| Year |
Citation |
Score |
| Low-probability matches (unlikely to be authored by this person) |
| 2024 |
Renawala HK, Chandrababu KB, Smith KJ, D'Addio SM, Topp EM. A Model Study to Assess Fibrillation and Product Stability to Support Peptide Drug Design. Molecular Pharmaceutics. PMID 38552144 DOI: 10.1021/acs.molpharmaceut.3c00996 |
0.01 |
|
| 2024 |
Wood VE, Kellerman MA, Groves K, Quaglia M, Topp EM, Matejtschuk P, Dalby PA. Investigation of the Solid-State Interactions in Lyophilized Human G-CSF Using Hydrogen-Deuterium Exchange Mass Spectrometry. Molecular Pharmaceutics. PMID 38516985 DOI: 10.1021/acs.molpharmaceut.3c01211 |
0.01 |
|
| 2023 |
Barros CHN, Alfaro M, Costello C, Wang F, Sapre K, Rastogi S, Chiruvolu S, Connolly J, Topp EM. Effect of Atomic Layer Coating on the Stability of Solid Myoglobin Formulations. Molecular Pharmaceutics. PMID 37466053 DOI: 10.1021/acs.molpharmaceut.3c00229 |
0.01 |
|
| 2022 |
Abdelraheem A, Tukra R, Kazarin P, Sinanis MD, Topp EM, Alexeenko A, Peroulis D. Statistical electromagnetics for industrial pharmaceutical lyophilization. Pnas Nexus. 1: pgac052. PMID 36741428 DOI: 10.1093/pnasnexus/pgac052 |
0.01 |
|
| 2022 |
Renawala HK, Topp EM. Fibrillation of human insulin B-chain by pulsed hydrogen-deuterium exchange mass spectrometry. Biophysical Journal. 121: 4505-4516. PMID 36325616 DOI: 10.1016/j.bpj.2022.10.042 |
0.01 |
|
| 2021 |
Bersin LM, Patel SM, Topp EM. Effect of 'pH' on the Rate of Pyroglutamate Formation in Solution and Lyophilized Solids. Molecular Pharmaceutics. PMID 34232660 DOI: 10.1021/acs.molpharmaceut.1c00338 |
0.01 |
|
| 2021 |
Chen Y, Ling J, Li M, Su Y, Arte KS, Mutukuri TT, Taylor LS, Munson EJ, Topp EM, Zhou QT. Understanding the Impact of Protein-Excipient Interactions on Physical Stability of Spray-Dried Protein Solids. Molecular Pharmaceutics. PMID 34096731 DOI: 10.1021/acs.molpharmaceut.1c00189 |
0.01 |
|
| 2021 |
Cho E, Mayhugh BM, Srinivasan JM, Sacha GA, Nail SL, Topp EM. Stability of Antibody Drug Conjugate Formulations Evaluated Using Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry. Journal of Pharmaceutical Sciences. PMID 33711346 DOI: 10.1016/j.xphs.2021.03.006 |
0.01 |
|
| 2021 |
Tukra R, Gardner S, Topp EM. Effects of Temperature and Relative Humidity in DO on Solid-state Hydrogen Deuterium Exchange Mass Spectrometry (ssHDX-MS). International Journal of Pharmaceutics. 120263. PMID 33486024 DOI: 10.1016/j.ijpharm.2021.120263 |
0.01 |
|
| 2020 |
Tejasvi Mutukuri T, Wilson NE, Taylor LS, Topp EM, Tony Zhou Q. Effects of Drying Method and Excipient on the Structure and Physical Stability of Protein Solids: Freeze Drying vs. Spray Freeze Drying. International Journal of Pharmaceutics. 120169. PMID 33333176 DOI: 10.1016/j.ijpharm.2020.120169 |
0.01 |
|
| 2020 |
Renawala HK, Chandrababu KB, Topp EM. Fibrillation of Human Calcitonin and its Analogs: Effects of Phosphorylation and Disulfide Reduction. Biophysical Journal. PMID 33220304 DOI: 10.1016/j.bpj.2020.11.009 |
0.01 |
|
| 2020 |
Kammari R, Topp EM. Prehydration and the Reversibility of Solid-State Hydrogen-Deuterium Exchange. Molecular Pharmaceutics. PMID 32786954 DOI: 10.1021/acs.molpharmaceut.0c00571 |
0.01 |
|
| 2020 |
Kammari R, Topp EM. Effects of Secondary Structure on Solid-State Hydrogen-Deuterium Exchange in Model α-Helix and β-Sheet Peptides. Molecular Pharmaceutics. PMID 32672982 DOI: 10.1021/acs.molpharmaceut.0c00521 |
0.01 |
|
| 2019 |
Wilson NE, Mutukuri TT, Zemlyanov DY, Taylor LS, Topp EM, Zhou QT. Surface Composition and Formulation Heterogeneity of Protein Solids Produced by Spray Drying. Pharmaceutical Research. 37: 14. PMID 31873808 DOI: 10.1007/S11095-019-2738-9 |
0.01 |
|
| 2019 |
Kumar L, Chandrababu KB, Balakrishnan SM, Allmendinger A, Walters B, Zarraga IE, Chang DP, Nayak P, Topp EM. Optimizing Formulation and Lyophilization Process for a Fragment Antigen Binding (Fab) Protein Using Solid-state Hydrogen Deuterium Exchange Mass Spectrometry (ssHDX-MS). Molecular Pharmaceutics. PMID 31568722 DOI: 10.1021/Acs.Molpharmaceut.9B00614 |
0.01 |
|
| 2019 |
AbouGhaly MHH, Du J, Patel SM, Topp EM. Effects of ionic interactions on protein stability prediction using solid-state hydrogen deuterium exchange with mass spectrometry (ssHDX-MS). International Journal of Pharmaceutics. 118512. PMID 31301464 DOI: 10.1016/j.ijpharm.2019.118512 |
0.01 |
|
| 2019 |
Wilson NE, Topp EM, Zhou QT. Effects of drying method and excipient on structure and stability of protein solids using solid-state hydrogen/deuterium exchange mass spectrometry (ssHDX-MS). International Journal of Pharmaceutics. 567: 118470. PMID 31252148 DOI: 10.1016/j.ijpharm.2019.118470 |
0.01 |
|
| 2019 |
Kammari R, Topp EM. Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry (ssHDX-MS) of Lyophilized Poly-d,l-Alanine. Molecular Pharmaceutics. 16: 2935-2946. PMID 31244225 DOI: 10.1021/acs.molpharmaceut.9b00162 |
0.01 |
|
| 2019 |
Chen Y, Topp EM. A Novel Photo-Reactive Excipient to Probe Peptide-Matrix Interactions in Lyophilized Solids. Journal of Pharmaceutical Sciences. PMID 31034909 DOI: 10.1016/j.xphs.2019.04.024 |
0.01 |
|
| 2019 |
Chen Y, Topp EM. Photolytic Labeling to Quantify Peptide-Water Interactions in Lyophilized Solids. Molecular Pharmaceutics. PMID 30721080 DOI: 10.1021/acs.molpharmaceut.8b01031 |
0.01 |
|
| 2018 |
Chen Y, Topp EM. Photolytic Labeling and Its Applications in Protein Drug Discovery and Development. Journal of Pharmaceutical Sciences. PMID 30339867 DOI: 10.1016/j.xphs.2018.10.017 |
0.01 |
|
| 2018 |
Chen Y, Topp EM. Quantitative Analysis of Peptide-Matrix Interactions in Lyophilized Solids Using Photolytic Labeling. Molecular Pharmaceutics. PMID 29792715 DOI: 10.1021/acs.molpharmaceut.8b00283 |
0.01 |
|
| 2018 |
Liechty ET, Strongrich AD, Moussa EM, Topp E, Alexeenko AA. In-Situ Molecular Vapor Composition Measurements During Lyophilization. Pharmaceutical Research. 35: 115. PMID 29644443 DOI: 10.1007/S11095-018-2395-4 |
0.01 |
|
| 2018 |
Moussa EM, Singh SK, Kimmel M, Nema S, Topp EM. Probing the Conformation of an IgG1 Monoclonal Antibody in Lyophilized Solids Using Solid-State Hydrogen-Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS). Molecular Pharmaceutics. PMID 29355022 DOI: 10.1021/acs.molpharmaceut.7b00696 |
0.01 |
|
| 2018 |
Moussa EM, Wilson NE, Zhou QT, Singh SK, Nema S, Topp EM. Effects of Drying Process on an IgG1 Monoclonal Antibody Using Solid-State Hydrogen Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS). Pharmaceutical Research. 35: 12. PMID 29299701 DOI: 10.1007/s11095-017-2318-9 |
0.01 |
|
| 2018 |
Moorthy BS, Zarraga IE, Kumar L, Walters BT, Goldbach P, Topp EM, Allmendinger A. Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry: Correlation of Deuterium Uptake and Long-Term Stability of Lyophilized Monoclonal Antibody Formulations. Molecular Pharmaceutics. 15: 1-11. PMID 29182876 DOI: 10.1021/Acs.Molpharmaceut.7B00504 |
0.01 |
|
| 2017 |
Gardner NW, McGinness SM, Panchal J, Topp EM, Park C. A cooperative folding unit as the structural link for energetic coupling within a protein. Biochemistry. PMID 29166011 DOI: 10.1021/Acs.Biochem.7B00850 |
0.01 |
|
| 2016 |
Tabatabaei Ghomi H, Topp EM, Lill MA. Fibpredictor: a computational method for rapid prediction of amyloid fibril structures. Journal of Molecular Modeling. 22: 206. PMID 27502172 DOI: 10.1007/s00894-016-3066-1 |
0.01 |
|
| 2016 |
Iyer LK, Sacha GA, Moorthy BS, Nail SL, Topp EM. Process and Formulation Effects on Protein Structure in Lyophilized Solids Using Mass Spectrometric Methods. Journal of Pharmaceutical Sciences. PMID 27044943 DOI: 10.1016/j.xphs.2016.02.033 |
0.01 |
|
| 2016 |
Moussa EM, Kotarek J, Blum JS, Marszal E, Topp EM. Physical Characterization and Innate Immunogenicity of Aggregated Intravenous Immunoglobulin (IGIV) in an In Vitro Cell-Based Model. Pharmaceutical Research. PMID 27037576 DOI: 10.1007/s11095-016-1914-4 |
0.01 |
|
| 2016 |
Chandrasekhar S, Moorthy BS, Xie R, Topp EM. Thiol-Disulfide Exchange in Human Growth Hormone. Pharmaceutical Research. PMID 26887678 DOI: 10.1007/s11095-016-1879-3 |
0.01 |
|
| 2016 |
Moussa EM, Panchal JP, Moorthy BS, Blum JS, Joubert MK, Narhi LO, Topp EM. Immunogenicity of Therapeutic Protein Aggregates. Journal of Pharmaceutical Sciences. 105: 417-30. PMID 26869409 DOI: 10.1016/j.xphs.2015.11.002 |
0.01 |
|
| 2015 |
Moorthy BS, Iyer LK, Topp EM. Characterizing Protein Structure, Dynamics and Conformation in Lyophilized Solids. Current Pharmaceutical Design. 21: 5845-53. PMID 26446463 |
0.01 |
|
| 2015 |
Iyer LK, Moorthy BS, Topp EM. Photolytic Cross-Linking to Probe Protein-Protein and Protein-Matrix Interactions in Lyophilized Powders. Molecular Pharmaceutics. 12: 3237-49. PMID 26204425 DOI: 10.1021/acs.molpharmaceut.5b00183 |
0.01 |
|
| 2015 |
Stavropoulos K, Johnston SC, Zhang Y, Rao BG, Hurrey M, Hurter P, Topp EM, Kadiyala I. Cocrystalline Solids of Telaprevir with Enhanced Oral Absorption. Journal of Pharmaceutical Sciences. PMID 26094780 DOI: 10.1002/Jps.24534 |
0.01 |
|
| 2015 |
Moorthy BS, Iyer LK, Topp EM. Mass spectrometric approaches to study protein structure and interactions in lyophilized powders. Journal of Visualized Experiments : Jove. PMID 25938927 DOI: 10.3791/52503 |
0.01 |
|
| 2015 |
Moorthy BS, Ghomi HT, Lill MA, Topp EM. Structural transitions and interactions in the early stages of human glucagon amyloid fibrillation. Biophysical Journal. 108: 937-48. PMID 25692598 DOI: 10.1016/j.bpj.2015.01.004 |
0.01 |
|
| 2015 |
Chandrasekhar S, Topp EM. Thiol-disulfide exchange in peptides derived from human growth hormone during lyophilization and storage in the solid state. Journal of Pharmaceutical Sciences. 104: 1291-302. PMID 25631887 DOI: 10.1002/jps.24370 |
0.01 |
|
| 2015 |
Moorthy BS, Xie B, Moussa EM, Iyer LK, Chandrasekhar S, Panchal JP, Topp EM. Effect of hydrolytic degradation on the in vivo properties of monoclonal antibodies Biobetters: Protein Engineering to Approach the Curative. 105-135. DOI: 10.1007/978-1-4939-2543-8_8 |
0.01 |
|
| 2015 |
Moorthy BS, Xie B, Moussa EM, Iyer LK, Chandrasekhar S, Panchal JP, Topp EM. Structure of monoclonal antibodies Biobetters: Protein Engineering to Approach the Curative. 81-89. DOI: 10.1007/978-1-4939-2543-8_6 |
0.01 |
|
| 2015 |
Chandrasekhar S, Topp EM. Thiol-Disulfide Exchange in Peptides Derived from Human Growth Hormone During Lyophilization and Storage in the Solid State Journal of Pharmaceutical Sciences. DOI: 10.1002/jps.24370 |
0.01 |
|
| 2014 |
Moorthy BS, Schultz SG, Kim SG, Topp EM. Predicting protein aggregation during storage in lyophilized solids using solid state amide hydrogen/deuterium exchange with mass spectrometric analysis (ssHDX-MS). Molecular Pharmaceutics. 11: 1869-79. PMID 24816133 DOI: 10.1021/mp500005v |
0.01 |
|
| 2014 |
Panchal J, Kotarek J, Marszal E, Topp EM. Analyzing subvisible particles in protein drug products: a comparison of dynamic light scattering (DLS) and resonant mass measurement (RMM). The Aaps Journal. 16: 440-51. PMID 24570341 DOI: 10.1208/s12248-014-9579-6 |
0.01 |
|
| 2014 |
Topp EM. Commentary: current perspectives on the aggregation of protein drugs. The Aaps Journal. 16: 413-4. PMID 24563118 DOI: 10.1208/s12248-014-9580-0 |
0.01 |
|
| 2014 |
Chandrasekhar S, Epling DE, Sophocleous AM, Topp EM. Thiol-disulfide exchange in peptides derived from human growth hormone. Journal of Pharmaceutical Sciences. 103: 1032-42. PMID 24549831 DOI: 10.1002/jps.23906 |
0.01 |
|
| 2013 |
Roughton BC, Iyer LK, Bertelsen E, Topp EM, Camarda KV. Protein aggregation and lyophilization: Protein structural descriptors as predictors of aggregation propensity. Computers & Chemical Engineering. 58: 369-377. PMID 24516290 DOI: 10.1016/J.Compchemeng.2013.07.008 |
0.01 |
|
| 2013 |
Iyer LK, Moorthy BS, Topp EM. Photolytic labeling to probe molecular interactions in lyophilized powders. Molecular Pharmaceutics. 10: 4629-39. PMID 24125175 DOI: 10.1021/mp4004332 |
0.01 |
|
| 2013 |
Chandrasekhar S, Iyer LK, Panchal JP, Topp EM, Cannon JB, Ranade VV. Microarrays and microneedle arrays for delivery of peptides, proteins, vaccines and other applications. Expert Opinion On Drug Delivery. 10: 1155-70. PMID 23662940 DOI: 10.1517/17425247.2013.797405 |
0.01 |
|
| 2013 |
Roughton BC, Camarda KV, Topp EM. Development and comparison of computer-aided methods for the optimal design of lyophilized protein formulations Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area At the 2013 Aiche Annual Meeting: Global Challenges For Engineering a Sustainable Future. 697. |
0.01 |
|
| 2012 |
Roughton BC, Topp EM, Camarda KV. Use of glass transitions in carbohydrate excipient design for lyophilized protein formulations. Computers & Chemical Engineering. 36. PMID 24385675 DOI: 10.1016/J.Compchemeng.2011.07.018 |
0.01 |
|
| 2012 |
Sophocleous AM, Topp EM. Localized hydration in lyophilized myoglobin by hydrogen-deuterium exchange mass spectrometry. 2. Exchange kinetics. Molecular Pharmaceutics. 9: 727-33. PMID 22352990 DOI: 10.1021/mp2004093 |
0.01 |
|
| 2012 |
Sophocleous AM, Zhang J, Topp EM. Localized hydration in lyophilized myoglobin by hydrogen-deuterium exchange mass spectrometry. 1. Exchange mapping. Molecular Pharmaceutics. 9: 718-26. PMID 22352965 DOI: 10.1021/mp3000088 |
0.01 |
|
| 2012 |
Zhang J, Topp EM. Protein G, protein A and protein A-derived peptides inhibit the agitation induced aggregation of IgG. Molecular Pharmaceutics. 9: 622-8. PMID 22304418 DOI: 10.1021/mp200548x |
0.01 |
|
| 2012 |
Roughton BC, Pokphanh AI, Topp EM, Camarda KV. Optimizing Protein-Excipient Interactions for the Development of Aggregation-Reducing Lyophilized Formulations Computer Aided Chemical Engineering. 31: 1351-1355. DOI: 10.1016/B978-0-444-59506-5.50101-2 |
0.01 |
|
| 2010 |
Thing M, Zhang J, Laurence J, Topp EM. Thiol-disulfide interchange in the tocinoic acid/glutathione system during freezing and drying. Journal of Pharmaceutical Sciences. 99: 4849-56. PMID 20821392 DOI: 10.1002/Jps.22206 |
0.01 |
|
| 2010 |
Spencer P, Ye Q, Park J, Topp EM, Misra A, Marangos O, Wang Y, Bohaty BS, Singh V, Sene F, Eslick J, Camarda K, Katz JL. Adhesive/Dentin interface: the weak link in the composite restoration. Annals of Biomedical Engineering. 38: 1989-2003. PMID 20195761 DOI: 10.1007/S10439-010-9969-6 |
0.01 |
|
| 2010 |
Park J, Ye Q, Topp EM, Misra A, Kieweg SL, Spencer P. Effect of photoinitiator system and water content on dynamic mechanical properties of a light-cured bisGMA/HEMA dental resin. Journal of Biomedical Materials Research. Part A. 93: 1245-51. PMID 19827107 DOI: 10.1002/Jbm.A.32617 |
0.01 |
|
| 2010 |
Zhao H, Kiptoo P, Williams TD, Siahaan TJ, Topp EM. Immune response to controlled release of immunomodulating peptides in a murine experimental autoimmune encephalomyelitis (EAE) model. Journal of Controlled Release : Official Journal of the Controlled Release Society. 141: 145-52. PMID 19748537 DOI: 10.1016/J.Jconrel.2009.09.002 |
0.01 |
|
| 2010 |
Topp EM, Zhang L, Zhao H, Payne RW, Evans GJ, Manning MC. Chemical Instability in Peptide and Protein Pharmaceuticals Formulation and Process Development Strategies For Manufacturing Biopharmaceuticals. 41-67. DOI: 10.1002/9780470595886.ch2 |
0.01 |
|
| 2010 |
Zhang L, Sinha S, Topp EM. Protein Conformation and Reactivity in Amorphous Solids Formulation and Process Development Strategies For Manufacturing Biopharmaceuticals. 493-506. DOI: 10.1002/9780470595886.ch19 |
0.01 |
|
| 2009 |
Eslick JC, Ye Q, Park J, Topp EM, Spencer P, Camarda KV. A computational molecular design framework for crosslinked polymer networks. Computers & Chemical Engineering. 33: 954-963. PMID 23904665 DOI: 10.1016/J.Compchemeng.2008.09.019 |
0.01 |
|
| 2009 |
Park JG, Ye Q, Topp EM, Misra A, Spencer P. Water sorption and dynamic mechanical properties of dentin adhesives with a urethane-based multifunctional methacrylate monomer. Dental Materials : Official Publication of the Academy of Dental Materials. 25: 1569-75. PMID 19709724 DOI: 10.1016/J.Dental.2009.07.010 |
0.01 |
|
| 2009 |
Park JG, Ye Q, Topp EM, Spencer P. Enzyme-catalyzed hydrolysis of dentin adhesives containing a new urethane-based trimethacrylate monomer. Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 91: 562-71. PMID 19582843 DOI: 10.1002/jbm.b.31430 |
0.01 |
|
| 2009 |
Sinha S, Zhang L, Duan S, Williams TD, Vlasak J, Ionescu R, Topp EM. Effect of protein structure on deamidation rate in the Fc fragment of an IgG1 monoclonal antibody. Protein Science : a Publication of the Protein Society. 18: 1573-84. PMID 19544580 DOI: 10.1002/Pro.173 |
0.01 |
|
| 2009 |
Park JG, Ye Q, Topp EM, Lee CH, Kostoryz EL, Misra A, Spencer P. Dynamic mechanical analysis and esterase degradation of dentin adhesives containing a branched methacrylate. Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 91: 61-70. PMID 19358261 DOI: 10.1002/Jbm.B.31374 |
0.01 |
|
| 2009 |
Ye Q, Park J, Topp E, Spencer P. Effect of photoinitiators on the in vitro performance of a dentin adhesive exposed to simulated oral environment. Dental Materials : Official Publication of the Academy of Dental Materials. 25: 452-8. PMID 19027937 DOI: 10.1016/j.dental.2008.09.011 |
0.01 |
|
| 2009 |
Zhang L, Williams TD, Topp EM. Reversibility and regioselectivity in thiol/disulfide interchange of tocinoic acid with glutathione in lyophilized solids. Journal of Pharmaceutical Sciences. 98: 3312-8. PMID 18683877 DOI: 10.1002/jps.21516 |
0.01 |
|
| 2009 |
Houchin ML, Topp EM. Physical properties of PLGA films during polymer degradation Journal of Applied Polymer Science. 114: 2848-2854. DOI: 10.1002/app.30813 |
0.01 |
|
| 2008 |
Park JG, Ye Q, Topp EM, Kostoryz EL, Wang Y, Kieweg SL, Spencer P. Preparation and Properties of Novel Dentin Adhesives with Esterase Resistance. Journal of Applied Polymer Science. Applied Polymer Symposium. 107: 3588-3597. PMID 22919119 DOI: 10.1002/App.27512 |
0.01 |
|
| 2008 |
Zhao H, Topp EM. Recent U.S. patents on protein drug formulation: 2000-2007. Recent Patents On Drug Delivery & Formulation. 2: 200-8. PMID 19075908 |
0.01 |
|
| 2008 |
Sinha S, Li Y, Williams TD, Topp EM. Protein conformation in amorphous solids by FTIR and by hydrogen/deuterium exchange with mass spectrometry. Biophysical Journal. 95: 5951-61. PMID 18835903 DOI: 10.1529/biophysj.108.139899 |
0.01 |
|
| 2008 |
Sinha S, Pipes G, Topp EM, Bondarenko PV, Treuheit MJ, Gadgil HS. Comparison of LC and LC/MS methods for quantifying N-glycosylation in recombinant IgGs. Journal of the American Society For Mass Spectrometry. 19: 1643-54. PMID 18707900 DOI: 10.1016/j.jasms.2008.07.004 |
0.01 |
|
| 2008 |
Houchin ML, Topp EM. Chemical degradation of peptides and proteins in PLGA: A review of reactions and mechanisms Journal of Pharmaceutical Sciences. 97: 2395-2404. PMID 17828756 DOI: 10.1002/jps.21176 |
0.01 |
|
| 2008 |
Li Y, Williams TD, Topp EM. Effects of excipients on protein conformation in lyophilized solids by hydrogen/deuterium exchange mass spectrometry. Pharmaceutical Research. 25: 259-67. PMID 17597380 DOI: 10.1007/s11095-007-9365-6 |
0.01 |
|
| 2007 |
Li Y, Williams TD, Schowen RL, Topp EM. Characterizing protein structure in amorphous solids using hydrogen/deuterium exchange with mass spectrometry. Analytical Biochemistry. 366: 18-28. PMID 17490599 DOI: 10.1016/J.Ab.2007.03.041 |
0.01 |
|
| 2007 |
Li Y, Williams TD, Schowen RL, Topp EM. Trehalose and calcium exert site-specific effects on calmodulin conformation in amorphous solids. Biotechnology and Bioengineering. 97: 1650-3. PMID 17286268 DOI: 10.1002/Bit.21362 |
0.01 |
|
| 2007 |
Houchin ML, Neuenswander SA, Topp EM. Effect of excipients on PLGA film degradation and the stability of an incorporated peptide Journal of Controlled Release. 117: 413-420. PMID 17207882 DOI: 10.1016/j.jconrel.2006.11.023 |
0.01 |
|
| 2006 |
Li B, Schowen RL, Topp EM, Borchardt RT. Effect of N-1 and N-2 residues on peptide deamidation rate in solution and solid state. The Aaps Journal. 8: E166-73. PMID 16584125 DOI: 10.1208/Aapsj080120 |
0.01 |
|
| 2006 |
Houchin ML, Heppert K, Topp EM. Deamidation, acylation and proteolysis of a model peptide in PLGA films Journal of Controlled Release. 112: 111-119. PMID 16529840 DOI: 10.1016/j.jconrel.2006.01.018 |
0.01 |
|
| 2006 |
Thompson SM, Sinha S, Topp EM, Camarda KV. A molecular design approach to peptide drug stabilization Molecular Simulation. 32: 291-295. DOI: 10.1080/08927020600612213 |
0.01 |
|
| 2005 |
Krogmeier SL, Reddy DS, Vander Velde D, Lushington GH, Siahaan TJ, Middaugh CR, Borchardt RT, Topp EM. Deamidation of model beta-turn cyclic peptides in the solid state. Journal of Pharmaceutical Sciences. 94: 2616-31. PMID 16258986 DOI: 10.1002/Jps.20468 |
0.01 |
|
| 2005 |
Li B, O'Meara MH, Lubach JW, Schowen RL, Topp EM, Munson EJ, Borchardt RT. Effects of sucrose and mannitol on asparagine deamidation rates of model peptides in solution and in the solid state. Journal of Pharmaceutical Sciences. 94: 1723-35. PMID 15986465 DOI: 10.1002/Jps.20372 |
0.01 |
|
| 2005 |
Li B, Gorman EM, Moore KD, Williams T, Schowen RL, Topp EM, Borchardt RT. Effects of acidic N + 1 residues on asparagine deamidation rates in solution and in the solid state. Journal of Pharmaceutical Sciences. 94: 666-75. PMID 15668945 DOI: 10.1002/Jps.20263 |
0.01 |
|
| 2004 |
Stotz CE, Topp EM. Applications of model beta-hairpin peptides. Journal of Pharmaceutical Sciences. 93: 2881-94. PMID 15452845 DOI: 10.1002/jps.20188 |
0.01 |
|
| 2004 |
D'Souza AJ, Topp EM. Release from polymeric prodrugs: linkages and their degradation. Journal of Pharmaceutical Sciences. 93: 1962-79. PMID 15236447 DOI: 10.1002/jps.20096 |
0.01 |
|
| 2004 |
Lubach JW, Padden BE, Winslow SL, Salsbury JS, Masters DB, Topp EM, Munson EJ. Solid-state NMR studies of pharmaceutical solids in polymer matrices. Analytical and Bioanalytical Chemistry. 378: 1504-10. PMID 15214410 DOI: 10.1007/S00216-003-2381-4 |
0.01 |
|
| 2004 |
Stotz CE, Borchardt RT, Middaugh CR, Siahaan TJ, Vander Velde D, Topp EM. Secondary structure of a dynamic type I' β-hairpin peptide Journal of Peptide Research. 63: 371-382. PMID 15102055 DOI: 10.1111/J.1399-3011.2004.00129.X |
0.01 |
|
| 2004 |
D'Souza AJ, Schowen RL, Topp EM. Polyvinylpyrrolidone-drug conjugate: synthesis and release mechanism. Journal of Controlled Release : Official Journal of the Controlled Release Society. 94: 91-100. PMID 14684274 DOI: 10.1016/J.Jconrel.2003.09.014 |
0.01 |
|
| 2003 |
Li B, Borchardt RT, Topp EM, VanderVelde D, Schowen RL. Racemization of an asparagine residue during peptide deamidation. Journal of the American Chemical Society. 125: 11486-7. PMID 13129337 DOI: 10.1021/Ja0360992 |
0.01 |
|
| 2003 |
Hurwitz A, Ruhl CE, Kimler BF, Topp EM, Mayo MS. Gastric function in the elderly: effects on absorption of ketoconazole. Journal of Clinical Pharmacology. 43: 996-1002. PMID 12971032 DOI: 10.1177/0091270003255645 |
0.01 |
|
| 2003 |
D'Souza AJ, Schowen RL, Borchardt RT, Salsbury JS, Munson EJ, Topp EM. Reaction of a peptide with polyvinylpyrrolidone in the solid state. Journal of Pharmaceutical Sciences. 92: 585-93. PMID 12587120 DOI: 10.1002/Jps.10316 |
0.01 |
|
| 2002 |
Li R, Topp EM, Hageman MJ. Effect of viscosity on the deamidation rate of a model Asn-hexapeptide Journal of Peptide Research. 59: 211-220. PMID 11966978 DOI: 10.1034/j.1399-3011.2002.00985.x |
0.01 |
|
| 2001 |
Song Y, Schowen RL, Borchardt RT, Topp EM. Formaldehyde production by Tris buffer in peptide formulations at elevated temperature. Journal of Pharmaceutical Sciences. 90: 1198-203. PMID 11536224 DOI: 10.1002/Jps.1073 |
0.01 |
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| 2001 |
Song Y, Schowen RL, Borchardt RT, Topp EM. Effect of 'pH' on the rate of asparagine deamidation in polymeric formulations: 'pH'-rate profile. Journal of Pharmaceutical Sciences. 90: 141-56. PMID 11169531 DOI: 10.1002/1520-6017(200102)90:2<141::Aid-Jps5>3.0.Co;2-Y |
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| 2000 |
Li R, D'Souza AJ, Laird BB, Schowen RL, Borchardt RT, Topp EM. Effects of solution polarity and viscosity on peptide deamidation. The Journal of Peptide Research : Official Journal of the American Peptide Society. 56: 326-34. PMID 11095186 DOI: 10.1034/J.1399-3011.2000.00783.X |
0.01 |
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| 2000 |
Xie M, Aubé J, Borchardt RT, Morton M, Topp EM, Vander Velde D, Schowen RL. Reactivity toward deamidation of asparagine residues in beta-turn structures. The Journal of Peptide Research : Official Journal of the American Peptide Society. 56: 165-71. PMID 11007273 DOI: 10.1034/J.1399-3011.2000.00764.X |
0.01 |
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| 2000 |
Lai MC, Schowen RL, Borchardt RT, Topp EM. Deamidation of a model hexapeptide in poly(vinyl alcohol) hydrogels and xerogels. The Journal of Peptide Research : Official Journal of the American Peptide Society. 55: 93-101. PMID 10784025 DOI: 10.1034/J.1399-3011.2000.00156.X |
0.01 |
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| 1999 |
Lai MC, Hageman MJ, Schowen RL, Borchardt RT, Laird BB, Topp EM. Chemical stability of peptides in polymers. 2. Discriminating between solvent and plasticizing effects of water on peptide deamidation in poly(vinylpyrrolidone). Journal of Pharmaceutical Sciences. 88: 1081-9. PMID 10514359 DOI: 10.1021/Js9802289 |
0.01 |
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| 1999 |
Lai MC, Hageman MJ, Schowen RL, Borchardt RT, Topp EM. Chemical stability of peptides in polymers. 1. Effect of water on peptide deamidation in poly(vinyl alcohol) and poly(vinyl pyrrolidone) matrixes. Journal of Pharmaceutical Sciences. 88: 1073-80. PMID 10514358 DOI: 10.1021/Js980227G |
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| 1999 |
Lai MC, Topp EM. Solid-state chemical stability of proteins and peptides. Journal of Pharmaceutical Sciences. 88: 489-500. PMID 10229638 DOI: 10.1021/js980374e |
0.01 |
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| 1998 |
Topp EM, Kitos PA, Vijaykumar V, Desilva BS, Hendrickson TL. Antibody transport in cultured tumor cell layers Journal of Controlled Release. 53: 15-23. PMID 9741910 DOI: 10.1016/S0168-3659(97)00234-4 |
0.01 |
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| 1997 |
Desilva BS, Hendrickson TL, Topp EM. Development of a cell culture system to study antibody convection in tumors Journal of Pharmaceutical Sciences. 86: 858-864. PMID 9232529 DOI: 10.1021/js9603414 |
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| 1997 |
Topp EM. Barriers to delivery of macromolecules Medicinal Chemistry Research. 7: 493-508. |
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| 1996 |
Vijaykumar V, Kitos PA, Topp EM. High density culture of mammalian cells in a nonwoven polyester matrix In Vitro Cellular &Amp; Developmental Biology. Animal. 32: 465-468. PMID 8889600 |
0.01 |
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| 1996 |
Ruiz-Cardona L, Sanzgiri YD, Benedetti LM, Stella VJ, Topp EM. Application of benzyl hyaluronate membranes as potential wound dressings: evaluation of water vapour and gas permeabilities. Biomaterials. 17: 1639-43. PMID 8842370 DOI: 10.1016/0142-9612(95)00324-X |
0.01 |
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| 1996 |
Sung KC, Nixon PR, Skoug JW, Ju TR, Gao P, Topp EM, Patel MV. Effect of formulation variables on drug and polymer release from HPMC-based matrix tablets International Journal of Pharmaceutics. 142: 53-60. DOI: 10.1016/0378-5173(96)04644-3 |
0.01 |
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| 1995 |
Knaub SR, Chang MF, Lunte CE, Topp EM, Riley CM. Automated analytical systems for drug development studies. Part IV. A microdialysis system to study the partitioning of lomefloxacin across an erythrocyte membrane in vitro. Journal of Pharmaceutical and Biomedical Analysis. 14: 121-9. PMID 8833974 DOI: 10.1016/0731-7085(95)01597-3 |
0.01 |
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| 1995 |
Vijaykumar V, Topp EM. Diffusion of an Anti-Transferrin Receptor Antibody in Cultured Murine Melanoma Cell Layers Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 12: 1907-1916. PMID 8786965 DOI: 10.1023/A:1016424321378 |
0.01 |
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| 1995 |
Sung KC, Topp EM. Effect of drug hydrophilicity and membrane hydration on diffusion in hyaluronic acid ester membranes Journal of Controlled Release. 37: 95-104. DOI: 10.1016/0168-3659(95)00068-J |
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| 1995 |
Topp EM, Sung KC. Solute diffusion in ionizable hydrogels Proceedings of the Controlled Release Society. 348-349. |
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| 1995 |
Lai MC, Topp EM, Schowen R, Borchardt RT. Peptide stability in polymer matrices Proceedings of the Controlled Release Society. 532-533. |
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| 1994 |
Simon LD, Ruiz-Cardona L, Topp EM, Stella VJ. Effect of ph on theophylline release from partially esterifted alginic acid matrices Drug Development and Industrial Pharmacy. 20: 2341-2351. DOI: 10.3109/03639049409042641 |
0.01 |
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| 1994 |
Sanzgiri YD, Topp EM, Benedetti L, Stella VJ. Evaluation of mucoadhesive properties of hyaluronic acid benzyl esters International Journal of Pharmaceutics. 107: 91-97. DOI: 10.1016/0378-5173(94)90446-4 |
0.01 |
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| 1994 |
Hume LR, Lee HK, Benedetti L, Sanzgiri YD, Topp EM, Stella VJ. Ocular sustained delivery of prednisolone using hyaluronic acid benzyl ester films International Journal of Pharmaceutics. 111: 295-298. DOI: 10.1016/0378-5173(94)90352-2 |
0.01 |
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| 1994 |
Sung KC, Topp EM. Swelling properties of hyaluronic acid ester membranes Journal of Membrane Science. 92: 157-167. DOI: 10.1016/0376-7388(94)00062-X |
0.01 |
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| 1993 |
Stenken JA, Topp EM, Southard MZ, Lunte CE. Examination of microdialysis sampling in a well-characterized hydrodynamic system Analytical Chemistry. 65: 2324-2328. PMID 8238928 DOI: 10.1021/Ac00065A026 |
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| 1993 |
Sanzgiri YD, Maschi S, Crescenzi V, Callegaro L, Topp EM, Stella VJ. Gellan-based systems for ophthalmic sustained delivery of methylprednisolone Journal of Controlled Release. 26: 195-201. DOI: 10.1016/0168-3659(93)90186-9 |
0.01 |
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| 1993 |
Papini D, Stella VJ, Topp EM. Diffusion of macromolecules in membranes of hyalyronic acid esters Journal of Controlled Release. 27: 47-57. DOI: 10.1016/0168-3659(93)90056-B |
0.01 |
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| 1993 |
Sung KC, Callegaro L, Topp EM. Swelling properties of hyaluronic acid ester films Proceedings of the Controlled Release Society. 376-377. |
0.01 |
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| 1992 |
Joshi HN, Topp EM. Hydration in hyaluronic acid and its esters using differential scanning calorimetry International Journal of Pharmaceutics. 80: 213-225. DOI: 10.1016/0378-5173(92)90279-B |
0.01 |
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| 1992 |
Rajewski LG, Stinnett AA, Stella VJ, Topp EM. Enzymic and non-enzymic hydrolysis of a polymeric prodrug: Hydrocortisone esters of hyaluronic acid International Journal of Pharmaceutics. 82: 205-213. DOI: 10.1016/0378-5173(92)90176-3 |
0.01 |
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| 1992 |
Joshi HN, Stella VJ, Topp EM. Drug release from membranes of hyaluronic acid and its esters Journal of Controlled Release. 20: 109-121. DOI: 10.1016/0168-3659(92)90157-M |
0.01 |
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| 1991 |
Bhatt PP, Rytting JH, Topp EM. Influence of Azone ® and lauryl alcohol on the transport of acetaminophen and ibuprofen through shed snake skin International Journal of Pharmaceutics. 72: 219-226. DOI: 10.1016/0378-5173(91)90111-Z |
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| 1991 |
Benedetti JM, Joshi HN, Goei L, Hunt JA, Callegaro L, Stella VJ, Topp EM. Dosage forms from polymeric prodrugs. Hydrocortisone esters of hyaluronic acid New Polymeric Materials. 3: 41-48. |
0.01 |
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| 1990 |
Trapp S, Matthies M, Scheunert I, Topp EM. Modeling the bioconcentration of organic chemicals in plants Environmental Science and Technology. 24: 1246-1252. DOI: 10.1021/es00078a013 |
0.01 |
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| 1990 |
Hunt JA, Joshi HN, Stella VJ, Topp EM. Diffusion and drug release in polymer films prepared from ester derivatives of hyaluronic acid Journal of Controlled Release. 12: 159-169. DOI: 10.1016/0168-3659(90)90092-8 |
0.01 |
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| 1990 |
Benedetti LM, Topp EM, Stella VJ. Microspheres of hyaluronic acid esters-Fabrication methods and in vitro hydrocortisone release Journal of Controlled Release. 13: 33-41. DOI: 10.1016/0168-3659(90)90072-2 |
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| 1989 |
Garren KW, Topp EM, Repta AJ. Buccal Absorption. III. Simultaneous Diffusion and Metabolism of an Aminopeptidase Substrate in the Hamster Cheek Pouch Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 6: 966-970. PMID 2594690 DOI: 10.1023/A:1015949614437 |
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| 1989 |
Joshi HN, Kral MA, Topp EM. Microwave drying of aqueous tablet film coatings: a study on free films International Journal of Pharmaceutics. 51: 19-25. DOI: 10.1016/0378-5173(89)90070-7 |
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