| Year |
Citation |
Score |
| 2016 |
Brown DP, Rogers DT, Pomerleau F, Siripurapu KB, Kulshrestha M, Gerhardt GA, Littleton JM. Novel multifunctional pharmacology of lobinaline, the major alkaloid from Lobelia cardinalis. Fitoterapia. PMID 27105955 DOI: 10.1016/J.Fitote.2016.04.013 |
0.323 |
|
| 2016 |
Barron S, Hawkey A, Fields L, Littleton JM. Animal Models for Medication Development and Application to Treat Fetal Alcohol Effects. International Review of Neurobiology. 126: 423-40. PMID 27055621 DOI: 10.1016/Bs.Irn.2016.02.002 |
0.45 |
|
| 2015 |
Lutz JA, Carter M, Fields L, Barron S, Littleton JM. The Dietary Flavonoid Rhamnetin Inhibits Both Inflammation and Excitotoxicity During Ethanol Withdrawal in Rat Organotypic Hippocampal Slice Cultures. Alcoholism, Clinical and Experimental Research. PMID 26577991 DOI: 10.1111/Acer.12896 |
0.502 |
|
| 2015 |
Lutz JA, Carter M, Fields L, Barron S, Littleton JM. Altered relation between lipopolysaccharide-induced inflammatory response and excitotoxicity in rat organotypic hippocampal slice cultures during ethanol withdrawal. Alcoholism, Clinical and Experimental Research. 39: 827-35. PMID 25845566 DOI: 10.1111/Acer.12705 |
0.519 |
|
| 2014 |
Lutz JA, Kulshrestha M, Rogers DT, Littleton JM. A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia. Fitoterapia. 98: 11-21. PMID 24972350 DOI: 10.1016/J.Fitote.2014.06.012 |
0.34 |
|
| 2012 |
Barron S, Lewis B, Wellmann K, Carter M, Farook J, Ring J, Rogers DT, Holley R, Crooks P, Littleton J. Polyamine modulation of NMDARs as a mechanism to reduce effects of alcohol dependence. Recent Patents On Cns Drug Discovery. 7: 129-44. PMID 22574674 DOI: 10.2174/157488912800673128 |
0.366 |
|
| 2010 |
D'Souza El-Guindy NB, Kovacs EJ, De Witte P, Spies C, Littleton JM, de Villiers WJ, Lott AJ, Plackett TP, Lanzke N, Meadows GG. Laboratory models available to study alcohol-induced organ damage and immune variations: choosing the appropriate model. Alcoholism, Clinical and Experimental Research. 34: 1489-511. PMID 20586763 DOI: 10.1111/J.1530-0277.2010.01234.X |
0.309 |
|
| 2010 |
Butler TR, Self RL, Smith KJ, Sharrett-Field LJ, Berry JN, Littleton JM, Pauly JR, Mulholland PJ, Prendergast MA. Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors. Neuroscience. 165: 525-34. PMID 19837138 DOI: 10.1016/J.Neuroscience.2009.10.018 |
0.433 |
|
| 2009 |
Farook JM, Lewis B, Gaddis JG, Littleton JM, Barron S. Effects of mecamylamine on alcohol consumption and preference in male C57BL/6J mice. Pharmacology. 83: 379-84. PMID 19468256 DOI: 10.1159/000219488 |
0.349 |
|
| 2009 |
Farook JM, Lewis B, Gaddis JG, Littleton JM, Barron S. Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice. Physiology & Behavior. 97: 503-6. PMID 19268674 DOI: 10.1016/J.Physbeh.2009.02.031 |
0.342 |
|
| 2009 |
Rubin MA, Wellmann KA, Lewis B, Overgaauw BJ, Littleton JM, Barron S. Difluoromethylornithine (DFMO) reduces deficits in isolation-induced ultrasonic vocalizations and balance following neonatal ethanol exposure in rats. Pharmacology, Biochemistry, and Behavior. 92: 44-50. PMID 18992275 DOI: 10.1016/J.Pbb.2008.10.008 |
0.469 |
|
| 2009 |
Farook JM, Lewis B, Littleton JM, Barron S. Topiramate attenuates the stress-induced increase in alcohol consumption and preference in male C57BL/6J mice. Physiology & Behavior. 96: 189-93. PMID 18786555 DOI: 10.1016/J.Physbeh.2008.08.011 |
0.336 |
|
| 2008 |
Stepanyan TD, Farook JM, Kowalski A, Kaplan E, Barron S, Littleton JM. Alcohol withdrawal-induced hippocampal neurotoxicity in vitro and seizures in vivo are both reduced by memantine. Alcoholism, Clinical and Experimental Research. 32: 2128-35. PMID 18828800 DOI: 10.1111/J.1530-0277.2008.00801.X |
0.762 |
|
| 2008 |
Farook JM, Krazem A, Lewis B, Morrell DJ, Littleton JM, Barron S. Acamprosate attenuates the handling induced convulsions during alcohol withdrawal in Swiss Webster mice. Physiology & Behavior. 95: 267-70. PMID 18577392 DOI: 10.1016/J.Physbeh.2008.05.020 |
0.322 |
|
| 2008 |
Mann K, Kiefer F, Spanagel R, Littleton J. Acamprosate: recent findings and future research directions. Alcoholism, Clinical and Experimental Research. 32: 1105-10. PMID 18540918 DOI: 10.1111/J.1530-0277.2008.00690.X |
0.393 |
|
| 2008 |
Barron S, Mulholland PJ, Littleton JM, Prendergast MA. Age and gender differences in response to neonatal ethanol withdrawal and polyamine challenge in organotypic hippocampal cultures. Alcoholism, Clinical and Experimental Research. 32: 929-36. PMID 18445110 DOI: 10.1111/J.1530-0277.2008.00649.X |
0.526 |
|
| 2007 |
Littleton JM. Acamprosate in alcohol dependence: implications of a unique mechanism of action. Journal of Addiction Medicine. 1: 115-25. PMID 21768946 DOI: 10.1097/Adm.0B013E318156C26F |
0.41 |
|
| 2007 |
Farook JM, Morrell DJ, Lewis B, Littleton JM, Barron S. Topiramate (Topamax) reduces conditioned abstinence behaviours and handling-induced convulsions (HIC) after chronic administration of alcohol in Swiss-Webster mice. Alcohol and Alcoholism (Oxford, Oxfordshire). 42: 296-300. PMID 17548369 DOI: 10.1093/Alcalc/Agm047 |
0.322 |
|
| 2007 |
Littleton J, Barron S, Prendergast M, Nixon SJ. Smoking kills (alcoholics)! shouldn't we do something about it? Alcohol and Alcoholism (Oxford, Oxfordshire). 42: 167-73. PMID 17526626 DOI: 10.1093/Alcalc/Agm019 |
0.304 |
|
| 2007 |
Smith KJ, Self RL, Butler TR, Mullins MM, Ghayoumi L, Holley RC, Littleton JM, Prendergast MA. Methamphetamine exposure antagonizes N-methyl-D-aspartate receptor-mediated neurotoxicity in organotypic hippocampal slice cultures. Brain Research. 1157: 74-80. PMID 17524372 DOI: 10.1016/J.Brainres.2007.04.056 |
0.495 |
|
| 2007 |
Mello CF, Rubin MA, Sultana R, Barron S, Littleton JM, Butterfield DA. Difluoromethylornithine decreases long-lasting protein oxidation induced by neonatal ethanol exposure in the hippocampus of adolescent rats. Alcoholism, Clinical and Experimental Research. 31: 887-94. PMID 17386069 DOI: 10.1111/J.1530-0277.2007.00369.X |
0.462 |
|
| 2006 |
Wilkins LH, Prendergast MA, Blanchard J, Holley RC, Chambers ER, Littleton JM. Potential value of changes in cell markers in organotypic hippocampal cultures associated with chronic EtOH exposure and withdrawal: comparison with NMDA-induced changes. Alcoholism, Clinical and Experimental Research. 30: 1768-80. PMID 17010144 DOI: 10.1111/J.1530-0277.2006.00210.X |
0.502 |
|
| 2006 |
Mulholland PJ, Self RL, Hensley AK, Little HJ, Littleton JM, Prendergast MA. A 24 h corticosterone exposure exacerbates excitotoxic insult in rat hippocampal slice cultures independently of glucocorticoid receptor activation or protein synthesis. Brain Research. 1082: 165-72. PMID 16510135 DOI: 10.1016/J.Brainres.2006.01.069 |
0.488 |
|
| 2005 |
Mulholland PJ, Stepanyan TD, Self RL, Hensley AK, Harris BR, Kowalski A, Littleton JM, Prendergast MA. Corticosterone and dexamethasone potentiate cytotoxicity associated with oxygen-glucose deprivation in organotypic cerebellar slice cultures. Neuroscience. 136: 259-67. PMID 16182452 DOI: 10.1016/J.Neuroscience.2005.07.043 |
0.706 |
|
| 2005 |
Mulholland PJ, Self RL, Stepanyan TD, Little HJ, Littleton JM, Prendergast MA. Thiamine deficiency in the pathogenesis of chronic ethanol-associated cerebellar damage in vitro. Neuroscience. 135: 1129-39. PMID 16165302 DOI: 10.1016/J.Neuroscience.2005.06.077 |
0.773 |
|
| 2005 |
De Witte P, Littleton J, Parot P, Koob G. Neuroprotective and abstinence-promoting effects of acamprosate: elucidating the mechanism of action. Cns Drugs. 19: 517-37. PMID 15963001 DOI: 10.2165/00023210-200519060-00004 |
0.445 |
|
| 2005 |
Mulholland PJ, Self RL, Harris BR, Little HJ, Littleton JM, Prendergast MA. Corticosterone increases damage and cytosolic calcium accumulation associated with ethanol withdrawal in rat hippocampal slice cultures. Alcoholism, Clinical and Experimental Research. 29: 871-81. PMID 15897733 DOI: 10.1097/01.Alc.0000163509.27577.Da |
0.757 |
|
| 2004 |
Mulholland PJ, Self RL, Harris BR, Littleton JM, Prendergast MA. Choline exposure reduces potentiation of N-methyl-D-aspartate toxicity by corticosterone in the developing hippocampus. Brain Research. Developmental Brain Research. 153: 203-11. PMID 15527888 DOI: 10.1016/J.Devbrainres.2004.08.008 |
0.712 |
|
| 2004 |
Crews FT, Collins MA, Dlugos C, Littleton J, Wilkins L, Neafsey EJ, Pentney R, Snell LD, Tabakoff B, Zou J, Noronha A. Alcohol-induced neurodegeneration: when, where and why? Alcoholism, Clinical and Experimental Research. 28: 350-64. PMID 15112943 DOI: 10.1097/01.Alc.0000113416.65546.01 |
0.446 |
|
| 2004 |
Mulholland PJ, Self RL, Harris BR, Littleton JM, Prendergast MA. (-)-nicotine ameliorates corticosterone's potentiation of N-methyl-d-aspartate receptor-mediated cornu ammonis 1 toxicity. Neuroscience. 125: 671-82. PMID 15099681 DOI: 10.1016/J.Neuroscience.2004.02.007 |
0.716 |
|
| 2004 |
Prendergast MA, Harris BR, Mullholland PJ, Blanchard JA, Gibson DA, Holley RC, Littleton JM. Hippocampal CA1 region neurodegeneration produced by ethanol withdrawal requires activation of intrinsic polysynaptic hippocampal pathways and function of N-methyl-D-aspartate receptors. Neuroscience. 124: 869-77. PMID 15026127 DOI: 10.1016/J.Neuroscience.2003.12.013 |
0.728 |
|
| 2004 |
Rogers DT, Barron S, Littleton JM. Neonatal ethanol exposure produces a hyperalgesia that extends into adolescence, and is associated with increased analgesic and rewarding properties of nicotine in rats. Psychopharmacology. 171: 204-11. PMID 13680078 DOI: 10.1007/S00213-003-1574-Z |
0.416 |
|
| 2003 |
Littleton J, Zieglgänsberger W. Pharmacological mechanisms of naltrexone and acamprosate in the prevention of relapse in alcohol dependence. The American Journal On Addictions / American Academy of Psychiatrists in Alcoholism and Addictions. 12: S3-11. PMID 14972776 DOI: 10.1111/J.1521-0391.2003.Tb00492.X |
0.349 |
|
| 2003 |
Harris BR, Gibson DA, Prendergast MA, Blanchard JA, Holley RC, Hart SR, Scotland RL, Foster TC, Pedigo NW, Littleton JM. The neurotoxicity induced by ethanol withdrawal in mature organotypic hippocampal slices might involve cross-talk between metabotropic glutamate type 5 receptors and N-methyl-D-aspartate receptors. Alcoholism, Clinical and Experimental Research. 27: 1724-35. PMID 14634487 DOI: 10.1097/01.Alc.0000093601.33119.E3 |
0.766 |
|
| 2003 |
Mulholland PJ, Harris BR, Wilkins LH, Self RL, Blanchard JA, Holley RC, Littleton JM, Prendergast MA. Opposing effects of ethanol and nicotine on hippocampal calbindin-D28k expression. Alcohol (Fayetteville, N.Y.). 31: 1-10. PMID 14615005 DOI: 10.1016/J.Alcohol.2003.09.001 |
0.728 |
|
| 2003 |
Gibson DA, Harris BR, Prendergast MA, Hart SR, Blanchard JA, Holley RC, Pedigo NW, Littleton JM. Polyamines contribute to ethanol withdrawal-induced neurotoxicity in rat hippocampal slice cultures through interactions with the NMDA receptor. Alcoholism, Clinical and Experimental Research. 27: 1099-106. PMID 12878916 DOI: 10.1097/01.Alc.0000075824.10502.Dd |
0.759 |
|
| 2002 |
Prendergast MA, Rogers DT, Barron S, Bardo MT, Littleton JM. Ethanol and nicotine: a pharmacologic balancing act? Alcoholism, Clinical and Experimental Research. 26: 1917-8. PMID 12500119 DOI: 10.1111/J.1530-0277.2002.Tb02502.X |
0.434 |
|
| 2002 |
Harris BR, Prendergast MA, Gibson DA, Rogers DT, Blanchard JA, Holley RC, Fu MC, Hart SR, Pedigo NW, Littleton JM. Acamprosate inhibits the binding and neurotoxic effects of trans-ACPD, suggesting a novel site of action at metabotropic glutamate receptors. Alcoholism, Clinical and Experimental Research. 26: 1779-93. PMID 12500101 DOI: 10.1111/J.1530-0277.2002.Tb02484.X |
0.694 |
|
| 2002 |
Prendergast MA, Rogers DT, Mulholland PJ, Littleton JM, Wilkins LH, Self RL, Nath A. Neurotoxic effects of the human immunodeficiency virus type-1 transcription factor Tat require function of a polyamine sensitive-site on the N-methyl-D-aspartate receptor. Brain Research. 954: 300-7. PMID 12414113 DOI: 10.1016/S0006-8993(02)03360-7 |
0.396 |
|
| 2002 |
Mayer S, Harris BR, Gibson DA, Blanchard JA, Prendergast MA, Holley RC, Littleton J. Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus. Alcoholism, Clinical and Experimental Research. 26: 1468-78. PMID 12394279 DOI: 10.1097/01.Alc.0000033261.14548.D2 |
0.765 |
|
| 2002 |
Gibson DA, Harris BR, Rogers DT, Littleton JM. Radioligand binding studies reveal agmatine is a more selective antagonist for a polyamine-site on the NMDA receptor than arcaine or ifenprodil. Brain Research. 952: 71-7. PMID 12363406 DOI: 10.1016/S0006-8993(02)03198-0 |
0.647 |
|
| 2002 |
Mayer S, Harris B, Gibson DA, Blanchard J, Prendergast MA, Holley RC, Littleton J. Acamprosate has no effect on NMDA-induced toxicity but reduces toxicity induced by spermidine or by changing the medium in organotypic hippocampal slice cultures from rat. Alcoholism, Clinical and Experimental Research. 26: 655-62. PMID 12045473 |
0.676 |
|
| 2002 |
Koob GF, Mason BJ, De Witte P, Littleton J, Siggins GR. Potential neuroprotective effects of acamprosate. Alcoholism, Clinical and Experimental Research. 26: 586-92. PMID 11981137 |
0.358 |
|
| 2002 |
Mayer S, Harris B, Gibson DA, Blanchard J, Prendergast MA, Holley RC, Littleton J. Acamprosate Has No Effect on NMDA-Induced Toxicity But Reduces Toxicity Induced by Spermidine or by Changing the Medium in Organotypic Hippocampal Slice Cultures From Rat Alcoholism: Clinical and Experimental Research. 26: 655-662. DOI: 10.1111/J.1530-0277.2002.Tb02587.X |
0.725 |
|
| 2002 |
Koob GF, Mason BJ, Witte P, Littleton J, Siggins GR. Potential Neuroprotective Effects of Acamprosate Alcoholism: Clinical and Experimental Research. 26: 586-592. DOI: 10.1111/J.1530-0277.2002.Tb02578.X |
0.462 |
|
| 2002 |
Littleton J, Little H. Interactions Between Alcohol and Nicotine Dependence: A Summary of Potential Mechanisms and Implications for Treatment Alcoholism: Clinical and Experimental Research. 26: 1922-1924. DOI: 10.1111/J.1530-0277.2002.Tb02504.X |
0.327 |
|
| 2002 |
Mayer S, Harris BR, Gibson DA, Blanchard JA, Prendergast MA, Holley RC, Littleton J. Acamprosate, MK-801, and Ifenprodil Inhibit Neurotoxicity and Calcium Entry Induced by Ethanol Withdrawal in Organotypic Slice Cultures From Neonatal Rat Hippocampus Alcoholism: Clinical and Experimental Research. 26: 1468-1478. DOI: 10.1111/j.1530-0277.2002.tb02445.x |
0.7 |
|
| 2001 |
Prendergast MA, Harris BR, Mayer S, Holley RC, Pauly JR, Littleton JM. Nicotine exposure reduces N-methyl-D-aspartate toxicity in the hippocampus: relation to distribution of the alpha7 nicotinic acetylcholine receptor subunit. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research. 7: 1153-60. PMID 11687723 |
0.652 |
|
| 2001 |
Qatari MA, Khan S, Harris B, Littleton J. Acamprosate is neuroprotective against glutamate-induced excitotoxicity when enhanced by ethanol withdrawal in neocortical cultures of fetal rat brain. Alcoholism: Clinical and Experimental Research. 25: 1276-1283. PMID 11584146 DOI: 10.1097/00000374-200109000-00006 |
0.739 |
|
| 2001 |
Littleton JM, Lovinger D, Liljequist S, Ticku R, Matsumoto I, Barron S. Role of polyamines and NMDA receptors in ethanol dependence and withdrawal Alcoholism: Clinical and Experimental Research. 25. PMID 11391062 |
0.471 |
|
| 2001 |
Prendergast MA, Harris BR, Mayer S, Holley RC, Hauser KF, Littleton JM. Chronic nicotine exposure reduces N-methyl-D-aspartate receptor-mediated damage in the hippocampus without altering calcium accumulation or extrusion: evidence of calbindin-D28K overexpression. Neuroscience. 102: 75-85. PMID 11226671 DOI: 10.1016/S0306-4522(00)00450-4 |
0.684 |
|
| 2001 |
Worthen DR, Gibson DA, Rogers DT, Bence AK, Fu M, Littleton JM, Crooks PA. Endogenous indoles as novel polyamine site ligands at the N-methyl-D-aspartate receptor complex. Brain Research. 890: 343-6. PMID 11164802 DOI: 10.1016/S0006-8993(00)03201-7 |
0.315 |
|
| 2001 |
Littleton JM, Lovinger D, Liljequist S, Ticku R, Matsumoto I, Barron S. Role of polyamines and NMDA receptors in ethanol dependence and withdrawal. Alcoholism: Clinical and Experimental Research. 25. DOI: 10.1111/J.1530-0277.2001.Tb02387.X |
0.492 |
|
| 2000 |
Prendergast MA, Harris BR, Blanchard JA, Mayer S, Gibson DA, Littleton JM. In vitro effects of ethanol withdrawal and spermidine on viability of hippocampus from male and female rat. Alcoholism, Clinical and Experimental Research. 24: 1855-61. PMID 11141045 DOI: 10.1111/J.1530-0277.2000.Tb01990.X |
0.743 |
|
| 2000 |
Bence AK, Rogers DT, Worthen DR, Fu M, Littleton JM, Crooks PA. Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex. Bioorganic & Medicinal Chemistry Letters. 10: 2621-3. PMID 11128637 DOI: 10.1016/S0960-894X(00)00530-8 |
0.336 |
|
| 2000 |
Prendergast MA, Harris BR, Mayer S, Littleton JM. Chronic, but not acute, nicotine exposure attenuates ethanol withdrawal-induced hippocampal damage in vitro. Alcoholism, Clinical and Experimental Research. 24: 1583-92. PMID 11045868 DOI: 10.1111/J.1530-0277.2000.Tb04578.X |
0.749 |
|
| 2000 |
Cole JC, Littleton JM, Little HJ. Acamprosate, but not naltrexone, inhibits conditioned abstinence behaviour associated with repeated ethanol administration and exposure to a plus-maze. Psychopharmacology. 147: 403-11. PMID 10672634 DOI: 10.1007/S002130050009 |
0.431 |
|
| 2000 |
Bence AK, Rogers DT, Worthen DR, Fu M, Littleton JM, Crooks PA. Dapsone analogs as potential polyamine binding site modulators of the N-methyl-D-aspartate receptor complex Drug Development Research. 51: 268-272. DOI: 10.1002/Ddr.8 |
0.338 |
|
| 1999 |
Guppy LJ, Littleton JM. Damaging effects of the calcium paradox are reduced in isolated hearts from ethanol-dependent rats: Paradoxic effects of dihydropyridine drugs Journal of Cardiovascular Pharmacology. 34: 765-771. PMID 10598118 DOI: 10.1097/00005344-199912000-00001 |
0.414 |
|
| 1999 |
Guppy LJ, Littleton JM. Increased sensitivity to damaging effects of hypoxia and anoxia of isolated hearts from rats after prolonged exposure to ethanol: Apparent protection by nitrendipine Journal of Cardiovascular Pharmacology. 34: 628-634. PMID 10547077 DOI: 10.1097/00005344-199911000-00002 |
0.457 |
|
| 1999 |
Guppy LJ, Littleton JM. Effect of calcium, Bay K 8644, and reduced perfusion on basic indices of myocardial function in isolated hearts from rats after prolonged exposure to ethanol Journal of Cardiovascular Pharmacology. 34: 480-487. PMID 10511121 DOI: 10.1097/00005344-199910000-00002 |
0.376 |
|
| 1999 |
Guppy LJ, Littleton JM. Effects of prolonged exposure to ethanol in vivo on functional parameters and sensitivity to nitrendipine in the isolated rat heart Journal of Cardiovascular Pharmacology. 34: 414-419. PMID 10471001 DOI: 10.1097/00005344-199909000-00015 |
0.423 |
|
| 1999 |
Cole JC, Littleton JM, Little HJ. Effects of repeated ethanol administration in the plus maze; a simple model for conditioned abstinence behaviour. Psychopharmacology. 142: 270-9. PMID 10208319 DOI: 10.1007/S002130050889 |
0.492 |
|
| 1998 |
Bouchenafa O, Littleton JM. Expression of c-Fos protein immunoreactivity in rat brain during ethanol withdrawal is prevented by nifedipine Alcohol. 15: 71-76. PMID 9426840 DOI: 10.1016/S0741-8329(97)00100-6 |
0.334 |
|
| 1998 |
Qatari M, Bouchenafa O, Littleton J. Mechanism of Action of Acamprosate. Part II. Ethanol Dependence Modifies Effects of Acamprosate on NMDA Receptor Binding in Membranes from Rat Cerebral Cortex Alcoholism: Clinical and Experimental Research. 22: 810-814. DOI: 10.1111/J.1530-0277.1998.Tb03872.X |
0.489 |
|
| 1997 |
Littleton J, Mayer S, al Qatari M. Repeated alcohol consumption: Implications for craving, kindling and treatment Biological Psychiatry. 42: 275S-276S. DOI: 10.1016/S0006-3223(97)88058-4 |
0.301 |
|
| 1995 |
Guppy LJ, Crabbe JC, Littleton JM. Time course and genetic variation in the regulation of calcium channel antagonist binding sites in rodent tissues during the induction of ethanol physical dependence and withdrawal. Alcohol and Alcoholism (Oxford, Oxfordshire). 30: 607-15. PMID 8554643 DOI: 10.1093/Oxfordjournals.Alcalc.A045770 |
0.45 |
|
| 1995 |
RUHE C, LITTLETON JM. EFFECT OF CALCIUM CHANNEL ANTAGONISTS ON EAA-MEDIATED EXCITOTOXICITY IN ETHANOL WITHDRAWN NEOCORTICAL CULTURES Behavioural Pharmacology. 6: 629. DOI: 10.1097/00008877-199508000-00069 |
0.345 |
|
| 1994 |
Ruhe CA, Littleton JM. The possible role of voltage-operated calcium channels in the enhancement of excitatory amino acid toxicity following chronic ethanol exposure in vitro Alcohol and Alcoholism (Oxford, Oxfordshire). Supplement.. 2: 217-221. PMID 8974339 |
0.417 |
|
| 1994 |
Guppy LJ, Littleton JM. Binding characteristics of the calcium channel antagonist [3h]-nitrendipine in tissues from ethanol-dependent rats Alcohol and Alcoholism. 29: 283-293. PMID 7945569 DOI: 10.1093/Oxfordjournals.Alcalc.A045535 |
0.43 |
|
| 1991 |
Littleton JM, Brennan C, Bouchenafa O. The role of calcium flux in the central nervous system actions of ethanol Annals of the New York Academy of Sciences. 625: 388-394. PMID 2058895 DOI: 10.1111/J.1749-6632.1991.Tb33866.X |
0.384 |
|
| 1991 |
Brennan CH, Littleton JM. Chronic exposure to anxiolytic drugs, working by different mechanisms causes up-regulation of dihydropyridine binding sites on cultured bovine adrenal chromaffin cells Neuropharmacology. 30: 199-205. PMID 1674364 DOI: 10.1016/0028-3908(91)90204-O |
0.477 |
|
| 1991 |
Harper JC, Littleton JM. Characteristics of catecholamine release from adrenal chromaffin cells cultured in medium containing ethanol - II. Carbachol and veratrine-induced release Alcohol and Alcoholism. 26: 33-38. PMID 1649608 |
0.343 |
|
| 1991 |
Harper JC, Littleton JM. Characteristics of catecholamine release from adrenal chromaffin cells cultured in medium containing ethanol - I. Spontaneous and K+-induced release Alcohol and Alcoholism. 26: 25-32. PMID 1649607 |
0.38 |
|
| 1990 |
Brennan CH, Crabbe J, Littleton JM. Genetic regulation of dihydropyridine-sensitive calcium channels in brain may determine susceptibility to physical dependence on alcohol Neuropharmacology. 29: 429-432. PMID 2162493 DOI: 10.1016/0028-3908(90)90163-L |
0.418 |
|
| 1990 |
Harper JC, Littleton JM. Development of tolerance to ethanol in cultured adrenal chromaffin cells Alcoholism: Clinical and Experimental Research. 14: 508-512. PMID 1699441 DOI: 10.1111/j.1530-0277.1990.tb01189.x |
0.408 |
|
| 1990 |
Littleton JM, Little HJ, Whittington MA. Effects of dihydropyridine calcium channel antagonists in ethanol withdrawal; doses required, stereospecificity and actions of Bay K 8644. Psychopharmacology. 100: 387-92. PMID 1690434 DOI: 10.1007/Bf02244612 |
0.431 |
|
| 1989 |
Brennan CH, Lewis A, Littleton JM. Membrane receptors, involved in up-regulation of calcium channels in bovine adrenal chromaffin cells, chronically exposed to ethanol Neuropharmacology. 28: 1303-1307. PMID 2482458 DOI: 10.1016/0028-3908(89)90003-8 |
0.376 |
|
| 1989 |
Harper JC, Brennan CH, Littleton JM. Genetic up-regulation of calcium channels in a cellular model of ethanol dependence Neuropharmacology. 28: 1299-1302. PMID 2482457 DOI: 10.1016/0028-3908(89)90002-6 |
0.367 |
|
| 1989 |
Brennan CH, Guppy LJ, Littleton JM. Chronic exposure to ethanol increases dihydropyridine-sensitive calcium channels in excitable cells Annals of the New York Academy of Sciences. 560: 467-469. DOI: 10.1111/J.1749-6632.1989.Tb24140.X |
0.405 |
|
| 1988 |
Littleton JM, Little HJ. Dihydropyridine-sensitive Ca2+ channels in brain are involved in the central nervous system hyperexcitability associated with alcohol withdrawal states Annals of the New York Academy of Sciences. 522: 199-202. DOI: 10.1111/J.1749-6632.1988.Tb33355.X |
0.311 |
|
| 1988 |
Littleton J, Harper J, Brennan C, Guppy L. Adaptation in membrane Ca2+ channels as a basis for alcohol-related pathology Drug and Alcohol Review. 7: 35-38. DOI: 10.1080/09595238880000091 |
0.374 |
|
| 1987 |
Harper JC, Pagonis C, Littleton JM. Altered characteristics of catecholamine release from rat cortical slices and bovine adrenal chromaffin cells in cutlure after chronic exposure to ethanol and the effect of the dihydropyridine drugs on these systems Alcohol and Alcoholism. 725-729. PMID 2447907 |
0.327 |
|
| 1987 |
Dolin S, Little H, Hudspith M, Pagonis C, Littleton J. Increased dihydropyridine-sensitive calcium channels in rat brain may underlie ethanol physical dependence. Neuropharmacology. 26: 275-9. PMID 2438583 DOI: 10.1016/0028-3908(87)90220-6 |
0.428 |
|
| 1985 |
John GR, Littleton JM, Nhamburo PT. Increased activity of Ca2+-dependent enzymes of membrane lipid metabolism in synaptosomal preparations from ethanol-dependent rats. Journal of Neurochemistry. 44: 1235-41. PMID 3919159 |
0.348 |
|
| 1985 |
Lynch MA, Samuel D, Littleton JM. Altered characteristics of [3H]dopamine release from superfused slices of corpus striatum obtained from rats receiving ethanol in vivo Neuropharmacology. 24: 479-485. PMID 2862601 DOI: 10.1016/0028-3908(85)90052-8 |
0.338 |
|
| 1985 |
Lynch MA, Littleton JM. Enhanced [3H]-noradrenaline release in synaptosomes from ethanol-tolerant animals: The role of nerve terminal calcium ion concentrations Alcohol and Alcoholism. 20: 5-11. PMID 2409991 DOI: 10.1093/Oxfordjournals.Alcalc.A044504 |
0.413 |
|
| 1985 |
Littleton JM, Pagonis C. Biochemical effects of ethanol on central neurotransmitter function Alcohol and Alcoholism. 20: 77-78. |
0.333 |
|
| 1984 |
Fenn CG, Littleton JM. Interactions between ethanol and dietary fat in determining human platelet function Thrombosis and Haemostasis. 51: 50-53. PMID 6719388 DOI: 10.1055/S-0038-1661017 |
0.303 |
|
| 1983 |
Anderson RL, Ahier RG, Littleton JM. Observations on the cellular effects of ethanol and hyperthermia in vivo Radiation Research. 94: 318-325. PMID 6856777 |
0.365 |
|
| 1983 |
Samuel D, Lynch MA, Littleton JM. Picrotoxin inhibits the effect of ethanol on the spontaneous efflux of [3H]-dopamine from superfused slices of rat corpus striatum Neuropharmacology. 22: 1413-1415. PMID 6664470 DOI: 10.1016/0028-3908(83)90234-4 |
0.305 |
|
| 1983 |
Connelly MS, Littleton JM. Lack of stereoselectivity in ability of nicotine to release dopamine from rat synaptosomal preparations Journal of Neurochemistry. 41: 1297-1302. PMID 6619866 DOI: 10.1111/J.1471-4159.1983.Tb00824.X |
0.348 |
|
| 1983 |
Patrikiou-Caberos L, Lynch MA, Leroy C, Fenn GC, Littleton JM. Interactions of ethanol with ionophore A23187 in human platelets and erythrocytes and in rat brain slices Biochemical Pharmacology. 32: 2211-2216. PMID 6409118 DOI: 10.1016/0006-2952(83)90228-9 |
0.382 |
|
| 1983 |
Fenn CG, Littleton JM. The human blood platelet as a model for studying interactions of ethanol with membrane lipids Alcoholism: Clinical and Experimental Research. 7: 59-64. PMID 6405649 DOI: 10.1111/J.1530-0277.1983.Tb05412.X |
0.399 |
|
| 1983 |
Lynch M, Littleton J, McKernan RM, Durcan MJ, McMillan T, Campbell IC. α-Adrenoceptor number and function in rat cortex after ethanol and immobilization stress Brain Research. 288: 145-149. PMID 6318884 DOI: 10.1016/0006-8993(83)90088-4 |
0.382 |
|
| 1983 |
Fenn GC, Lynch MA, Nhamburo PT, Caberos L, Littleton JM. Comparison of effects of ethanol on platelet function and synaptic transmission Pharmacology, Biochemistry and Behavior. 18: 37-43. PMID 6314381 DOI: 10.1016/0091-3057(83)90144-2 |
0.445 |
|
| 1983 |
Lynch MA, Littleton JM. Possible association of alcohol tolerance with increased synaptic Ca 2+ sensitivity Nature. 303: 175-176. PMID 6302519 DOI: 10.1038/303175A0 |
0.442 |
|
| 1982 |
Nhamburo PT, John GR, Littleton JM. Alterations in phospholipid methylation in rat brain synaptosomal membranes produced by ethanol in vitro and in vivo. Biochemical Pharmacology. 31: 3936-8. PMID 6891589 DOI: 10.1016/0006-2952(82)90315-X |
0.312 |
|
| 1982 |
Littleton JM, Fenn CG, Umney ND, Yazdanbakhsh M. Effects of ethanol administration on platelet function in the rat Alcoholism: Clinical and Experimental Research. 6: 512-519. PMID 6817656 |
0.322 |
|
| 1982 |
Fenn CG, Littleton JM. Inhibition of platelet aggregation by ethanol in vitro shows specificity for aggregating agent used and is influenced by platelet lipid composition Thrombosis and Haemostasis. 48: 49-53. PMID 6813995 DOI: 10.1055/S-0038-1657214 |
0.374 |
|
| 1981 |
John GR, Littleton JM, Nhamburo PT. Ethanol-induced alterations in phospholipid methylation in rat brain synaptosomal membranes British Journal of Pharmacology. 74: 874P-875P. |
0.309 |
|
| 1980 |
Littleton JM, Grieve SJ, Griffiths PJ, John GR. Ethanol-induced alteration in membrane phospholipid composition : possible relationship to development of cellular tolerance to ethanol. Advances in Experimental Medicine and Biology. 126: 7-19. PMID 7405706 |
0.332 |
|
| 1979 |
Littleton JM, John GR, Grieve SJ. Alterations in phospholipid composition in ethanol tolerance and dependence. Alcoholism, Clinical and Experimental Research. 3: 50-6. PMID 371451 DOI: 10.1111/J.1530-0277.1979.Tb04768.X |
0.424 |
|
| 1979 |
Rigby M, Littleton JM. Experimental observations on the relationship between ethanol tolerance and physical dependence British Journal of Addiction. 74: 363-367. PMID 295659 DOI: 10.1111/J.1360-0443.1979.Tb01365.X |
0.42 |
|
| 1979 |
Griffiths PJ, Murad CA, Littleton JM. Ethanol-induced hepatic triglyceride accumulation in mice and genetic differences in the ethanol physical withdrawal syndrome British Journal of Addiction. 74: 37-42. PMID 283826 |
0.31 |
|
| 1979 |
Grieve SJ, Littleton JM, Jones P, John GR. Functional tolerance to ethanol in mice: relationship to lipid metabolism. The Journal of Pharmacy and Pharmacology. 31: 737-42. PMID 41903 DOI: 10.1111/J.2042-7158.1979.Tb13648.X |
0.451 |
|
| 1979 |
Grieve SJ, Littleton JM. The rapid development of functional tolerance to ethanol by mice Journal of Pharmacy and Pharmacology. 31: 605-610. PMID 41062 |
0.32 |
|
| 1979 |
Grieve SJ, Littleton JM. Ambient temperature and the development of functional tolerance to ethanol by mice Journal of Pharmacy and Pharmacology. 31: 707-708. PMID 41048 DOI: 10.1111/J.2042-7158.1979.Tb13636.X |
0.431 |
|
| 1979 |
Grieve SJ, Littleton JM. Age and strain differences in the rate of development of functional tolerance to ethanol by mice Journal of Pharmacy and Pharmacology. 31: 696-700. PMID 41043 |
0.323 |
|
| 1979 |
Littleton JM. Cellular tolerance to ethanol as membrane adaptation: A review British Journal On Alcohol and Alcoholism. 14: 23-36. DOI: 10.1093/Oxfordjournals.Alcalc.A044140 |
0.337 |
|
| 1978 |
Abu-Murad C, Littleton JM. Alteration in serum tyrosine and tryptophan concentrations associated with the induction of physical dependence on ethanol in mice Biochemical Pharmacology. 27: 1697-1698. PMID 567990 DOI: 10.1016/0006-2952(78)90182-X |
0.394 |
|
| 1978 |
Littleton J. Alcohol tolerance and dependence at the cellular level The British Journal of Addiction to Alcohol and Other Drugs. 73: 347-351. PMID 281956 DOI: 10.1111/J.1360-0443.1978.Tb00171.X |
0.303 |
|
| 1977 |
Griffiths PJ, Littleton JM. Concentrations of free amino acids in brains of mice during the induction of physical dependence on ethanol and during the ethanol withdrawal syndrome British Journal of Experimental Pathology. 58: 19-27. PMID 556941 |
0.343 |
|
| 1977 |
Littleton JM, John G. Synaptosomal membrane lipids of mice during continuous exposure to ethanol Journal of Pharmacy and Pharmacology. 29: 579-580. PMID 21273 DOI: 10.1111/J.2042-7158.1977.Tb11407.X |
0.395 |
|
| 1974 |
Griffiths PJ, Littleton JM, Ortiz A. Changes in monoamine concentrations in mouse brain associated with ethanol dependence and withdrawal Brit.J.Pharmacol.. 50: 489-498. PMID 4475606 |
0.359 |
|
| 1974 |
Griffiths PJ, Littleton JM, Ortiz A. Effect of p chlorophenylalanine on brain monoamines and behaviour during ethanol withdrawal in mice Brit.J.Pharmacol.. 51: 307-309. PMID 4281335 |
0.336 |
|
| 1974 |
Ortiz A, Griffiths PJ, Littleton JM. A comparison of the effects of chronic administration of ethanol and acetaldehyde to mice: evidence for a role of acetaldehyde in ethanol dependence Journal of Pharmacy and Pharmacology. 26: 249-260. PMID 4151380 |
0.342 |
|
| 1974 |
Littleton JM, Griffiths PJ, Ortiz A. The induction of ethanol dependence and the ethanol withdrawal syndrome: the effects of pyrazole Journal of Pharmacy and Pharmacology. 26: 81-91. PMID 4150837 |
0.386 |
|
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