| Year |
Citation |
Score |
| 2024 |
Jaroch M, Sun G, Tsui H-CT, Reed C, Sun J, Jörg M, Winkler ME, Rice KC, Dziergowska A, Stich TA, Dedon PC, Dos Santos PC, de Crécy-Lagard V. Alternate routes to mnmsU synthesis in Gram-positive bacteria. Journal of Bacteriology. e0045223. PMID 38551342 DOI: 10.1128/jb.00452-23 |
0.302 |
|
| 2023 |
Winkler ME, Joseph M, Tsui HT. Secrets of getting started: Regulation of the first committed step of peptidoglycan synthesis by protein phosphorylation in Enterococcus and other Gram-positive bacteria. Molecular Microbiology. PMID 38012814 DOI: 10.1111/mmi.15204 |
0.331 |
|
| 2023 |
De Lay NR, Verma N, Sinha D, Garrett A, Osterberg M, Reiling S, Porter D, Giedroc DP, Winkler ME. The five homologous CiaR-controlled Ccn sRNAs of modulate Zn-resistance. Biorxiv : the Preprint Server For Biology. PMID 37986909 DOI: 10.1101/2023.11.07.565944 |
0.804 |
|
| 2023 |
Tsui HT, Joseph M, Zheng JJ, Perez AJ, Manzoor I, Rued BE, Richardson JD, Branny P, Doubravová L, Massidda O, Winkler ME. Negative regulation of MurZ and MurA underlies the essentiality of GpsB- and StkP-mediated protein phosphorylation in Streptococcus pneumoniae D39. Molecular Microbiology. PMID 37452010 DOI: 10.1111/mmi.15122 |
0.409 |
|
| 2023 |
Tsui HT, Joseph M, Zheng JJ, Perez AJ, Manzoor I, Rued BE, Richardson JD, Branny P, Doubravová L, Massidda O, Winkler ME. Chromosomal Duplications of MurZ (MurA2) or MurA (MurA1), Amino Acid Substitutions in MurZ (MurA2), and Absence of KhpAB Obviate the Requirement for Protein Phosphorylation in D39. Biorxiv : the Preprint Server For Biology. PMID 37034771 DOI: 10.1101/2023.03.26.534294 |
0.371 |
|
| 2022 |
Lamanna MM, Manzoor I, Joseph M, Ye ZA, Benedet M, Zanardi A, Ren Z, Wang X, Massidda O, Tsui HT, Winkler ME. Roles of RodZ and class A PBP1b in the assembly and regulation of the peripheral peptidoglycan elongasome in ovoid-shaped cells of Streptococcus pneumoniae D39. Molecular Microbiology. PMID 36001060 DOI: 10.1111/mmi.14969 |
0.383 |
|
| 2021 |
Perez AJ, Villicana JB, Tsui HT, Danforth ML, Benedet M, Massidda O, Winkler ME. FtsZ-Ring Regulation and Cell Division Are Mediated by Essential EzrA and Accessory Proteins ZapA and ZapJ in . Frontiers in Microbiology. 12: 780864. PMID 34938281 DOI: 10.3389/fmicb.2021.780864 |
0.318 |
|
| 2021 |
Sinha D, Frick JP, Clemons K, Winkler ME, De Lay NR. Pivotal Roles for Ribonucleases in Streptococcus pneumoniae Pathogenesis. Mbio. e0238521. PMID 34544281 DOI: 10.1128/mBio.02385-21 |
0.832 |
|
| 2020 |
Sinha D, Zheng JJ, Tsui HT, Richardson JD, De Lay NR, Winkler ME. S1-Domain RNA-Binding Protein (CvfD) Is a New Post-Transcriptional Regulator That Mediates Cold Sensitivity, Phosphate Transport, and Virulence in D39. Journal of Bacteriology. PMID 32601068 DOI: 10.1128/Jb.00245-20 |
0.812 |
|
| 2020 |
Sharifzadeh S, Brown NW, Shirley JD, Bruce KE, Winkler ME, Carlson EE. Chemical tools for selective activity profiling of bacterial penicillin-binding proteins. Methods in Enzymology. 638: 27-55. PMID 32416917 DOI: 10.1016/Bs.Mie.2020.02.015 |
0.378 |
|
| 2019 |
Kocaoglu O, Calvo RA, Sham LT, Cozy LM, Lanning BR, Francis S, Winkler ME, Kearns DB, Carlson EE. Selective Penicillin-Binding Protein Imaging Probes Reveal Substructure in Bacterial Cell Division. Acs Chemical Biology. PMID 31265231 DOI: 10.1021/Acschembio.9B00459 |
0.325 |
|
| 2019 |
Martin JE, Le MT, Bhattarai N, Capdevila DA, Shen J, Winkler ME, Giedroc DP. A Mn-sensing riboswitch activates expression of a Mn2+/Ca2+ ATPase transporter in Streptococcus. Nucleic Acids Research. PMID 31165873 DOI: 10.1093/Nar/Gkz494 |
0.34 |
|
| 2019 |
Winkler ME, Morrison DA. Competence Beyond Genes: Filling in the Details of the Pneumococcal Competence Transcriptome by a Systems Approach. Journal of Bacteriology. PMID 30988030 DOI: 10.1128/Jb.00238-19 |
0.331 |
|
| 2019 |
Sinha D, Zimmer K, Cameron TA, Rusch DB, Winkler ME, De Lay NR. Redefining the sRNA Transcriptome in Serotype 2 Strain D39. Journal of Bacteriology. PMID 30833353 DOI: 10.1128/Jb.00764-18 |
0.809 |
|
| 2019 |
Perez AJ, Cesbron Y, Shaw SL, Bazan Villicana J, Tsui HT, Boersma MJ, Ye ZA, Tovpeko Y, Dekker C, Holden S, Winkler ME. Movement dynamics of divisome proteins and PBP2x:FtsW in cells of . Proceedings of the National Academy of Sciences of the United States of America. PMID 30718427 DOI: 10.1073/Pnas.1816018116 |
0.362 |
|
| 2019 |
Rued BE, Alcorlo M, Edmonds KA, Martínez-Caballero S, Straume D, Fu Y, Bruce KE, Wu H, Håvarstein LS, Hermoso JA, Winkler ME, Giedroc DP. Structure of the Large Extracellular Loop of FtsX and Its Interaction with the Essential Peptidoglycan Hydrolase PcsB in Streptococcus pneumoniae. Mbio. 10. PMID 30696736 DOI: 10.1128/Mbio.02622-18 |
0.445 |
|
| 2019 |
Cleverley RM, Rutter ZJ, Rismondo J, Corona F, Tsui HT, Alatawi FA, Daniel RA, Halbedel S, Massidda O, Winkler ME, Lewis RJ. The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes. Nature Communications. 10: 261. PMID 30651563 DOI: 10.2210/Pdb6Gp7/Pdb |
0.448 |
|
| 2018 |
Bruce KE, Rued BE, Tsui HT, Winkler ME. The Opp (AmiACDEF) Oligopeptide Transporter Mediates Resistance of Serotype 2D39 to Killing by Chemokine CXCL10 and Other Antimicrobial Peptides. Journal of Bacteriology. PMID 29581408 DOI: 10.1128/Jb.00745-17 |
0.441 |
|
| 2017 |
Zheng JJ, Perez AJ, Tsui HT, Massidda O, Winkler ME. Absence of the KhpA and KhpB (JAG/EloR) RNA-Binding Proteins Suppresses the Requirement for PBP2b by Overproduction of FtsA in Streptococcus pneumoniae D39. Molecular Microbiology. PMID 28941257 DOI: 10.1111/Mmi.13847 |
0.499 |
|
| 2017 |
Martin JE, Edmonds KA, Bruce KE, Campanello GC, Eijkelkamp BA, Brazel EB, McDevitt CA, Winkler ME, Giedroc DP. The zinc efflux activator SczA protects Streptococcus pneumoniae serotype 2 D39 from intracellular zinc toxicity. Molecular Microbiology. PMID 28249108 DOI: 10.1111/Mmi.13654 |
0.41 |
|
| 2017 |
Martin JE, Lisher JP, Winkler ME, Giedroc DP. Perturbation of manganese metabolism disrupts cell division in Streptococcus pneumoniae. Molecular Microbiology. PMID 28127804 DOI: 10.1111/Mmi.13630 |
0.386 |
|
| 2017 |
Lisher JP, Tsui HT, Ramos-Montañez S, Hentchel KL, Martin JE, Trinidad JC, Winkler ME, Giedroc DP. Biological and Chemical Adaptation to Endogenous Hydrogen Peroxide Production in Streptococcus pneumoniae D39. Msphere. 2. PMID 28070562 DOI: 10.1128/mSphere.00291-16 |
0.803 |
|
| 2016 |
Rued BE, Zheng JJ, Mura A, Tsui HT, Boersma MJ, Mazny JL, Corona F, Perez AJ, Fadda D, Doubravová L, Buriánková K, Branny P, Massidda O, Winkler ME. Suppression and Synthetic-Lethal Genetic Relationships of ΔgpsB Mutations Indicate That GpsB Mediates Protein Phosphorylation and Penicillin-Binding Protein Interactions in Streptococcus pneumoniae D39. Molecular Microbiology. PMID 28010038 DOI: 10.1111/Mmi.13613 |
0.409 |
|
| 2016 |
Mura A, Fadda D, Perez AJ, Danforth ML, Musu D, Rico AI, Krupka M, Denapaite D, Tsui HT, Winkler ME, Branny P, Vicente M, Margolin W, Massidda O. Roles of the essential protein FtsA in cell growth and division in Streptococcus pneumoniae. Journal of Bacteriology. PMID 27872183 DOI: 10.1128/Jb.00608-16 |
0.41 |
|
| 2016 |
Zheng JJ, Sinha D, Wayne KJ, Winkler ME. Physiological Roles of the Dual Phosphate Transporter Systems in Low and High Phosphate Conditions and in Capsule Maintenance of Streptococcus pneumoniae D39. Frontiers in Cellular and Infection Microbiology. 6: 63. PMID 27379215 DOI: 10.3389/Fcimb.2016.00063 |
0.784 |
|
| 2016 |
Tsui HT, Zheng JJ, Magallon AN, Ryan JD, Yunck R, Rued BE, Bernhardt TG, Winkler ME. Suppression of a Deletion Mutation in the Gene Encoding Essential PBP2b Reveals a New Lytic Transglycosylase Involved in Peripheral Peptidoglycan Synthesis in Streptococcus pneumoniae D39. Molecular Microbiology. PMID 26933838 DOI: 10.1111/Mmi.13366 |
0.7 |
|
| 2015 |
Fu Y, Bruce KE, Rued B, Winkler ME, Giedroc DP. (1)H, (13)C, (15)N resonance assignments of the extracellular loop 1 domain (ECL1) of Streptococcus pneumoniae D39 FtsX, an essential cell division protein. Biomolecular Nmr Assignments. PMID 26370567 DOI: 10.1007/S12104-015-9644-9 |
0.352 |
|
| 2015 |
Boersma MJ, Kuru E, Rittichier JT, VanNieuwenhze MS, Brun YV, Winkler ME. Minimal Peptidoglycan (PG) Turnover in Wild-Type and PG Hydrolase and Cell Division Mutants of Streptococcus pneumoniae D39 Growing Planktonically and in Host-Relevant Biofilms. Journal of Bacteriology. 197: 3472-85. PMID 26303829 DOI: 10.1128/Jb.00541-15 |
0.431 |
|
| 2015 |
Hoover SE, Perez AJ, Tsui HC, Sinha D, Smiley DL, DiMarchi RD, Winkler ME, Lazazzera BA. A new quorum-sensing system (TprA/PhrA) for Streptococcus pneumoniae D39 that regulates a lantibiotic biosynthesis gene cluster. Molecular Microbiology. 97: 229-43. PMID 25869931 DOI: 10.1111/Mmi.13029 |
0.784 |
|
| 2015 |
Kocaoglu O, Tsui HC, Winkler ME, Carlson EE. Profiling of β-Lactam Selectivity for Penicillin-Binding Proteins in Streptococcus pneumoniae D39. Antimicrobial Agents and Chemotherapy. 59: 3548-55. PMID 25845878 DOI: 10.1128/Aac.05142-14 |
0.326 |
|
| 2014 |
Tsui HC, Boersma MJ, Vella SA, Kocaoglu O, Kuru E, Peceny JK, Carlson EE, VanNieuwenhze MS, Brun YV, Shaw SL, Winkler ME. Pbp2x localizes separately from Pbp2b and other peptidoglycan synthesis proteins during later stages of cell division of Streptococcus pneumoniae D39. Molecular Microbiology. 94: 21-40. PMID 25099088 DOI: 10.1111/Mmi.12745 |
0.439 |
|
| 2013 |
Land AD, Tsui HC, Kocaoglu O, Vella SA, Shaw SL, Keen SK, Sham LT, Carlson EE, Winkler ME. Requirement of essential Pbp2x and GpsB for septal ring closure in Streptococcus pneumoniae D39. Molecular Microbiology. 90: 939-55. PMID 24118410 DOI: 10.1111/Mmi.12408 |
0.806 |
|
| 2013 |
Sham LT, Jensen KR, Bruce KE, Winkler ME. Involvement of FtsE ATPase and FtsX extracellular loops 1 and 2 in FtsEX-PcsB complex function in cell division of Streptococcus pneumoniae D39. Mbio. 4. PMID 23860769 DOI: 10.1128/Mbio.00431-13 |
0.419 |
|
| 2012 |
Wayne KJ, Li S, Kazmierczak KM, Tsui HC, Winkler ME. Involvement of WalK (VicK) phosphatase activity in setting WalR (VicR) response regulator phosphorylation level and limiting cross-talk in Streptococcus pneumoniae D39 cells. Molecular Microbiology. 86: 645-60. PMID 23013245 DOI: 10.1111/Mmi.12006 |
0.801 |
|
| 2012 |
Kocaoglu O, Calvo RA, Sham LT, Cozy LM, Lanning BR, Francis S, Winkler ME, Kearns DB, Carlson EE. Selective penicillin-binding protein imaging probes reveal substructure in bacterial cell division. Acs Chemical Biology. 7: 1746-53. PMID 22909777 DOI: 10.1021/Cb300329R |
0.37 |
|
| 2012 |
Sham LT, Tsui HC, Land AD, Barendt SM, Winkler ME. Recent advances in pneumococcal peptidoglycan biosynthesis suggest new vaccine and antimicrobial targets. Current Opinion in Microbiology. 15: 194-203. PMID 22280885 DOI: 10.1016/J.Mib.2011.12.013 |
0.772 |
|
| 2011 |
Sham LT, Barendt SM, Kopecky KE, Winkler ME. Essential PcsB putative peptidoglycan hydrolase interacts with the essential FtsXSpn cell division protein in Streptococcus pneumoniae D39. Proceedings of the National Academy of Sciences of the United States of America. 108: E1061-9. PMID 22006325 DOI: 10.1073/Pnas.1108323108 |
0.812 |
|
| 2011 |
Tsui HC, Keen SK, Sham LT, Wayne KJ, Winkler ME. Dynamic distribution of the SecA and SecY translocase subunits and septal localization of the HtrA surface chaperone/protease during Streptococcus pneumoniae D39 cell division. Mbio. 2. PMID 21990615 DOI: 10.1128/Mbio.00202-11 |
0.802 |
|
| 2011 |
Hsueh YH, Cozy LM, Sham LT, Calvo RA, Gutu AD, Winkler ME, Kearns DB. DegU-phosphate activates expression of the anti-sigma factor FlgM in Bacillus subtilis. Molecular Microbiology. 81: 1092-108. PMID 21736639 DOI: 10.1111/J.1365-2958.2011.07755.X |
0.41 |
|
| 2011 |
Land AD, Winkler ME. The requirement for pneumococcal MreC and MreD is relieved by inactivation of the gene encoding PBP1a. Journal of Bacteriology. 193: 4166-79. PMID 21685290 DOI: 10.1128/Jb.05245-11 |
0.835 |
|
| 2011 |
Barendt SM, Sham LT, Winkler ME. Characterization of mutants deficient in the L,D-carboxypeptidase (DacB) and WalRK (VicRK) regulon, involved in peptidoglycan maturation of Streptococcus pneumoniae serotype 2 strain D39. Journal of Bacteriology. 193: 2290-300. PMID 21378199 DOI: 10.1128/Jb.01555-10 |
0.831 |
|
| 2011 |
Jacobsen FE, Kazmierczak KM, Lisher JP, Winkler ME, Giedroc DP. Interplay between manganese and zinc homeostasis in the human pathogen Streptococcus pneumoniae. Metallomics : Integrated Biometal Science. 3: 38-41. PMID 21275153 DOI: 10.1039/C0Mt00050G |
0.304 |
|
| 2011 |
Nichols RJ, Sen S, Choo YJ, Beltrao P, Zietek M, Chaba R, Lee S, Kazmierczak KM, Lee KJ, Wong A, Shales M, Lovett S, Winkler ME, Krogan NJ, Typas A, et al. Phenotypic landscape of a bacterial cell. Cell. 144: 143-56. PMID 21185072 DOI: 10.1016/J.Cell.2010.11.052 |
0.366 |
|
| 2011 |
Biller SJ, Wayne KJ, Winkler ME, Burkholder WF. The putative hydrolase YycJ (WalJ) affects the coordination of cell division with DNA replication in Bacillus subtilis and may play a conserved role in cell wall metabolism. Journal of Bacteriology. 193: 896-908. PMID 21169496 DOI: 10.1128/Jb.00594-10 |
0.809 |
|
| 2010 |
Ramos-Montañez S, Kazmierczak KM, Hentchel KL, Winkler ME. Instability of ackA (acetate kinase) mutations and their effects on acetyl phosphate and ATP amounts in Streptococcus pneumoniae D39. Journal of Bacteriology. 192: 6390-400. PMID 20952579 DOI: 10.1128/Jb.00995-10 |
0.807 |
|
| 2010 |
Reyes-Caballero H, Guerra AJ, Jacobsen FE, Kazmierczak KM, Cowart D, Koppolu UM, Scott RA, Winkler ME, Giedroc DP. The metalloregulatory zinc site in Streptococcus pneumoniae AdcR, a zinc-activated MarR family repressor. Journal of Molecular Biology. 403: 197-216. PMID 20804771 DOI: 10.1016/J.Jmb.2010.08.030 |
0.334 |
|
| 2010 |
Wayne KJ, Sham LT, Tsui HC, Gutu AD, Barendt SM, Keen SK, Winkler ME. Localization and cellular amounts of the WalRKJ (VicRKX) two-component regulatory system proteins in serotype 2 Streptococcus pneumoniae. Journal of Bacteriology. 192: 4388-94. PMID 20622066 DOI: 10.1128/Jb.00578-10 |
0.799 |
|
| 2010 |
Gutu AD, Wayne KJ, Sham LT, Winkler ME. Kinetic characterization of the WalRKSpn (VicRK) two-component system of Streptococcus pneumoniae: dependence of WalKSpn (VicK) phosphatase activity on its PAS domain. Journal of Bacteriology. 192: 2346-58. PMID 20190050 DOI: 10.1128/Jb.01690-09 |
0.796 |
|
| 2010 |
Tsui HC, Mukherjee D, Ray VA, Sham LT, Feig AL, Winkler ME. Identification and characterization of noncoding small RNAs in Streptococcus pneumoniae serotype 2 strain D39. Journal of Bacteriology. 192: 264-79. PMID 19854910 DOI: 10.1128/Jb.01204-09 |
0.451 |
|
| 2010 |
Guerra AJ, Reyes-Caballero H, Jacobsen FE, Koppolu UK, Scott RA, Kazmierczak K, Winkler ME, Giedroc DP. On the Structure, Function and Metalloregulatory Properties of the Zinc-Activated Repressor Streptococcus Pneumoniae AdcR Biophysical Journal. 98: 73a. DOI: 10.1016/J.Bpj.2009.12.414 |
0.388 |
|
| 2009 |
Winkler ME, Ramos-Montañez S. Biosynthesis of Histidine. Ecosal Plus. 3. PMID 26443768 DOI: 10.1128/ecosalplus.3.6.1.9 |
0.787 |
|
| 2009 |
Kazmierczak KM, Wayne KJ, Rechtsteiner A, Winkler ME. Roles of rel(Spn) in stringent response, global regulation and virulence of serotype 2 Streptococcus pneumoniae D39. Molecular Microbiology. 72: 590-611. PMID 19426208 DOI: 10.1111/J.1365-2958.2009.06669.X |
0.819 |
|
| 2009 |
Barendt SM, Land AD, Sham LT, Ng WL, Tsui HC, Arnold RJ, Winkler ME. Influences of capsule on cell shape and chain formation of wild-type and pcsB mutants of serotype 2 Streptococcus pneumoniae. Journal of Bacteriology. 191: 3024-40. PMID 19270090 DOI: 10.1128/Jb.01505-08 |
0.792 |
|
| 2008 |
Winkler ME, Hoch JA. Essentiality, bypass, and targeting of the YycFG (VicRK) two-component regulatory system in gram-positive bacteria. Journal of Bacteriology. 190: 2645-8. PMID 18245295 DOI: 10.1128/Jb.01682-07 |
0.33 |
|
| 2008 |
Ramos-Montañez S, Tsui HC, Wayne KJ, Morris JL, Peters LE, Zhang F, Kazmierczak KM, Sham LT, Winkler ME. Polymorphism and regulation of the spxB (pyruvate oxidase) virulence factor gene by a CBS-HotDog domain protein (SpxR) in serotype 2 Streptococcus pneumoniae. Molecular Microbiology. 67: 729-46. PMID 18179423 DOI: 10.1111/J.1365-2958.2007.06082.X |
0.792 |
|
| 2007 |
Lanie JA, Ng WL, Kazmierczak KM, Andrzejewski TM, Davidsen TM, Wayne KJ, Tettelin H, Glass JI, Winkler ME. Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6. Journal of Bacteriology. 189: 38-51. PMID 17041037 DOI: 10.1128/Jb.01148-06 |
0.786 |
|
| 2005 |
Gilmour R, Foster JE, Sheng Q, McClain JR, Riley A, Sun PM, Ng WL, Yan D, Nicas TI, Henry K, Winkler ME. New class of competitive inhibitor of bacterial histidine kinases. Journal of Bacteriology. 187: 8196-200. PMID 16291694 DOI: 10.1128/Jb.187.23.8196-8200.2005 |
0.696 |
|
| 2005 |
Ng WL, Tsui HC, Winkler ME. Regulation of the pspA virulence factor and essential pcsB murein biosynthetic genes by the phosphorylated VicR (YycF) response regulator in Streptococcus pneumoniae. Journal of Bacteriology. 187: 7444-59. PMID 16237028 DOI: 10.1128/Jb.187.21.7444-7459.2005 |
0.763 |
|
| 2005 |
Valderas MW, Alcantara RB, Baumgartner JE, Bellaire BH, Robertson GT, Ng WL, Richardson JM, Winkler ME, Roop RM. Role of HdeA in acid resistance and virulence in Brucella abortus 2308. Veterinary Microbiology. 107: 307-12. PMID 15863292 DOI: 10.1016/J.Vetmic.2005.01.018 |
0.735 |
|
| 2005 |
Gee JM, Valderas MW, Kovach ME, Grippe VK, Robertson GT, Ng WL, Richardson JM, Winkler ME, Roop RM. The Brucella abortus Cu,Zn superoxide dismutase is required for optimal resistance to oxidative killing by murine macrophages and wild-type virulence in experimentally infected mice. Infection and Immunity. 73: 2873-80. PMID 15845493 DOI: 10.1128/Iai.73.5.2873-2880.2005 |
0.725 |
|
| 2004 |
Ng WL, Winkler ME. Singular structures and operon organizations of essential two-component systems in species of Streptococcus. Microbiology (Reading, England). 150: 3096-8. PMID 15470090 DOI: 10.1099/Mic.0.27550-0 |
0.666 |
|
| 2004 |
Ng WL, Kazmierczak KM, Winkler ME. Defective cell wall synthesis in Streptococcus pneumoniae R6 depleted for the essential PcsB putative murein hydrolase or the VicR (YycF) response regulator. Molecular Microbiology. 53: 1161-75. PMID 15306019 DOI: 10.1111/J.1365-2958.2004.04196.X |
0.763 |
|
| 2004 |
Gooding KB, Higgs R, Hodge B, Stauffer E, Heinz B, McKnight K, Phipps K, Shapiro M, Winkler M, Ng WL, Julian RK. High throughput screening of library compounds against an oligonucleotide substructure of an RNA target. Journal of the American Society For Mass Spectrometry. 15: 884-92. PMID 15144978 DOI: 10.1016/J.Jasms.2004.02.010 |
0.68 |
|
| 2004 |
Foster JE, Sheng Q, McClain JR, Bures M, Nicas TI, Henry K, Winkler ME, Gilmour R. Kinetic and mechanistic analyses of new classes of inhibitors of two-component signal transduction systems using a coupled assay containing HpkA-DrrA from Thermotoga maritima. Microbiology (Reading, England). 150: 885-96. PMID 15073298 DOI: 10.1099/Mic.0.26824-0 |
0.308 |
|
| 2003 |
Ng WL, Robertson GT, Kazmierczak KM, Zhao J, Gilmour R, Winkler ME. Constitutive expression of PcsB suppresses the requirement for the essential VicR (YycF) response regulator in Streptococcus pneumoniae R6. Molecular Microbiology. 50: 1647-63. PMID 14651645 DOI: 10.1046/J.1365-2958.2003.03806.X |
0.778 |
|
| 2003 |
Roop RM, Gee JM, Robertson GT, Richardson JM, Ng WL, Winkler ME. Brucella stationary-phase gene expression and virulence. Annual Review of Microbiology. 57: 57-76. PMID 12730323 DOI: 10.1146/Annurev.Micro.57.030502.090803 |
0.739 |
|
| 2003 |
Li B, Tsui HC, LeClerc JE, Dey M, Winkler ME, Cebula TA. Molecular analysis of mutS expression and mutation in natural isolates of pathogenic Escherichia coli. Microbiology (Reading, England). 149: 1323-31. PMID 12724393 DOI: 10.1099/Mic.0.26213-0 |
0.398 |
|
| 2003 |
Robertson GT, Ng WL, Gilmour R, Winkler ME. Essentiality of clpX, but not clpP, clpL, clpC, or clpE, in Streptococcus pneumoniae R6. Journal of Bacteriology. 185: 2961-6. PMID 12700276 DOI: 10.1128/Jb.185.9.2961-2966.2003 |
0.709 |
|
| 2003 |
Ng WL, Kazmierczak KM, Robertson GT, Gilmour R, Winkler ME. Transcriptional regulation and signature patterns revealed by microarray analyses of Streptococcus pneumoniae R6 challenged with sublethal concentrations of translation inhibitors. Journal of Bacteriology. 185: 359-70. PMID 12486074 DOI: 10.1128/Jb.185.1.359-370.2003 |
0.737 |
|
| 2002 |
Robertson GT, Zhao J, Desai BV, Coleman WH, Nicas TI, Gilmour R, Grinius L, Morrison DA, Winkler ME. Vancomycin tolerance induced by erythromycin but not by loss of vncRS, vex3, or pep27 function in Streptococcus pneumoniae. Journal of Bacteriology. 184: 6987-7000. PMID 12446649 DOI: 10.1128/Jb.184.24.6987-7000.2002 |
0.448 |
|
| 2002 |
Roop RM, Robertson GT, Ferguson GP, Milford LE, Winkler ME, Walker GC. Seeking a niche: putative contributions of the hfq and bacA gene products to the successful adaptation of the brucellae to their intracellular home. Veterinary Microbiology. 90: 349-63. PMID 12414155 DOI: 10.1016/S0378-1135(02)00220-1 |
0.314 |
|
| 2002 |
Cabello-Villegas J, Winkler ME, Nikonowicz EP. Solution conformations of unmodified and A(37)N(6)-dimethylallyl modified anticodon stem-loops of Escherichia coli tRNA(Phe). Journal of Molecular Biology. 319: 1015-34. PMID 12079344 DOI: 10.1016/S0022-2836(02)00382-0 |
0.33 |
|
| 2002 |
Robertson GT, Ng WL, Foley J, Gilmour R, Winkler ME. Global transcriptional analysis of clpP mutations of type 2 Streptococcus pneumoniae and their effects on physiology and virulence. Journal of Bacteriology. 184: 3508-20. PMID 12057945 DOI: 10.1128/Jb.184.13.3508-3520.2002 |
0.766 |
|
| 2002 |
Pease AJ, Roa BR, Luo W, Winkler ME. Positive growth rate-dependent regulation of the pdxA, ksgA, and pdxB genes of Escherichia coli K-12. Journal of Bacteriology. 184: 1359-69. PMID 11844765 DOI: 10.1128/Jb.184.5.1359-1369.2002 |
0.419 |
|
| 2001 |
Hoskins J, Alborn WE, Arnold J, Blaszczak LC, Burgett S, DeHoff BS, Estrem ST, Fritz L, Fu DJ, Fuller W, Geringer C, Gilmour R, Glass JS, Khoja H, Kraft AR, ... ... Winkler ME, et al. Genome of the bacterium Streptococcus pneumoniae strain R6. Journal of Bacteriology. 183: 5709-17. PMID 11544234 DOI: 10.1128/Jb.183.19.5709-5717.2001 |
0.386 |
|
| 2001 |
Zhao J, Leung HCE, Winkler ME. The miaA mutator phenotype of Escherichia coli K-12 requires recombination functions Journal of Bacteriology. 183: 1796-1800. PMID 11160115 DOI: 10.1128/Jb.183.5.1796-1800.2001 |
0.351 |
|
| 2000 |
Zhao J, Winkler ME. Reduction of GC → TA transversion mutation by overexpression of MutS in Escherichia coli K-12 Journal of Bacteriology. 182: 5025-5028. PMID 10940054 DOI: 10.1128/Jb.182.17.5025-5028.2000 |
0.38 |
|
| 1999 |
Esberg B, Leung HCE, Tsui HCT, Bjork GR, Winkler ME. Identification of the miaB gene, involved in methylthiolation of isopentenylated A37 derivatives in the tRNA of Salmonella typhimurium and Escherichia coli Journal of Bacteriology. 181: 7256-7265. PMID 10572129 DOI: 10.1128/Jb.181.23.7256-7265.1999 |
0.392 |
|
| 1998 |
Karlinsey JE, Tsui HCT, Winkler ME, Hughes KT. Flk couples flgM translation to flagellar ring assembly in Salmonella typhimurium Journal of Bacteriology. 180: 5384-5397. PMID 9765570 DOI: 10.1128/Jb.180.20.5384-5397.1998 |
0.438 |
|
| 1998 |
Yang Y, Zhao G, Man TK, Winkler ME. Involvement of the gapA- and epd (gapB)-encoded dehydrogenases in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12 Journal of Bacteriology. 180: 4294-4299. PMID 9696782 DOI: 10.1128/Jb.180.16.4294-4299.1998 |
0.37 |
|
| 1998 |
Di Salvo M, Yang E, Zhao G, Winkler ME, Schirch V. Expression, purification, and characterization of recombinant Escherichia coil pyridoxine 5'-phosphate oxidase Protein Expression and Purification. 13: 349-356. PMID 9693059 DOI: 10.1006/Prep.1998.0904 |
0.334 |
|
| 1998 |
Yang Y, Tsui HCT, Man TK, Winkler ME. Identification and function of the pdxY gene, which encodes a novel pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate biosynthesis in Escherichia coli K-12 Journal of Bacteriology. 180: 1814-1821. PMID 9537380 DOI: 10.1128/Jb.180.7.1814-1821.1998 |
0.398 |
|
| 1997 |
Tsui HCT, Feng G, Winkler ME. Negative regulation of mutS and mutH repair gene expression by the Hfq and RpoS global regulators of Escherichia coli K-12 Journal of Bacteriology. 179: 7476-7487. PMID 9393714 DOI: 10.1128/Jb.179.23.7476-7487.1997 |
0.443 |
|
| 1997 |
Harris RS, Feng G, Ross KJ, Sidhu R, Thulin C, Longerich S, Szigety SK, Winkler ME, Rosenberg SM. Mismatch repair protein MutL becomes limiting during stationary-phase mutation Genes and Development. 11: 2426-2437. PMID 9308969 DOI: 10.1101/Gad.11.18.2426 |
0.321 |
|
| 1997 |
Schuppli D, Miranda G, Tsui HCT, Winkler ME, Sogo JM, Weber H. Altered 3'-terminal RNA structure in phage Qβ adapted to host factor- less Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 94: 10239-10242. PMID 9294194 DOI: 10.1073/Pnas.94.19.10239 |
0.38 |
|
| 1997 |
Man TK, Pease AJ, Winkler ME. Maximization of transcription of the serC (pdxF)-aroA multifunctional operon by antagonistic effects of the cyclic AMP (cAMP) receptor protein- cAMP complex and Lrp global regulators of Escherichia coli K-12 Journal of Bacteriology. 179: 3458-3469. PMID 9171388 DOI: 10.1128/Jb.179.11.3458-3469.1997 |
0.456 |
|
| 1997 |
Leung HCE, Chen Y, Winkler ME. Regulation of substrate recognition by the MiaA tRNA prenyltransferase modification enzyme of Escherichia coli K-12 Journal of Biological Chemistry. 272: 13073-13083. PMID 9148919 DOI: 10.1074/Jbc.272.20.13073 |
0.34 |
|
| 1997 |
Karlinsey JE, Pease AJ, Winkler ME, Bailey JL, Hughes KT. The flk gene of Salmonella typhimurium couples flagellar P-and L-ring assembly to flagellar morphogenesis Journal of Bacteriology. 179: 2389-2400. PMID 9079927 |
0.308 |
|
| 1997 |
Su Q, Schuppli D, Tsui HCT, Winkler ME, Weber H. Strongly reduced phage Qβ replication, but normal phage MS2 replication in an Escherichia coli K12 mutant with inactivated Qβ host factor (hfq) gene Virology. 227: 211-214. PMID 9007075 DOI: 10.1006/Viro.1996.8302 |
0.376 |
|
| 1996 |
Tsui HCT, Feng G, Winkler ME. Transcription of the mutL repair, miaA tRNA modification, hfq pleiotropic regulator, and hflA region protease genes of Escherichia coli K- 12 from clustered Eσ32-specific promoters during heat shock Journal of Bacteriology. 178: 5719-5731. PMID 8824618 DOI: 10.1128/Jb.178.19.5719-5731.1996 |
0.346 |
|
| 1996 |
Yang Y, Zhao G, Winkler ME. Identification of the pdxK gene that encodes pyridoxine (vitamin B6) kinase in Escherichia coli K-12 Fems Microbiology Letters. 141: 89-95. PMID 8764513 DOI: 10.1111/J.1574-6968.1996.Tb08368.X |
0.371 |
|
| 1996 |
Man TK, Zhao G, Winkler ME. Isolation of a pdxJ point mutation that bypasses the requirement for the PdxH oxidase in pyridoxal 5′-phosphate coenzyme biosynthesis in Escherichia coli K-12 Journal of Bacteriology. 178: 2445-2449. PMID 8636054 DOI: 10.1128/Jb.178.8.2445-2449.1996 |
0.372 |
|
| 1996 |
Feng G, Tsui HCT, Winkler ME. Depletion of the cellular amounts of the MutS and MutH methyl-directed mismatch repair proteins in stationary-phase Escherichia coli K-12 cells Journal of Bacteriology. 178: 2388-2396. PMID 8636043 DOI: 10.1128/Jb.178.8.2388-2396.1996 |
0.412 |
|
| 1996 |
Zhao G, Winkler ME. 4-phospho-hydroxy-l-threonine is an obligatory intermediate in pyridoxal 5′-phosphate coenzyme biosynthesis in Escherichia coli K-12 Fems Microbiology Letters. 135: 275-280. PMID 8595869 DOI: 10.1111/J.1574-6968.1996.Tb08001.X |
0.333 |
|
| 1996 |
Zhao G, Winkler ME. A novel α-ketoglutarate reductase activity of the sera-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria Journal of Bacteriology. 178: 232-239. PMID 8550422 DOI: 10.1128/Jb.178.1.232-239.1996 |
0.362 |
|
| 1995 |
Zhao G, Pease AJ, Bharani N, Winkler ME. Biochemical characterization of gapB-encoded erythrose 4-phosphate dehydrogenase of Escherichia coli K-12 and its possible role in pyridoxal 5'- phosphate biosynthesis Journal of Bacteriology. 177: 2804-2812. PMID 7751290 DOI: 10.1128/Jb.177.10.2804-2812.1995 |
0.343 |
|
| 1994 |
Tsui HCT, Leung HCE, Winkler ME. Characterization of broadly pleiotropic phenotypes caused by an hfq insertion mutation in Escherichia coli K-12 Molecular Microbiology. 13: 35-49. PMID 7984093 DOI: 10.1111/J.1365-2958.1994.Tb00400.X |
0.427 |
|
| 1994 |
Zhao G, Winkler ME. An Escherichia coli K-12 tktA tktB mutant deficient in transketolase activity requires pyridoxine (vitamin B6) as well as the aromatic amino acids and vitamins for growth Journal of Bacteriology. 176: 6134-6138. PMID 7928977 DOI: 10.1128/Jb.176.19.6134-6138.1994 |
0.333 |
|
| 1994 |
Tsui HCT, Winkler ME. Transcriptional patterns of the mutL-miaA superoperon of Escherichia coli K-12 suggest a model for posttranscriptional regulation Biochimie. 76: 1168-1177. PMID 7748952 DOI: 10.1016/0300-9084(94)90046-9 |
0.319 |
|
| 1994 |
Tsui HCT, Zhao G, Feng G, Leung HCE, Winkler ME. The mutL repair gene of Escherichia coli K-12 forms a superoperon with a gene encoding a new cell-wall amidase Molecular Microbiology. 11: 189-202. PMID 7511774 DOI: 10.1111/J.1365-2958.1994.Tb00300.X |
0.427 |
|
| 1992 |
Lam HM, Tancula E, Dempsey WB, Winkler ME. Suppression of insertions in the complex pdxJ operon of Escherichia coli K-12 by lon and other mutations Journal of Bacteriology. 174: 1554-1567. PMID 1537800 DOI: 10.1128/Jb.174.5.1554-1567.1992 |
0.632 |
|
| 1992 |
Lam HM, Winkler ME. Characterization of the complex pdxH-tyrS operon of Escherichia coli K-12 and pleiotropic phenotypes caused by pdxH insertion mutations Journal of Bacteriology. 174: 6033-6045. PMID 1356963 DOI: 10.1128/Jb.174.19.6033-6045.1992 |
0.652 |
|
| 1990 |
Lam HM, Winkler ME. Metabolic relationships between pyridoxine (vitamin B6) and serine biosynthesis in Escherichia coli K-12 Journal of Bacteriology. 172: 6518-6528. PMID 2121717 DOI: 10.1128/Jb.172.11.6518-6528.1990 |
0.623 |
|
| 1989 |
van der Zel A, Lam HM, Winkler ME. Extensive homology between the Escherichia coli K-12 SerC(PdxF) aminotransferese and a protein encoded by a progesterone-induced mRNA in rabbit and human endometria Nucleic Acids Research. 17: 8379. PMID 2682527 DOI: 10.1093/Nar/17.20.8379 |
0.565 |
|
| 1989 |
Schoenlein PV, Roa BB, Winkler ME. Divergent transcription of pdxB and homology between the pdxB and serA gene products in Escherichia coli K-12 Journal of Bacteriology. 171: 6084-6092. PMID 2681152 |
0.324 |
|
| 1989 |
Connolly DM, Winkler ME. Genetic and physiological relationships among the miaA gene, 2-methylthio-N6-(Δ2-isopentenyl)-adenosine tRNA modification, and spontaneous mutagenesis in Escherichia coli K-12 Journal of Bacteriology. 171: 3233-3246. PMID 2656644 |
0.31 |
|
| 1985 |
Arps PJ, Marvel CC, Rubin BC, Tolan DA, Penhoet EE, Winkler ME. Structural features of the hisT operon of Escherichia coli K-12 Nucleic Acids Research. 13: 5297-5315. PMID 2991861 DOI: 10.1093/Nar/13.14.5297 |
0.388 |
|
| 1985 |
Marvel CC, Arps PJ, Rubin BC, Kammen HO, Penhoet EE, Winkler ME. hisT is part of a multigene operon in Escherichia coli K-12 Journal of Bacteriology. 161: 60-71. PMID 2981810 DOI: 10.1128/Jb.161.1.60-71.1985 |
0.421 |
|
| 1985 |
Fisher RF, Das A, Kolter R, Winkler ME, Yanofsky C. Analysis of the requirements for transcription pausing in the tryptophan operon. Journal of Molecular Biology. 182: 397-409. PMID 2409288 DOI: 10.1016/0022-2836(85)90199-8 |
0.618 |
|
| 1982 |
Winkler ME, Mullis K, Barnett J, Stroynowski I, Yanofsky C. Transcription termination at the tryptophan operon attenuator is decreased in vitro by an oligomer complementary to a segment of the leader transcript Proceedings of the National Academy of Sciences of the United States of America. 79: 2181-2185. PMID 6179092 DOI: 10.1073/Pnas.79.7.2181 |
0.478 |
|
| 1981 |
Winkler ME, Yanofsky C. Pausing of RNA polymerase during in vitro transcription of the tryptophan operon leader region Biochemistry. 20: 3738-3744. PMID 6168281 DOI: 10.1021/Bi00516A011 |
0.455 |
|
| 1979 |
Winkler ME, Zawodny RV, Hartman PE. Mutation spoT of Escherichia coli increases expression of the histidine operon deleted for the attenuator Journal of Bacteriology. 139: 993-1000. PMID 383702 |
0.522 |
|
| 1978 |
Winkler ME, Roth DJ, Hartman PE. Promoter and attenuator-related metabolic regulation of the Salmonella typhimurium histidine operon Journal of Bacteriology. 133: 830-843. PMID 342509 |
0.558 |
|
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