| Year |
Citation |
Score |
| 2017 |
Devine WG, Díaz González R, Ceballos-Perez G, Rojas-Barros DI, Satoh T, Tear W, Ranade RM, Barros-Álvarez X, Hol WG, Buckner FS, Navarro M, Pollastri MP. From cells, to mice, to target: Characterization of NEU-1053 (SB-443342) and its analogs for treatment of human African trypanosomiasis. Acs Infectious Diseases. PMID 28110521 DOI: 10.1021/Acsinfecdis.6B00202 |
0.746 |
|
| 2016 |
Huang W, Zhang Z, Barros-Álvarez X, Koh CY, Ranade RM, Gillespie JR, Creason SA, Shibata S, Verlinde CL, Hol WG, Buckner FS, Fan E. Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors. European Journal of Medicinal Chemistry. 124: 1081-1092. PMID 27788467 DOI: 10.1016/J.Ejmech.2016.10.024 |
0.781 |
|
| 2016 |
Zhang Z, Koh CY, Ranade RM, Shibata S, Gillespie JR, Hulverson MA, Huang W, Nguyen J, Pendem N, Gelb MH, Verlinde CL, Hol WG, Buckner FS, Fan E. 5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors. Acs Infectious Diseases. 2: 399-404. PMID 27627628 DOI: 10.1021/Acsinfecdis.6B00036 |
0.605 |
|
| 2015 |
Ranade RM, Zhang Z, Gillespie JR, Shibata S, Verlinde CL, Hol WG, Fan E, Buckner FS. Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites. Antimicrobial Agents and Chemotherapy. 59: 7128-31. PMID 26324270 DOI: 10.1128/Aac.01573-15 |
0.571 |
|
| 2015 |
Koh CY, Siddaramaiah LK, Ranade RM, Nguyen J, Jian T, Zhang Z, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG. A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens. Acta Crystallographica. Section D, Biological Crystallography. 71: 1684-98. PMID 26249349 DOI: 10.1107/S1399004715007683 |
0.639 |
|
| 2015 |
Pedró-Rosa L, Buckner FS, Ranade RM, Eberhart C, Madoux F, Gillespie JR, Koh CY, Brown S, Lohse J, Verlinde CL, Fan E, Bannister T, Scampavia L, Hol WG, Spicer T, et al. Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening. Journal of Biomolecular Screening. 20: 122-30. PMID 25163684 DOI: 10.1177/1087057114548832 |
0.571 |
|
| 2014 |
Koh CY, Kim JE, Wetzel AB, de van der Schueren WJ, Shibata S, Ranade RM, Liu J, Zhang Z, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG. Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness. Plos Neglected Tropical Diseases. 8: e2775. PMID 24743796 DOI: 10.1371/Journal.Pntd.0002775 |
0.685 |
|
| 2014 |
Zhang Z, Ojo KK, Vidadala R, Huang W, Geiger JA, Scheele S, Choi R, Reid MC, Keyloun KR, Rivas K, Siddaramaiah LK, Comess KM, Robinson KP, Merta PJ, Kifle L, ... Hol WG, et al. Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold. Acs Medicinal Chemistry Letters. 5: 40-44. PMID 24494061 DOI: 10.1021/Ml400315S |
0.565 |
|
| 2014 |
Gadwal S, Korotkov KV, Delarosa JR, Hol WG, Sandkvist M. Functional and structural characterization of Vibrio cholerae extracellular serine protease B, VesB. The Journal of Biological Chemistry. 289: 8288-98. PMID 24459146 DOI: 10.1074/Jbc.M113.525261 |
0.346 |
|
| 2014 |
Koh CY, Nguyen J, Shibata S, Zhang Z, Ranade R, Gillespie JR, Hodder P, Pedro-Rosa L, Bannister T, Buckner F, Verlinde C, Fan E, Hol W. Structure-based drug design against Trypanosoma brucei methionyl-tRNA synthetase Acta Crystallographica Section a Foundations and Advances. 70: C708-C708. DOI: 10.1107/S2053273314092912 |
0.62 |
|
| 2013 |
Khamrui S, Turley S, Pardon E, Steyaert J, Fan E, Verlinde CL, Bergman LW, Hol WG. The structure of the D3 domain of Plasmodium falciparum myosin tail interacting protein MTIP in complex with a nanobody. Molecular and Biochemical Parasitology. 190: 87-91. PMID 23831371 DOI: 10.1016/J.Molbiopara.2013.06.003 |
0.642 |
|
| 2013 |
Koh CY, Kim JE, Napoli AJ, Verlinde CL, Fan E, Buckner FS, Van Voorhis WC, Hol WG. Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design. Molecular and Biochemical Parasitology. 189: 26-32. PMID 23665145 DOI: 10.1016/J.Molbiopara.2013.04.007 |
0.629 |
|
| 2013 |
Ranade RM, Gillespie JR, Shibata S, Verlinde CL, Fan E, Hol WG, Buckner FS. Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target. Antimicrobial Agents and Chemotherapy. 57: 3021-8. PMID 23587950 DOI: 10.1128/Aac.02578-12 |
0.542 |
|
| 2013 |
Legler PM, Zabetakis D, Anderson GP, Lam A, Hol WG, Goldman ER. Structure of a low-melting-temperature anti-cholera toxin: llama V(H)H domain. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 69: 90-3. PMID 23385744 DOI: 10.1107/S1744309112050750 |
0.672 |
|
| 2012 |
Larson ET, Kim JE, Napuli AJ, Verlinde CL, Fan E, Zucker FH, Van Voorhis WC, Buckner FS, Hol WG, Merritt EA. Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia. Acta Crystallographica. Section D, Biological Crystallography. 68: 1194-200. PMID 22948920 DOI: 10.1107/S0907444912024699 |
0.647 |
|
| 2012 |
Koh CY, Kim JE, Shibata S, Ranade RM, Yu M, Liu J, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG. Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection. Structure (London, England : 1993). 20: 1681-91. PMID 22902861 DOI: 10.1016/J.Str.2012.07.011 |
0.66 |
|
| 2012 |
Shibata S, Gillespie JR, Ranade RM, Koh CY, Kim JE, Laydbak JU, Zucker FH, Hol WG, Verlinde CL, Buckner FS, Fan E. Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization. Journal of Medicinal Chemistry. 55: 6342-51. PMID 22720744 DOI: 10.1021/Jm300303E |
0.58 |
|
| 2012 |
Bosch J, Paige MH, Vaidya AB, Bergman LW, Hol WG. Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum. Journal of Structural Biology. 178: 61-73. PMID 22387043 DOI: 10.1016/J.Jsb.2012.02.009 |
0.301 |
|
| 2012 |
Larson ET, Ojo KK, Murphy RC, Johnson SM, Zhang Z, Kim JE, Leibly DJ, Fox AM, Reid MC, Dale EJ, Perera BG, Kim J, Hewitt SN, Hol WG, Verlinde CL, et al. Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. Journal of Medicinal Chemistry. 55: 2803-10. PMID 22369268 DOI: 10.1021/Jm201725V |
0.597 |
|
| 2011 |
Shibata S, Zhang Z, Korotkov KV, Delarosa J, Napuli A, Kelley AM, Mueller N, Ross J, Zucker FH, Buckner FS, Merritt EA, Verlinde CL, Van Voorhis WC, Hol WG, Fan E. Screening a fragment cocktail library using ultrafiltration. Analytical and Bioanalytical Chemistry. 401: 1585-91. PMID 21750879 DOI: 10.1007/S00216-011-5225-7 |
0.595 |
|
| 2011 |
Larson ET, Kim JE, Castaneda LJ, Napuli AJ, Zhang Z, Fan E, Zucker FH, Verlinde CL, Buckner FS, Van Voorhis WC, Hol WG, Merritt EA. The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer. Journal of Molecular Biology. 409: 159-76. PMID 21420975 DOI: 10.1016/J.Jmb.2011.03.026 |
0.654 |
|
| 2011 |
Shibata S, Gillespie JR, Kelley AM, Napuli AJ, Zhang Z, Kovzun KV, Pefley RM, Lam J, Zucker FH, Van Voorhis WC, Merritt EA, Hol WG, Verlinde CL, Fan E, Buckner FS. Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice. Antimicrobial Agents and Chemotherapy. 55: 1982-9. PMID 21282428 DOI: 10.1128/Aac.01796-10 |
0.608 |
|
| 2011 |
Merritt EA, Arakaki TL, Gillespie R, Napuli AJ, Kim JE, Buckner FS, Van Voorhis WC, Verlinde CL, Fan E, Zucker F, Hol WG. Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase. Molecular and Biochemical Parasitology. 177: 20-8. PMID 21255615 DOI: 10.1016/J.Molbiopara.2011.01.003 |
0.64 |
|
| 2011 |
Ojo KK, Arakaki TL, Napuli AJ, Inampudi KK, Keyloun KR, Zhang L, Hol WG, Verlinde CL, Merritt EA, Van Voorhis WC. Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure-activity relationships with Trypanosoma brucei GSK-3. Molecular and Biochemical Parasitology. 176: 98-108. PMID 21195115 DOI: 10.1016/J.Molbiopara.2010.12.009 |
0.625 |
|
| 2011 |
Larson ET, Kim JE, Zucker FH, Kelley A, Mueller N, Napuli AJ, Verlinde CL, Fan E, Buckner FS, Van Voorhis WC, Merritt EA, Hol WG. Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate. Biochimie. 93: 570-82. PMID 21144880 DOI: 10.1016/J.Biochi.2010.11.015 |
0.663 |
|
| 2010 |
Arakaki TL, Carter M, Napuli AJ, Verlinde CL, Fan E, Zucker F, Buckner FS, Van Voorhis WC, Hol WG, Merritt EA. The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs. Journal of Structural Biology. 171: 238-43. PMID 20438846 DOI: 10.1016/J.Jsb.2010.04.010 |
0.649 |
|
| 2010 |
Ojo KK, Larson ET, Keyloun KR, Castaneda LJ, Derocher AE, Inampudi KK, Kim JE, Arakaki TL, Murphy RC, Zhang L, Napuli AJ, Maly DJ, Verlinde CL, Buckner FS, Parsons M, ... Hol WG, et al. Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors. Nature Structural & Molecular Biology. 17: 602-7. PMID 20436472 DOI: 10.1038/Nsmb.1818 |
0.599 |
|
| 2010 |
Zucker FH, Stewart C, dela Rosa J, Kim J, Zhang L, Xiao L, Ross J, Napuli AJ, Mueller N, Castaneda LJ, Nakazawa Hewitt SR, Arakaki TL, Larson ET, Subramanian E, Verlinde CL, ... ... Hol WG, et al. Prediction of protein crystallization outcome using a hybrid method. Journal of Structural Biology. 171: 64-73. PMID 20347992 DOI: 10.1016/J.Jsb.2010.03.016 |
0.6 |
|
| 2010 |
Merritt EA, Arakaki TL, Gillespie JR, Larson ET, Kelley A, Mueller N, Napuli AJ, Kim J, Zhang L, Verlinde CL, Fan E, Zucker F, Buckner FS, van Voorhis WC, Hol WG. Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs. Journal of Molecular Biology. 397: 481-94. PMID 20132829 DOI: 10.1016/J.Jmb.2010.01.051 |
0.671 |
|
| 2010 |
Larson ET, Mudeppa DG, Gillespie JR, Mueller N, Napuli AJ, Arif JA, Ross J, Arakaki TL, Lauricella A, Detitta G, Luft J, Zucker F, Verlinde CL, Fan E, Van Voorhis WC, ... ... Hol WG, et al. The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase. Journal of Molecular Biology. 396: 1244-59. PMID 20070944 DOI: 10.1016/J.Jmb.2010.01.013 |
0.595 |
|
| 2010 |
Merritt EA, Arakaki TL, Larson ET, Kelley A, Mueller N, Napuli AJ, Zhang L, Deditta G, Luft J, Verlinde CL, Fan E, Zucker F, Buckner FS, Van Voorhis WC, Hol WG. Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica. Molecular and Biochemical Parasitology. 169: 95-100. PMID 19874856 DOI: 10.1016/J.Molbiopara.2009.10.005 |
0.646 |
|
| 2009 |
Verlinde CL, Fan E, Shibata S, Zhang Z, Sun Z, Deng W, Ross J, Kim J, Xiao L, Arakaki TL, Bosch J, Caruthers JM, Larson ET, Letrong I, Napuli A, ... ... Hol WG, et al. Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium. Current Topics in Medicinal Chemistry. 9: 1678-87. PMID 19929835 DOI: 10.2174/156802609790102383 |
0.591 |
|
| 2009 |
Crowther GJ, Napuli AJ, Thomas AP, Chung DJ, Kovzun KV, Leibly DJ, Castaneda LJ, Bhandari J, Damman CJ, Hui R, Hol WG, Buckner FS, Verlinde CL, Zhang Z, Fan E, et al. Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands. Journal of Biomolecular Screening. 14: 700-7. PMID 19470714 DOI: 10.1177/1087057109335749 |
0.569 |
|
| 2009 |
Lam AY, Pardon E, Korotkov KV, Hol WG, Steyaert J. Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus. Journal of Structural Biology. 166: 8-15. PMID 19118632 DOI: 10.1016/J.Jsb.2008.11.008 |
0.729 |
|
| 2008 |
Larson ET, Deng W, Krumm BE, Napuli A, Mueller N, Van Voorhis WC, Buckner FS, Fan E, Lauricella A, DeTitta G, Luft J, Zucker F, Hol WG, Verlinde CL, Merritt EA. Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. Journal of Molecular Biology. 381: 975-88. PMID 18602399 DOI: 10.1016/J.Jmb.2008.06.048 |
0.638 |
|
| 2008 |
Sampathkumar P, Roach C, Michels PA, Hol WG. Structural insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5. Journal of Molecular Biology. 381: 867-80. PMID 18598704 DOI: 10.1016/j.jmb.2008.05.089 |
0.361 |
|
| 2008 |
Fan E, Baker D, Fields S, Gelb MH, Buckner FS, Van Voorhis WC, Phizicky E, Dumont M, Mehlin C, Grayhack E, Sullivan M, Verlinde C, Detitta G, Meldrum DR, Merritt EA, ... ... Hol WG, et al. Structural genomics of pathogenic protozoa: an overview. Methods in Molecular Biology (Clifton, N.J.). 426: 497-513. PMID 18542886 DOI: 10.1007/978-1-60327-058-8_33 |
0.614 |
|
| 2008 |
Korotkov KV, Hol WG. Structure of the GspK-GspI-GspJ complex from the enterotoxigenic Escherichia coli type 2 secretion system. Nature Structural & Molecular Biology. 15: 462-8. PMID 18438417 DOI: 10.1038/nsmb.1426 |
0.32 |
|
| 2008 |
Wisedchaisri G, Wu M, Sherman DR, Hol WG. Crystal structures of the response regulator DosR from Mycobacterium tuberculosis suggest a helix rearrangement mechanism for phosphorylation activation. Journal of Molecular Biology. 378: 227-42. PMID 18353359 DOI: 10.1016/J.Jmb.2008.02.029 |
0.76 |
|
| 2008 |
Arakaki TL, Buckner FS, Gillespie JR, Malmquist NA, Phillips MA, Kalyuzhniy O, Luft JR, Detitta GT, Verlinde CL, Van Voorhis WC, Hol WG, Merritt EA. Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies. Molecular Microbiology. 68: 37-50. PMID 18312275 DOI: 10.1111/J.1365-2958.2008.06131.X |
0.61 |
|
| 2008 |
Yanez ME, Korotkov KV, Abendroth J, Hol WG. Structure of the minor pseudopilin EpsH from the Type 2 secretion system of Vibrio cholerae. Journal of Molecular Biology. 377: 91-103. PMID 18241884 DOI: 10.1016/J.Jmb.2007.08.041 |
0.798 |
|
| 2008 |
Yanez ME, Korotkov KV, Abendroth J, Hol WG. The crystal structure of a binary complex of two pseudopilins: EpsI and EpsJ from the type 2 secretion system of Vibrio vulnificus. Journal of Molecular Biology. 375: 471-86. PMID 18022192 DOI: 10.1016/J.Jmb.2007.10.035 |
0.804 |
|
| 2007 |
Arakaki T, Neely H, Boni E, Mueller N, Buckner FS, Van Voorhis WC, Lauricella A, DeTitta G, Luft J, Hol WG, Merritt EA. The structure of Plasmodium vivax phosphatidylethanolamine-binding protein suggests a functional motif containing a left-handed helix. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 63: 178-82. PMID 17329808 DOI: 10.1107/S1744309107007580 |
0.321 |
|
| 2007 |
Wisedchaisri G, Chou CJ, Wu M, Roach C, Rice AE, Holmes RK, Beeson C, Hol WG. Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis. Biochemistry. 46: 436-47. PMID 17209554 DOI: 10.2210/Pdb2Isy/Pdb |
0.753 |
|
| 2007 |
Buscaglia CA, Hol WG, Nussenzweig V, Cardozo T. Modeling the interaction between aldolase and the thrombospondin-related anonymous protein, a key connection of the malaria parasite invasion machinery. Proteins. 66: 528-37. PMID 17154157 DOI: 10.1002/Prot.21266 |
0.335 |
|
| 2006 |
Bosch J, Robien MA, Mehlin C, Boni E, Riechers A, Buckner FS, Van Voorhis WC, Myler PJ, Worthey EA, DeTitta G, Luft JR, Lauricella A, Gulde S, Anderson LA, Kalyuzhniy O, ... ... Hol WG, et al. Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. Journal of Medicinal Chemistry. 49: 5939-46. PMID 17004709 DOI: 10.1021/Jm060429M |
0.642 |
|
| 2006 |
Sampathkumar P, Turley S, Sibley CH, Hol WG. NADP+ expels both the co-factor and a substrate analog from the Mycobacterium tuberculosis ThyX active site: opportunities for anti-bacterial drug design. Journal of Molecular Biology. 360: 1-6. PMID 16730023 DOI: 10.1016/J.Jmb.2006.04.061 |
0.317 |
|
| 2006 |
Holmes MA, Buckner FS, Van Voorhis WC, Verlinde CL, Mehlin C, Boni E, DeTitta G, Luft J, Lauricella A, Anderson L, Kalyuzhniy O, Zucker F, Schoenfeld LW, Earnest TN, Hol WG, et al. Structure of ribose 5-phosphate isomerase from Plasmodium falciparum. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 427-31. PMID 16682767 DOI: 10.1107/S1744309106010876 |
0.581 |
|
| 2006 |
Arakaki T, Le Trong I, Phizicky E, Quartley E, DeTitta G, Luft J, Lauricella A, Anderson L, Kalyuzhniy O, Worthey E, Myler PJ, Kim D, Baker D, Hol WG, Merritt EA. Structure of Lmaj006129AAA, a hypothetical protein from Leishmania major. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 175-9. PMID 16511295 DOI: 10.1107/S1744309106005902 |
0.326 |
|
| 2006 |
Robien MA, Bosch J, Buckner FS, Van Voorhis WC, Worthey EA, Myler P, Mehlin C, Boni EE, Kalyuzhniy O, Anderson L, Lauricella A, Gulde S, Luft JR, DeTitta G, Caruthers JM, ... ... Hol WG, et al. Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site. Proteins. 62: 570-7. PMID 16345073 DOI: 10.1002/Prot.20801 |
0.643 |
|
| 2005 |
Wisedchaisri G, Wu M, Rice AE, Roberts DM, Sherman DR, Hol WG. Structures of Mycobacterium tuberculosis DosR and DosR-DNA complex involved in gene activation during adaptation to hypoxic latency. Journal of Molecular Biology. 354: 630-41. PMID 16246368 DOI: 10.1016/J.Jmb.2005.09.048 |
0.746 |
|
| 2005 |
Caruthers J, Zucker F, Worthey E, Myler PJ, Buckner F, Van Voorhuis W, Mehlin C, Boni E, Feist T, Luft J, Gulde S, Lauricella A, Kaluzhniy O, Anderson L, Le Trong I, ... ... Hol WG, et al. Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily. Protein Science : a Publication of the Protein Society. 14: 2887-94. PMID 16199669 DOI: 10.1110/Ps.051783005 |
0.347 |
|
| 2005 |
Schnick C, Robien MA, Brzozowski AM, Dodson EJ, Murshudov GN, Anderson L, Luft JR, Mehlin C, Hol WG, Brannigan JA, Wilkinson AJ. Structures of Plasmodium falciparum purine nucleoside phosphorylase complexed with sulfate and its natural substrate inosine. Acta Crystallographica. Section D, Biological Crystallography. 61: 1245-54. PMID 16131758 DOI: 10.1107/S0907444905020251 |
0.392 |
|
| 2005 |
O'Neal CJ, Jobling MG, Holmes RK, Hol WG. Structural basis for the activation of cholera toxin by human ARF6-GTP. Science (New York, N.Y.). 309: 1093-6. PMID 16099990 DOI: 10.1126/Science.1113398 |
0.811 |
|
| 2005 |
Liu J, Zhang Z, Tan X, Hol WG, Verlinde CL, Fan E. Protein heterodimerization through ligand-bridged multivalent pre-organization: enhancing ligand binding toward both protein targets. Journal of the American Chemical Society. 127: 2044-5. PMID 15713072 DOI: 10.1021/Ja043817R |
0.6 |
|
| 2005 |
Hol W, Deng J, Abendroth J, Mitchell D, Yanez M, Roach C, Krumm B, Turley S. Molecular machines and tropical pathogens Acta Crystallographica Section a Foundations of Crystallography. 61: c93-c93. DOI: 10.1107/S0108767305096078 |
0.745 |
|
| 2004 |
Moyersoen J, Choe J, Fan E, Hol WG, Michels PA. Biogenesis of peroxisomes and glycosomes: trypanosomatid glycosome assembly is a promising new drug target. Fems Microbiology Reviews. 28: 603-43. PMID 15539076 DOI: 10.1016/J.Femsre.2004.06.004 |
0.534 |
|
| 2004 |
Fan E, O'Neal CJ, Mitchell DD, Robien MA, Zhang Z, Pickens JC, Tan XJ, Korotkov K, Roach C, Krumm B, Verlinde CL, Merritt EA, Hol WG. Structural biology and structure-based inhibitor design of cholera toxin and heat-labile enterotoxin. International Journal of Medical Microbiology : Ijmm. 294: 217-23. PMID 15532979 DOI: 10.1016/J.Ijmm.2004.07.002 |
0.803 |
|
| 2004 |
Zhang Z, Liu J, Verlinde CL, Hol WG, Fan E. Large cyclic peptides as cores of multivalent ligands: application to inhibitors of receptor binding by cholera toxin. The Journal of Organic Chemistry. 69: 7737-40. PMID 15498005 DOI: 10.1021/Jo0489770 |
0.573 |
|
| 2004 |
Chou CJ, Wisedchaisri G, Monfeli RR, Oram DM, Holmes RK, Hol WG, Beeson C. Functional studies of the Mycobacterium tuberculosis iron-dependent regulator. The Journal of Biological Chemistry. 279: 53554-61. PMID 15456786 DOI: 10.1074/Jbc.M407385200 |
0.724 |
|
| 2004 |
Pickens JC, Mitchell DD, Liu J, Tan X, Zhang Z, Verlinde CL, Hol WG, Fan E. Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer. Chemistry & Biology. 11: 1205-15. PMID 15380181 DOI: 10.1016/J.Chembiol.2004.06.008 |
0.785 |
|
| 2004 |
Wisedchaisri G, Holmes RK, Hol WG. Crystal structure of an IdeR-DNA complex reveals a conformational change in activated IdeR for base-specific interactions. Journal of Molecular Biology. 342: 1155-69. PMID 15351642 DOI: 10.1016/J.Jmb.2004.07.083 |
0.763 |
|
| 2004 |
Sastry MS, Quigley PM, Hol WG, Baneyx F. The linker-loop region of Escherichia coli chaperone Hsp31 functions as a gate that modulates high-affinity substrate binding at elevated temperatures. Proceedings of the National Academy of Sciences of the United States of America. 101: 8587-92. PMID 15173574 DOI: 10.1073/Pnas.0403033101 |
0.815 |
|
| 2004 |
Zhang Z, Pickens JC, Hol WG, Fan E. Solution- and solid-phase syntheses of guanidine-bridged, water-soluble linkers for multivalent ligand design. Organic Letters. 6: 1377-80. PMID 15101746 DOI: 10.1021/Ol049835V |
0.692 |
|
| 2004 |
Abendroth J, Rice AE, McLuskey K, Bagdasarian M, Hol WG. The crystal structure of the periplasmic domain of the type II secretion system protein EpsM from Vibrio cholerae: the simplest version of the ferredoxin fold. Journal of Molecular Biology. 338: 585-96. PMID 15081815 DOI: 10.1016/J.Jmb.2004.01.064 |
0.324 |
|
| 2004 |
O'Neal CJ, Amaya EI, Jobling MG, Holmes RK, Hol WG. Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism. Biochemistry. 43: 3772-82. PMID 15049684 DOI: 10.1021/Bi0360152 |
0.798 |
|
| 2004 |
Roberts DM, Liao RP, Wisedchaisri G, Hol WG, Sherman DR. Two sensor kinases contribute to the hypoxic response of Mycobacterium tuberculosis. The Journal of Biological Chemistry. 279: 23082-7. PMID 15033981 DOI: 10.1074/Jbc.M401230200 |
0.695 |
|
| 2004 |
Robien MA, Nguyen KT, Kumar A, Hirsh I, Turley S, Pei D, Hol WG. An improved crystal form of Plasmodium falciparum peptide deformylase. Protein Science : a Publication of the Protein Society. 13: 1155-63. PMID 15010544 DOI: 10.1110/Ps.03456404 |
0.343 |
|
| 2004 |
Mitchell DD, Pickens JC, Korotkov K, Fan E, Hol WG. 3,5-Substituted phenyl galactosides as leads in designing effective cholera toxin antagonists; synthesis and crystallographic studies. Bioorganic & Medicinal Chemistry. 12: 907-20. PMID 14980603 DOI: 10.1016/J.Bmc.2003.12.019 |
0.757 |
|
| 2004 |
Quigley PM, Korotkov K, Baneyx F, Hol WG. A new native EcHsp31 structure suggests a key role of structural flexibility for chaperone function. Protein Science : a Publication of the Protein Society. 13: 269-77. PMID 14691241 DOI: 10.1110/Ps.03399604 |
0.81 |
|
| 2004 |
Deng J, Davies DR, Wisedchaisri G, Wu M, Hol WG, Mehlin C. An improved protocol for rapid freezing of protein samples for long-term storage. Acta Crystallographica. Section D, Biological Crystallography. 60: 203-4. PMID 14684931 DOI: 10.1107/S0907444903024491 |
0.709 |
|
| 2004 |
Interthal H, Quigley PM, Hol WG, Champoux JJ. The role of lysine 532 in the catalytic mechanism of human topoisomerase I. The Journal of Biological Chemistry. 279: 2984-92. PMID 14594810 DOI: 10.1074/Jbc.M309959200 |
0.799 |
|
| 2003 |
Robien MA, Krumm BE, Sandkvist M, Hol WG. Crystal structure of the extracellular protein secretion NTPase EpsE of Vibrio cholerae. Journal of Molecular Biology. 333: 657-74. PMID 14556751 DOI: 10.1016/J.Jmb.2003.07.015 |
0.31 |
|
| 2003 |
Choe J, Moyersoen J, Roach C, Carter TL, Fan E, Michels PA, Hol WG. Analysis of the sequence motifs responsible for the interactions of peroxins 14 and 5, which are involved in glycosome biogenesis in Trypanosoma brucei. Biochemistry. 42: 10915-22. PMID 12974625 DOI: 10.1021/Bi034248N |
0.565 |
|
| 2003 |
Hu X, Nguyen KT, Verlinde CL, Hol WG, Pei D. Structure-based design of a macrocyclic inhibitor for peptide deformylase. Journal of Medicinal Chemistry. 46: 3771-4. PMID 12930137 DOI: 10.1021/Jm034113F |
0.565 |
|
| 2003 |
Choe J, Guerra D, Michels PA, Hol WG. Leishmania mexicana glycerol-3-phosphate dehydrogenase showed conformational changes upon binding a bi-substrate adduct. Journal of Molecular Biology. 329: 335-49. PMID 12758080 DOI: 10.1016/S0022-2836(03)00421-2 |
0.627 |
|
| 2003 |
Moyersoen J, Choe J, Kumar A, Voncken FG, Hol WG, Michels PA. Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins. European Journal of Biochemistry / Febs. 270: 2059-67. PMID 12709066 DOI: 10.1046/J.1432-1033.2003.03582.X |
0.533 |
|
| 2003 |
Quigley PM, Korotkov K, Baneyx F, Hol WG. The 1.6-A crystal structure of the class of chaperones represented by Escherichia coli Hsp31 reveals a putative catalytic triad. Proceedings of the National Academy of Sciences of the United States of America. 100: 3137-42. PMID 12621151 DOI: 10.1073/Pnas.0530312100 |
0.823 |
|
| 2002 |
Choe J, Suresh S, Wisedchaisri G, Kennedy KJ, Gelb MH, Hol WG. Anomalous differences of light elements in determining precise binding modes of ligands to glycerol-3-phosphate dehydrogenase. Chemistry & Biology. 9: 1189-97. PMID 12445769 DOI: 10.1016/S1074-5521(02)00243-0 |
0.813 |
|
| 2002 |
Zhang Z, Merritt EA, Ahn M, Roach C, Hou Z, Verlinde CL, Hol WG, Fan E. Solution and crystallographic studies of branched multivalent ligands that inhibit the receptor-binding of cholera toxin. Journal of the American Chemical Society. 124: 12991-8. PMID 12405825 DOI: 10.1021/Ja027584K |
0.616 |
|
| 2002 |
Martinez SE, Wu AY, Glavas NA, Tang XB, Turley S, Hol WG, Beavo JA. The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding. Proceedings of the National Academy of Sciences of the United States of America. 99: 13260-5. PMID 12271124 DOI: 10.1073/Pnas.192374899 |
0.313 |
|
| 2002 |
Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WG, Fan E. Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin. Journal of the American Chemical Society. 124: 8818-24. PMID 12137534 DOI: 10.1021/Ja0202560 |
0.763 |
|
| 2002 |
Kumar A, Nguyen KT, Srivathsan S, Ornstein B, Turley S, Hirsh I, Pei D, Hol WG. Crystals of peptide deformylase from Plasmodium falciparum reveal critical characteristics of the active site for drug design. Structure (London, England : 1993). 10: 357-67. PMID 12005434 DOI: 10.1016/S0969-2126(02)00719-0 |
0.323 |
|
| 2002 |
Pickens JC, Merritt EA, Ahn M, Verlinde CL, Hol WG, Fan E. Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes. Chemistry & Biology. 9: 215-24. PMID 11880036 DOI: 10.1016/S1074-5521(02)00097-2 |
0.805 |
|
| 2002 |
Davies DR, Interthal H, Champoux JJ, Hol WG. The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1. Structure (London, England : 1993). 10: 237-48. PMID 11839309 DOI: 10.1016/S0969-2126(02)00707-4 |
0.301 |
|
| 2001 |
Verlinde CL, Hannaert V, Blonski C, Willson M, Périé JJ, Fothergill-Gilmore LA, Opperdoes FR, Gelb MH, Hol WG, Michels PA. Glycolysis as a target for the design of new anti-trypanosome drugs. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 4: 50-65. PMID 11512153 DOI: 10.1054/Drup.2000.0177 |
0.609 |
|
| 2001 |
Bressi JC, Verlinde CL, Aronov AM, Shaw ML, Shin SS, Nguyen LN, Suresh S, Buckner FS, Van Voorhis WC, Kuntz ID, Hol WG, Gelb MH. Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design. Journal of Medicinal Chemistry. 44: 2080-93. PMID 11405646 DOI: 10.1021/Jm000472O |
0.593 |
|
| 2001 |
Suresh S, Bressi JC, Kennedy KJ, Verlinde CL, Gelb MH, Hol WG. Conformational changes in Leishmania mexicana glyceraldehyde-3-phosphate dehydrogenase induced by designed inhibitors. Journal of Molecular Biology. 309: 423-35. PMID 11371162 DOI: 10.1006/Jmbi.2001.4588 |
0.68 |
|
| 2001 |
Pohl E, Goranson-Siekierke J, Choi MK, Roosild T, Holmes RK, Hol WG. Structures of three diphtheria toxin repressor (DtxR) variants with decreased repressor activity. Acta Crystallographica. Section D, Biological Crystallography. 57: 619-27. PMID 11320302 DOI: 10.1107/S090744490100230X |
0.332 |
|
| 2001 |
Fan E, Merritt EA, Zhang Z, Pickens JC, Roach C, Ahn M, Hol WG. Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives. Acta Crystallographica. Section D, Biological Crystallography. 57: 201-12. PMID 11173465 DOI: 10.1107/S0907444900016814 |
0.761 |
|
| 2000 |
Fan E, Merritt EA, Verlinde CL, Hol WG. AB(5) toxins: structures and inhibitor design. Current Opinion in Structural Biology. 10: 680-6. PMID 11114505 DOI: 10.1016/S0959-440X(00)00152-4 |
0.656 |
|
| 2000 |
Bressi JC, Choe J, Hough MT, Buckner FS, Van Voorhis WC, Verlinde CL, Hol WG, Gelb MH. Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine. Journal of Medicinal Chemistry. 43: 4135-50. PMID 11063610 DOI: 10.1021/Jm000287A |
0.716 |
|
| 2000 |
Baca AM, Sirawaraporn R, Turley S, Sirawaraporn W, Hol WG. Crystal structure of Mycobacterium tuberculosis 7,8-dihydropteroate synthase in complex with pterin monophosphate: new insight into the enzymatic mechanism and sulfa-drug action. Journal of Molecular Biology. 302: 1193-212. PMID 11007651 DOI: 10.1006/Jmbi.2000.4094 |
0.828 |
|
| 2000 |
Minke WE, Pickens J, Merritt EA, Fan E, Verlinde CL, Hol WG. Structure of m-carboxyphenyl-alpha-D-galactopyranoside complexed to heat-labile enterotoxin at 1.3 A resolution: surprising variations in ligand-binding modes. Acta Crystallographica. Section D, Biological Crystallography. 56: 795-804. PMID 10930826 DOI: 10.1107/S090744490000514X |
0.81 |
|
| 2000 |
Chudzik DM, Michels PA, de Walque S, Hol WG. Structures of type 2 peroxisomal targeting signals in two trypanosomatid aldolases. Journal of Molecular Biology. 300: 697-707. PMID 10891264 DOI: 10.1006/jmbi.2000.3910 |
0.81 |
|
| 2000 |
Redinbo MR, Champoux JJ, Hol WG. Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA. Biochemistry. 39: 6832-40. PMID 10841763 DOI: 10.1021/Bi992690T |
0.577 |
|
| 2000 |
Baca AM, Hol WG. Overcoming codon bias: a method for high-level overexpression of Plasmodium and other AT-rich parasite genes in Escherichia coli. International Journal For Parasitology. 30: 113-8. PMID 10704592 DOI: 10.1016/S0020-7519(00)00019-9 |
0.757 |
|
| 1999 |
Minke WE, Hong F, Verlinde CL, Hol WG, Fan E. Using a galactose library for exploration of a novel hydrophobic pocket in the receptor binding site of the Escherichia coli heat-labile enterotoxin. The Journal of Biological Chemistry. 274: 33469-73. PMID 10559230 DOI: 10.1074/Jbc.274.47.33469 |
0.805 |
|
| 1999 |
Redinbo MR, Stewart L, Champoux JJ, Hol WG. Structural flexibility in human topoisomerase I revealed in multiple non-isomorphous crystal structures. Journal of Molecular Biology. 292: 685-96. PMID 10497031 DOI: 10.1006/Jmbi.1999.3065 |
0.612 |
|
| 1999 |
Diller DJ, Redinbo MR, Pohl E, Hol WG. A database method for automated map interpretation in protein crystallography. Proteins. 36: 526-41. PMID 10450094 DOI: 10.1002/(Sici)1097-0134(19990901)36:4<526::Aid-Prot16>3.0.Co;2-F |
0.566 |
|
| 1999 |
Diller DJ, Pohl E, Redinbo MR, Hovey BT, Hol WG. A rapid method for positioning small flexible molecules, nucleic acids, and large protein fragments in experimental electron density maps. Proteins. 36: 512-25. PMID 10450093 DOI: 10.1002/(Sici)1097-0134(19990901)36:4<512::Aid-Prot15>3.0.Co;2-V |
0.776 |
|
| 1999 |
Minke WE, Diller DJ, Hol WG, Verlinde CL. The role of waters in docking strategies with incremental flexibility for carbohydrate derivatives: heat-labile enterotoxin, a multivalent test case. Journal of Medicinal Chemistry. 42: 1778-88. PMID 10346930 DOI: 10.1021/Jm980472C |
0.806 |
|
| 1999 |
Minke WE, Roach C, Hol WG, Verlinde CL. Structure-based exploration of the ganglioside GM1 binding sites of Escherichia coli heat-labile enterotoxin and cholera toxin for the discovery of receptor antagonists. Biochemistry. 38: 5684-92. PMID 10231518 DOI: 10.1021/Bi982649A |
0.803 |
|
| 1999 |
Aronov AM, Suresh S, Buckner FS, Van Voorhis WC, Verlinde CL, Opperdoes FR, Hol WG, Gelb MH. Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. 96: 4273-8. PMID 10200252 DOI: 10.1073/Pnas.96.8.4273 |
0.618 |
|
| 1999 |
van den Akker F, Hol WG. Difference density quality (DDQ): a method to assess the global and local correctness of macromolecular crystal structures. Acta Crystallographica. Section D, Biological Crystallography. 55: 206-18. PMID 10089411 DOI: 10.1107/S0907444998007161 |
0.646 |
|
| 1999 |
Redinbo MR, Champoux JJ, Hol WG. Structural insights into the function of type IB topoisomerases. Current Opinion in Structural Biology. 9: 29-36. PMID 10047584 DOI: 10.1016/S0959-440X(99)80005-0 |
0.566 |
|
| 1999 |
Hovey BT, Verlinde CL, Merritt EA, Hol WG. Structure-based discovery of a pore-binding ligand: towards assembly inhibitors for cholera and related AB5 toxins. Journal of Molecular Biology. 285: 1169-78. PMID 9887271 DOI: 10.1006/Jmbi.1998.2340 |
0.804 |
|
| 1999 |
Hol WG, Suresh S, Choe J, Chudzik D, Verlinde CL. Structural motifs in drug target proteins of global infectious agents Comparative Biochemistry and Physiology Part a: Molecular & Integrative Physiology. 124: S57. DOI: 10.1016/S1095-6433(99)90227-1 |
0.689 |
|
| 1998 |
Feil IK, Platas AA, van den Akker F, Reddy R, Merritt EA, Storm DR, Hol WG. Stepwise transplantation of an active site loop between heat-labile enterotoxins LT-II and LT-I and characterization of the obtained hybrid toxins. Protein Engineering. 11: 1103-9. PMID 9876933 DOI: 10.1093/protein/11.11.1103 |
0.63 |
|
| 1998 |
Aronov AM, Verlinde CL, Hol WG, Gelb MH. Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design. Journal of Medicinal Chemistry. 41: 4790-9. PMID 9822549 DOI: 10.1021/Jm9802620 |
0.629 |
|
| 1998 |
Bernstein BE, Williams DM, Bressi JC, Kuhn P, Gelb MH, Blackburn GM, Hol WG. A bisubstrate analog induces unexpected conformational changes in phosphoglycerate kinase from Trypanosoma brucei. Journal of Molecular Biology. 279: 1137-48. PMID 9642090 DOI: 10.1006/Jmbi.1998.1835 |
0.617 |
|
| 1998 |
Kim H, Hol WG. Crystal structure of Leishmania mexicana glycosomal glyceraldehyde-3-phosphate dehydrogenase in a new crystal form confirms the putative physiological active site structure. Journal of Molecular Biology. 278: 5-11. PMID 9571030 DOI: 10.1006/jmbi.1998.1661 |
0.317 |
|
| 1998 |
Chandra NR, Muirhead H, Holbrook JJ, Bernstein BE, Hol WG, Sessions RB. A general method of domain closure is applied to phosphoglycerate kinase and the result compared with the crystal structure of a closed conformation of the enzyme. Proteins. 30: 372-80. PMID 9533621 DOI: 10.1002/(Sici)1097-0134(19980301)30:4<372::Aid-Prot4>3.0.Co;2-L |
0.56 |
|
| 1998 |
Bernstein BE, Hol WG. Crystal structures of substrates and products bound to the phosphoglycerate kinase active site reveal the catalytic mechanism. Biochemistry. 37: 4429-36. PMID 9521762 DOI: 10.1021/Bi9724117 |
0.6 |
|
| 1998 |
Kim H, Certa U, Döbeli H, Jakob P, Hol WG. Crystal structure of fructose-1,6-bisphosphate aldolase from the human malaria parasite Plasmodium falciparum. Biochemistry. 37: 4388-96. PMID 9521758 DOI: 10.1021/bi972233h |
0.303 |
|
| 1998 |
Bernstein BE, Michels PA, Kim H, Petra PH, Hol WG. The importance of dynamic light scattering in obtaining multiple crystal forms of Trypanosoma brucei PGK. Protein Science : a Publication of the Protein Society. 7: 504-7. PMID 9521128 DOI: 10.1002/Pro.5560070232 |
0.569 |
|
| 1998 |
Stewart L, Redinbo MR, Qiu X, Hol WG, Champoux JJ. A model for the mechanism of human topoisomerase I. Science (New York, N.Y.). 279: 1534-41. PMID 9488652 DOI: 10.1126/Science.279.5356.1534 |
0.586 |
|
| 1998 |
Redinbo MR, Stewart L, Kuhn P, Champoux JJ, Hol WG. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science (New York, N.Y.). 279: 1504-13. PMID 9488644 DOI: 10.1126/Science.279.5356.1504 |
0.577 |
|
| 1998 |
van den Akker F, Pizza M, Rappuoli R, Hol WG. Crystal structure of a non-toxic mutant of heat-labile enterotoxin, which is a potent mucosal adjuvant. Protein Science : a Publication of the Protein Society. 6: 2650-4. PMID 9416617 DOI: 10.1002/pro.5560061220 |
0.667 |
|
| 1997 |
Bernstein BE, Hol WG. Probing the limits of the molecular replacement method: the case of Trypanosoma brucei phosphoglycerate kinase. Acta Crystallographica. Section D, Biological Crystallography. 53: 756-64. PMID 15299865 DOI: 10.1107/S0907444997010214 |
0.559 |
|
| 1997 |
van den Akker F, Feil IK, Roach C, Platas AA, Merritt EA, Hol WG. Crystal structure of heat-labile enterotoxin from Escherichia coli with increased thermostability introduced by an engineered disulfide bond in the A subunit. Protein Science : a Publication of the Protein Society. 6: 2644-9. PMID 9416616 DOI: 10.1002/pro.5560061219 |
0.642 |
|
| 1997 |
Lapatto R, Krengel U, Schreuder HA, Arkema A, de Boer B, Kalk KH, Hol WG, Grootenhuis PD, Mulders JW, Dijkema R, Theunissen HJ, Dijkstra BW. X-ray structure of antistasin at 1.9 A resolution and its modelled complex with blood coagulation factor Xa. The Embo Journal. 16: 5151-61. PMID 9311976 DOI: 10.1093/Emboj/16.17.5151 |
0.527 |
|
| 1997 |
Bernstein BE, Michels PA, Hol WG. Synergistic effects of substrate-induced conformational changes in phosphoglycerate kinase activation. Nature. 385: 275-8. PMID 9000079 DOI: 10.1038/385275A0 |
0.584 |
|
| 1996 |
Teplyakov A, Gros P, Hol WG. Crystallographic study of eglin-C binding to thermitase. Advances in Experimental Medicine and Biology. 379: 5-9. PMID 8796305 DOI: 10.1007/978-1-4613-0319-0_2 |
0.505 |
|
| 1996 |
Feil IK, Reddy R, de Haan L, Merritt EA, van den Akker F, Storm DR, Hol WG. Protein engineering studies of A-chain loop 47-56 of Escherichia coli heat-labile enterotoxin point to a prominent role of this loop for cytotoxicity. Molecular Microbiology. 20: 823-32. PMID 8793878 DOI: 10.1111/j.1365-2958.1996.tb02520.x |
0.649 |
|
| 1996 |
van den Akker F, Steensma E, Hol WG. Tumor marker disaccharide D-Gal-beta 1, 3-GalNAc complexed to heat-labile enterotoxin from Escherichia coli. Protein Science : a Publication of the Protein Society. 5: 1184-8. PMID 8762150 DOI: 10.1002/pro.5560050621 |
0.609 |
|
| 1995 |
Merritt EA, Sarfaty S, Chang Tt, Palmer LM, Jobling MG, Holmes RK, Hol WG. Surprising leads for a cholera toxin receptor-binding antagonist: crystallographic studies of CTB mutants Structure. 3: 561-570. PMID 8590017 DOI: 10.1016/S0969-2126(01)00190-3 |
0.384 |
|
| 1995 |
Qiu X, Verlinde CL, Zhang S, Schmitt MP, Holmes RK, Hol WG. Three-dimensional structure of the diphtheria toxin repressor in complex with divalent cation co-repressors Structure. 3: 87-100. PMID 7743135 DOI: 10.1016/S0969-2126(01)00137-X |
0.639 |
|
| 1995 |
van den Akker F, Merritt EA, Pizza M, Domenighini M, Rappuoli R, Hol WG. The Arg7Lys mutant of heat-labile enterotoxin exhibits great flexibility of active site loop 47-56 of the A subunit. Biochemistry. 34: 10996-1004. PMID 7669757 DOI: 10.1021/bi00035a005 |
0.671 |
|
| 1995 |
Merritt EA, Hol WG. AB5 toxins. Current Opinion in Structural Biology. 5: 165-71. PMID 7648317 DOI: 10.1016/0959-440x(95)80071-9 |
0.343 |
|
| 1995 |
Kim H, Feil IK, Verlinde CL, Petra PH, Hol WG. Crystal structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Leishmania mexicana: implications for structure-based drug design and a new position for the inorganic phosphate binding site. Biochemistry. 34: 14975-86. PMID 7578111 DOI: 10.1021/Bi00046A004 |
0.65 |
|
| 1995 |
Van Calenbergh S, Verlinde CL, Soenens J, De Bruyn A, Callens M, Blaton NM, Peeters OM, Rozenski J, Hol WG, Herdewijn P. Synthesis and structure-activity relationships of analogs of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a selective inhibitor of trypanosomal glycosomal glyceraldehyde-3-phosphate dehydrogenase. Journal of Medicinal Chemistry. 38: 3838-49. PMID 7562915 DOI: 10.1021/Jm00019A014 |
0.614 |
|
| 1995 |
Shoham M, Scherf T, Anglister J, Levitt M, Merritt EA, Hol WG. Structural diversity in a conserved cholera toxin epitope involved in ganglioside binding. Protein Science : a Publication of the Protein Society. 4: 841-8. PMID 7545048 DOI: 10.1002/Pro.5560040503 |
0.373 |
|
| 1994 |
Merritt EA, Pronk SE, Sixma TK, Kalk KH, van Zanten BA, Hol WG. Structure of partially-activated E. coli heat-labile enterotoxin (LT) at 2.6 A resolution. Febs Letters. 337: 88-92. PMID 8276119 DOI: 10.1016/0014-5793(94)80635-7 |
0.602 |
|
| 1994 |
Merritt EA, Sixma TK, Kalk KH, van Zanten BA, Hol WG. Galactose-binding site in Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT). Molecular Microbiology. 13: 745-53. PMID 7997185 DOI: 10.1111/J.1365-2958.1994.Tb00467.X |
0.644 |
|
| 1994 |
Verlinde CL, Callens M, Van Calenbergh S, Van Aerschot A, Herdewijn P, Hannaert V, Michels PA, Opperdoes FR, Hol WG. Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness. Journal of Medicinal Chemistry. 37: 3605-13. PMID 7932587 DOI: 10.1021/Jm00047A017 |
0.599 |
|
| 1994 |
Verlinde CL, Hol WG. Structure-based drug design: progress, results and challenges. Structure (London, England : 1993). 2: 577-87. PMID 7922037 DOI: 10.1016/S0969-2126(00)00060-5 |
0.573 |
|
| 1994 |
Verlinde CL, Merritt EA, Van den Akker F, Kim H, Feil I, Delboni LF, Mande SC, Sarfaty S, Petra PH, Hol WG. Protein crystallography and infectious diseases. Protein Science : a Publication of the Protein Society. 3: 1670-86. PMID 7849584 DOI: 10.1002/Pro.5560031006 |
0.767 |
|
| 1994 |
Schreuder HA, Mattevi A, Obmolova G, Kalk KH, Hol WG, van der Bolt FJ, van Berkel WJ. Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate,2,4-dihydroxybenzoate, and 2-hydroxy-4-aminobenzoate and of the Tyr222Ala mutant complexed with 2-hydroxy-4-aminobenzoate. Evidence for a proton channel and a new binding mode of the flavin ring. Biochemistry. 33: 10161-70. PMID 7520279 DOI: 10.1021/Bi00199A044 |
0.592 |
|
| 1994 |
Van Calenbergh S, Van Den Eeckhout E, Herdewijn P, De Bruyn A, Verlinde C, Hol W, Callens M, Van Aerschot A, Rozenski J. Synthesis and Conformational Analysis of 2?-Deoxy-2?-(3-methoxybenzamido)adenosine, a rational-designed inhibitor of trypanosomal glyceraldehyde phosphate dehydrogenase (GAPDH) Helvetica Chimica Acta. 77: 631-644. DOI: 10.1002/Hlca.19940770306 |
0.59 |
|
| 1993 |
Hazes B, Magnus KA, Bonaventura C, Bonaventura J, Dauter Z, Kalk KH, Hol WG. Crystal structure of deoxygenated Limulus polyphemus subunit II hemocyanin at 2.18 A resolution: clues for a mechanism for allosteric regulation. Protein Science : a Publication of the Protein Society. 2: 597-619. PMID 8518732 DOI: 10.1002/Pro.5560020411 |
0.313 |
|
| 1993 |
Mattevi A, Obmolova G, Kalk KH, van Berkel WJ, Hol WG. Three-dimensional structure of lipoamide dehydrogenase from Pseudomonas fluorescens at 2.8 A resolution. Analysis of redox and thermostability properties. Journal of Molecular Biology. 230: 1200-15. PMID 8487301 DOI: 10.1006/Jmbi.1993.1236 |
0.603 |
|
| 1993 |
Mattevi A, Obmolova G, Kalk KH, Westphal AH, de Kok A, Hol WG. Refined crystal structure of the catalytic domain of dihydrolipoyl transacetylase (E2p) from Azotobacter vinelandii at 2.6 A resolution. Journal of Molecular Biology. 230: 1183-99. PMID 8487300 DOI: 10.1006/Jmbi.1993.1235 |
0.618 |
|
| 1993 |
Sixma TK, Kalk KH, van Zanten BA, Dauter Z, Kingma J, Witholt B, Hol WG. Refined structure of Escherichia coli heat-labile enterotoxin, a close relative of cholera toxin. Journal of Molecular Biology. 230: 890-918. PMID 8478941 DOI: 10.1006/Jmbi.1993.1209 |
0.609 |
|
| 1993 |
Mattevi A, Obmolova G, Kalk KH, Teplyakov A, Hol WG. Crystallographic analysis of substrate binding and catalysis in dihydrolipoyl transacetylase (E2p). Biochemistry. 32: 3887-901. PMID 8471601 DOI: 10.1021/Bi00066A007 |
0.557 |
|
| 1993 |
Sixma TK, Stein PE, Hol WG, Read RJ. Comparison of the B-pentamers of heat-labile enterotoxin and verotoxin-1: two structures with remarkable similarity and dissimilarity. Biochemistry. 32: 191-8. PMID 8418837 DOI: 10.1021/Bi00052A025 |
0.626 |
|
| 1993 |
Van Calenbergh S, Verlinde C, De Bruyn A, Callens M, Van Den Eeckhout E, Van Aerschot A, Michels P, Opperdoes F, Hol W, Herdewijn P. 2'-Substituted adenosine analogues as trypanosomal glyceraldehyde phosphate dehydrogenase (GAPDH) inhibitors Collection of Czechoslovak Chemical Communications. 58: 52-55. DOI: 10.1135/Cccc1993S052 |
0.558 |
|
| 1992 |
Sixma TK, Pronk SE, Kalk KH, van Zanten BA, Berghuis AM, Hol WG. Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography. Nature. 355: 561-4. PMID 1741035 DOI: 10.1038/355561A0 |
0.606 |
|
| 1992 |
Verlinde CL, Rudenko G, Hol WG. In search of new lead compounds for trypanosomiasis drug design: a protein structure-based linked-fragment approach. Journal of Computer-Aided Molecular Design. 6: 131-47. PMID 1624956 DOI: 10.1007/Bf00129424 |
0.584 |
|
| 1992 |
Sixma TK, Aguirre A, Terwisscha van Scheltinga AC, Wartna ES, Kalk KH, Hol WG. Heat-labile enterotoxin crystal forms with variable A/B5 orientation. Analysis of conformational flexibility. Febs Letters. 305: 81-5. PMID 1618345 DOI: 10.1016/0014-5793(92)80869-I |
0.582 |
|
| 1992 |
Gros P, Teplyakov AV, Hol WG. Effects of eglin-c binding to thermitase: three-dimensional structure comparison of native thermitase and thermitase eglin-c complexes. Proteins. 12: 63-74. PMID 1553381 DOI: 10.1002/Prot.340120108 |
0.557 |
|
| 1992 |
Sixma TK, Terwisscha van Scheltinga AC, Kalk KH, Zhou K, Wartna ES, Hol WG. X-ray studies reveal lanthanide binding sites at the A/B5 interface of E. coli heat labile enterotoxin. Febs Letters. 297: 179-82. PMID 1551426 DOI: 10.1016/0014-5793(92)80355-K |
0.608 |
|
| 1992 |
Mattevi A, Obmolova G, Schulze E, Kalk KH, Westphal AH, de Kok A, Hol WG. Atomic structure of the cubic core of the pyruvate dehydrogenase multienzyme complex. Science (New York, N.Y.). 255: 1544-50. PMID 1549782 DOI: 10.1126/Science.1549782 |
0.572 |
|
| 1992 |
Streatfield SJ, Sandkvist M, Sixma TK, Bagdasarian M, Hol WG, Hirst TR. Intermolecular interactions between the A and B subunits of heat-labile enterotoxin from Escherichia coli promote holotoxin assembly and stability in vivo. Proceedings of the National Academy of Sciences of the United States of America. 89: 12140-4. PMID 1465452 DOI: 10.1073/Pnas.89.24.12140 |
0.562 |
|
| 1992 |
Schreuder HA, van der Laan JM, Swarte MB, Kalk KH, Hol WG, Drenth J. Crystal structure of the reduced form of p-hydroxybenzoate hydroxylase refined at 2.3 A resolution. Proteins. 14: 178-90. PMID 1409567 DOI: 10.1002/Prot.340140205 |
0.53 |
|
| 1992 |
Mattevi A, Obmolova G, Sokatch JR, Betzel C, Hol WG. The refined crystal structure of Pseudomonas putida lipoamide dehydrogenase complexed with NAD+ at 2.45 A resolution. Proteins. 13: 336-51. PMID 1325638 DOI: 10.1002/Prot.340130406 |
0.62 |
|
| 1992 |
Verlinde CL, Witmans CJ, Pijning T, Kalk KH, Hol WG, Callens M, Opperdoes FR. Structure of the complex between trypanosomal triosephosphate isomerase and N-hydroxy-4-phosphono-butanamide: binding at the active site despite an "open" flexible loop conformation. Protein Science : a Publication of the Protein Society. 1: 1578-84. PMID 1304889 DOI: 10.1002/Pro.5560011205 |
0.665 |
|
| 1991 |
Verlinde CL, Noble ME, Kalk KH, Groendijk H, Wierenga RK, Hol WG. Anion binding at the active site of trypanosomal triosephosphate isomerase. Monohydrogen phosphate does not mimic sulphate. European Journal of Biochemistry / Febs. 198: 53-7. PMID 2040290 DOI: 10.1111/J.1432-1033.1991.Tb15985.X |
0.743 |
|
| 1991 |
Sixma TK, Pronk SE, Kalk KH, Wartna ES, van Zanten BA, Witholt B, Hol WG. Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli. Nature. 351: 371-7. PMID 2034287 DOI: 10.1038/351371A0 |
0.587 |
|
| 1991 |
Gros P, Kalk KH, Hol WG. Calcium binding to thermitase. Crystallographic studies of thermitase at 0, 5, and 100 mM calcium. The Journal of Biological Chemistry. 266: 2953-61. PMID 1993669 DOI: 10.2210/Pdb3Tec/Pdb |
0.474 |
|
| 1991 |
Schulze E, Westphal AH, Obmolova G, Mattevi A, Hol WG, de Kok A. The catalytic domain of the dihydrolipoyl transacetylase component of the pyruvate dehydrogenase complex from Azotobacter vinelandii and Escherichia coli. Expression, purification, properties and preliminary X-ray analysis. European Journal of Biochemistry / Febs. 201: 561-8. PMID 1935951 DOI: 10.1111/J.1432-1033.1991.Tb16315.X |
0.53 |
|
| 1991 |
Noble ME, Verlinde CL, Groendijk H, Kalk KH, Wierenga RK, Hol WG. Crystallographic and molecular modeling studies on trypanosomal triosephosphate isomerase: a critical assessment of the predicted and observed structures of the complex with 2-phosphoglycerate. Journal of Medicinal Chemistry. 34: 2709-18. PMID 1895291 DOI: 10.1021/Jm00113A007 |
0.741 |
|
| 1991 |
Mattevi A, Schierbeek AJ, Hol WG. Refined crystal structure of lipoamide dehydrogenase from Azotobacter vinelandii at 2.2 A resolution. A comparison with the structure of glutathione reductase. Journal of Molecular Biology. 220: 975-94. PMID 1880807 DOI: 10.1016/0022-2836(91)90367-F |
0.597 |
|
| 1990 |
Volbeda A, Hol WG. Crystal structure of hexameric haemocyanin from Panulirus interruptus refined at 3.2 A resolution. Journal of Molecular Biology. 209: 249-79. PMID 2585484 DOI: 10.1016/0022-2836(89)90276-3 |
0.315 |
|
| 1990 |
Gros P, van Gunsteren WF, Hol WG. Inclusion of thermal motion in crystallographic structures by restrained molecular dynamics. Science (New York, N.Y.). 249: 1149-52. PMID 2396108 DOI: 10.1126/Science.2396108 |
0.475 |
|
| 1990 |
Schreuder HA, Hol WG, Drenth J. Analysis of the active site of the flavoprotein p-hydroxybenzoate hydroxylase and some ideas with respect to its reaction mechanism. Biochemistry. 29: 3101-8. PMID 2337581 DOI: 10.1021/Bi00464A029 |
0.48 |
|
| 1990 |
Eschrich K, van Berkel WJ, Westphal AH, de Kok A, Mattevi A, Obmolova G, Kalk KH, Hol WG. Engineering of microheterogeneity-resistant p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens. Febs Letters. 277: 197-9. PMID 2269354 DOI: 10.1016/0014-5793(90)80843-8 |
0.512 |
|
| 1990 |
Vellieux FM, Kalk KH, Drenth J, Hol WG. Structure determination of quinoprotein methylamine dehydrogenase from Thiobacillus versutus. Acta Crystallographica. Section B, Structural Science. 46: 806-23. PMID 2085423 DOI: 10.1107/S010876819000636X |
0.486 |
|
| 1989 |
Van der Laan JM, Swarte MB, Groendijk H, Hol WG, Drenth J. The influence of purification and protein heterogeneity on the crystallization of p-hydroxybenzoate hydroxylase. European Journal of Biochemistry / Febs. 179: 715-24. PMID 2920736 DOI: 10.1111/J.1432-1033.1989.Tb14605.X |
0.51 |
|
| 1989 |
van der Laan JM, Schreuder HA, Swarte MB, Wierenga RK, Kalk KH, Hol WG, Drenth J. The coenzyme analogue adenosine 5-diphosphoribose displaces FAD in the active site of p-hydroxybenzoate hydroxylase. An x-ray crystallographic investigation. Biochemistry. 28: 7199-205. PMID 2819062 DOI: 10.1021/Bi00444A011 |
0.689 |
|
| 1989 |
Vellieux FM, Huitema F, Groendijk H, Kalk KH, Jzn JF, Jongejan JA, Duine JA, Petratos K, Drenth J, Hol WG. Structure of quinoprotein methylamine dehydrogenase at 2.25 A resolution. The Embo Journal. 8: 2171-8. PMID 2792083 DOI: 10.1002/J.1460-2075.1989.Tb08339.X |
0.532 |
|
| 1989 |
Schierbeek AJ, Swarte MB, Dijkstra BW, Vriend G, Read RJ, Hol WG, Drenth J, Betzel C. X-ray structure of lipoamide dehydrogenase from Azotobacter vinelandii determined by a combination of molecular and isomorphous replacement techniques. Journal of Molecular Biology. 206: 365-79. PMID 2716052 DOI: 10.1016/0022-2836(89)90486-5 |
0.732 |
|
| 1989 |
Gros P, Betzel C, Dauter Z, Wilson KS, Hol WG. Molecular dynamics refinement of a thermitase-eglin-c complex at 1.98 A resolution and comparison of two crystal forms that differ in calcium content. Journal of Molecular Biology. 210: 347-67. PMID 2689655 DOI: 10.1016/0022-2836(89)90336-7 |
0.528 |
|
| 1989 |
Gros P, Fujinaga M, Dijkstra BW, Kalk KH, Hol WG. Crystallographic refinement by incorporation of molecular dynamics: thermostable serine protease thermitase complexed with eglin c. Acta Crystallographica. Section B, Structural Science. 45: 488-99. PMID 2688688 DOI: 10.1107/S0108768189006038 |
0.61 |
|
| 1989 |
Schreuder HA, Prick PA, Wierenga RK, Vriend G, Wilson KS, Hol WG, Drenth J. Crystal structure of the p-hydroxybenzoate hydroxylase-substrate complex refined at 1.9 A resolution. Analysis of the enzyme-substrate and enzyme-product complexes. Journal of Molecular Biology. 208: 679-96. PMID 2553983 DOI: 10.1016/0022-2836(89)90158-7 |
0.736 |
|
| 1989 |
Van der Klei IJ, Lawson CL, Rozeboom H, Dijkstra BW, Veenhuis M, Harder W, Hol WG. Use of electron microscopy in the examination of lattice defects in crystals of alcohol oxidase. Febs Letters. 244: 213-6. PMID 2494064 DOI: 10.1016/0014-5793(89)81195-0 |
0.681 |
|
| 1989 |
Voorintholt R, Kosters MT, Vegter G, Vriend G, Hol WG. A very fast program for visualizing protein surfaces, channels and cavities. Journal of Molecular Graphics. 7: 243-5. PMID 2486827 DOI: 10.1016/0263-7855(89)80010-4 |
0.42 |
|
| 1988 |
Schreuder HA, van der Laan JM, Hol WG, Drenth J. Crystal structure of p-hydroxybenzoate hydroxylase complexed with its reaction product 3,4-dihydroxybenzoate. Journal of Molecular Biology. 199: 637-48. PMID 3351945 DOI: 10.1016/0022-2836(88)90307-5 |
0.505 |
|
| 1988 |
Schreuder HA, Hol WG, Drenth J. Molecular modeling reveals the possible importance of a carbonyl oxygen binding pocket for the catalytic mechanism of p-hydroxybenzoate hydroxylase. The Journal of Biological Chemistry. 263: 3131-6. PMID 3343242 |
0.507 |
|
| 1987 |
Kelders HA, Kalk KH, Gros P, Hol WG. Automated protein crystallization and a new crystal form of a subtilisin:eglin complex. Protein Engineering. 1: 301-3. PMID 3334088 DOI: 10.1093/Protein/1.4.301 |
0.477 |
|
| 1986 |
Vellieux FM, Frank J, Swarte MB, Groendijk H, Duine JA, Drenth J, Hol WG. Purification, crystallization and preliminary X-ray investigation of quinoprotein methylamine dehydrogenase from Thiobacillus versutus. European Journal of Biochemistry / Febs. 154: 383-6. PMID 3943535 DOI: 10.1111/J.1432-1033.1986.Tb09409.X |
0.487 |
|
| 1985 |
Pronk SE, Hofstra H, Groendijk H, Kingma J, Swarte MB, Dorner F, Drenth J, Hol WG, Witholt B. Heat-labile enterotoxin of Escherichia coli. Characterization of different crystal forms. The Journal of Biological Chemistry. 260: 13580-4. PMID 3902820 |
0.503 |
|
| 1984 |
Hol WG, Lijk LJ, Kalk KH. The high resolution three-dimensional structure of bovine liver rhodanese. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 3: 370-6. PMID 6357922 DOI: 10.1016/S0272-0590(83)80007-4 |
0.341 |
|
| 1983 |
Dijkstra BW, Renetseder R, Kalk KH, Hol WG, Drenth J. Structure of porcine pancreatic phospholipase A2 at 2.6 A resolution and comparison with bovine phospholipase A2. Journal of Molecular Biology. 168: 163-79. PMID 6876174 DOI: 10.1016/S0022-2836(83)80328-3 |
0.649 |
|
| 1981 |
Dijkstra BW, Kalk KH, Hol WG, Drenth J. Structure of bovine pancreatic phospholipase A2 at 1.7A resolution. Journal of Molecular Biology. 147: 97-123. PMID 7265241 DOI: 10.1016/0022-2836(81)90081-4 |
0.662 |
|
| 1979 |
Wierenga RK, de Jong RJ, Kalk KH, Hol WG, Drenth J. Crystal structure of p-hydroxybenzoate hydroxylase. Journal of Molecular Biology. 131: 55-73. PMID 40036 DOI: 10.1016/0022-2836(79)90301-2 |
0.653 |
|
| 1975 |
Drenth J, Hol WG, Wierenga RK. Crystallization and preliminary x-ray investigation of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens. The Journal of Biological Chemistry. 250: 5268-9. PMID 807574 |
0.62 |
|
| 1972 |
Drenth J, Hol WG, Jansonius JN, Koekoek R. Subtilisin Novo. The three-dimensional structure and its comparison with subtilisin BPN'. European Journal of Biochemistry / Febs. 26: 177-81. PMID 5046041 DOI: 10.1111/J.1432-1033.1972.Tb01754.X |
0.493 |
|
| 1972 |
Drenth J, Hol WG, Jansonius JN, Koekoek R. A comparison of the three-dimensional structures of subtilisin BPN' and subtilisin novo. Cold Spring Harbor Symposia On Quantitative Biology. 36: 107-16. PMID 4508127 DOI: 10.1101/Sqb.1972.036.01.016 |
0.493 |
|
| 1968 |
Drenth J, Hol WG, Visser JW, Sluyterman LA. Papain in water-rich and in methanol-rich media; crystallization and conformation. Journal of Molecular Biology. 34: 369-71. PMID 5760462 DOI: 10.1016/0022-2836(68)90262-3 |
0.45 |
|
| 1967 |
Drenth J, Hol WG. A comparison of crystallographic data of the subtilopeptidases B and C. Journal of Molecular Biology. 28: 543-4. PMID 6052650 DOI: 10.1016/S0022-2836(67)80104-9 |
0.4 |
|
| Show low-probability matches. |
