Demetrius Moskophidis - Publications

Affiliations: 
Medical College of Georgia, Augusta, GA, United States 
Area:
Genetics, Cell Biology, Molecular Biology

36/47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Eroglu B, Pang J, Jin X, Xi C, Moskophidis D, Mivechi NF. HSF1-mediated Control of Cellular Energy Metabolism and mTORC1 Activation Drive Acute T Cell Lymphoblastic Leukemia Progression. Molecular Cancer Research : McR. PMID 31744878 DOI: 10.1158/1541-7786.Mcr-19-0217  0.447
2019 Cho W, Jin X, Pang J, Wang Y, Mivechi NF, Moskophidis D. The Molecular Chaperone HSP70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA-Damage and MAPK/ERK Signaling Pathways. Molecular and Cellular Biology. PMID 30745413 DOI: 10.1128/Mcb.00391-18  0.32
2018 Jin X, Qiao A, Moskophidis D, Mivechi NF. Modulation of HSF1 Activity Through Silencing of Ser303/Ser307 Phosphorylation Supports A Metabolic Program Leading to Age-related Obesity and Insulin Resistance. Molecular and Cellular Biology. PMID 29941492 DOI: 10.1128/Mcb.00095-18  0.303
2017 Jin X, Qiao A, Moskophidis D, Mivechi NF. Abrogation of heat shock factor 1 (Hsf1) phosphorylation deregulates its activity and lowers activation threshold, leading to obesity in mice. The Journal of Biological Chemistry. PMID 28724629 DOI: 10.1074/Jbc.M117.789354  0.309
2017 Qiao A, Jin X, Pang J, Moskophidis D, Mivechi NF. The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis. The Journal of Cell Biology. PMID 28183717 DOI: 10.1083/Jcb.201607091  0.321
2009 Jin X, Moskophidis D, Hu Y, Phillips A, Mivechi NF. Heat shock factor 1 deficiency via its downstream target gene alphaB-crystallin (Hspb5) impairs p53 degradation. Journal of Cellular Biochemistry. 107: 504-15. PMID 19343786 DOI: 10.1002/Jcb.22151  0.315
2008 Chen M, Lan S, Ou R, Price GE, Jiang H, de la Torre JC, Moskophidis D. Genomic and biological characterization of aggressive and docile strains of lymphocytic choriomeningitis virus rescued from a plasmid-based reverse-genetics system. The Journal of General Virology. 89: 1421-33. PMID 18474558 DOI: 10.1099/Vir.0.83464-0  0.724
2008 Ou R, Zhang M, Huang L, Flavell RA, Koni PA, Moskophidis D. Regulation of immune response and inflammatory reactions against viral infection by VCAM-1. Journal of Virology. 82: 2952-65. PMID 18216105 DOI: 10.1128/Jvi.02191-07  0.776
2008 Ou R, Zhang M, Huang L, Moskophidis D. Control of virus-specific CD8+ T-cell exhaustion and immune-mediated pathology by E3 ubiquitin ligase Cbl-b during chronic viral infection. Journal of Virology. 82: 3353-68. PMID 18199651 DOI: 10.1128/Jvi.01350-07  0.784
2007 Huang L, Min JN, Masters S, Mivechi NF, Moskophidis D. Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption. Genesis (New York, N.Y. : 2000). 45: 487-501. PMID 17661394 DOI: 10.1002/Dvg.20319  0.329
2005 Price GE, Huang L, Ou R, Zhang M, Moskophidis D. Perforin and Fas cytolytic pathways coordinately shape the selection and diversity of CD8+-T-cell escape variants of influenza virus. Journal of Virology. 79: 8545-59. PMID 15956596 DOI: 10.1128/Jvi.79.13.8545-8559.2005  0.769
2004 Min JN, Zhang Y, Moskophidis D, Mivechi NF. Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation. Genesis (New York, N.Y. : 2000). 40: 205-17. PMID 15593327 DOI: 10.1002/Gene.20087  0.304
2004 Gronski MA, Boulter JM, Moskophidis D, Nguyen LT, Holmberg K, Elford AR, Deenick EK, Kim HO, Penninger JM, Odermatt B, Gallimore A, Gascoigne NR, Ohashi PS. TCR affinity and negative regulation limit autoimmunity. Nature Medicine. 10: 1234-9. PMID 15467726 DOI: 10.1038/Nm1114  0.468
2004 Zhou S, Ou R, Huang L, Price GE, Moskophidis D. Differential tissue-specific regulation of antiviral CD8+ T-cell immune responses during chronic viral infection. Journal of Virology. 78: 3578-600. PMID 15016881 DOI: 10.1128/Jvi.78.7.3578-3600.2004  0.771
2004 Wang G, Ying Z, Jin X, Tu N, Zhang Y, Phillips M, Moskophidis D, Mivechi NF. Essential requirement for both hsf1 and hsf2 transcriptional activity in spermatogenesis and male fertility. Genesis (New York, N.Y. : 2000). 38: 66-80. PMID 14994269 DOI: 10.1002/Gene.20005  0.339
2003 Wang G, Zhang J, Moskophidis D, Mivechi NF. Targeted disruption of the heat shock transcription factor (hsf)-2 gene results in increased embryonic lethality, neuronal defects, and reduced spermatogenesis. Genesis (New York, N.Y. : 2000). 36: 48-61. PMID 12748967 DOI: 10.1002/Gene.10200  0.313
2002 Zhang Y, Huang L, Zhang J, Moskophidis D, Mivechi NF. Targeted disruption of hsf1 leads to lack of thermotolerance and defines tissue-specific regulation for stress-inducible Hsp molecular chaperones. Journal of Cellular Biochemistry. 86: 376-93. PMID 12112007 DOI: 10.1002/Jcb.10232  0.34
2002 Zhou S, Ou R, Huang L, Moskophidis D. Critical role for perforin-, Fas/FasL-, and TNFR1-mediated cytotoxic pathways in down-regulation of antigen-specific T cells during persistent viral infection. Journal of Virology. 76: 829-40. PMID 11752172 DOI: 10.1128/Jvi.76.2.829-840.2002  0.784
2001 Huang L, Mivechi NF, Moskophidis D. Insights into regulation and function of the major stress-induced hsp70 molecular chaperone in vivo: analysis of mice with targeted gene disruption of the hsp70.1 or hsp70.3 gene. Molecular and Cellular Biology. 21: 8575-91. PMID 11713291 DOI: 10.1128/Mcb.21.24.8575-8591.2001  0.302
2001 Ou R, Zhou S, Huang L, Moskophidis D. Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells. Journal of Virology. 75: 8407-23. PMID 11507186 DOI: 10.1128/Jvi.75.18.8407-8423.2001  0.784
2000 Price GE, Ou R, Jiang H, Huang L, Moskophidis D. Viral escape by selection of cytotoxic T cell-resistant variants in influenza A virus pneumonia. The Journal of Experimental Medicine. 191: 1853-67. PMID 10839802 DOI: 10.1084/Jem.191.11.1853  0.771
2000 Price GE, Gaszewska-Mastarlarz A, Moskophidis D. The Role of Alpha/Beta and Gamma Interferons in Development of Immunity to Influenza A Virus in Mice Journal of Virology. 74: 3996-4003. PMID 10756011 DOI: 10.1128/Jvi.74.9.3996-4003.2000  0.591
1998 Moskophidis D, Kioussis D. Contribution of virus-specific CD8+ cytotoxic T cells to virus clearance or pathologic manifestations of influenza virus infection in a T cell receptor transgenic mouse model. The Journal of Experimental Medicine. 188: 223-32. PMID 9670035 DOI: 10.1084/Jem.188.2.223  0.622
1995 Moskophidis D, Zinkernagel RM. Immunobiology of cytotoxic T-cell escape mutants of lymphocytic choriomeningitis virus. Journal of Virology. 69: 2187-93. PMID 7533851 DOI: 10.1128/Jvi.69.4.2187-2193.1995  0.601
1995 Moskophidis D, Battegay M, van den Broek M, Laine E, Hoffmann-Rohrer U, Zinkernagel RM. Role of virus and host variables in virus persistence or immunopathological disease caused by a non-cytolytic virus. The Journal of General Virology. 76: 381-91. PMID 7531218 DOI: 10.1099/0022-1317-76-2-381  0.581
1994 Moskophidis D, Battegay M, Bruendler MA, Laine E, Gresser I, Zinkernagel RM. Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon. Journal of Virology. 68: 1951-5. PMID 8107255 DOI: 10.1128/Jvi.68.3.1951-1955.1994  0.341
1993 Moskophidis D, Lechner F, Pircher H, Zinkernagel RM. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature. 362: 758-61. PMID 8469287 DOI: 10.1038/362758A0  0.663
1993 Moskophidis D, Laine E, Zinkernagel RM. Peripheral clonal deletion of antiviral memory CD8+ T cells. European Journal of Immunology. 23: 3306-11. PMID 8258345 DOI: 10.1002/Eji.1830231237  0.568
1993 Zinkernagel RM, Moskophidis D, Kündig T, Oehen S, Pircher H, Hengartner H. Effector T-cell induction and T-cell memory versus peripheral deletion of T cells. Immunological Reviews. 133: 199-223. PMID 8225368 DOI: 10.1111/J.1600-065X.1993.Tb01517.X  0.423
1992 Althage A, Odermatt B, Moskophidis D, Kündig T, Hoffman-Rohrer U, Hengartner H, Zinkernagel RM. Immunosuppression by lymphocytic choriomeningitis virus infection: competent effector T and B cells but impaired antigen presentation. European Journal of Immunology. 22: 1803-12. PMID 1623925 DOI: 10.1002/Eji.1830220720  0.642
1992 Moskophidis D, Pircher H, Ciernik I, Odermatt B, Hengartner H, Zinkernagel RM. Suppression of virus-specific antibody production by CD8+ class I-restricted antiviral cytotoxic T cells in vivo. Journal of Virology. 66: 3661-8. PMID 1583725 DOI: 10.1128/Jvi.66.6.3661-3668.1992  0.631
1991 Moskophidis D, Frei K, Löhler J, Fontana A, Zinkernagel RM. Production of random classes of immunoglobulins in brain tissue during persistent viral infection paralleled by secretion of interleukin-6 (IL-6) but not IL-4, IL-5, and gamma interferon. Journal of Virology. 65: 1364-9. PMID 1899893 DOI: 10.1128/Jvi.65.3.1364-1369.1991  0.377
1991 Aebischer T, Moskophidis D, Rohrer UH, Zinkernagel RM, Hengartner H. In vitro selection of lymphocytic choriomeningitis virus escape mutants by cytotoxic T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 88: 11047-51. PMID 1722316 DOI: 10.1073/Pnas.88.24.11047  0.571
1991 Pircher H, Rohrer UH, Moskophidis D, Zinkernagel RM, Hengartner H. Lower receptor avidity required for thymic clonal deletion than for effector T-cell function. Nature. 351: 482-5. PMID 1710780 DOI: 10.1038/351482A0  0.545
1990 Pircher H, Moskophidis D, Rohrer U, Bürki K, Hengartner H, Zinkernagel RM. Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo. Nature. 346: 629-33. PMID 1696684 DOI: 10.1038/346629A0  0.598
1989 Moskophidis D, Fang L, Gossmann J, Lehmann-Grube F. Mechanism of recovery from acute virus infection. IX. Clearance of lymphocytic choriomeningitis (LCM) virus from the feet of mice undergoing LCM virus-specific delayed-type hypersensitivity reaction Journal of General Virology. 70: 3305-3316. PMID 2575136 DOI: 10.1099/0022-1317-70-12-3305  0.555
Low-probability matches (unlikely to be authored by this person)
2012 Xi C, Hu Y, Buckhaults P, Moskophidis D, Mivechi NF. Heat shock factor Hsf1 cooperates with ErbB2 (Her2/Neu) protein to promote mammary tumorigenesis and metastasis. The Journal of Biological Chemistry. 287: 35646-57. PMID 22847003 DOI: 10.1074/Jbc.M112.377481  0.29
2011 Jin X, Moskophidis D, Mivechi NF. Heat shock transcription factor 1 is a key determinant of HCC development by regulating hepatic steatosis and metabolic syndrome. Cell Metabolism. 14: 91-103. PMID 21723507 DOI: 10.1016/J.Cmet.2011.03.025  0.282
2001 Koushik SV, Wang J, Rogers R, Moskophidis D, Lambert NA, Creazzo TL, Conway SJ. Targeted inactivation of the sodium-calcium exchanger (Ncx1) results in the lack of a heartbeat and abnormal myofibrillar organization. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 1209-11. PMID 11344090 DOI: 10.1096/Fj.00-0696Fje  0.247
2012 Jin X, Eroglu B, Cho W, Yamaguchi Y, Moskophidis D, Mivechi NF. Inactivation of heat shock factor Hsf4 induces cellular senescence and suppresses tumorigenesis in vivo. Molecular Cancer Research : McR. 10: 523-34. PMID 22355043 DOI: 10.1158/1541-7786.MCR-11-0530  0.23
2023 Jin X, Moskophidis D, Mivechi NF. Targeted Replacement of HSF1 Phosphorylation Sites at S303/S307 with Alanine Residues in Mice Increases Cell Proliferation and Drug Resistance. Methods in Molecular Biology (Clifton, N.J.). 2693: 81-94. PMID 37540428 DOI: 10.1007/978-1-0716-3342-7_7  0.191
2014 Eroglu B, Min JN, Zhang Y, Szurek E, Moskophidis D, Eroglu A, Mivechi NF. An essential role for heat shock transcription factor binding protein 1 (HSBP1) during early embryonic development. Developmental Biology. 386: 448-60. PMID 24380799 DOI: 10.1016/J.Ydbio.2013.12.038  0.19
2014 Eroglu B, Kimbler DE, Pang J, Choi J, Moskophidis D, Yanasak N, Dhandapani KM, Mivechi NF. Therapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injury. Journal of Neurochemistry. 130: 626-41. PMID 24903326 DOI: 10.1111/Jnc.12781  0.172
2011 Jin X, Eroglu B, Moskophidis D, Mivechi NF. Targeted deletion of Hsf1, 2, and 4 genes in mice. Methods in Molecular Biology (Clifton, N.J.). 787: 1-20. PMID 21898223 DOI: 10.1007/978-1-61779-295-3_1  0.166
2010 Eroglu B, Moskophidis D, Mivechi NF. Loss of Hsp110 leads to age-dependent tau hyperphosphorylation and early accumulation of insoluble amyloid beta. Molecular and Cellular Biology. 30: 4626-43. PMID 20679486 DOI: 10.1128/MCB.01493-09  0.165
2022 Eroglu B, Jin X, Deane S, Öztürk B, Ross OA, Moskophidis D, Mivechi NF. Dusp26 phosphatase regulates mitochondrial respiration and oxidative stress and protects neuronal cell death. Cellular and Molecular Life Sciences : Cmls. 79: 198. PMID 35313355 DOI: 10.1007/s00018-022-04162-z  0.14
2018 Jin X, Eroglu B, Moskophidis D, Mivechi NF. Targeted Deletion of Hsf1, 2, and 4 Genes in Mice. Methods in Molecular Biology (Clifton, N.J.). 1709: 1-22. PMID 29177647 DOI: 10.1007/978-1-4939-7477-1_1  0.084
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