Franz Hefti - Publications

Affiliations: 
Rinat, Bishkek, Chuy Province, Kyrgyzstan 

145 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Wang X, Kastanenka KV, Arbel-Ornath M, Commins C, Kuzuya A, Lariviere AJ, Krafft GA, Hefti F, Jerecic J, Bacskai BJ. An acute functional screen identifies an effective antibody targeting amyloid-β oligomers based on calcium imaging. Scientific Reports. 8: 4634. PMID 29545579 DOI: 10.1038/S41598-018-22979-2  0.313
2004 Grimm J, Mueller A, Hefti F, Rosenthal A. Molecular basis for catecholaminergic neuron diversity. Proceedings of the National Academy of Sciences of the United States of America. 101: 13891-6. PMID 15353588 DOI: 10.1073/pnas.0405340101  0.423
2000 Harper SJ, Saporito MS, Hewson L, Young L, Smith D, Rigby M, Jackson P, Curtis N, Swain C, Hefti F, Vaught JL, Sirinathsinghji D. CEP-1347 increases ChAT activity in culture and promotes cholinergic neurone survival following fimbria-fornix lesion. Neuroreport. 11: 2271-6. PMID 10923684 DOI: 10.1097/00001756-200007140-00041  0.425
1999 Harper S, Bilsland J, Young L, Bristow L, Boyce S, Mason G, Rigby M, Hewson L, Smith D, O'Donnell R, O'Connor D, Hill RG, Evans D, Swain C, Williams B, ... Hefti F, et al. Analysis of the neurotrophic effects of GPI-1046 on neuron survival and regeneration in culture and in vivo. Neuroscience. 88: 257-67. PMID 10051205 DOI: 10.1016/S0306-4522(98)00221-8  0.322
1998 Venero JL, Hefti F. Regionally specific induction of BDNF and truncated trkB.T1 receptors in the hippocampal formation after intraseptal injection of kainic acid. Brain Research. 790: 270-7. PMID 9593933 DOI: 10.1016/S0006-8993(98)00071-7  0.346
1997 Hughes PE, Alexi T, Hefti F, Knusel B. Axotomized septal cholinergic neurons rescued by nerve growth factor or neurotrophin-4/5 fail to express the inducible transcription factor c-Jun. Neuroscience. 78: 1037-49. PMID 9174072 DOI: 10.1016/S0306-4522(96)00623-9  0.333
1997 Knusel B, Gao H, Okazaki T, Yoshida T, Mori N, Hefti F, Kaplan DR. Ligand-induced down-regulation of Trk messenger RNA, protein and tyrosine phosphorylation in rat cortical neurons. Neuroscience. 78: 851-62. PMID 9153663 DOI: 10.1016/S0306-4522(96)00616-1  0.421
1997 Alexi T, Venero JL, Hefti F. Protective effects of neurotrophin-4/5 and transforming growth factor-alpha on striatal neuronal phenotypic degeneration after excitotoxic lesioning with quinolinic acid. Neuroscience. 78: 73-86. PMID 9135090 DOI: 10.1016/S0306-4522(97)83046-1  0.439
1996 Beck KD, Irwin I, Valverde J, Brennan TJ, Langston JW, Hefti F. GDNF induces a dystonia-like state in neonatal rats and stimulates dopamine and serotonin synthesis. Neuron. 16: 665-73. PMID 8785063 DOI: 10.1016/S0896-6273(00)80085-9  0.48
1996 Alexi T, Hefti F. Neurotrophin-4/5 selectively protects nigral calbindin-containing neurons in rats with medial forebrain bundle transections. Neuroscience. 72: 911-21. PMID 8735219 DOI: 10.1016/0306-4522(95)00607-9  0.471
1996 Qiao X, Hughes PE, Venero JL, Dugich-Djordjevic MM, Nichols NR, Hefti F, Knusel B. NT-4/5 protects against adrenalectomy-induced apoptosis of rat hippocampal granule cells. Neuroreport. 7: 682-6. PMID 8730856 DOI: 10.1097/00001756-199601310-00071  0.377
1996 Goodman LJ, Valverde J, Lim F, Geschwind MD, Federoff HJ, Geller AI, Hefti F. Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons. Molecular and Cellular Neurosciences. 7: 222-38. PMID 8726105 DOI: 10.1006/Mcne.1996.0017  0.378
1996 Treanor JJ, Goodman L, de Sauvage F, Stone DM, Poulsen KT, Beck CD, Gray C, Armanini MP, Pollock RA, Hefti F, Phillips HS, Goddard A, Moore MW, Buj-Bello A, Davies AM, et al. Characterization of a multicomponent receptor for GDNF. Nature. 382: 80-3. PMID 8657309 DOI: 10.1038/382080A0  0.547
1996 Knusel B, Kaplan DR, Hefti F. Intraparenchymal NGF injections in adult and aged rats induce long-lasting Trk tyrosine phosphorylation. Experimental Neurology. 139: 121-30. PMID 8635559 DOI: 10.1006/exnr.1996.0087  0.386
1996 Venero JL, Hefti F, Knusel B. Trophic effect of exogenous nerve growth factor on rat striatal cholinergic neurons: comparison between intraparenchymal and intraventricular administration. Molecular Pharmacology. 49: 303-10. PMID 8632763  0.32
1996 Qiao X, Hefti F, Knusel B, Noebels JL. Selective failure of brain-derived neurotrophic factor mRNA expression in the cerebellum of stargazer, a mutant mouse with ataxia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 640-8. PMID 8551348 DOI: 10.1523/Jneurosci.16-02-00640.1996  0.335
1995 Dugich-Djordjevic MM, Peterson C, Isono F, Ohsawa F, Widmer HR, Denton TL, Bennett GL, Hefti F. Immunohistochemical visualization of brain-derived neurotrophic factor in the rat brain. The European Journal of Neuroscience. 7: 1831-9. PMID 8528456 DOI: 10.1111/j.1460-9568.1995.tb00703.x  0.367
1995 Beck KD, Valverde J, Alexi T, Poulsen K, Moffat B, Vandlen RA, Rosenthal A, Hefti F. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature. 373: 339-41. PMID 7830767 DOI: 10.1038/373339a0  0.465
1995 Venero JL, Hefti F, Beck KD. Retrograde transport of nerve growth factor from hippocampus and amygdala to trkA messenger RNA expressing neurons in paraventricular and reuniens nuclei of the thalamus. Neuroscience. 64: 855-60. PMID 7753386 DOI: 10.1016/0306-4522(94)00533-B  0.378
1995 Winslow JW, Moran P, Valverde J, Shih A, Yuan JQ, Wong SC, Tsai SP, Goddard A, Henzel WJ, Hefti F. Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation. Neuron. 14: 973-81. PMID 7748564 DOI: 10.1016/0896-6273(95)90335-6  0.322
1995 Beck KD, Powell-Braxton L, Widmer HR, Valverde J, Hefti F. Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons. Neuron. 14: 717-30. PMID 7718235 DOI: 10.1016/0896-6273(95)90216-3  0.357
1995 Dugich-Djordjevic MM, Ohsawa F, Okazaki T, Mori N, Day JR, Beck KD, Hefti F. Differential regulation of catalytic and non-catalytic trkB messenger RNAs in the rat hippocampus following seizures induced by systemic administration of kainate. Neuroscience. 66: 861-77. PMID 7651614 DOI: 10.1016/0306-4522(94)00631-E  0.323
1995 Gao WQ, Dybdal N, Shinsky N, Murnane A, Schmelzer C, Siegel M, Keller G, Hefti F, Phillips HS, Winslow JW. Neurotrophin-3 reverses experimental cisplatin-induced peripheral sensory neuropathy. Annals of Neurology. 38: 30-7. PMID 7611721 DOI: 10.1002/ana.410380108  0.334
1995 Beck KD, Hefti F. Induction of non-catalytic TrkB neurotrophin receptors during lesion-induced synaptic rearrangement in the adult rat hippocampus. Progress in Brain Research. 105: 197-210. PMID 7568878 DOI: 10.1016/S0079-6123(08)63296-3  0.397
1995 Treanor JJ, Schmelzer C, Knusel B, Winslow JW, Shelton DL, Hefti F, Nikolics K, Burton LE. Heterodimeric neurotrophins induce phosphorylation of Trk receptors and promote neuronal differentiation in PC12 cells. The Journal of Biological Chemistry. 270: 23104-10. PMID 7559453 DOI: 10.1074/jbc.270.39.23104  0.581
1994 Lapchak PA, Araujo DM, Hefti F. Effects of chronic nerve growth factor treatment on hippocampal [3H]cytisine/nicotinic binding sites and presynaptic nicotinic receptor function following fimbrial transections. Neuroscience. 60: 293-8. PMID 8072684 DOI: 10.1016/0306-4522(94)90243-7  0.419
1994 Venero JL, Knüsel B, Beck KD, Hefti F. Expression of neurotrophin and trk receptor genes in adult rats with fimbria transections: effect of intraventricular nerve growth factor and brain-derived neurotrophic factor administration. Neuroscience. 59: 797-815. PMID 8058122 DOI: 10.1016/0306-4522(94)90285-2  0.413
1994 Venero JL, Beck KD, Hefti F. 6-Hydroxydopamine lesions reduce BDNF mRNA levels in adult rat brain substantia nigra. Neuroreport. 5: 429-32. PMID 8003668 DOI: 10.1097/00001756-199401120-00014  0.418
1994 Venero JL, Beck KD, Hefti F. Intrastriatal infusion of nerve growth factor after quinolinic acid prevents reduction of cellular expression of choline acetyltransferase messenger RNA and trkA messenger RNA, but not glutamate decarboxylase messenger RNA. Neuroscience. 61: 257-68. PMID 7969907 DOI: 10.1016/0306-4522(94)90229-1  0.399
1994 Widmer HR, Hefti F. Stimulation of GABAergic neuron differentiation by NT-4/5 in cultures of rat cerebral cortex. Brain Research. Developmental Brain Research. 80: 279-84. PMID 7955354 DOI: 10.1016/0165-3806(94)90114-7  0.424
1994 Widmer HR, Hefti F. Neurotrophin-4/5 promotes survival and differentiation of rat striatal neurons developing in culture. The European Journal of Neuroscience. 6: 1669-79. PMID 7874306 DOI: 10.1111/j.1460-9568.1994.tb00559.x  0.441
1994 Beck KD, Hefti F, Widmer HR. Deafferentation removes calretinin immunopositive terminals, but does not induce degeneration of calbindin D-28k and parvalbumin expressing neurons in the hippocampus of adult rats. Journal of Neuroscience Research. 39: 298-304. PMID 7869422 DOI: 10.1002/jnr.490390307  0.381
1994 Hefti F. Neurotrophic factor therapy for nervous system degenerative diseases. Journal of Neurobiology. 25: 1418-35. PMID 7852995 DOI: 10.1002/neu.480251109  0.4
1994 Hefti F. Development of effective therapy for Alzheimer's disease based on neurotrophic factors. Neurobiology of Aging. 15: S193-4. PMID 7700452 DOI: 10.1016/0197-4580(94)90204-6  0.385
1993 Efange SM, Michelson RH, Knusel B, Hefti F, Boudreau RJ, Thomas JR, Tennison JR. Synthesis and biological evaluation of radioiodinated N-2-(4-piperidyl)ethyl benzamides. Nuclear Medicine and Biology. 20: 527-38. PMID 8504292 DOI: 10.1016/0969-8051(93)90083-7  0.309
1993 Hefti F, Lapchak PA. Pharmacology of nerve growth factor in the brain. Advances in Pharmacology (San Diego, Calif.). 24: 239-73. PMID 8504065 DOI: 10.1016/S1054-3589(08)60939-4  0.439
1993 Widmer HR, Alexi T, Valverde J, Knüsel B, Hefti F. TGF alpha stimulation of phosphatidylinositol hydrolysis in mesencephalic cultures requires neuron-glia interactions. Neuroreport. 4: 407-10. PMID 8499599 DOI: 10.1097/00001756-199304000-00017  0.37
1993 Widmer HR, Knüsel B, Hefti F. BDNF protection of basal forebrain cholinergic neurons after axotomy: complete protection of p75NGFR-positive cells. Neuroreport. 4: 363-6. PMID 8499589 DOI: 10.1097/00001756-199304000-00005  0.45
1993 Lapchak PA, Araujo DM, Hefti F. Systemic interleukin-1 beta decreases brain-derived neurotrophic factor messenger RNA expression in the rat hippocampal formation. Neuroscience. 53: 297-301. PMID 8492907 DOI: 10.1016/0306-4522(93)90196-M  0.427
1993 Widmer HR, Kaplan DR, Rabin SJ, Beck KD, Hefti F, Knüsel B. Rapid phosphorylation of phospholipase C gamma 1 by brain-derived neurotrophic factor and neurotrophin-3 in cultures of embryonic rat cortical neurons. Journal of Neurochemistry. 60: 2111-23. PMID 8492120 DOI: 10.1111/J.1471-4159.1993.Tb03496.X  0.39
1993 Lapchak PA, Araujo DM, Beck KD, Finch CE, Johnson SA, Hefti F. BDNF and trkB mRNA expression in the hippocampal formation of aging rats. Neurobiology of Aging. 14: 121-6. PMID 8487914 DOI: 10.1016/0197-4580(93)90087-R  0.311
1993 Lapchak PA, Araujo DM, Hefti F. BDNF and trkB mRNA expression in the rat hippocampus following entorhinal cortex lesions. Neuroreport. 4: 191-4. PMID 8453058 DOI: 10.1097/00001756-199302000-00019  0.358
1993 Lapchak PA, Araujo DM, Hefti F. Cholinergic regulation of hippocampal brain-derived neurotrophic factor mRNA expression: evidence from lesion and chronic cholinergic drug treatment studies. Neuroscience. 52: 575-85. PMID 8450959 DOI: 10.1016/0306-4522(93)90407-7  0.365
1993 Beck KD, Lamballe F, Klein R, Barbacid M, Schauwecker PE, McNeill TH, Finch CE, Hefti F, Day JR. Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 4001-14. PMID 8396171 DOI: 10.1523/Jneurosci.13-09-04001.1993  0.393
1993 Lapchak PA, Araujo DM, Hefti F. Regulation of hippocampal muscarinic receptor function by chronic nerve growth factor treatment in adult rats with fimbrial transections. Neuroscience. 53: 379-94. PMID 8388084 DOI: 10.1016/0306-4522(93)90202-Q  0.374
1993 Venero JL, Hefti F. TrkA NGF receptor expression by non-cholinergic thalamic neurons. Neuroreport. 4: 959-62. PMID 8369489 DOI: 10.1097/00001756-199307000-00031  0.37
1993 Araujo DM, Lapchak PA, Hefti F. Effects of chronic basic fibroblast growth factor administration to rats with partial fimbrial transections on presynaptic cholinergic parameters and muscarinic receptors in the hippocampus: comparison with nerve growth factor. Journal of Neurochemistry. 61: 899-910. PMID 8360689 DOI: 10.1111/J.1471-4159.1993.Tb03601.X  0.406
1993 Widmer HR, Ohsawa F, Knüsel B, Hefti F. Down-regulation of phosphatidylinositol response to BDNF and NT-3 in cultures of cortical neurons. Brain Research. 614: 325-34. PMID 8348325 DOI: 10.1016/0006-8993(93)91051-S  0.414
1993 Lapchak PA, Araujo DM, Carswell S, Hefti F. Distribution of [125I]nerve growth factor in the rat brain following a single intraventricular injection: correlation with the topographical distribution of trkA messenger RNA-expressing cells. Neuroscience. 54: 445-60. PMID 8336831 DOI: 10.1016/0306-4522(93)90265-H  0.356
1993 Hefti F, Knusel B, Lapchak PA. Protective effects of nerve growth factor and brain-derived neurotrophic factor on basal forebrain cholinergic neurons in adult rats with partial fimbrial transections. Progress in Brain Research. 98: 257-63. PMID 8248515 DOI: 10.1016/S0079-6123(08)62407-3  0.443
1993 Lapchak PA, Araujo DM, Pasinetti G, Hefti F. Differential alterations of cortical cholinergic and neurotensin markers following ibotenic acid lesions of the nucleus basalis magnocellularis. Brain Research. 613: 239-46. PMID 8186970 DOI: 10.1016/0006-8993(93)90904-2  0.371
1993 Lapchak PA, Beck KD, Araujo DM, Irwin I, Langston JW, Hefti F. Chronic intranigral administration of brain-derived neurotrophic factor produces striatal dopaminergic hypofunction in unlesioned adult rats and fails to attenuate the decline of striatal dopaminergic function following medial forebrain bundle transection. Neuroscience. 53: 639-50. PMID 8098137 DOI: 10.1016/0306-4522(93)90612-J  0.46
1993 Beck KD, Knüsel B, Hefti F. The nature of the trophic action of brain-derived neurotrophic factor, des(1-3)-insulin-like growth factor-1, and basic fibroblast growth factor on mesencephalic dopaminergic neurons developing in culture. Neuroscience. 52: 855-66. PMID 8095710 DOI: 10.1016/0306-4522(93)90534-M  0.393
1993 Ohsawa F, Widmer HR, Knusel B, Denton TL, Hefti F. Response of embryonic rat hippocampal neurons in culture to neurotrophin-3, brain-derived neurotrophic factor and basic fibroblast growth factor. Neuroscience. 57: 67-77. PMID 8074745 DOI: 10.1016/0306-4522(93)90112-S  0.427
1993 Pallage V, Knusel B, Hefti F, Will B. Functional consequences of a single nerve growth factor administration following septal damage in rats. The European Journal of Neuroscience. 5: 669-79. PMID 7903189 DOI: 10.1111/J.1460-9568.1993.Tb00532.X  0.397
1993 Alexi T, Hefti F. Trophic actions of transforming growth factor alpha on mesencephalic dopaminergic neurons developing in culture. Neuroscience. 55: 903-18. PMID 7901801 DOI: 10.1016/0306-4522(93)90307-2  0.354
1993 Knüsel B, Hefti F. Multiple and interactive responses of central neurons to neurotrophic factors Seminars in Neuroscience. 5: 259-267. DOI: 10.1016/S1044-5765(05)80031-4  0.406
1993 Araujo D, Lapchak P, Hefti F. Chronic NGF treatment alters hippocampal muscarinic receptor function in rats with fimbrial transections Life Sciences. 52: 588. DOI: 10.1016/0024-3205(93)90393-H  0.331
1993 Lapchak P, Araujo D, Hefti F. Muscarinic receptor-mediated control of hippocampal brain-derived neurotrophic factor (BDNF) mRNA expression Life Sciences. 52: 585. DOI: 10.1016/0024-3205(93)90387-I  0.315
1992 Dugich-Djordjevic MM, Tocco G, Lapchak PA, Pasinetti GM, Najm I, Baudry M, Hefti F. Regionally specific and rapid increases in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid. Neuroscience. 47: 303-15. PMID 1641125 DOI: 10.1016/0306-4522(92)90246-X  0.315
1992 Lapchak PA, Hefti F. BDNF and NGF treatment in lesioned rats: effects on cholinergic function and weight gain. Neuroreport. 3: 405-8. PMID 1633277 DOI: 10.1097/00001756-199205000-00007  0.439
1992 Knüsel B, Kaplan DR, Winslow JW, Rosenthal A, Burton LE, Beck KD, Rabin S, Nikolics K, Hefti F. K-252b selectively potentiates cellular actions and trk tyrosine phosphorylation mediated by neurotrophin-3. Journal of Neurochemistry. 59: 715-22. PMID 1629741 DOI: 10.1111/j.1471-4159.1992.tb09427.x  0.375
1992 Dugich-Djordjevic MM, Tocco G, Willoughby DA, Najm I, Pasinetti G, Thompson RF, Baudry M, Lapchak PA, Hefti F. BDNF mRNA expression in the developing rat brain following kainic acid-induced seizure activity. Neuron. 8: 1127-38. PMID 1610567 DOI: 10.1016/0896-6273(92)90133-X  0.318
1992 Lapchak PA, Jenden DJ, Hefti F. Pharmacological stimulation reveals recombinant human nerve growth factor-induced increases of in vivo hippocampal cholinergic function measured in rats with partial fimbrial transections. Neuroscience. 50: 847-56. PMID 1448201 DOI: 10.1016/0306-4522(92)90208-J  0.407
1992 Knüsel B, Beck KD, Winslow JW, Rosenthal A, Burton LE, Widmer HR, Nikolics K, Hefti F. Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 4391-402. PMID 1432101 DOI: 10.1523/Jneurosci.12-11-04391.1992  0.485
1992 Widmer HR, Knüsel B, Hefti F. Stimulation of phosphatidylinositol hydrolysis by brain-derived neurotrophic factor and neurotrophin-3 in rat cerebral cortical neurons developing in culture. Journal of Neurochemistry. 59: 2113-24. PMID 1431896 DOI: 10.1111/J.1471-4159.1992.Tb10102.X  0.424
1992 Knüsel B, Hefti F. K-252 compounds: modulators of neurotrophin signal transduction. Journal of Neurochemistry. 59: 1987-96. PMID 1431889 DOI: 10.1111/J.1471-4159.1992.Tb10085.X  0.309
1992 Knüsel B, Rabin S, Widmer HR, Hefti F, Kaplan DR. Neurotrophin-induced trk receptor phosphorylation and cholinergic neuron response in primary cultures of embryonic rat brain neurons. Neuroreport. 3: 885-8. PMID 1421094 DOI: 10.1097/00001756-199210000-00016  0.445
1992 Lorenzi MV, Knusel B, Hefti F, Strauss WL. Nerve growth factor regulation of choline acetyltransferase gene expression in rat embryo basal forebrain cultures. Neuroscience Letters. 140: 185-8. PMID 1380145 DOI: 10.1016/0304-3940(92)90098-R  0.404
1991 Koliatsos VE, Applegate MD, Knüsel B, Junard EO, Burton LE, Mobley WC, Hefti FF, Price DL. Recombinant human nerve growth factor prevents retrograde degeneration of axotomized basal forebrain cholinergic neurons in the rat. Experimental Neurology. 112: 161-73. PMID 2037030 DOI: 10.1016/0014-4886(91)90066-L  0.388
1991 Knüsel B, Winslow JW, Rosenthal A, Burton LE, Seid DP, Nikolics K, Hefti F. Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3. Proceedings of the National Academy of Sciences of the United States of America. 88: 961-5. PMID 1992488 DOI: 10.1073/Pnas.88.3.961  0.485
1991 Lapchak PA, Hefti F. Effect of recombinant human nerve growth factor on presynaptic cholinergic function in rat hippocampal slices following partial septohippocampal lesions: measures of [3H]acetylcholine synthesis, [3H]acetylcholine release and choline acetyltransferase activity. Neuroscience. 42: 639-49. PMID 1956513 DOI: 10.1016/0306-4522(91)90033-K  0.391
1991 Hefti F, Schneider LS. Nerve growth factor and Alzheimer's disease. Clinical Neuropharmacology. 14: S62-76. PMID 1913710 DOI: 10.1097/00002826-199114001-00008  0.409
1991 Lapchak PA, Jenden DJ, Hefti F. Compensatory elevation of acetylcholine synthesis in vivo by cholinergic neurons surviving partial lesions of the septohippocampal pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 2821-8. PMID 1880551 DOI: 10.1523/Jneurosci.11-09-02821.1991  0.403
1991 Knüsel B, Hefti F. K-252b is a selective and nontoxic inhibitor of nerve growth factor action on cultured brain neurons. Journal of Neurochemistry. 57: 955-62. PMID 1861160 DOI: 10.1111/J.1471-4159.1991.Tb08243.X  0.366
1991 Koliatsos VE, Clatterbuck RE, Nauta HJ, Knüsel B, Burton LE, Hefti FF, Mobley WC, Price DL. Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates. Annals of Neurology. 30: 831-40. PMID 1789695 DOI: 10.1002/Ana.410300613  0.378
1991 Knusel B, Hefti F. Trophic actions of IGF-I, IGF-II and insulin on cholinergic and dopaminergic brain neurons. Advances in Experimental Medicine and Biology. 293: 351-60. PMID 1767736 DOI: 10.1007/978-1-4684-5949-4_31  0.304
1991 Lapchak PA, Hefti F. Emerging pharmacology of nerve growth factor. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 15: 851-60. PMID 1763196 DOI: 10.1016/0278-5846(91)90013-Q  0.372
1991 Hefti F, Junard EO, Knüsel B, Strauss WL, Strang PF, Przybylski A, Vaughan G, Fox SW. Promotion of neuronal survival in vitro by thermal proteins and poly(dicarboxylic)amino acids. Brain Research. 541: 273-83. PMID 1711399 DOI: 10.1016/0006-8993(91)91028-Y  0.361
1991 Beck KD, Knusel B, Pasinetti G, Michel PP, Zawadzka H, Goldstein M, Hefti F. Tyrosine hydroxylase mRNA expression by dopaminergic neurons in culture: effect of 1-methyl-4-phenylpyridinium treatment. Journal of Neurochemistry. 57: 527-32. PMID 1677030 DOI: 10.1111/J.1471-4159.1991.Tb03782.X  0.433
1991 Schwaber JS, Due BR, Rogers WT, Junard EO, Sharma A, Hefti F. Use of a digital brain atlas to compare the distribution of NGF- and bFGF-protected cholinergic neurons. The Journal of Comparative Neurology. 309: 27-39. PMID 1654343 DOI: 10.1002/cne.903090104  0.446
1990 Knusel B, Michel PP, Schwaber JS, Hefti F. Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 558-70. PMID 2406380 DOI: 10.1523/Jneurosci.10-02-00558.1990  0.373
1990 Michel PP, Dandapani BK, Efange SM, Hefti F. Potential environmental neurotoxins related to 1-methyl-4-phenylpyridinium: selective toxicity of 1-methyl-4-(4'-acetamidophenyl)-pyridinium and 1-methyl-4-cyclohexylpyridinium for dopaminergic neurons in culture. Experimental Neurology. 108: 141-50. PMID 2335192 DOI: 10.1016/0014-4886(90)90021-J  0.37
1990 Knüsel B, Burton LE, Longo FM, Mobley WC, Koliatsos VE, Price DL, Hefti F. Trophic actions of recombinant human nerve growth factor on cultured rat embryonic CNS cells. Experimental Neurology. 110: 274-83. PMID 2249737 DOI: 10.1016/0014-4886(90)90039-U  0.448
1990 Junard EO, Montero CN, Hefti F. Long-term administration of mouse nerve growth factor to adult rats with partial lesions of the cholinergic septohippocampal pathway. Experimental Neurology. 110: 25-38. PMID 2170164 DOI: 10.1016/0014-4886(90)90048-W  0.439
1990 Hefti F, Knusel B, Michel PP. Selective and non-selective trophic actions on central cholinergic and dopaminergic neurons in vitro. Progress in Brain Research. 86: 145-55. PMID 2087555 DOI: 10.1016/S0079-6123(08)63173-8  0.448
1990 Michel PP, Hefti F. Toxicity of 6-hydroxydopamine and dopamine for dopaminergic neurons in culture. Journal of Neuroscience Research. 26: 428-35. PMID 1977925 DOI: 10.1002/jnr.490260405  0.445
1990 Michel PP, Dandapani BK, Knusel B, Sanchez-Ramos J, Hefti F. Toxicity of 1-methyl-4-phenylpyridinium for rat dopaminergic neurons in culture: selectivity and irreversibility. Journal of Neurochemistry. 54: 1102-9. PMID 1968953 DOI: 10.1111/J.1471-4159.1990.Tb01935.X  0.416
1989 Efange SM, Mash D, Hefti F, Kung HF, Billings J. Selective visualization of rodent locus ceruleus by a radiolabeled N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analog. Journal of Neurochemistry. 53: 459-64. PMID 2787390 DOI: 10.1111/J.1471-4159.1989.Tb07356.X  0.366
1989 Hefti F, Hartikka J, Knusel B. Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases. Neurobiology of Aging. 10: 515-33. PMID 2682327 DOI: 10.1016/0197-4580(89)90118-8  0.321
1989 Phelps CH, Gage FH, Growdon JH, Hefti F, Harbaugh R, Johnston MV, Khachaturian ZS, Mobley WC, Price DL, Raskind M. Potential use of nerve growth factor to treat Alzheimer's disease. Neurobiology of Aging. 10: 205-7. PMID 2657468 DOI: 10.1016/0197-4580(89)90032-8  0.501
1989 Montero CN, Hefti F. Intraventricular nerve growth factor administration prevents lesion-induced loss of septal cholinergic neurons in aging rats. Neurobiology of Aging. 10: 739-43. PMID 2628784 DOI: 10.1016/0197-4580(89)90011-0  0.448
1989 Hefti F, Mash DC. Localization of nerve growth factor receptors in the normal human brain and in Alzheimer's disease. Neurobiology of Aging. 10: 75-87. PMID 2547172 DOI: 10.1016/S0197-4580(89)80014-4  0.423
1988 Knusel B, Hefti F. Development of cholinergic pedunculopontine neurons in vitro: comparison with cholinergic septal cells and response to nerve growth factor, ciliary neuronotrophic factor, and retinoic acid. Journal of Neuroscience Research. 21: 365-75. PMID 3216429 DOI: 10.1002/jnr.490210228  0.465
1988 Hartikka J, Hefti F. Comparison of nerve growth factor's effects on development of septum, striatum, and nucleus basalis cholinergic neurons in vitro. Journal of Neuroscience Research. 21: 352-64. PMID 3216428 DOI: 10.1002/jnr.490210227  0.458
1988 Hefti F, Knusel B. Chronic administration of nerve growth factor and other neurotrophic factors to the brain. Neurobiology of Aging. 9: 689-90. PMID 3211267 DOI: 10.1016/S0197-4580(88)80133-7  0.379
1988 Sanchez-Ramos JR, Michel P, Weiner WJ, Hefti F. Selective destruction of cultured dopaminergic neurons from fetal rat mesencephalon by 1-methyl-4-phenylpyridinium: cytochemical and morphological evidence. Journal of Neurochemistry. 50: 1934-44. PMID 2897430 DOI: 10.1111/J.1471-4159.1988.Tb02500.X  0.415
1988 Montero CN, Hefti F. Rescue of lesioned septal cholinergic neurons by nerve growth factor: specificity and requirement for chronic treatment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 8: 2986-99. PMID 2842469 DOI: 10.1523/Jneurosci.08-08-02986.1988  0.457
1988 Hartikka J, Hefti F. Development of septal cholinergic neurons in culture: plating density and glial cells modulate effects of NGF on survival, fiber growth, and expression of transmitter-specific enzymes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 8: 2967-85. PMID 2842468 DOI: 10.1523/Jneurosci.08-08-02967.1988  0.417
1987 Fox SW, Hefti F, Hartikka J, Junard E, Przybylski AT, Vaughan G. Pharmacological activities in thermal proteins: relationships in molecular evolution. International Journal of Quantum Chemistry. Quantum Biology Symposium : Proceedings of the International Symposium On Quantum Biology and Quantum Pharmacology. International Symposium On Quantum Biology and Quantum Pharmacology. 14: 347-9. PMID 11542106 DOI: 10.1002/Qua.560320832  0.35
1987 Vibulsreth S, Hefti F, Ginsberg MD, Dietrich WD, Busto R. Astrocytes protect cultured neurons from degeneration induced by anoxia. Brain Research. 422: 303-11. PMID 3676791 DOI: 10.1016/0006-8993(87)90937-1  0.382
1987 Gähwiler BH, Enz A, Hefti F. Nerve growth factor promotes development of the rat septo-hippocampal cholinergic projection in vitro. Neuroscience Letters. 75: 6-10. PMID 3574769 DOI: 10.1016/0304-3940(87)90066-8  0.367
1987 Hefti F. (1S,2R)-5-methoxy-1-methyl-2-(n-propylamino)tetralin ([+]-AJ-76) elevates transmitter synthesis in dopaminergic neurons surviving a partial nigrostriatal lesion. Neuropharmacology. 26: 1239-41. PMID 2889167 DOI: 10.1016/0028-3908(87)90276-0  0.459
1987 Hefti F, Will B. Nerve growth factor is a neurotrophic factor for forebrain cholinergic neurons; implications for Alzheimer's disease. Journal of Neural Transmission. Supplementum. 24: 309-15. PMID 2824691  0.384
1986 Pallage V, Toniolo G, Will B, Hefti F. Long-term effects of nerve growth factor and neural transplants on behavior of rats with medial septal lesions. Brain Research. 386: 197-208. PMID 3779409 DOI: 10.1016/0006-8993(86)90156-3  0.376
1986 Hefti F, Hartikka J, Bolger MB. Effect of thyroid hormone analogs on the activity of choline acetyltransferase in cultures of dissociated septal cells. Brain Research. 375: 413-6. PMID 3730832 DOI: 10.1016/0006-8993(86)90769-9  0.41
1986 Korsching S, Heumann R, Thoenen H, Hefti F. Cholinergic denervation of the rat hippocampus by fimbrial transection leads to a transient accumulation of nerve growth factor (NGF) without change in mRNANGF content. Neuroscience Letters. 66: 175-80. PMID 3725184 DOI: 10.1016/0304-3940(86)90186-2  0.412
1986 Hefti F, Weiner WJ. Nerve growth factor and Alzheimer's disease. Annals of Neurology. 20: 275-81. PMID 3532929 DOI: 10.1002/Ana.410200302  0.444
1986 Hefti F, Hartikka J, Salvatierra A, Weiner WJ, Mash DC. Localization of nerve growth factor receptors in cholinergic neurons of the human basal forebrain. Neuroscience Letters. 69: 37-41. PMID 3018635 DOI: 10.1016/0304-3940(86)90410-6  0.442
1986 Sanchez-Ramos J, Barrett JN, Goldstein M, Weiner WJ, Hefti F. 1-Methyl-4-phenylpyridinium (MPP+) but not 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) selectively destroys dopaminergic neurons in cultures of dissociated rat mesencephalic neurons. Neuroscience Letters. 72: 215-20. PMID 2880321 DOI: 10.1016/0304-3940(86)90083-2  0.45
1986 Toniolo G, Dunnett S, Hefti F, Will B. Influence of endogenous and exogenous growth factors on choline-acetyltransferase (ChAT) activity in rats with fimbria-fornix lesions and acetylcholine-rich transplants in the hippocampus Behavioural Brain Research. 20: 152. DOI: 10.1016/0166-4328(86)90217-2  0.374
1985 Hefti F, Hartikka J, Schlumpf M. Implantation of PC12 cells into the corpus striatum of rats with lesions of the dopaminergic nigrostriatal neurons. Brain Research. 348: 283-8. PMID 4075086 DOI: 10.1016/0006-8993(85)90446-9  0.45
1985 Toniolo G, Dunnett SB, Hefti F, Will B. Acetylcholine-rich transplants in the hippocampus: influence of intrinsic growth factors and application of nerve growth factor on choline acetyltransferase activity. Brain Research. 345: 141-6. PMID 4063798 DOI: 10.1016/0006-8993(85)90844-3  0.393
1985 Melamed E, Hefti F. Altered pharmacokinetics of L-dopa metabolism. Neurology. 35: 939-41. PMID 4000502 DOI: 10.1212/Wnl.35.6.939-A  0.465
1985 Hefti F, Hartikka J, Eckenstein F, Gnahn H, Heumann R, Schwab M. Nerve growth factor increases choline acetyltransferase but not survival or fiber outgrowth of cultured fetal septal cholinergic neurons. Neuroscience. 14: 55-68. PMID 3974885 DOI: 10.1016/0306-4522(85)90163-0  0.418
1985 Hefti F, Enz A, Melamed E. Partial lesions of the nigrostriatal pathway in the rat. Acceleration of transmitter synthesis and release of surviving dopaminergic neurones by drugs. Neuropharmacology. 24: 19-23. PMID 2858830 DOI: 10.1016/0028-3908(85)90090-5  0.597
1984 Hefti F, Dravid A, Hartikka J. Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions. Brain Research. 293: 305-11. PMID 6697222  0.311
1984 Melamed E, Hefti F, Bitton V, Globus M. Suppression of L-dopa-induced circling in rats with nigral lesions by blockade of central dopa-decarboxylase: implications for mechanism of action of L-dopa in parkinsonism. Neurology. 34: 1566-70. PMID 6504328 DOI: 10.1212/WNL.34.12.1566  0.595
1984 Enz A, Hefti F, Frick W. Acute administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) reduces dopamine and serotonin but accelerates norepinephrine metabolism in the rat brain. Effect of chronic pretreatment with MPTP. European Journal of Pharmacology. 101: 37-44. PMID 6086364  0.347
1983 Gnahn H, Hefti F, Heumann R, Schwab ME, Thoenen H. NGF-mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: evidence for a physiological role of NGF in the brain? Brain Research. 285: 45-52. PMID 6136314 DOI: 10.1016/0165-3806(83)90107-4  0.431
1983 Harper GP, Barde YA, Edgar D, Ganten D, Hefti F, Heumann R, Naujoks KW, Rohrer H, Turner JE, Thoenen H. Biological and immunological properties of the nerve growth factor from bovine seminal plasma: comparison with the properties of mouse nerve growth factor. Neuroscience. 8: 375-87. PMID 6133237 DOI: 10.1016/0306-4522(83)90073-8  0.376
1982 Lichtensteiger W, Hefti F, Felix D, Huwyler T, Melamed E, Schlumpf M. Stimulation of nigrostriatal dopamine neurones by nicotine. Neuropharmacology. 21: 963-8. PMID 7145035 DOI: 10.1016/0028-3908(82)90107-1  0.57
1982 Melamed E, Hefti F, Bird ED. Huntington chorea is not associated with hyperactivity of nigrostriatal dopaminergic neurons: studies in postmortem tissues and in rats with kainic acid lesions. Neurology. 32: 640-4. PMID 6211637 DOI: 10.1212/WNL.32.6.640  0.592
1982 Growdon JH, Melamed E, Logue M, Hefti F, Wurtman RJ. Effects of oral L-tyrosine administration on CSF tyrosine and homovanillic acid levels in patients with Parkinson's disease. Life Sciences. 30: 827-32. PMID 6175872 DOI: 10.1016/0024-3205(82)90596-3  0.686
1982 Hefti F, Gnahn H, Schwab ME, Thoenen H. Induction of tyrosine hydroxylase by nerve growth factor and by elevated K+ concentrations in cultures of dissociated sympathetic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 2: 1554-66. PMID 6128379 DOI: 10.1523/Jneurosci.02-11-01554.1982  0.377
1982 Melamed E, Hefti F, Wurtman RJ. Compensatory mechanisms in the nigrostriatal dopaminergic system in Parkinson's disease: studies in an animal model. Israel Journal of Medical Sciences. 18: 159-63. PMID 6121770  0.589
1982 Hefti F, Melamed E. Chronic dopa feeding of mice Neurology. 32: 685-685. DOI: 10.1212/WNL.32.6.685  0.433
1981 Hefti F, Melamed E. Dopamine release in rat striatum after administration of L-dope as studied with in vivo electrochemistry. Brain Research. 225: 333-46. PMID 7306794 DOI: 10.1016/0006-8993(81)90840-4  0.569
1981 Hefti F, Melamed E, Wurtman RJ. The site of dopamine formation in rat striatum after L-dopa administration. The Journal of Pharmacology and Experimental Therapeutics. 217: 189-97. PMID 7205652  0.58
1981 Melamed E, Hefti F, Pettibone DJ, Liebman J, Wurtman RJ. Aromatic L-amino acid decarboxylase in rat corpus striatum: implications for action of L-dopa in parkinsonism. Neurology. 31: 651-5. PMID 7195482 DOI: 10.1212/WNL.31.6.651  0.759
1981 Hefti F, Melamed E, Bhawan J, Wurtman RJ. Long-term administration of L-DOPA does not damage dopaminergic neurons in the mouse Neurology. 31: 1194-1194. DOI: 10.1212/WNL.31.9.1194  0.657
1981 Hefti F, Melamed E. Reply from Hefti and Melamed Trends in Neurosciences. 4: 150. DOI: 10.1016/0166-2236(81)90050-3  0.404
1980 Morre MC, Hefti F, Wurtman RJ. Regional tyrosine levels in rat brain after tyrosine administration. Journal of Neural Transmission. 49: 45-50. PMID 7441238 DOI: 10.1007/BF01249188  0.495
1980 Melamed E, Hefti F, Wurtman RJ. Decarboxylation of exogenous L-DOPA in rat striatum after lesions of the dopaminergic nigrostriatal neurons: the role of striatal capillaries. Brain Research. 198: 244-8. PMID 7407592 DOI: 10.1016/0006-8993(80)90363-7  0.68
1980 Melamed E, Hefti F, Wurtman RJ. Diminished decarboxylation of L-DOPA in rat striatum after intrastriatal injections of kainic acid. Neuropharmacology. 19: 409-11. PMID 7383284 DOI: 10.1016/0028-3908(80)90194-X  0.682
1980 Melamed E, Hefti F, Wurtman RJ. L-3,4-Dihydroxyphenylalanine and L-5-hydroxytryptophan decarboxylase activities in rat striatum: effect of selective destruction of dopaminergic or serotoninergic input. Journal of Neurochemistry. 34: 1753-6. PMID 7381499 DOI: 10.1111/j.1471-4159.1980.tb11270.x  0.615
1980 Hefti F, Melamed E, Sahakian BJ, Wurtman RJ. Circling behavior in rats with partial, unilateral nigro-striatal lesions: effect of amphetamine, apomorphine, and DOPA. Pharmacology, Biochemistry, and Behavior. 12: 185-8. PMID 7189592 DOI: 10.1016/0091-3057(80)90353-6  0.703
1980 Hefti F, Melamed E, Wurtman RJ. The decarboxylation of DOPA in the parkinsonian brain: in vivo studies on an animal model. Journal of Neural Transmission. Supplementum. 95-101. PMID 6776238 DOI: 10.1007/978-3-7091-8582-7_10  0.661
1980 Melamed E, Hefti F, Wurtman RJ. Nonaminergic striatal neurons convert exogenous L-dopa to dopamine in parkinsonism. Annals of Neurology. 8: 558-63. PMID 6260009 DOI: 10.1002/ana.410080603  0.683
1980 Melamed E, Hefti F, Wurtman RJ. Tyrosine administration increases striatal dopamine release in rats with partial nigrostriatal lesions. Proceedings of the National Academy of Sciences of the United States of America. 77: 4305-9. PMID 6254020 DOI: 10.1073/PNAS.77.7.4305  0.678
1980 Wurtman RJ, Hefti F, Melamed E. Precursor control of neurotransmitter synthesis. Pharmacological Reviews. 32: 315-35. PMID 6115400  0.506
1980 Hefti F, Melamed E, Wurtman RJ. Partial lesions of the dopaminergic nigrostriatal system in rat brain: biochemical characterization. Brain Research. 195: 123-37. PMID 6105003 DOI: 10.1016/0006-8993(80)90871-9  0.703
1980 Melamed E, Hefti F, Liebman J, Schlosberg AJ, Wurtman RJ. Serotonergic neurones are not involved in action of L-dopa in Parkinson's disease. Nature. 283: 772-4. PMID 6101905 DOI: 10.1038/283772A0  0.688
1980 Hefti F, Melamed E. l-DOPA's mechanism of action in Parkinson's disease Trends in Neurosciences. 3: 229-231. DOI: 10.1016/S0166-2236(80)80070-1  0.502
1977 Lichtensteiger W, Felix D, Lienhart R, Hefti F. A quantitative correlation between single unit activity and fluorescence intensity of dopamine neurones in zona compacta of substantia nigra, as demonstrated under the influence of nicotine and physostigmine. Brain Research. 117: 85-103. PMID 990937 DOI: 10.1016/0006-8993(76)90558-8  0.303
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