGregori J. Mutation-specific control of BCR-ABL T315I positive leukemia with a recombinant yeast-based therapeutic vaccine in a murine model. Vaccine. 28: 6028-35. PMID 20619375 DOI: 10.1016/J.Vaccine.2010.06.085 |
0.787 |
|
| 2010 |
Gregory MA, Phang TL, Neviani P, Alvarez-Calderon F, Eide CA, O'Hare T, Zaberezhnyy V, Williams RT, Druker BJ, Perrotti D, Degregori J. Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl. Cancer Cell. 18: 74-87. PMID 20609354 DOI: 10.1016/J.Ccr.2010.04.025 |
0.782 |
|
| 2010 |
Le ON, Rodier F, Fontaine F, Coppe JP, Campisi J, DeGregori J, Laverdière C, Kokta V, Haddad E, Beauséjour CM. Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status. Aging Cell. 9: 398-409. PMID 20331441 DOI: 10.1111/J.1474-9726.2010.00567.X |
0.341 |
|
| 2010 |
Marusyk A, Porter CC, Zaberezhnyy V, DeGregori J. Irradiation selects for p53-deficient hematopoietic progenitors. Plos Biology. 8: e1000324. PMID 20208998 DOI: 10.1371/Journal.Pbio.1000324 |
0.694 |
|
| 2010 |
Porter CC, Gregory MA, Zaberezhnyy V, Klawitter J, Christians U, DeGregori J. The Addition of Cyclosporine to Dasatinib Therapy of Murine Bcr-Abl+ Leukemia Improves Disease Control Independent of Altered Pharmacokinetics Blood. 116: 600-600. DOI: 10.1182/Blood.V116.21.600.600 |
0.339 |
|
| 2010 |
Choudhary R, Freed B, DeGregori J, Porter CC. Knockdown of HPRT Enables Selection of Genetically Modified Human Hematopoietic Progenitor Cells. Blood. 116: 3772-3772. DOI: 10.1182/Blood.V116.21.3772.3772 |
0.405 |
|
| 2009 |
Marusyk A, Casás-Selves M, Henry CJ, Zaberezhnyy V, Klawitter J, Christians U, DeGregori J. Irradiation alters selection for oncogenic mutations in hematopoietic progenitors. Cancer Research. 69: 7262-9. PMID 19738065 DOI: 10.1158/0008-5472.Can-09-0604 |
0.703 |
|
| 2008 |
Porter CC, DeGregori J. Interfering RNA-mediated purine analog resistance for in vitro and in vivo cell selection. Blood. 112: 4466-74. PMID 18587011 DOI: 10.1182/Blood-2008-03-146571 |
0.393 |
|
| 2008 |
Tessem JS, Jensen JN, Pelli H, Dai XM, Zong XH, Stanley ER, Jensen J, DeGregori J. Critical roles for macrophages in islet angiogenesis and maintenance during pancreatic degeneration. Diabetes. 57: 1605-17. PMID 18375440 DOI: 10.2337/Db07-1577 |
0.681 |
|
| 2008 |
Marusyk A, DeGregori J. Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations. Biochimica Et Biophysica Acta. 1785: 1-11. PMID 17980163 DOI: 10.1016/J.Bbcan.2007.09.001 |
0.698 |
|
| 2007 |
Marusyk A, DeGregori J. Replicational stress selects for p53 mutation. Cell Cycle (Georgetown, Tex.). 6: 2148-51. PMID 17786047 DOI: 10.4161/Cc.6.17.4732 |
0.673 |
|
| 2007 |
Marusyk A, Wheeler LJ, Mathews CK, DeGregori J. p53 mediates senescence-like arrest induced by chronic replicational stress. Molecular and Cellular Biology. 27: 5336-51. PMID 17515610 DOI: 10.1128/Mcb.01316-06 |
0.68 |
|
| 2007 |
Sawczyn KK, Porter CC, DeGregori J, Graham DK. Ectopic expression and oncogenesis of Mer tyrosine kinase in E2A-PBX1 expressing B-cell acute lymphoblastic leukemia Journal of Clinical Oncology. 25: 9561-9561. DOI: 10.1200/Jco.2007.25.18_Suppl.9561 |
0.328 |
|
| 2007 |
Porter CC, DeGregori J. In Vitro and In Vivo Selection of Genetically Modified Cells Using shRNA Against HPRT and Treatment with 6-thioguanine. Blood. 110: 2590-2590. DOI: 10.1182/Blood.V110.11.2590.2590 |
0.414 |
|
| 2007 |
Tessem JS, Pelli H, Dai X, Zong X, Stanley ER, Jensen J, Jensen JN, DeGregori J. A CRITICAL ROLE FOR MACROPHAGES IN PREVENTING PANCREATITIS ASSOCIATED DIABETES Pancreas. 35: 431. DOI: 10.1097/01.Mpa.0000297798.65422.79 |
0.65 |
|
| 2006 |
DeGregori J, Johnson DG. Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis. Current Molecular Medicine. 6: 739-48. PMID 17100600 DOI: 10.2174/1566524010606070739 |
0.33 |
|
| 2006 |
Johnson DG, Degregori J. Putting the Oncogenic and Tumor Suppressive Activities of E2F into Context. Current Molecular Medicine. 6: 731-8. PMID 17100599 DOI: 10.2174/1566524010606070731 |
0.38 |
|
| 2006 |
Marusyk A, DeGregori J. Building a better model of cancer. Cell Division. 1: 24. PMID 17049090 DOI: 10.1186/1747-1028-1-24 |
0.65 |
|
| 2006 |
Shapiro GS, Van Peursem C, Ornelles DA, Schaack J, DeGregori J. Recombinant adenoviral vectors can induce expression of p73 via the E4-orf6/7 protein. Journal of Virology. 80: 5349-60. PMID 16699015 DOI: 10.1128/Jvi.02016-05 |
0.359 |
|
| 2006 |
DeGregori J. Surprising dependency for retinoblastoma protein in ras-mediated tumorigenesis. Molecular and Cellular Biology. 26: 1165-9. PMID 16449632 DOI: 10.1128/Mcb.26.4.1165-1169.2006 |
0.378 |
|
| 2005 |
Bilousova G, Marusyk A, Porter CC, Cardiff RD, DeGregori J. Impaired DNA replication within progenitor cell pools promotes leukemogenesis. Plos Biology. 3: e401. PMID 16277552 DOI: 10.1371/Journal.Pbio.0030401 |
0.795 |
|
| 2005 |
DeGregori J. E2F and cell survival: context really is key. Developmental Cell. 9: 442-4. PMID 16198285 DOI: 10.1016/J.Devcel.2005.09.006 |
0.361 |
|
| 2005 |
DeRyckere D, DeGregori J. E2F1 and E2F2 are differentially required for homeostasis-driven and antigen-induced T cell proliferation in vivo. Journal of Immunology (Baltimore, Md. : 1950). 175: 647-55. PMID 16002659 DOI: 10.4049/Jimmunol.175.2.647 |
0.344 |
|
| 2005 |
Pappa A, Brown D, Koutalos Y, DeGregori J, White C, Vasiliou V. Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells. The Journal of Biological Chemistry. 280: 27998-8006. PMID 15905174 DOI: 10.1074/Jbc.M503698200 |
0.428 |
|
| 2005 |
Porter CC, DeGregori JV. The Leukemia Oncogene E2a-Hlf Impairs Checkpoint Activation. Blood. 106: 2857-2857. DOI: 10.1182/Blood.V106.11.2857.2857 |
0.43 |
|
| 2004 |
Tessem JS, DeGregori J. Roles for bone-marrow-derived cells in beta-cell maintenance. Trends in Molecular Medicine. 10: 558-64. PMID 15519282 DOI: 10.1016/J.Molmed.2004.09.002 |
0.686 |
|
| 2004 |
DeGregori J. The Rb network. Journal of Cell Science. 117: 3411-3. PMID 15252123 DOI: 10.1242/Jcs.01189 |
0.378 |
|
| 2004 |
Chau BN, Chen TT, Wan YY, DeGregori J, Wang JY. Tumor necrosis factor alpha-induced apoptosis requires p73 and c-ABL activation downstream of RB degradation. Molecular and Cellular Biology. 24: 4438-47. PMID 15121862 DOI: 10.1128/Mcb.24.10.4438-4447.2004 |
0.546 |
|
| 2003 |
Li FX, Zhu JW, Tessem JS, Beilke J, Varella-Garcia M, Jensen J, Hogan CJ, DeGregori J. The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss. Proceedings of the National Academy of Sciences of the United States of America. 100: 12935-40. PMID 14566047 DOI: 10.1073/Pnas.2231861100 |
0.701 |
|
| 2003 |
DeRyckere D, Mann DL, DeGregori J. Characterization of transcriptional regulation during negative selection in vivo. Journal of Immunology (Baltimore, Md. : 1950). 171: 802-11. PMID 12847248 DOI: 10.4049/Jimmunol.171.2.802 |
0.331 |
|
| 2003 |
Marchbank A, Su LJ, Walsh P, DeGregori J, Penheiter K, Grayson TB, Dellavalle RP, Lee LA. The CUSP DeltaNp63alpha isoform of human p63 is downregulated by solar-simulated ultraviolet radiation. Journal of Dermatological Science. 32: 71-4. PMID 12788532 DOI: 10.1016/S0923-1811(03)00040-9 |
0.304 |
|
| 2003 |
Li FX, Zhu JW, Hogan CJ, DeGregori J. Defective gene expression, S phase progression, and maturation during hematopoiesis in E2F1/E2F2 mutant mice. Molecular and Cellular Biology. 23: 3607-22. PMID 12724419 DOI: 10.1128/Mcb.23.10.3607-3622.2003 |
0.418 |
|
| 2003 |
Wan YY, DeGregori J. The survival of antigen-stimulated T cells requires NFkappaB-mediated inhibition of p73 expression. Immunity. 18: 331-42. PMID 12648451 DOI: 10.1016/S1074-7613(03)00053-0 |
0.546 |
|
| 2003 |
Roshon M, DeGregori JV, Ruley HE. Gene trap mutagenesis of hnRNP A2/B1: a cryptic 3' splice site in the neomycin resistance gene allows continued expression of the disrupted cellular gene. Bmc Genomics. 4: 2. PMID 12546712 DOI: 10.1186/1471-2164-4-2 |
0.638 |
|
| 2002 |
Dellavalle RP, Walsh P, Marchbank A, Grayson TE, Su LJ, Parker ER, DeGregori J, Penheiter K, Aszterbaum M, Epstein EH, Lee LA. CUSP/p63 expression in basal cell carcinoma. Experimental Dermatology. 11: 203-8. PMID 12102658 DOI: 10.1034/J.1600-0625.2002.110302.X |
0.338 |
|
| 2002 |
Bhattacharya D, Logue EC, Bakkour S, DeGregori J, Sha WC. Identification of gene function by cyclical packaging rescue of retroviral cDNA libraries. Proceedings of the National Academy of Sciences of the United States of America. 99: 8838-43. PMID 12084928 DOI: 10.1073/Pnas.132274799 |
0.381 |
|
| 2002 |
Angus SP, Fribourg AF, Markey MP, Williams SL, Horn HF, DeGregori J, Kowalik TF, Fukasawa K, Knudsen ES. Active RB elicits late G1/S inhibition. Experimental Cell Research. 276: 201-13. PMID 12027450 DOI: 10.1006/Excr.2002.5510 |
0.37 |
|
| 2002 |
DeGregori J. The genetics of the E2F family of transcription factors: shared functions and unique roles. Biochimica Et Biophysica Acta. 1602: 131-50. PMID 12020800 DOI: 10.1016/S0304-419X(02)00051-3 |
0.34 |
|
| 2002 |
Cook JG, Park CH, Burke TW, Leone G, DeGregori J, Engel A, Nevins JR. Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. Proceedings of the National Academy of Sciences of the United States of America. 99: 1347-52. PMID 11805305 DOI: 10.1073/Pnas.032677499 |
0.568 |
|
| 2001 |
Zhu JW, Field SJ, Gore L, Thompson M, Yang H, Fujiwara Y, Cardiff RD, Greenberg M, Orkin SH, DeGregori J. E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis Molecular and Cellular Biology. 21: 8547-8564. PMID 11713289 DOI: 10.1128/Mcb.21.24.8547-8564.2001 |
0.376 |
|
| 2000 |
Wan YY, Leon RP, Marks R, Cham CM, Schaack J, Gajewski TF, DeGregori J. Transgenic expression of the coxsackie/adenovirus receptor enables adenoviral-mediated gene delivery in naive T cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 13784-9. PMID 11095726 DOI: 10.1073/Pnas.250356297 |
0.578 |
|
| 2000 |
Schwertfeger KL, Hunter S, Heasley LE, Levresse V, Leon RP, DeGregori J, Anderson SM. Prolactin stimulates activation of c-jun N-terminal kinase (JNK). Molecular Endocrinology (Baltimore, Md.). 14: 1592-602. PMID 11043575 DOI: 10.1210/Mend.14.10.0536 |
0.362 |
|
| 2000 |
Williamson DJ, Banik-Maiti S, DeGregori J, Ruley HE. hnRNP C is required for postimplantation mouse development but Is dispensable for cell viability. Molecular and Cellular Biology. 20: 4094-105. PMID 10805751 DOI: 10.1128/Mcb.20.11.4094-4105.2000 |
0.722 |
|
| 1999 |
Zhu JW, DeRyckere D, Li FX, Wan YY, DeGregori J. A role for E2F1 in the induction of ARF, p53, and apoptosis during thymic negative selection. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 10: 829-38. PMID 10616908 |
0.547 |
|
| 1999 |
Leone G, DeGregori J, Jakoi L, Cook JG, Nevins JR. Collaborative role of E2F transcriptional activity and G1 cyclin- dependent kinase activity in the induction of S phase Proceedings of the National Academy of Sciences of the United States of America. 96: 6626-6631. PMID 10359762 DOI: 10.1073/Pnas.96.12.6626 |
0.524 |
|
| 1999 |
Sears R, Leone G, DeGregori J, Nevins JR. Ras enhances Myc protein stability Molecular Cell. 3: 169-179. PMID 10078200 DOI: 10.1016/S1097-2765(00)80308-1 |
0.499 |
|
| 1998 |
Leon RP, Hedlund T, Meech SJ, Li S, Schaack J, Hunger SP, Duke RC, DeGregori J. Adenoviral-mediated gene transfer in lymphocytes Proceedings of the National Academy of Sciences of the United States of America. 95: 13159-13164. PMID 9789058 DOI: 10.1073/Pnas.95.22.13159 |
0.326 |
|
| 1998 |
Leone G, DeGregori J, Yan Z, Jakoi L, Ishida S, Williams RS, Nevins JR. E2F3 activity is regulated during the cell cycle and is required for the induction of S phase Genes and Development. 12: 2120-2130. PMID 9679057 DOI: 10.1101/Gad.12.14.2120 |
0.574 |
|
| 1998 |
Yan Z, Degregori J, Shohet R, Leone G, Stillman B, Nevins JR, Williams RS. Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells Proceedings of the National Academy of Sciences of the United States of America. 95: 3603-3608. PMID 9520412 DOI: 10.1073/Pnas.95.7.3603 |
0.575 |
|
| 1997 |
Nevins JR, Leone G, DeGregori J, Jakoi L. Role of the Rb/E2F pathway in cell growth control Journal of Cellular Physiology. 173: 233-236. PMID 9365528 DOI: 10.1002/(Sici)1097-4652(199711)173:2<233::Aid-Jcp27>3.0.Co;2-F |
0.528 |
|
| 1997 |
Nevins JR, Degregori J, Jakoi L, Leone G. Functional analysis of E2F transcription factor Methods in Enzymology. 283: 205-219. PMID 9251021 DOI: 10.1016/S0076-6879(97)83017-0 |
0.539 |
|
| 1997 |
Degregori J, Leone G, Miron A, Jakoi L, Nevins JR. Distinct roles for E2F proteins in cell growth control and apoptosis Proceedings of the National Academy of Sciences of the United States of America. 94: 7245-7250. PMID 9207076 DOI: 10.1073/Pnas.94.14.7245 |
0.57 |
|
| 1997 |
Leone G, DeGregori J, Sears R, Jakoi L, Nevins JR. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F Nature. 387: 422-426. PMID 9163430 DOI: 10.1038/387422A0 |
0.535 |
|
| 1997 |
Leone G, DeGregori J, Sears R, Jakoi L, Nevins JR. Erratum: Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F Nature. 387: 932-932. DOI: 10.1038/43230 |
0.494 |
|
| 1996 |
Ohtani K, DeGregori J, Leone G, Herendeen DR, Kelly TJ, Nevins JR. Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor. Molecular and Cellular Biology. 16: 6977-84. PMID 8943353 DOI: 10.1128/Mcb.16.12.6977 |
0.589 |
|
| 1996 |
Smith EJ, Leone G, DeGregori J, Jakoi L, Nevins JR. The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state Molecular and Cellular Biology. 16: 6965-6976. PMID 8943352 DOI: 10.1128/Mcb.16.12.6965 |
0.562 |
|
| 1996 |
Khleif SN, DeGregori J, Yee CL, Otterson GA, Kaye FJ, Nevins JR, Howley PM. Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. Proceedings of the National Academy of Sciences of the United States of America. 93: 4350-4. PMID 8633069 DOI: 10.1073/Pnas.93.9.4350 |
0.586 |
|
| 1995 |
Ohtani K, Degregori J, Nevins JR. Regulation of the cyclin E gene by transcription factor E2F1 Proceedings of the National Academy of Sciences of the United States of America. 92: 12146-12150. PMID 8618861 DOI: 10.1073/Pnas.92.26.12146 |
0.557 |
|
| 1995 |
Kowalik TF, DeGregori J, Schwarz JK, Nevins JR. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis Journal of Virology. 69: 2491-2500. PMID 7884898 DOI: 10.1128/Jvi.69.4.2491-2500.1995 |
0.58 |
|
| 1995 |
DeGregori J, Kowalik T, Nevins JR. Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes Molecular and Cellular Biology. 15: 4215-4224. PMID 7623816 DOI: 10.1128/Mcb.15.8.4215 |
0.568 |
|
| 1995 |
DeGregori J, Leone G, Ohtani K, Miron A, Nevins JR. E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity Genes and Development. 9: 2783-2887. PMID 7498785 DOI: 10.1101/Gad.9.23.2873 |
0.523 |
|
| 1994 |
DeGregori J, Russ A, Von Melchner H, Rayburn H, Priyaranjan P, Jenkins NA, Copeland NG, Ruley HE. A murine homolog of the yeast RNA1 gene is required for postimplantation development Genes and Development. 8: 265-276. PMID 8314081 DOI: 10.1101/Gad.8.3.265 |
0.634 |
|
| 1992 |
von Melchner H, DeGregori JV, Rayburn H, Reddy S, Friedel C, Ruley HE. Selective disruption of genes expressed in totipotent embryonal stem cells. Genes & Development. 6: 919-27. PMID 1317320 DOI: 10.1101/Gad.6.6.919 |
0.662 |
|
| 1991 |
Ragozzino MM, Kuo A, DeGregori J, Kohl N, Ruley HE. Mechanisms of oncogene cooperation: activation and inactivation of a growth antagonist. Environmental Health Perspectives. 93: 97-103. PMID 1837777 DOI: 10.1289/Ehp.919397 |
0.654 |
|
| 1991 |
Reddy S, DeGregori JV, von Melchner H, Ruley HE. Retrovirus promoter-trap vector to induce lacZ gene fusions in mammalian cells. Journal of Virology. 65: 1507-15. PMID 1704929 DOI: 10.1128/Jvi.65.3.1507-1515.1991 |
0.643 |
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