Stanley Nattel - Publications

Affiliations: 
McGill University, Montreal, QC, Canada 
Area:
Animal Physiology Biology, Molecular Biology

500 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Mehdizadeh M, Naud P, Abu-Taha IH, Hiram R, Xiong F, Xiao J, Saljic A, Kamler M, Vuong-Robillard N, Thorin E, Ferbeyre G, Tardif JC, Sirois MG, Tanguay JF, Dobrev D, ... Nattel S, et al. The role of cellular senescence in profibrillatory atrial remodeling associated with cardiac pathology. Cardiovascular Research. PMID 38181429 DOI: 10.1093/cvr/cvae003  0.329
2023 Hiram R, Xiong F, Naud P, Xiao J, Sosnowski DK, Le Quilliec E, Saljic A, Abu-Taha IH, Kamler M, LeBlanc CA, Al-U'Datt DGF, Sirois MG, Hebert T, Tanguay JF, Tardif JC, ... ... Nattel S, et al. An inflammation resolution-promoting intervention prevents atrial fibrillation due to left-ventricular dysfunction. Cardiovascular Research. PMID 38091977 DOI: 10.1093/cvr/cvad175  0.323
2023 Marcoux E, Sosnowski D, Ninni S, Mackasey M, Cadrin-Tourigny J, Roberts JD, Olesen MS, Fatkin D, Nattel S. Genetic Atrial Cardiomyopathies: Common Features, Specific Differences, and Broader Relevance to Understanding Atrial Cardiomyopathy. Circulation. Arrhythmia and Electrophysiology. e003750. PMID 38018478 DOI: 10.1161/CIRCEP.123.003750  0.313
2023 Parent S, Vaka R, Risha Y, Ngo C, Kanda P, Nattel S, Khan S, Courtman D, Stewart DJ, Davis DR. Prevention of atrial fibrillation after open chest surgery with extracellular vesicle therapy. Jci Insight. PMID 37384420 DOI: 10.1172/jci.insight.163297  0.306
2023 Li L, Coarfa C, Yuan Y, Abu-Taha I, Wang X, Song J, Koirala A, Grimm SL, Kamler M, Mullany LK, Tallquist M, Nattel S, Dobrev D, Li N. Fibroblast-specific inflammasome activation predisposes to atrial fibrillation. Biorxiv : the Preprint Server For Biology. PMID 37292708 DOI: 10.1101/2023.05.18.541326  0.322
2023 Nattel S. Atrial Fibrosis, Endocardial Damage, and Thrombosis in Atrial Fibrillation: Association With Underlying Conditions or Causal? Jacc. Clinical Electrophysiology. PMID 37115117 DOI: 10.1016/j.jacep.2023.02.012  0.303
2023 Heijman J, Zhou X, Morotti S, Molina CE, Abu-Taha IH, Tekook M, Jespersen T, Zhang Y, Dobrev S, Milting H, Gummert J, Karck M, Kamler M, El-Armouche A, Saljic A, ... ... Nattel S, et al. Enhanced Ca-Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation. Circulation Research. PMID 36927079 DOI: 10.1161/CIRCRESAHA.122.321858  0.337
2022 Piccini JP, Russo AM, Sharma PS, Kron J, Tzou W, Sauer W, Park DS, Birgersdotter-Green U, Frankel DS, Healey JS, Hummel J, Koruth J, Linz D, Mittal S, Nair DG, ... Nattel S, et al. Advances in Cardiac Electrophysiology. Circulation. Arrhythmia and Electrophysiology. e009911. PMID 36441565 DOI: 10.1161/CIRCEP.121.009911  0.343
2022 Dobrev D, Heijman J, Hiram R, Li N, Nattel S. Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology. Nature Reviews. Cardiology. PMID 36109633 DOI: 10.1038/s41569-022-00759-w  0.324
2022 Ajoolabady A, Nattel S, Lip GYH, Ren J. Inflammasome Signaling in Atrial Fibrillation: JACC State-of-the-Art Review. Journal of the American College of Cardiology. 79: 2349-2366. PMID 35680186 DOI: 10.1016/j.jacc.2022.03.379  0.341
2021 Hulsurkar MM, Lahiri SK, Moore O, Moreira LM, Abu-Taha I, Kamler M, Dobrev D, Nattel S, Reilly S, Wehrens XHT. Atrial-Specific LKB1 Knockdown Represents a Novel Mouse Model of Atrial Cardiomyopathy With Spontaneous Atrial Fibrillation. Circulation. 144: 909-912. PMID 34516304 DOI: 10.1161/CIRCULATIONAHA.121.055373  0.357
2021 Künzel SR, Hoffmann M, Weber S, Künzel K, Kämmerer S, Günscht M, Klapproth E, Rausch JSE, Sadek M, Kolanowski T, Meyer-Roxlau S, Piorkowski C, Tugtekin SM, Rose-John S, Yin X, ... ... Nattel S, et al. Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation. Circulation Research. PMID 34433292 DOI: 10.1161/CIRCRESAHA.121.319425  0.382
2021 Vigneault P, Parent S, Kanda P, Michie C, Davis DR, Nattel S. Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection. Nature Communications. 12: 4963. PMID 34400625 DOI: 10.1038/s41467-021-25180-8  0.795
2021 Leblanc FJA, Vahdati Hassani F, Liesinger L, Qi X, Naud P, Birner-Gruenberger R, Lettre G, Nattel S. Transcriptomic Profiling of Canine Atrial Fibrillation Models after One Week of Sustained Arrhythmia. Circulation. Arrhythmia and Electrophysiology. PMID 34270327 DOI: 10.1161/CIRCEP.121.009887  0.309
2021 Cheung CC, Nattel S, Macle L, Andrade JG. Atrial Fibrillation Management in 2021: An Updated Comparison of the Current CCS/CHRS, ESC, and AHA/ACC/HRS Guidelines. The Canadian Journal of Cardiology. PMID 34186113 DOI: 10.1016/j.cjca.2021.06.011  0.306
2021 Liu D, Song AT, Qi X, van Vliet PP, Xiao J, Xiong F, Andelfinger G, Nattel S. Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel. Nature Communications. 12: 2551. PMID 33953173 DOI: 10.1038/s41467-021-22737-5  0.351
2021 Heijman J, Sutanto H, Crijns HJGM, Nattel S, Trayanova NA. Computational models of atrial fibrillation: achievements, challenges and perspectives for improving clinical care. Cardiovascular Research. PMID 33890620 DOI: 10.1093/cvr/cvab138  0.308
2021 Nattel S, Sager P, Huser J, Heijman J, Dobrev D. Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it. Cardiovascular Research. PMID 33769493 DOI: 10.1093/cvr/cvab093  0.334
2021 Aguilar M, Rose RA, Takawale A, Nattel S, Reilly S. New aspects of endocrine control of atrial fibrillation and possibilities for clinical translation. Cardiovascular Research. PMID 33723575 DOI: 10.1093/cvr/cvab080  0.387
2021 Li X, Garcia-Elias A, Benito B, Nattel S. The effects of cardiac stretch on atrial fibroblasts: Analysis of the evidence and potential role in atrial fibrillation. Cardiovascular Research. PMID 33576384 DOI: 10.1093/cvr/cvab035  0.354
2021 Harada M, Nattel S. Implications of Inflammation and Fibrosis in Atrial Fibrillation Pathophysiology. Cardiac Electrophysiology Clinics. 13: 25-35. PMID 33516403 DOI: 10.1016/j.ccep.2020.11.002  0.346
2021 Hulsurkar M, Lahiri S, Moore O, Moreira L, Abu-Taha I, Dobrev D, Reilly S, Nattel S, Wehrens XH. B-PO01-052 ATRIAL-SPECIFIC LKB1 KNOCKDOWN REPRESENTS A NOVEL MOUSE MODEL OF ATRIAL CARDIOMYOPATHY WITH SPONTANEOUS ATRIAL FIBRILLATION Heart Rhythm. 18: S72. DOI: 10.1016/j.hrthm.2021.06.198  0.333
2020 Nattel S, Aguilar M. Do Atrial Fibrillation-Promoting Gene Variants Act by Enhancing Atrial Remodeling? Jacc. Clinical Electrophysiology. 6: 1522-1524. PMID 33213812 DOI: 10.1016/j.jacep.2020.07.008  0.314
2020 Moreira LM, Takawale A, Hulsurkar M, Menassa DA, Antanaviciute A, Lahiri SK, Mehta N, Evans N, Psarros C, Robinson P, Sparrow AJ, Gillis MA, Ashley N, Naud P, Barallobre-Barreiro J, ... ... Nattel S, et al. Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia. Nature. PMID 33149301 DOI: 10.1038/s41586-020-2890-8  0.381
2020 Nattel S, Guichard JB. Reply: Could Different Thresholds for Tachycardic-Induced Atrial Myopathy Reflect Different Rates Between Atrial Fibrillation and Flutter? Journal of the American College of Cardiology. 76: 2179-2180. PMID 33121729 DOI: 10.1016/j.jacc.2020.08.076  0.309
2020 Nattel S, Aguilar M. Electrophysiological Effects of Atrial Epicardial Adipose Tissue: Keep Your Friends Close and Your Enemies Closer. Journal of the American College of Cardiology. 76: 1212-1214. PMID 32883414 DOI: 10.1016/J.Jacc.2020.07.031  0.317
2020 Hiram R, Xiong F, Naud P, Xiao J, Sirois M, Tanguay JF, Tardif JC, Nattel S. The inflammation-resolution promoting molecule resolvin-D1 prevents atrial proarrhythmic remodeling in experimental right heart disease. Cardiovascular Research. PMID 32866246 DOI: 10.1093/Cvr/Cvaa186  0.4
2020 Heijman J, Muna AP, Veleva T, Molina CE, Sutanto H, Tekook MA, Wang Q, Abu-Taha I, Gorka M, Künzel S, El-Armouche A, Reichenspurner H, Kamler M, Nikolaev VO, Ravens U, ... ... Nattel S, et al. Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Post-Operative Atrial Fibrillation. Circulation Research. PMID 32762493 DOI: 10.1161/Circresaha.120.316710  0.394
2020 Nattel S, Heijman J, Zhou L, Dobrev D. Molecular Basis of Atrial Fibrillation Pathophysiology and Therapy: A Translational Perspective. Circulation Research. 127: 51-72. PMID 32717172 DOI: 10.1161/Circresaha.120.316363  0.439
2020 Guichard JB, Naud P, Xiong F, Qi X, L'Heureux N, Hiram R, Tardif JC, Cartier R, Da Costa A, Nattel S. Comparison of Atrial Remodeling Caused by Sustained Atrial Flutter Versus Atrial Fibrillation. Journal of the American College of Cardiology. 76: 374-388. PMID 32703507 DOI: 10.1016/J.Jacc.2020.05.062  0.465
2020 Nattel S, Graham M, Krahn A. A Focus on Covid-19: Fast and Accurate Information to Guide Management for Pandemic-Related Issues in Cardiac Patients. The Canadian Journal of Cardiology. PMID 32343999 DOI: 10.1016/J.Cjca.2020.04.029  0.311
2020 Chakraborty P, Nattel S, Nanthakumar K. Linking Cellular Energy State to Atrial Fibrillation Pathogenesis: Potential Role of Adenosine Monophosphate-Activated Protein Kinase. Heart Rhythm. PMID 32268208 DOI: 10.1016/J.Hrthm.2020.03.025  0.383
2020 Liu T, Xiong F, Qi XY, Xiao J, Villeneuve L, Abu-Taha I, Dobrev D, Huang C, Nattel S. Altered calcium-handling produces reentry-promoting action potential alternans in atrial fibrillation-remodeled hearts. Jci Insight. PMID 32255765 DOI: 10.1172/Jci.Insight.133754  0.413
2020 Andrade JG, Deyell MW, Nattel S, Khairy P, Dubuc M, Champagne J, Leong-Sit P, Jolly U, Badra M, Sapp J, Verma A, Macle L. Prevalence and clinical impact of spontaneous and adenosine-induced pulmonary vein reconduction in the Contact-Force vs. Cryoballoon Atrial Fibrillation Ablation (CIRCA-DOSE) Study. Heart Rhythm. PMID 31978593 DOI: 10.1016/J.Hrthm.2020.01.017  0.393
2020 Guichard JB, Xiong F, Qi XY, L'Heureux N, Hiram R, Xiao J, Naud P, Tardif JC, Costa AD, Nattel S. Role of atrial arrhythmia and ventricular response in atrial fibrillation induced atrial remodeling. Cardiovascular Research. PMID 31977017 DOI: 10.1093/Cvr/Cvaa007  0.481
2020 Nattel S. Physical activity and atrial fibrillation risk: it's complicated; and sex is critical. European Heart Journal. PMID 31951253 DOI: 10.1093/Eurheartj/Ehz906  0.338
2020 Guichard J, Xiong F, Costa AD, Nattel S. Differential contributions of atrial tachycardia and ventricular response to AF-promoting refractoriness and conduction remodeling Archives of Cardiovascular Diseases Supplements. 12: 144. DOI: 10.1016/J.Acvdsp.2019.09.314  0.446
2020 Guichard J, Tajiri K, Xiong F, Costa AD, Nattel S. An N-/L-Type calcium channel blocker, cilnidipine, reduces electrical and structural atrial remodeling associated with atrial fibrillation in a chronic dog model Archives of Cardiovascular Diseases Supplements. 12: 142. DOI: 10.1016/J.Acvdsp.2019.09.309  0.41
2019 Dharmaprani D, Schopp M, Kuklik P, Chapman D, Lahiri A, Dykes L, Xiong F, Aguilar M, Strauss B, Mitchell L, Pope K, Meyer C, Willems S, Akar FG, Nattel S, et al. Renewal Theory as a Universal Quantitative Framework to Characterize Phase Singularity Regeneration in Mammalian Cardiac Fibrillation. Circulation. Arrhythmia and Electrophysiology. 12: e007569. PMID 31813270 DOI: 10.1161/Circep.119.007569  0.364
2019 Aguilar M, Nattel S. Postoperative Atrial Fibrillation After Noncardiac Surgery: Maybe Not So Benign After All. The Canadian Journal of Cardiology. PMID 31582274 DOI: 10.1016/J.Cjca.2019.08.013  0.327
2019 Al-U'datt D, Allen BG, Nattel S. Role of the lysyl oxidase enzyme family in cardiac function and disease. Cardiovascular Research. PMID 31504232 DOI: 10.1093/Cvr/Cvz176  0.377
2019 Hiram R, Naud P, Xiong F, Al-U'datt D, Algalarrondo V, Sirois MG, Tanguay JF, Tardif JC, Nattel S. Right Atrial Mechanisms of Atrial Fibrillation in a Rat Model of Right Heart Disease. Journal of the American College of Cardiology. 74: 1332-1347. PMID 31488271 DOI: 10.1016/J.Jacc.2019.06.066  0.431
2019 Rivard L, Khairy P, Talajic M, Tardif JC, Nattel S, Bherer L, Black S, Healey J, Lanthier S, Andrade J, Massoud F, Nault I, Guertin MC, Dorian P, Kouz S, et al. Blinded Randomized Trial of Anticoagulation to Prevent Ischemic Stroke and Neurocognitive Impairment in Atrial Fibrillation (BRAIN-AF): Methods and Design. The Canadian Journal of Cardiology. 35: 1069-1077. PMID 31376908 DOI: 10.1016/J.Cjca.2019.04.022  0.371
2019 Biliczki P, Boon RA, Girmatsion Z, Bukowska A, Ördög B, Kaess BM, Hohnloser SH, Goette A, Varró A, Moritz A, Nattel S, Ehrlich JR. Age-related regulation and region-specific distribution of ion channel subunits promoting atrial fibrillation in human left and right atria. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. PMID 31131392 DOI: 10.1093/Europace/Euz135  0.404
2019 Tajiri K, Guichard JB, Qi X, Xiong F, Naud P, Tardif JC, Costa AD, Aonuma K, Nattel S. An N-/L-Type Calcium Channel Blocker, Cilnidipine, Suppresses Autonomic, Electrical and Structural Remodeling Associated with Atrial Fibrillation. Cardiovascular Research. PMID 31119260 DOI: 10.1093/Cvr/Cvz136  0.445
2019 Nattel S. Computational models of the atrial fibrillation substrate: can they explain post-ablation recurrences and help to prevent them. Cardiovascular Research. PMID 31086942 DOI: 10.1093/Cvr/Cvz121  0.374
2019 Nattel S, Lip GYH. Guideline Implications of Prothrombotic State Assessment in Low-Risk Atrial Fibrillation Patients: Consistency With CHADS-VASc and Support for CHADS-65. The Canadian Journal of Cardiology. 35: 547-549. PMID 31030855 DOI: 10.1016/J.Cjca.2019.03.001  0.34
2019 Dobrev D, Aguilar M, Heijman J, Guichard JB, Nattel S. Postoperative atrial fibrillation: mechanisms, manifestations and management. Nature Reviews. Cardiology. PMID 30792496 DOI: 10.1038/S41569-019-0166-5  0.451
2018 Aguilar M, Nattel S. Clarity and controversy around rate control in AF, the orphan child in AF therapeutics. International Journal of Cardiology. PMID 30501984 DOI: 10.1016/J.Ijcard.2018.11.024  0.439
2018 Linz D, Elliott AD, Hohl M, Malik V, Schotten U, Dobrev D, Nattel S, Böhm M, Floras J, Lau DH, Sanders P. Role of autonomic nervous system in atrial fibrillation. International Journal of Cardiology. PMID 30497894 DOI: 10.1016/J.Ijcard.2018.11.091  0.456
2018 Nattel S. Natriuretic Protein Receptors and Atrial Selective Fibrosis: Potential Role in Atrial Fibrillation. Cardiovascular Research. PMID 30462167 DOI: 10.1093/Cvr/Cvy287  0.41
2018 Aguilar M, Nattel S. Taking the Pulse of Atrial Fibrillation: A Practical Approach to Rate Control. The Canadian Journal of Cardiology. 34: 1526-1530. PMID 30404755 DOI: 10.1016/J.Cjca.2018.07.015  0.431
2018 Raymond-Paquin A, Nattel S, Wakili R, Tadros R. Mechanisms and Clinical Significance of Arrhythmia-Induced Cardiomyopathy. The Canadian Journal of Cardiology. 34: 1449-1460. PMID 30404750 DOI: 10.1016/J.Cjca.2018.07.475  0.478
2018 Laredo M, Waldmann V, Khairy P, Nattel S. Age as a Critical Determinant of Atrial Fibrillation: A Two-sided Relationship. The Canadian Journal of Cardiology. 34: 1396-1406. PMID 30404745 DOI: 10.1016/J.Cjca.2018.08.007  0.416
2018 Andrade JG, Verma A, Mitchell LB, Parkash R, Leblanc K, Atzema C, Healey JS, Bell A, Cairns J, Connolly S, Cox J, Dorian P, Gladstone D, McMurtry MS, Nair GM, ... ... Nattel S, et al. 2018 Focused Update of the Canadian Cardiovascular Society Guidelines for the Management of Atrial Fibrillation. The Canadian Journal of Cardiology. 34: 1371-1392. PMID 30404743 DOI: 10.1016/J.Cjca.2018.08.026  0.426
2018 Molina CE, Abu-Taha IH, Wang Q, Roselló-Díez E, Kamler M, Nattel S, Ravens U, Wehrens XHT, Hove-Madsen L, Heijman J, Dobrev D. Profibrotic, Electrical, and Calcium-Handling Remodeling of the Atria in Heart Failure Patients With and Without Atrial Fibrillation. Frontiers in Physiology. 9: 1383. PMID 30356673 DOI: 10.3389/Fphys.2018.01383  0.461
2018 Voigt N, Nattel S. Prof Niels Voigt talks to Prof Stanley Nattel about advances in atrial fibrillation research and career insights. Cardiovascular Research. 114: e65. PMID 30052897 DOI: 10.1093/Cvr/Cvy142  0.381
2018 Surinkaew S, Aflaki M, Takawale A, Chen Y, Qi XY, Gillis MA, Shi YF, Tardif JC, Chattipakorn N, Nattel S. Exchange-protein activated by cyclic-AMP (EPAC) regulates atrial fibroblast function and controls cardiac remodeling. Cardiovascular Research. PMID 30016400 DOI: 10.1093/Cvr/Cvy173  0.447
2018 Meijering RAM, Wiersma M, Zhang D, Lanters EAH, Hoogstra-Berends F, Scholma J, Diks S, Qi X, de Groot NMS, Nattel S, Henning RH, Brundel BJJM. The application of kinomic array analysis to screen for altered kinases in atrial fibrillation remodeling. Heart Rhythm. PMID 29902583 DOI: 10.1016/J.Hrthm.2018.06.014  0.397
2018 Yao C, Veleva T, Scott L, Cao S, Li L, Chen G, Jeyabal P, Pan X, Alsina KM, Abu-Taha I, Ghezelbash S, Reynolds CL, Shen YH, LeMaire SA, Schmitz W, ... ... Nattel S, et al. Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation. Circulation. PMID 29802206 DOI: 10.1161/Circulationaha.118.035202  0.417
2018 Nattel S. Catheter ablation of atrial fibrillation and outcomes in heart failure patients: seeking the treasure in the CASTLE. Cardiovascular Research. 114: e50-e52. PMID 29800377 DOI: 10.1093/Cvr/Cvy101  0.397
2018 Nattel S. Aging and Protein Kinase Activation: Is It the Missing Link Between Age and Atrial Fibrillation? Circulation Research. 122: 799-801. PMID 29700079 DOI: 10.1161/Circresaha.118.312786  0.384
2018 Lau DH, Nattel S, Kalman JM, Sanders P. Response by Lau et al to Letters Regarding Article, "Modifiable Risk Factors and Atrial Fibrillation". Circulation. 137: 1534-1535. PMID 29610135 DOI: 10.1161/Circulationaha.117.032205  0.393
2018 Vigneault P, Naud P, Qi X, Xiao J, Villeneuve L, Davis DR, Nattel S. Calcium-dependent potassium channels control proliferation of cardiac progenitor cells and bone marrow-derived mesenchymal stem cells. The Journal of Physiology. PMID 29574723 DOI: 10.1113/Jp275388  0.793
2018 Avula UMR, Hernandez JJ, Yamazaki M, Valdivia CR, Chu A, Rojas-Pena A, Kaur K, Ramos-Mondragón R, Anumonwo JM, Nattel S, Valdivia HH, Kalifa J. Atrial Infarction-Induced Spontaneous Focal Discharges and Atrial Fibrillation in Sheep: Role of Dantrolene-Sensitive Aberrant Ryanodine Receptor Calcium Release. Circulation. Arrhythmia and Electrophysiology. 11: e005659. PMID 29540372 DOI: 10.1161/Circep.117.005659  0.453
2018 Heijman J, Guichard JB, Dobrev D, Nattel S. Translational Challenges in Atrial Fibrillation. Circulation Research. 122: 752-773. PMID 29496798 DOI: 10.1161/Circresaha.117.311081  0.441
2018 Joos JP, Saadatmand AR, Schnabel C, Viktorinová I, Brand T, Kramer M, Nattel S, Dobrev D, Tomancak P, Backs J, Kleinbongard P, Heusch G, Lorenz K, Koch E, Weber S, et al. Ectopic expression of S28A-mutated Histone H3 modulates longevity, stress resistance and cardiac function in Drosophila. Scientific Reports. 8: 2940. PMID 29440697 DOI: 10.1038/S41598-018-21372-3  0.319
2017 Nattel S. Molecular and Cellular Mechanisms of Atrial Fibrosis in Atrial Fibrillation. Jacc. Clinical Electrophysiology. 3: 425-435. PMID 29759598 DOI: 10.1016/J.Jacep.2017.03.002  0.435
2017 Peng W, Li M, Li H, Tang K, Zhuang J, Zhang J, Xiao J, Jiang H, Li D, Yu Y, Sham PC, Nattel S, Xu Y. Dysfunction of Myosin Light-Chain 4 (MYL4) Leads to Heritable Atrial Cardiomyopathy With Electrical, Contractile, and Structural Components: Evidence From Genetically-Engineered Rats. Journal of the American Heart Association. 6. PMID 29080865 DOI: 10.1161/Jaha.117.007030  0.369
2017 Harada M, Melka J, Sobue Y, Nattel S. Metabolic Considerations in Atrial Fibrillation - Mechanistic Insights and Therapeutic Opportunities. Circulation Journal : Official Journal of the Japanese Circulation Society. PMID 29070758 DOI: 10.1253/Circj.Cj-17-1058  0.401
2017 Wiersma M, Meijering RAM, Qi XY, Zhang D, Liu T, Hoogstra-Berends F, Sibon OCM, Henning RH, Nattel S, Brundel BJJM. Endoplasmic Reticulum Stress Is Associated With Autophagy and Cardiomyocyte Remodeling in Experimental and Human Atrial Fibrillation. Journal of the American Heart Association. 6. PMID 29066441 DOI: 10.1161/Jaha.117.006458  0.417
2017 Calkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen JC, Curtis AB, ... ... Nattel S, et al. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary. Journal of Arrhythmia. 33: 369-409. PMID 29021841 DOI: 10.1016/J.Joa.2017.08.001  0.41
2017 Calkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen JC, Curtis AB, ... ... Nattel S, et al. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary. Journal of Interventional Cardiac Electrophysiology : An International Journal of Arrhythmias and Pacing. PMID 28914401 DOI: 10.1007/S10840-017-0277-Z  0.426
2017 Nattel S. Allele-Specific Gene Silencing: Another Step in the Inexorable Advance of Gene Therapy for Cardiac Arrhythmia Management. Circulation Research. 121: 480-482. PMID 28819033 DOI: 10.1161/Circresaha.117.311541  0.396
2017 Lau DH, Nattel S, Kalman JM, Sanders P. Modifiable Risk Factors and Atrial Fibrillation. Circulation. 136: 583-596. PMID 28784826 DOI: 10.1161/Circulationaha.116.023163  0.403
2017 Guichard JB, Nattel S. Atrial Cardiomyopathy: A Useful Notion in Cardiac Disease Management or a Passing Fad? Journal of the American College of Cardiology. 70: 756-765. PMID 28774383 DOI: 10.1016/J.Jacc.2017.06.033  0.465
2017 Andrade JG, Macle L, Nattel S, Verma A, Cairns J. Contemporary Atrial Fibrillation Management: A Comparison of the Current AHA/ACC/HRS, CCS, and ESC Guidelines. The Canadian Journal of Cardiology. 33: 965-976. PMID 28754397 DOI: 10.1016/J.Cjca.2017.06.002  0.41
2017 Nattel S. Atrial Fibrillation and Body Composition: Is it Fat or Lean That Ultimately Determines the Risk? Journal of the American College of Cardiology. 69: 2498-2501. PMID 28521887 DOI: 10.1016/J.Jacc.2017.03.566  0.321
2017 Calkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen JC, Curtis AB, ... ... Nattel S, et al. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation. Heart Rhythm. PMID 28506916 DOI: 10.1016/j.hrthm.2017.05.012  0.412
2017 Aguilar M, Feng J, Vigmond E, Comtois P, Nattel S. Rate-Dependent Role of IKur in Human Atrial Repolarization and Atrial Fibrillation Maintenance. Biophysical Journal. 112: 1997-2010. PMID 28494969 DOI: 10.1016/J.Bpj.2017.03.022  0.441
2017 Nattel S, Dobrev D. Controversies About Atrial Fibrillation Mechanisms: Aiming for Order in Chaos and Whether it Matters. Circulation Research. 120: 1396-1398. PMID 28450363 DOI: 10.1161/Circresaha.116.310489  0.383
2017 Nattel S, Xiong F, Aguilar M. Demystifying rotors and their place in clinical translation of atrial fibrillation mechanisms. Nature Reviews. Cardiology. PMID 28383023 DOI: 10.1038/Nrcardio.2017.37  0.364
2017 Tadevosyan A, Xiao J, Surinkaew S, Naud P, Merlen C, Harada M, Qi X, Chatenet D, Fournier A, Allen BG, Nattel S. Intracellular Angiotensin-II Interacts With Nuclear Angiotensin Receptors in Cardiac Fibroblasts and Regulates RNA Synthesis, Cell Proliferation, and Collagen Secretion. Journal of the American Heart Association. 6. PMID 28381466 DOI: 10.1161/Jaha.116.004965  0.324
2017 Duong E, Xiao J, Qi XY, Nattel S. MicroRNA-135a Regulates Sodium-Calcium Exchanger Gene Expression and Cardiac Electrical Activity. Heart Rhythm. PMID 28188930 DOI: 10.1016/J.Hrthm.2017.01.045  0.335
2017 Chen Y, Surinkaew S, Naud P, Qi XY, Gillis MA, Shi YF, Tardif JC, Dobrev D, Nattel S. JAK-STAT signaling and the atrial fibrillation promoting fibrotic substrate. Cardiovascular Research. PMID 28158495 DOI: 10.1093/Cvr/Cvx004  0.396
2017 Nattel S. Close connections between contraction and rhythm: a new genetic cause of atrial fibrillation/cardiomyopathy and what it can teach us. European Heart Journal. 38: 35-37. PMID 28110309 DOI: 10.1093/Eurheartj/Ehw457  0.416
2017 Yao C, Scott L, Veleva T, Müller FU, Nattel S, Dobrev D, Wehrens XHT, Li N. 039Enhanced Activation of Inflammasome Promotes Atrial Fibrillation Journal of Molecular and Cellular Cardiology. 112: 147. DOI: 10.1016/J.Yjmcc.2017.07.051  0.405
2017 Calkins H, Hindricks G, Cappato R, Kim Y, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen P, Chen S, Chung MK, Nielsen JC, Curtis AB, ... ... Nattel S, et al. WITHDRAWN: 2017 HRS/EHRA/ECAS/APHRS/SOLAECE Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation Journal of Arrhythmia. DOI: 10.1016/J.Joa.2017.05.001  0.412
2016 Nattel S. Direct Effects of Activation and Inhibition of the Coagulation System on the Atrial Fibrillation Substrate: Is Anticoagulation Antiarrhythmic? Jacc. Basic to Translational Science. 1: 340-343. PMID 30167523 DOI: 10.1016/J.Jacbts.2016.05.006  0.412
2016 Macle L, Cairns J, Leblanc K, Tsang T, Skanes A, Cox JL, Healey JS, Bell A, Pilote L, Andrade JG, Mitchell LB, Atzema C, Gladstone D, Sharma M, Verma S, ... ... Nattel S, et al. 2016 Focused Update of the Canadian Cardiovascular Society Guidelines for the Management of Atrial Fibrillation. The Canadian Journal of Cardiology. PMID 27609430 DOI: 10.1016/J.Cjca.2016.07.591  0.388
2016 Willems S, Khairy P, Andrade JG, Hoffmann BA, Levesque S, Verma A, Weerasooriya R, Novak P, Arentz T, Deisenhofer I, Rostock T, Steven D, Rivard L, Guerra PG, Dyrda K, ... ... Nattel S, et al. Redefining the Blanking Period After Catheter Ablation for Paroxysmal Atrial Fibrillation: Insights From the ADVICE (Adenosine Following Pulmonary Vein Isolation to Target Dormant Conduction Elimination) Trial. Circulation. Arrhythmia and Electrophysiology. 9. PMID 27516462 DOI: 10.1161/Circep.115.003909  0.417
2016 Nattel S, Dobrev D. Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation. Nature Reviews. Cardiology. PMID 27489190 DOI: 10.1038/Nrcardio.2016.118  0.419
2016 Goette A, Kalman JM, Aguinaga L, Akar J, Cabrera JA, Chen SA, Chugh SS, Corradi D, D'Avila A, Dobrev D, Fenelon G, Gonzalez M, Hatem SN, Helm R, Hindricks G, ... ... Nattel S, et al. EHRA/HRS/APHRS/SOLAECE expert consensus on Atrial cardiomyopathies: definition, characterization, and clinical implication. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. PMID 27402624 DOI: 10.1093/Europace/Euw161  0.467
2016 Shenasa M, Nattel S. Cardiac Potassium Channel Disorders: From Basics to Clinics. Cardiac Electrophysiology Clinics. 8: xv-xvi. PMID 27261839 DOI: 10.1016/J.Ccep.2016.03.001  0.38
2016 Tadros R, Nattel S, Andrade JG. Dronedarone: Basic Pharmacology and Clinical Use. Cardiac Electrophysiology Clinics. 8: 453-65. PMID 27261834 DOI: 10.1016/J.Ccep.2016.02.008  0.454
2016 Algalarrondo V, Nattel S. Potassium Channel Remodeling in Heart Disease. Cardiac Electrophysiology Clinics. 8: 337-47. PMID 27261825 DOI: 10.1016/J.Ccep.2016.01.006  0.417
2016 Nattel S. How does fibrosis promote atrial fibrillation persistence: in silico findings, clinical observations, and experimental data. Cardiovascular Research. 110: 295-7. PMID 27131507 DOI: 10.1093/Cvr/Cvw092  0.458
2016 Major P, Baczkó I, Hiripi L, Odening KE, Juhász V, Kohajda Z, Horváth A, Seprényi G, Kovács M, Virág L, Jost N, Prorok J, Ördög B, Doleschall Z, Nattel S, et al. A novel transgenic rabbit model with reduced repolarization reserve: long QT syndrome caused by a dominant-negative mutation of KCNE1 gene. British Journal of Pharmacology. PMID 27076034 DOI: 10.1111/Bph.13500  0.331
2016 Nattel S, Dobrev D. Deciphering the fundamental mechanisms of atrial fibrillation: a quest for over a century. Cardiovascular Research. 109: 465-6. PMID 26857417 DOI: 10.1093/Cvr/Cvw028  0.478
2016 Macle L, Nattel S. Arrhythmias in 2015: Advances in drug, ablation, and device therapy for cardiac arrhythmias. Nature Reviews. Cardiology. 13: 67-8. PMID 26727299 DOI: 10.1038/Nrcardio.2015.196  0.368
2016 Heijman J, Algalarrondo V, Voigt N, Melka J, Wehrens XH, Dobrev D, Nattel S. The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis. Cardiovascular Research. 109: 467-79. PMID 26705366 DOI: 10.1093/Cvr/Cvv275  0.44
2016 Heijman J, Erfanian Abdoust P, Voigt N, Nattel S, Dobrev D. Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation. The Journal of Physiology. 594: 537-53. PMID 26582329 DOI: 10.1113/Jp271404  0.455
2016 Shenasa M, Nattel S. Cardiac Potassium Channel Disorders Cardiac Electrophysiology Clinics. 8. DOI: 10.1016/S1877-9182(16)30047-8  0.349
2016 Heijman J, Qi XY, Dobrev D, Nattel S. Computational Analysis of Heart-Failure-Related Remodeling of Cytosolic and Nuclear Calcium Handling in the Canine Atrial Cardiomyocyte Biophysical Journal. 110: 4-5. DOI: 10.1016/J.Bpj.2015.11.2345  0.393
2015 Proietti R, Hadjis A, AlTurki A, Thanassoulis G, Roux JF, Verma A, Healey JS, Bernier ML, Birnie D, Nattel S, Essebag V. A Systematic Review on the Progression of Paroxysmal to Persistent Atrial Fibrillation: Shedding New Light on the Effects of Catheter Ablation. Jacc. Clinical Electrophysiology. 1: 105-115. PMID 29759352 DOI: 10.1016/J.Jacep.2015.04.010  0.424
2015 Aguilar M, Nattel S. The pioneering work of George Mines on cardiac arrhythmias: groundbreaking ideas that remain influential in contemporary cardiac electrophysiology. The Journal of Physiology. PMID 26607760 DOI: 10.1113/Jp270506  0.436
2015 Aguilar M, Xiong F, Qi XY, Comtois P, Nattel S. Potassium Channel Blockade Enhances Atrial Fibrillation-Selective Antiarrhythmic Effects of Optimized State-Dependent Sodium Channel Blockade. Circulation. PMID 26499964 DOI: 10.1161/Circulationaha.115.018016  0.409
2015 Macle L, Cairns JA, Andrade JG, Mitchell LB, Nattel S, Verma A. The 2014 Atrial Fibrillation Guidelines Companion: A Practical Approach to the Use of the Canadian Cardiovascular Society Guidelines. The Canadian Journal of Cardiology. 31: 1207-18. PMID 26429352 DOI: 10.1016/J.Cjca.2015.06.005  0.393
2015 Nattel S, Dobrev D. Innovative Therapeutics for Atrial Fibrillation: Imminent Breakthroughs or Much Ado About Nothing? Journal of Cardiovascular Pharmacology. 66: 409-11. PMID 26371951 DOI: 10.1097/Fjc.0000000000000319  0.446
2015 Anneken L, Baumann S, Vigneault P, Biliczki P, Friedrich C, Xiao L, Girmatsion Z, Takac I, Brandes RP, Kissler S, Wiegratz I, Zumhagen S, Stallmeyer B, Hohnloser SH, Klingenheben T, ... ... Nattel S, et al. Estradiol regulates human QT-interval: acceleration of cardiac repolarization by enhanced KCNH2 membrane trafficking. European Heart Journal. PMID 26271031 DOI: 10.1093/Eurheartj/Ehv371  0.783
2015 Macle L, Khairy P, Weerasooriya R, Novak P, Verma A, Willems S, Arentz T, Deisenhofer I, Veenhuyzen G, Scavée C, Jaïs P, Puererfellner H, Levesque S, Andrade JG, Rivard L, ... ... Nattel S, et al. Adenosine-guided pulmonary vein isolation for the treatment of paroxysmal atrial fibrillation: an international, multicentre, randomised superiority trial. Lancet (London, England). PMID 26211828 DOI: 10.1016/S0140-6736(15)60026-5  0.416
2015 Harada M, Tadevosyan A, Qi X, Xiao J, Liu T, Voigt N, Karck M, Kamler M, Kodama I, Murohara T, Dobrev D, Nattel S. Atrial Fibrillation Activates AMP-Dependent Protein Kinase and its Regulation of Cellular Calcium Handling: Potential Role in Metabolic Adaptation and Prevention of Progression. Journal of the American College of Cardiology. 66: 47-58. PMID 26139058 DOI: 10.1016/J.Jacc.2015.04.056  0.367
2015 Le Quang K, Maguy A, Qi XY, Naud P, Xiong F, Tadevosyan A, Shi YF, Chartier D, Tardif JC, Dobrev D, Nattel S. Loss of Cardiomyocyte Integrin Linked Kinase Produces an Arrhythmogenic Cardiomyopathy in Mice. Circulation. Arrhythmia and Electrophysiology. PMID 26071395 DOI: 10.1161/Circep.115.001668  0.38
2015 Tadros R, Cadrin-Tourigny J, Abadir S, Rivard L, Nattel S, Talajic M, Khairy P. Pharmacotherapy for inherited arrhythmia syndromes: mechanistic basis, clinical trial evidence and practical application. Expert Review of Cardiovascular Therapy. 13: 769-82. PMID 25994014 DOI: 10.1586/14779072.2015.1049156  0.367
2015 Khrapko K, Trayanova N, Nattel S. Modeling the aging heart: from local respiratory defects to global rhythm disturbances. Cell Metabolism. 21: 662-3. PMID 25955202 DOI: 10.1016/J.Cmet.2015.04.024  0.36
2015 Aguilar M, Nattel S. The Past, Present, and Potential Future of Sodium Channel Block as an Atrial Fibrillation Suppressing Strategy. Journal of Cardiovascular Pharmacology. 66: 432-40. PMID 25923324 DOI: 10.1097/Fjc.0000000000000271  0.473
2015 Nattel S. Targeting MicroRNA-208a to Suppress Adverse Postmyocardial Infarction Remodelling Related to RNA Activation of Endoglin Gene Expression. The Canadian Journal of Cardiology. 31: 591-2. PMID 25828373 DOI: 10.1016/J.Cjca.2015.03.013  0.305
2015 Andrade JG, Nattel S, Macle L. Pulmonary vein exit block despite recovery of entry conduction during redo-ablation for atrial fibrillation. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 17: 752. PMID 25782452 DOI: 10.1093/Europace/Euv033  0.408
2015 Harada M, Van Wagoner DR, Nattel S. Role of inflammation in atrial fibrillation pathophysiology and management. Circulation Journal : Official Journal of the Japanese Circulation Society. 79: 495-502. PMID 25746525 DOI: 10.1253/Circj.Cj-15-0138  0.433
2015 Nattel S. Changes in the atrial transcriptome and atrial fibrillation: susceptibility, persistence, causes, and consequences. Circulation. Arrhythmia and Electrophysiology. 8: 5-7. PMID 25691550 DOI: 10.1161/Circep.115.002673  0.473
2015 Qi XY, Huang H, Ordog B, Luo X, Naud P, Sun Y, Wu CT, Dawson K, Tadevosyan A, Chen Y, Harada M, Dobrev D, Nattel S. Fibroblast inward-rectifier potassium current upregulation in profibrillatory atrial remodeling. Circulation Research. 116: 836-45. PMID 25608527 DOI: 10.1161/Circresaha.116.305326  0.458
2015 Nattel S. Canadian Cardiovascular Society 2014 algorithm for anticoagulation therapy in atrial fibrillation debated. The Canadian Journal of Cardiology. 31: 1-2. PMID 25547543 DOI: 10.1016/J.Cjca.2014.11.022  0.346
2015 Luo X, Yang B, Nattel S. MicroRNAs and atrial fibrillation: mechanisms and translational potential. Nature Reviews. Cardiology. 12: 80-90. PMID 25421165 DOI: 10.1038/Nrcardio.2014.178  0.371
2015 Tadevosyan A, Allen BG, Nattel S. Isolation and study of cardiac nuclei from canine myocardium and adult ventricular myocytes. Methods in Molecular Biology (Clifton, N.J.). 1234: 69-80. PMID 25304349 DOI: 10.1007/978-1-4939-1755-6_7  0.32
2014 Nattel S, Talajic M, Tardif JC. A look into the future of cardiology: perspectives from the Montreal Heart Institute. The Canadian Journal of Cardiology. 30: S399-400. PMID 25530087 DOI: 10.1016/J.Cjca.2014.10.006  0.363
2014 Nattel S. Atrial ectopic activity in long-standing persistent atrial fibrillation: an unanticipated potentially important role? The Canadian Journal of Cardiology. 30: 1496-7. PMID 25475450 DOI: 10.1016/J.Cjca.2014.10.019  0.462
2014 Nattel S. Serum uric acid concentration and left atrial thrombus: biomarker, pathophysiological indicator, or innocent bystander? The Canadian Journal of Cardiology. 30: 1259-61. PMID 25442429 DOI: 10.1016/J.Cjca.2014.07.730  0.422
2014 Iwasaki YK, Kato T, Xiong F, Shi YF, Naud P, Maguy A, Mizuno K, Tardif JC, Comtois P, Nattel S. Atrial fibrillation promotion with long-term repetitive obstructive sleep apnea in a rat model. Journal of the American College of Cardiology. 64: 2013-23. PMID 25440097 DOI: 10.1016/J.Jacc.2014.05.077  0.349
2014 Nattel S, Andrade J, Macle L, Rivard L, Dyrda K, Mondesert B, Khairy P. New directions in cardiac arrhythmia management: present challenges and future solutions. The Canadian Journal of Cardiology. 30: S420-30. PMID 25432137 DOI: 10.1016/J.Cjca.2014.09.027  0.356
2014 Aguilar M, Qi XY, Huang H, Comtois P, Nattel S. Fibroblast electrical remodeling in heart failure and potential effects on atrial fibrillation. Biophysical Journal. 107: 2444-55. PMID 25418313 DOI: 10.1016/J.Bpj.2014.10.014  0.463
2014 Chen Y, Wakili R, Xiao J, Wu CT, Luo X, Clauss S, Dawson K, Qi X, Naud P, Shi YF, Tardif JC, Kääb S, Dobrev D, Nattel S. Detailed characterization of microRNA changes in a canine heart failure model: Relationship to arrhythmogenic structural remodeling. Journal of Molecular and Cellular Cardiology. 77: 113-24. PMID 25315712 DOI: 10.1016/J.Yjmcc.2014.10.001  0.312
2014 Nigam A, Talajic M, Roy D, Nattel S, Lambert J, Nozza A, Jones P, Ramprasath VR, O'Hara G, Kopecky S, Brophy JM, Tardif JC. Fish oil for the reduction of atrial fibrillation recurrence, inflammation, and oxidative stress. Journal of the American College of Cardiology. 64: 1441-8. PMID 25277614 DOI: 10.1016/J.Jacc.2014.07.956  0.325
2014 Verma A, Cairns JA, Mitchell LB, Macle L, Stiell IG, Gladstone D, McMurtry MS, Connolly S, Cox JL, Dorian P, Ivers N, Leblanc K, Nattel S, Healey JS. 2014 focused update of the Canadian Cardiovascular Society Guidelines for the management of atrial fibrillation. The Canadian Journal of Cardiology. 30: 1114-30. PMID 25262857 DOI: 10.1016/J.Cjca.2014.08.001  0.393
2014 Nattel S. Decade in review--arrhythmias: Cardiac fibrillation--challenges and evolving solutions. Nature Reviews. Cardiology. 11: 626-7. PMID 25200282 DOI: 10.1038/Nrcardio.2014.133  0.397
2014 Lip GY, Al-Khatib SM, Cosio FG, Banerjee A, Savelieva I, Ruskin J, Blendea D, Nattel S, De Bono J, Conroy JM, Hess PL, Guasch E, Halperin JL, Kirchhof P, G Cosio MD, et al. Contemporary management of atrial fibrillation: what can clinical registries tell us about stroke prevention and current therapeutic approaches? Journal of the American Heart Association. 3. PMID 25164944 DOI: 10.1161/Jaha.114.001179  0.388
2014 Nattel S. N-type calcium channel blockade: a new approach to preventing sudden cardiac death? Cardiovascular Research. 104: 1-2. PMID 25145700 DOI: 10.1093/Cvr/Cvu197  0.422
2014 Nishida K, Datino T, Macle L, Nattel S. Atrial fibrillation ablation: translating basic mechanistic insights to the patient. Journal of the American College of Cardiology. 64: 823-31. PMID 25145528 DOI: 10.1016/J.Jacc.2014.06.1172  0.429
2014 Li J, Maguy A, Duverger JE, Vigneault P, Comtois P, Shi Y, Tardif JC, Thomas D, Nattel S. Induced KCNQ1 autoimmunity accelerates cardiac repolarization in rabbits: potential significance in arrhythmogenesis and antiarrhythmic therapy. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 11: 2092-100. PMID 25087487 DOI: 10.1016/J.Hrthm.2014.07.040  0.816
2014 Andrade JG, Monir G, Pollak SJ, Khairy P, Dubuc M, Roy D, Talajic M, Deyell M, Rivard L, Thibault B, Guerra PG, Nattel S, Macle L. Pulmonary vein isolation using "contact force" ablation: the effect on dormant conduction and long-term freedom from recurrent atrial fibrillation--a prospective study. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 11: 1919-24. PMID 25068575 DOI: 10.1016/J.Hrthm.2014.07.033  0.353
2014 Tadros R, Ton AT, Fiset C, Nattel S. Sex differences in cardiac electrophysiology and clinical arrhythmias: epidemiology, therapeutics, and mechanisms. The Canadian Journal of Cardiology. 30: 783-92. PMID 24970790 DOI: 10.1016/J.Cjca.2014.03.032  0.425
2014 Chen PS, Chen LS, Fishbein MC, Lin SF, Nattel S. Role of the autonomic nervous system in atrial fibrillation: pathophysiology and therapy. Circulation Research. 114: 1500-15. PMID 24763467 DOI: 10.1161/Circresaha.114.303772  0.445
2014 Heijman J, Voigt N, Nattel S, Dobrev D. Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression. Circulation Research. 114: 1483-99. PMID 24763466 DOI: 10.1161/Circresaha.114.302226  0.463
2014 Andrade J, Khairy P, Dobrev D, Nattel S. The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms. Circulation Research. 114: 1453-68. PMID 24763464 DOI: 10.1161/Circresaha.114.303211  0.445
2014 Nishida K, Nattel S. Atrial fibrillation compendium: historical context and detailed translational perspective on an important clinical problem. Circulation Research. 114: 1447-52. PMID 24763463 DOI: 10.1161/Circresaha.114.303466  0.456
2014 Le Grand B, Letienne R, Dupont-Passelaigue E, Lantoine-Adam F, Longo F, David-Dufilho M, Michael G, Nishida K, Catheline D, Legrand P, Hatem S, Nattel S. F 16915 prevents heart failure-induced atrial fibrillation: a promising new drug as upstream therapy. Naunyn-Schmiedeberg's Archives of Pharmacology. 387: 667-77. PMID 24722816 DOI: 10.1007/S00210-014-0975-3  0.38
2014 Nattel S, Harada M. Atrial remodeling and atrial fibrillation: recent advances and translational perspectives. Journal of the American College of Cardiology. 63: 2335-45. PMID 24613319 DOI: 10.1016/J.Jacc.2014.02.555  0.48
2014 Wu CT, Qi XY, Huang H, Naud P, Dawson K, Yeh YH, Harada M, Kuo CT, Nattel S. Disease and region-related cardiac fibroblast potassium current variations and potential functional significance. Cardiovascular Research. 102: 487-96. PMID 24596399 DOI: 10.1093/Cvr/Cvu055  0.451
2014 Nattel S, Guasch E, Savelieva I, Cosio FG, Valverde I, Halperin JL, Conroy JM, Al-Khatib SM, Hess PL, Kirchhof P, De Bono J, Lip GY, Banerjee A, Ruskin J, Blendea D, et al. Early management of atrial fibrillation to prevent cardiovascular complications. European Heart Journal. 35: 1448-56. PMID 24536084 DOI: 10.1093/Eurheartj/Ehu028  0.444
2014 Wyse DG, Van Gelder IC, Ellinor PT, Go AS, Kalman JM, Narayan SM, Nattel S, Schotten U, Rienstra M. Lone atrial fibrillation: does it exist? Journal of the American College of Cardiology. 63: 1715-23. PMID 24530673 DOI: 10.1016/J.Jacc.2014.01.023  0.457
2014 Harada M, Luo X, Murohara T, Yang B, Dobrev D, Nattel S. MicroRNA regulation and cardiac calcium signaling: role in cardiac disease and therapeutic potential. Circulation Research. 114: 689-705. PMID 24526675 DOI: 10.1161/Circresaha.114.301798  0.305
2014 Aflaki M, Qi XY, Xiao L, Ordog B, Tadevosyan A, Luo X, Maguy A, Shi Y, Tardif JC, Nattel S. Exchange protein directly activated by cAMP mediates slow delayed-rectifier current remodeling by sustained β-adrenergic activation in guinea pig hearts. Circulation Research. 114: 993-1003. PMID 24508724 DOI: 10.1161/Circresaha.113.302982  0.331
2014 Sivagangabalan G, Nazzari H, Bignolais O, Maguy A, Naud P, Farid T, Massé S, Gaborit N, Varro A, Nair K, Backx P, Vigmond E, Nattel S, Demolombe S, Nanthakumar K. Regional ion channel gene expression heterogeneity and ventricular fibrillation dynamics in human hearts. Plos One. 9: e82179. PMID 24427266 DOI: 10.1371/Journal.Pone.0082179  0.402
2014 Li N, Chiang DY, Wang S, Wang Q, Sun L, Voigt N, Respress JL, Ather S, Skapura DG, Jordan VK, Horrigan FT, Schmitz W, Müller FU, Valderrabano M, Nattel S, et al. Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model. Circulation. 129: 1276-85. PMID 24398018 DOI: 10.1161/Circulationaha.113.006611  0.416
2014 Nattel S, Qi XY. Calcium-dependent potassium channels in the heart: clarity and confusion. Cardiovascular Research. 101: 185-6. PMID 24385343 DOI: 10.1093/Cvr/Cvt340  0.42
2014 Voigt N, Heijman J, Wang Q, Chiang DY, Li N, Karck M, Wehrens XH, Nattel S, Dobrev D. Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation. Circulation. 129: 145-56. PMID 24249718 DOI: 10.1161/Circulationaha.113.006641  0.389
2014 Qi XY, Diness JG, Brundel BJ, Zhou XB, Naud P, Wu CT, Huang H, Harada M, Aflaki M, Dobrev D, Grunnet M, Nattel S. Role of small-conductance calcium-activated potassium channels in atrial electrophysiology and fibrillation in the dog. Circulation. 129: 430-40. PMID 24190961 DOI: 10.1161/Circulationaha.113.003019  0.491
2014 Zhang D, Wu CT, Qi X, Meijering RA, Hoogstra-Berends F, Tadevosyan A, Cubukcuoglu Deniz G, Durdu S, Akar AR, Sibon OC, Nattel S, Henning RH, Brundel BJ. Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation. Circulation. 129: 346-58. PMID 24146251 DOI: 10.1161/Circulationaha.113.005300  0.443
2014 Guasch E, Benito B, Nattel S. Reply: Of mice and men: atrial fibrillation in veteran endurance runners. Journal of the American College of Cardiology. 63: 89-90. PMID 24076488 DOI: 10.1016/J.Jacc.2013.07.102  0.305
2013 Andrade JG, Pollak SJ, Monir G, Khairy P, Dubuc M, Roy D, Talajic M, Deyell M, Rivard L, Thibault B, Guerra PG, Nattel S, Macle L. Pulmonary vein isolation using a pace-capture-guided versus an adenosine-guided approach: effect on dormant conduction and long-term freedom from recurrent atrial fibrillation--a prospective study. Circulation. Arrhythmia and Electrophysiology. 6: 1103-8. PMID 24097372 DOI: 10.1161/Circep.113.000454  0.366
2013 Nattel S. Paroxysmal atrial fibrillation and pulmonary veins: relationships between clinical forms and automatic versus re-entrant mechanisms. The Canadian Journal of Cardiology. 29: 1147-9. PMID 23993351 DOI: 10.1016/J.Cjca.2013.07.797  0.44
2013 Gillis AM, Krahn AD, Skanes AC, Nattel S. Management of atrial fibrillation in the year 2033: new concepts, tools, and applications leading to personalized medicine. The Canadian Journal of Cardiology. 29: 1141-6. PMID 23988338 DOI: 10.1016/J.Cjca.2013.07.006  0.355
2013 Andrade JG, Khairy P, Nattel S, Vanella A, Rivard L, Guerra PG, Dubuc M, Dyrda K, Thibault B, Talajic M, Mondesert B, Roy D, Macle L. Corticosteroid use during pulmonary vein isolation is associated with a higher prevalence of dormant pulmonary vein conduction. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 10: 1569-75. PMID 23892341 DOI: 10.1016/J.Cjca.2012.07.731  0.346
2013 Le Quang K, Benito B, Naud P, Qi XY, Shi YF, Tardif JC, Gillis MA, Dobrev D, Charpentier F, Nattel S. T-type calcium current contributes to escape automaticity and governs the occurrence of lethal arrhythmias after atrioventricular block in mice. Circulation. Arrhythmia and Electrophysiology. 6: 799-808. PMID 23884198 DOI: 10.1161/Circep.113.000407  0.318
2013 Yeh YH, Kuo CT, Chang GJ, Qi XY, Nattel S, Chen WJ. Nicotinamide adenine dinucleotide phosphate oxidase 4 mediates the differential responsiveness of atrial versus ventricular fibroblasts to transforming growth factor-β. Circulation. Arrhythmia and Electrophysiology. 6: 790-8. PMID 23884197 DOI: 10.1161/Circep.113.000338  0.405
2013 Jost N, Virág L, Comtois P, Ordög B, Szuts V, Seprényi G, Bitay M, Kohajda Z, Koncz I, Nagy N, Szél T, Magyar J, Kovács M, Puskás LG, Lengyel C, ... ... Nattel S, et al. Ionic mechanisms limiting cardiac repolarization reserve in humans compared to dogs. The Journal of Physiology. 591: 4189-206. PMID 23878377 DOI: 10.1113/Jphysiol.2013.261198  0.36
2013 Mehel H, Emons J, Vettel C, Wittköpper K, Seppelt D, Dewenter M, Lutz S, Sossalla S, Maier LS, Lechêne P, Leroy J, Lefebvre F, Varin A, Eschenhagen T, Nattel S, et al. Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes. Journal of the American College of Cardiology. 62: 1596-606. PMID 23810893 DOI: 10.1016/J.Jacc.2013.05.057  0.319
2013 Nattel S, Cairns J, Healey JS, Talajic M. Anticoagulation for atrial fibrillation: state of the art and recommendations for a quickly moving target. The Canadian Journal of Cardiology. 29: S1-3. PMID 23790593 DOI: 10.1016/J.Cjca.2013.05.001  0.349
2013 Chauvet C, Crespo K, Shi Y, Gelinas D, Duval F, L'Heureux N, Nattel S, Tardif JC, Deng AY. Unique quantitative trait loci in synergy permanently improve diastolic dysfunction. The Canadian Journal of Cardiology. 29: 1302-9. PMID 23773896 DOI: 10.1016/J.Cjca.2013.03.012  0.358
2013 Merlen C, Farhat N, Luo X, Chatenet D, Tadevosyan A, Villeneuve LR, Gillis MA, Nattel S, Thorin E, Fournier A, Allen BG. Intracrine endothelin signaling evokes IP3-dependent increases in nucleoplasmic Ca²⁺ in adult cardiac myocytes. Journal of Molecular and Cellular Cardiology. 62: 189-202. PMID 23756157 DOI: 10.1016/J.Yjmcc.2013.05.021  0.315
2013 Obeyesekere MN, Klein GJ, Nattel S, Leong-Sit P, Gula LJ, Skanes AC, Yee R, Krahn AD. A clinical approach to early repolarization. Circulation. 127: 1620-9. PMID 23588960 DOI: 10.1161/Circulationaha.112.143149  0.309
2013 Guasch E, Benito B, Qi X, Cifelli C, Naud P, Shi Y, Mighiu A, Tardif JC, Tadevosyan A, Chen Y, Gillis MA, Iwasaki YK, Dobrev D, Mont L, Heximer S, ... Nattel S, et al. Atrial fibrillation promotion by endurance exercise: demonstration and mechanistic exploration in an animal model. Journal of the American College of Cardiology. 62: 68-77. PMID 23583240 DOI: 10.1016/J.Jacc.2013.01.091  0.374
2013 Xiao L, Koopmann TT, Ördög B, Postema PG, Verkerk AO, Iyer V, Sampson KJ, Boink GJ, Mamarbachi MA, Varro A, Jordaens L, Res J, Kass RS, Wilde AA, Bezzina CR, ... Nattel S, et al. Unique cardiac Purkinje fiber transient outward current β-subunit composition: a potential molecular link to idiopathic ventricular fibrillation. Circulation Research. 112: 1310-22. PMID 23532596 DOI: 10.1161/Circresaha.112.300227  0.407
2013 Dawson K, Wakili R, Ordög B, Clauss S, Chen Y, Iwasaki Y, Voigt N, Qi XY, Sinner MF, Dobrev D, Kääb S, Nattel S. MicroRNA29: a mechanistic contributor and potential biomarker in atrial fibrillation. Circulation. 127: 1466-75, 1475e1-28. PMID 23459615 DOI: 10.1161/Circulationaha.112.001207  0.427
2013 Crespo K, Chauvet C, Ménard A, Roy J, Shi Y, Gelinas D, Duval F, L'heureux N, Nattel S, Tardif JC, Deng AY. Combining distinctive and novel loci doubles BP reduction, reverses diastolic dysfunction and mitigates LV hypertrophy. Journal of Hypertension. 31: 927-35. PMID 23442991 DOI: 10.1097/Hjh.0B013E32835Edc7E  0.327
2013 Tsuji Y, Heijman J, Nattel S, Dobrev D. Electrical storm: recent pathophysiological insights and therapeutic consequences. Basic Research in Cardiology. 108: 336. PMID 23429935 DOI: 10.1007/S00395-013-0336-2  0.365
2013 Andrade JG, Nattel S, Macle L. Late pulmonary vein reconnection: insights into mechanisms of atrial fibrillation recurrence after pulmonary vein isolation. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 15: 1143. PMID 23362020 DOI: 10.1093/Europace/Eut005  0.347
2013 Dawson K, Aflaki M, Nattel S. Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential. The Journal of Physiology. 591: 1409-1432. PMID 23207593 DOI: 10.1113/Jphysiol.2012.235382  0.334
2013 Yeh YH, Kuo CT, Lee YS, Lin YM, Nattel S, Tsai FC, Chen WJ. Region-specific gene expression profiles in the left atria of patients with valvular atrial fibrillation. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 10: 383-91. PMID 23183193 DOI: 10.1016/J.Hrthm.2012.11.013  0.412
2013 Postema PG, Sande JNT, Christiaans I, Ling X, Alders M, Boekholdt M, Varro A, Nattel S, Bezzina CR, Wilde AAM. Characterisation of familial idiopathic ventricular fibrillation linked to DPP6 European Heart Journal. 34: 4559-4559. DOI: 10.1093/Eurheartj/Eht310.4559  0.423
2013 Nigam A, Talajic M, Roy D, Nattel S, Lambert J, Nozza A, Jones P, O'Hara G, Kopecky S, Brophy J, Tardif J. Multicentre Trial of Fish Oil for the Reduction of Atrial Fibrillation Recurrence, Inflammation and Oxidative Stress: the Atrial Fibrillation Fish Oil Research Study Canadian Journal of Cardiology. 29. DOI: 10.1016/J.Cjca.2013.07.658  0.305
2013 Andrade J, Pollak S, Monir G, Khairy P, Dubuc M, Roy D, Talajic M, Deyell M, Bennett M, Dyrda K, Rivard L, Thibault B, Guerra P, Nattel S, Macle L. Pulmonary Vein Isolation Using a “Pace-Capture Guided” Versus an “Adenosine Guided” Approach: the Effect on Dormant Conduction and Long-Term Freedom From Recurrent Af: A Prospective Study Canadian Journal of Cardiology. 29. DOI: 10.1016/J.Cjca.2013.07.289  0.319
2013 Xiong F, Kato T, Iwasaki Y, Maguy A, Comtois P, Nattel S. Repetitive OSA Promotes Atrial Fibrillation by Impairing Atrial Conduction Canadian Journal of Cardiology. 29: S148. DOI: 10.1016/J.Cjca.2013.07.215  0.437
2013 Aguilar M, Qi X, Huang H, Comtois P, Nattel S. Effect of Fibroblast Electrical Remodeling on Atrial Arrhythmogenesis in Atrial Fibrillation Canadian Journal of Cardiology. 29: S108-S109. DOI: 10.1016/J.Cjca.2013.07.139  0.447
2013 Wu C, Qi X, Naud P, Shi Y, Huang H, Tardif J, Yeh Y, Kuo C, Nattel S. Ion-Current Remodeling and AF Promotion With Paroxysmal Atrial Fibrillation in a Canine Model Canadian Journal of Cardiology. 29: S104-S105. DOI: 10.1016/J.Cjca.2013.07.131  0.421
2013 Nattel S, Voigt N, Dobrev D. The Molecular Pathophysiology of Atrial Fibrillation Cardiac Electrophysiology: From Cell to Bedside: Sixth Edition. 449-458. DOI: 10.1016/B978-1-4557-2856-5.00045-5  0.306
2012 Dawson K, Wu CT, Qi XY, Nattel S. Congestive heart failure effects on atrial fibroblast phenotype: differences between freshly-isolated and cultured cells. Plos One. 7: e52032. PMID 23251678 DOI: 10.1371/Journal.Pone.0052032  0.377
2012 Nishida K, Chiba K, Iwasaki YK, Katsouras G, Shi YF, Blostein MD, Khairy P, Guerra PG, Dubuc M, Tardif JC, Tanguay JF, Nattel S. Atrial fibrillation-associated remodeling does not promote atrial thrombus formation in canine models. Circulation. Arrhythmia and Electrophysiology. 5: 1168-75. PMID 23095228 DOI: 10.1161/Circep.112.974410  0.476
2012 Harada M, Luo X, Qi XY, Tadevosyan A, Maguy A, Ordog B, Ledoux J, Kato T, Naud P, Voigt N, Shi Y, Kamiya K, Murohara T, Kodama I, Tardif JC, ... ... Nattel S, et al. Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation. Circulation. 126: 2051-64. PMID 22992321 DOI: 10.1161/Circulationaha.112.121830  0.444
2012 Camm AJ, Al-Khatib SM, Calkins H, Halperin JL, Kirchhof P, Lip GY, Nattel S, Ruskin J, Banerjee A, Blendea D, Guasch E, Needleman M, Savelieva I, Viles-Gonzalez J, Williams ES. A proposal for new clinical concepts in the management of atrial fibrillation. American Heart Journal. 164: 292-302.e1. PMID 22980294 DOI: 10.1016/J.Ahj.2012.05.017  0.443
2012 Cardin S, Guasch E, Luo X, Naud P, Le Quang K, Shi Y, Tardif JC, Comtois P, Nattel S. Role for MicroRNA-21 in atrial profibrillatory fibrotic remodeling associated with experimental postinfarction heart failure. Circulation. Arrhythmia and Electrophysiology. 5: 1027-35. PMID 22923342 DOI: 10.1161/Circep.112.973214  0.423
2012 Comtois P, Nattel S. Atrial repolarization alternans as a path to atrial fibrillation. Journal of Cardiovascular Electrophysiology. 23: 1013-5. PMID 22788865 DOI: 10.1111/J.1540-8167.2012.02391.X  0.348
2012 Heijman J, Voigt N, Nattel S, Dobrev D. Calcium handling and atrial fibrillation Wiener Medizinische Wochenschrift. 162: 287-291. PMID 22695810 DOI: 10.1007/S10354-012-0109-9  0.459
2012 Nattel S, Dobrev D. The multidimensional role of calcium in atrial fibrillation pathophysiology: Mechanistic insights and therapeutic opportunities European Heart Journal. 33. PMID 22507975 DOI: 10.1093/Eurheartj/Ehs079  0.401
2012 Nattel S. Adenosine and atrial arrhythmias: exploring electrophysiological mechanisms in vivo. Pacing and Clinical Electrophysiology : Pace. 35: 553-5. PMID 22486300 DOI: 10.1111/j.1540-8159.2012.03395.x  0.32
2012 Dobrev D, Carlsson L, Nattel S. Novel molecular targets for atrial fibrillation therapy Nature Reviews Drug Discovery. 11: 275-291. PMID 22460122 DOI: 10.1038/Nrd3682  0.433
2012 Voigt N, Li N, Wang Q, Wang W, Trafford AW, Abu-Taha I, Sun Q, Wieland T, Ravens U, Nattel S, Wehrens XHT, Dobrev D. Enhanced sarcoplasmic reticulum Ca 2+ Leak and increased Na +-Ca 2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation Circulation. 125: 2059-2070. PMID 22456474 DOI: 10.1161/Circulationaha.111.067306  0.318
2012 Voigt N, Nattel S, Dobrev D. Proarrhythmic atrial calcium cycling in the diseased heart. Advances in Experimental Medicine and Biology. 740: 1175-1191. PMID 22453988 DOI: 10.1007/978-94-007-2888-2_53  0.451
2012 Iwasaki YK, Shi Y, Benito B, Gillis MA, Mizuno K, Tardif JC, Nattel S. Determinants of atrial fibrillation in an animal model of obesity and acute obstructive sleep apnea. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 9: 1409-16.e1. PMID 22440155 DOI: 10.1016/J.Hrthm.2012.03.024  0.333
2012 Skanes AC, Healey JS, Cairns JA, Dorian P, Gillis AM, McMurtry MS, Mitchell LB, Verma A, Nattel S. Focused 2012 update of the Canadian Cardiovascular Society atrial fibrillation guidelines: recommendations for stroke prevention and rate/rhythm control. The Canadian Journal of Cardiology. 28: 125-36. PMID 22433576 DOI: 10.1016/J.Cjca.2012.01.021  0.397
2012 Wu CT, Nattel S. Triggering of cardiac arrhythmic events in long QT syndrome: lessons from funny bunnies. The Journal of Physiology. 590: 1311-2. PMID 22422115 DOI: 10.1113/Jphysiol.2012.229344  0.331
2012 Aguilar-Shardonofsky M, Vigmond EJ, Nattel S, Comtois P. In silico optimization of atrial fibrillation-selective sodium channel blocker pharmacodynamics. Biophysical Journal. 102: 951-60. PMID 22404917 DOI: 10.1016/J.Bpj.2012.01.032  0.478
2012 Calkins H, Kuck KH, Cappato R, Brugada J, Camm AJ, Chen SA, Crijns HJ, Damiano RJ, Davies DW, DiMarco J, Edgerton J, Ellenbogen K, Ezekowitz MD, Haines DE, Haissaguerre M, ... ... Nattel S, et al. 2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 14: 528-606. PMID 22389422 DOI: 10.1093/Europace/Eus027  0.423
2012 Calkins H, Kuck KH, Cappato R, Brugada J, Camm AJ, Chen SA, Crijns HJ, Damiano RJ, Davies DW, DiMarco J, Edgerton J, Ellenbogen K, Ezekowitz MD, Haines DE, Haissaguerre M, ... ... Nattel S, et al. 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design: a report of the Heart Rhythm Society (HRS) Task Force on Catheter and Surgical Ablation of Atrial Fibrillation. Developed in partnership with the European Heart Rhythm Association (EHRA), a registered branch of the European Society of Cardiology (ESC) and the European Cardiac Arrhythmia Society (ECAS); and in collaboration with the American College of Cardiology (ACC), American Heart Association (AHA), the Asia Pacific Heart Rhythm Society (APHRS), and the Society of Thoracic Surgeons (STS). Endorsed by the governing bodies of the American College of Cardiology Foundation, the American Heart Association, the European Cardiac Arrhythmia Society, the European Heart Rhythm Association, the Society of Thoracic Surgeons, the Asia Pacific Heart Rhythm Society, and the Heart Rhythm Society. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 9: 632-696.e21. PMID 22386883 DOI: 10.1016/J.Hrthm.2011.12.016  0.387
2012 Calkins H, Kuck KH, Cappato R, Brugada J, Camm AJ, Chen SA, Crijns HJ, Damiano RJ, Davies DW, DiMarco J, Edgerton J, Ellenbogen K, Ezekowitz MD, Haines DE, Haissaguerre M, ... ... Nattel S, et al. 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design. Journal of Interventional Cardiac Electrophysiology : An International Journal of Arrhythmias and Pacing. 33: 171-257. PMID 22382715 DOI: 10.1007/S10840-012-9672-7  0.402
2012 Rivard L, Hocini M, Rostock T, Cauchemez B, Forclaz A, Jadidi AS, Linton N, Nault I, Miyazaki S, Liu X, Xhaet O, Shah A, Sacher F, Derval N, Jaïs P, ... ... Nattel S, et al. Improved outcome following restoration of sinus rhythm prior to catheter ablation of persistent atrial fibrillation: a comparative multicenter study Heart Rhythm. 9: 1025-1030. PMID 22342863 DOI: 10.1016/J.Hrthm.2012.02.016  0.38
2012 Macle L, Khairy P, Verma A, Weerasooriya R, Willems S, Arentz T, Novak P, Veenhuyzen G, Scavée C, Skanes A, Puererfellner H, Jaïs P, Khaykin Y, Rivard L, Guerra PG, ... ... Nattel S, et al. Adenosine following pulmonary vein isolation to target dormant conduction elimination (ADVICE): methods and rationale. Canadian Journal of Cardiology. 28: 184-190. PMID 22217936 DOI: 10.1016/J.Cjca.2011.10.008  0.391
2012 Kato T, Iwasaki Y, Nattel S. Connexins and Atrial Fibrillation Filling in the Gaps Circulation. 125: 203-206. PMID 22158757 DOI: 10.1161/Circulationaha.111.075432  0.441
2012 Del Duca D, Tadevosyan A, Karbassi F, Akhavein F, Vaniotis G, Rodaros D, Villeneuve LR, Allen BG, Nattel S, Rohlicek CV, Hébert TE. Hypoxia in early life is associated with lasting changes in left ventricular structure and function at maturity in the rat. International Journal of Cardiology. 156: 165-73. PMID 21131074 DOI: 10.1016/J.Ijcard.2010.10.135  0.347
2012 Macle L, Khairy P, Weerasooriya R, Novak P, Verma A, Willems S, Arentz T, Deisenhofer I, Veenhuyzen Y, Scavee C, Nault I, Parkash R, Skanes A, Roux J, David D, ... ... Nattel S, et al. 812 Complications From Catheter Ablation of AF: Insights From the Contemporary Multicenter International ADVICE Trial Canadian Journal of Cardiology. 28. DOI: 10.1016/J.Cjca.2012.07.730  0.345
2011 Iwasaki Y, Nishida K, Kato T, Nattel S. Atrial Fibrillation Pathophysiology Implications for Management Circulation. 124: 2264-2274. PMID 22083148 DOI: 10.1161/Circulationaha.111.019893  0.484
2011 Nattel S. Dronedarone in atrial fibrillation--Jekyll and Hyde? The New England Journal of Medicine. 365: 2321-2322. PMID 22082122 DOI: 10.1056/Nejme1111997  0.433
2011 Farid TA, Nair K, Massé S, Azam MA, Maguy A, Lai PF, Umapathy K, Dorian P, Chauhan V, Varró A, Al-Hesayen A, Waxman M, Nattel S, Nanthakumar K. Role of KATP channels in the maintenance of ventricular fibrillation in cardiomyopathic human hearts. Circulation Research. 109: 1309-18. PMID 21980123 DOI: 10.1161/Circresaha.110.232918  0.394
2011 Makary S, Voigt N, Maguy A, Wakili R, Nishida K, Harada M, Dobrev D, Nattel S. Differential Protein Kinase C Isoform Regulation and Increased Constitutive Activity of Acetylcholine-Regulated Potassium Channels in Atrial Remodeling Circulation Research. 109: 1031-1043. PMID 21903936 DOI: 10.1161/Circresaha.111.253120  0.402
2011 Wakili R, Voigt N, Kääb S, Dobrev D, Nattel S. Recent advances in the molecular pathophysiology of atrial fibrillation Journal of Clinical Investigation. 121: 2955-2968. PMID 21804195 DOI: 10.1172/Jci46315  0.462
2011 Quinn TA, Granite S, Allessie MA, Antzelevitch C, Bollensdorff C, Bub G, Burton RA, Cerbai E, Chen PS, Delmar M, Difrancesco D, Earm YE, Efimov IR, Egger M, Entcheva E, ... ... Nattel S, et al. Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing. Progress in Biophysics and Molecular Biology. 107: 4-10. PMID 21745496 DOI: 10.1016/J.Pbiomolbio.2011.07.001  0.348
2011 Datino T, Macle L, Chartier D, Comtois P, Khairy P, Guerra PG, Fernandez-Aviles F, Nattel S. Differential effectiveness of pharmacological strategies to reveal dormant pulmonary vein conduction: a clinical-experimental correlation. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 8: 1426-33. PMID 21699824 DOI: 10.1016/J.Hrthm.2011.04.011  0.395
2011 Lemoine MD, Duverger JE, Naud P, Chartier D, Qi XY, Comtois P, Fabritz L, Kirchhof P, Nattel S. Arrhythmogenic left atrial cellular electrophysiology in a murine genetic long QT syndrome model. Cardiovascular Research. 92: 67-74. PMID 21672931 DOI: 10.1093/Cvr/Cvr166  0.452
2011 Le Quang K, Naud P, Qi XY, Duval F, Shi YF, Gillis MA, Comtois P, Tardif JC, Li D, Levesque PC, Dobrev D, Charpentier F, Nattel S. Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice. Cardiovascular Research. 91: 420-8. PMID 21622683 DOI: 10.1093/Cvr/Cvr082  0.384
2011 Tsuji Y, Hojo M, Voigt N, El-Armouche A, Inden Y, Murohara T, Dobrev D, Nattel S, Kodama I, Kamiya K. Ca2+-Related Signaling and Protein Phosphorylation Abnormalities Play Central Roles in a New Experimental Model of Electrical Storm Circulation. 123: 2192-2203. PMID 21555709 DOI: 10.1161/Circulationaha.110.016683  0.348
2011 Comtois P, Nattel S. Impact of tissue geometry on simulated cholinergic atrial fibrillation: a modeling study. Chaos (Woodbury, N.Y.). 21: 013108. PMID 21456822 DOI: 10.1063/1.3544470  0.445
2011 Nattel S, Van Wagoner DR. Atrial fibrillation: therapy with omega-3 fatty acids-is the case closed? Nature Reviews. Cardiology. 8: 126-8. PMID 21350576 DOI: 10.1038/Nrcardio.2011.11  0.404
2011 Gillis AM, Verma A, Talajic M, Nattel S, Dorian P. Canadian Cardiovascular Society atrial fibrillation guidelines 2010: rate and rhythm management. The Canadian Journal of Cardiology. 27: 47-59. PMID 21329862 DOI: 10.1016/J.Cjca.2010.11.001  0.429
2011 Nattel S. From Guidelines to Bench: Implications of Unresolved Clinical Issues for Basic Investigations of Atrial Fibrillation Mechanisms Canadian Journal of Cardiology. 27: 19-26. PMID 21329858 DOI: 10.1016/J.Cjca.2010.11.004  0.436
2011 Nattel S. A proud tradition and a new beginning with a theme issue on atrial fibrillation. Canadian Journal of Cardiology. 27: 5-6. PMID 21329855 DOI: 10.1016/J.Cjca.2010.12.001  0.395
2011 Dobrev D, Nattel S. New insights into the molecular basis of atrial fibrillation: Mechanistic and therapeutic implications Cardiovascular Research. 89: 689-691. PMID 21296897 DOI: 10.1093/Cvr/Cvr021  0.38
2011 Yeh YH, Kuo CT, Chan TH, Chang GJ, Qi XY, Tsai F, Nattel S, Chen WJ. Transforming growth factor-β and oxidative stress mediate tachycardia-induced cellular remodelling in cultured atrial-derived myocytes. Cardiovascular Research. 91: 62-70. PMID 21289011 DOI: 10.1093/Cvr/Cvr041  0.332
2011 Nishida K, Qi XY, Wakili R, Comtois P, Chartier D, Harada M, Iwasaki YK, Romeo P, Maguy A, Dobrev D, Michael G, Talajic M, Nattel S. Mechanisms of atrial tachyarrhythmias associated with coronary artery occlusion in a chronic canine model. Circulation. 123: 137-46. PMID 21200008 DOI: 10.1161/Circulationaha.110.972778  0.358
2011 Benito B, Gay-Jordi G, Serrano-Mollar A, Guasch E, Shi Y, Tardif J, Brugada J, Nattel S, Mont L. Cardiac Arrhythmogenic Remodeling in a Rat Model of Long-Term Intensive Exercise Training Circulation. 123: 13-22. PMID 21173356 DOI: 10.1161/Circulationaha.110.938282  0.342
2011 Voigt N, Makary S, Nattel S, Dobrev D. Voltage-clamp-based methods for the detection of constitutively active acetylcholine-gated I(K,ACh) channels in the diseased heart. Methods in Enzymology. 484: 653-75. PMID 21036255 DOI: 10.1016/B978-0-12-381298-8.00032-0  0.326
2011 Voigt N, Makary S, Nattel S, Dobrev D. Voltage-clamp-based methods for the detection of constitutively active acetylcholine-gated I(K,ACh) channels in the diseased heart. Methods in Enzymology. 484: 653-75. PMID 21036255 DOI: 10.1016/B978-0-12-381298-8.00032-0  0.326
2011 Yue L, Xie J, Nattel S. Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation. Cardiovascular Research. 89: 744-53. PMID 20962103 DOI: 10.1093/Cvr/Cvq329  0.485
2011 Nishida K, Maguy A, Sakabe M, Comtois P, Inoue H, Nattel S. The role of pulmonary veins vs. autonomic ganglia in different experimental substrates of canine atrial fibrillation. Cardiovascular Research. 89: 825-33. PMID 20962102 DOI: 10.1093/Cvr/Cvq332  0.466
2011 Kirchhof P, Bax J, Blomstrom-Lundquist C, Calkins H, Camm AJ, Cappato R, Cosio F, Crijns H, Diener HC, Goette A, Israel CW, Kuck KH, Lip GY, Nattel S, Page RL, et al. Early and comprehensive management of atrial fibrillation: executive summary of the proceedings from the 2nd AFNET-EHRA consensus conference 'research perspectives in AF'. European Heart Journal. 30: 2969-77c. PMID 19535417 DOI: 10.1093/Eurheartj/Ehp235  0.432
2011 Postema PG, Christiaans I, Koopmann T, Alders M, Xiao L, Varro A, Bezzina C, Nattel S, Wilde AA. Familial Idiopathic Ventricular Fibrillation Linked to Chromosome 7q36 Harboring DPP6 Journal of Arrhythmia. 27. DOI: 10.4020/Jhrs.27.Op59_4  0.316
2011 Buckley R, Nattel S. New Horizons in Atrial Fibrillation Md Conference Express. 11: 20-21. DOI: 10.1177/155989771115013  0.302
2011 Macle L, Khairy P, Verma A, Weerasooriya R, Willems S, Arentz T, Veenhuyzen G, Novak P, Skanes A, Rivard L, Dubuc M, Jaïs P, Scavée C, Khaykin Y, Nault I, ... ... Nattel S, et al. 346 Dormant conduction after pulmonary vein isolation for AF: Prevalence and predictive factors from the advice trial Canadian Journal of Cardiology. 27. DOI: 10.1016/J.Cjca.2011.07.296  0.301
2011 Nattel S. Pathophysiology of atrial fibrillation Cardiac Electrophysiology Review. 1: 20-34. DOI: 10.1002/9781119963868.Ch2  0.481
2010 Naud P, Guasch E, Nattel S. Physiological versus pathological cardiac electrical remodelling: potential basis and relevance to clinical management The Journal of Physiology. 588: 4855-4856. PMID 21173087 DOI: 10.1113/Jphysiol.2010.202556  0.406
2010 Nishida K, Sarrazin J, Fujiki A, Oral H, Inoue H, Morady F, Nattel S. Roles of the left atrial roof and pulmonary veins in the anatomic substrate for persistent atrial fibrillation and ablation in a canine model. Journal of the American College of Cardiology. 56: 1728-1736. PMID 21070924 DOI: 10.1016/J.Jacc.2010.05.051  0.449
2010 Benito B, Guasch E, Rivard L, Nattel S. Clinical and mechanistic issues in early repolarization of normal variants and lethal arrhythmia syndromes. Journal of the American College of Cardiology. 56: 1177-1186. PMID 20883924 DOI: 10.1016/J.Jacc.2010.05.037  0.344
2010 Blana A, Kaese S, Fortmüller L, Laakmann S, Damke D, Bragt Kv, Eckstein J, Piccini I, Kirchhefer U, Nattel S, Breithardt G, Carmeliet P, Carmeliet E, Schotten U, Verheule S, et al. Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability. Heart Rhythm. 7: 1862-1869. PMID 20728579 DOI: 10.1016/J.Hrthm.2010.08.016  0.488
2010 Levine RA, Nattel S. Looking into the left atrial crystal ball: a ray of hope for patients with organic mitral regurgitation. Journal of the American College of Cardiology. 56: 579-581. PMID 20688213 DOI: 10.1016/J.Jacc.2009.11.103  0.312
2010 Koo SH, Wakili R, Heo JH, Chartier D, Kim HS, Kim SJ, Lee JW, Qi XY, Nattel S, Cha TJ. Role of constitutively active acetylcholine-mediated potassium current in atrial contractile dysfunction caused by atrial tachycardia remodelling. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 12: 1490-7. PMID 20682556 DOI: 10.1093/Europace/Euq280  0.394
2010 Wakili R, Yeh Y, Qi XY, Greiser M, Chartier D, Nishida K, Maguy A, Villeneuve L, Boknik P, Voigt N, Krysiak J, Kääb S, Ravens U, Linke WA, Stienen GJM, ... ... Nattel S, et al. Multiple Potential Molecular Contributors to Atrial Hypocontractility Caused by Atrial Tachycardia Remodeling in Dogs Circulation-Arrhythmia and Electrophysiology. 3: 530-541. PMID 20660541 DOI: 10.1161/Circep.109.933036  0.386
2010 Voigt N, Trausch A, Knaut M, Matschke K, Varró A, Van Wagoner DR, Nattel S, Ravens U, Dobrev D. Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillation. Circulation. Arrhythmia and Electrophysiology. 3: 472-80. PMID 20657029 DOI: 10.1161/Circep.110.954636  0.416
2010 Souza AID, Cardin S, Wait R, Chung Y, Vijayakumar M, Maguy A, Camm AJ, Nattel S. Proteomic and metabolomic analysis of atrial profibrillatory remodelling in congestive heart failure. Journal of Molecular and Cellular Cardiology. 49: 851-863. PMID 20655923 DOI: 10.1016/J.Yjmcc.2010.07.008  0.375
2010 Guasch E, Benito B, Nattel S. Exercise training, inflammation and heart failure: working out to cool down The Journal of Physiology. 588: 2525-2526. PMID 20634182 DOI: 10.1113/Jphysiol.2010.194134  0.313
2010 Gaborit N, Varro A, Bouter SL, Szuts V, Escande D, Nattel S, Demolombe S. Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts. Journal of Molecular and Cellular Cardiology. 49: 639-646. PMID 20600101 DOI: 10.1016/J.Yjmcc.2010.06.005  0.366
2010 Nattel S. Sudden Cardio Arrest: When normal ECG variants turn lethal Nature Medicine. 16: 646-647. PMID 20526318 DOI: 10.1038/Nm0610-646  0.358
2010 Talajic M, Khairy P, Levesque S, Connolly SJ, Dorian P, Dubuc M, Guerra PG, Hohnloser SH, Lee KL, Macle L, Nattel S, Pedersen OD, Stevenson LW, Thibault B, Waldo AL, et al. Maintenance of Sinus Rhythm and Survival in Patients With Heart Failure and Atrial Fibrillation Journal of the American College of Cardiology. 55: 1796-1802. PMID 20413028 DOI: 10.1016/J.Jacc.2010.01.023  0.367
2010 Waroux JLPD, Nattel S, Dubuc M, Talajic M, Macle L. Concealed automaticity from an island of atrial myocardium post cavotricuspid ablation. Journal of Cardiovascular Electrophysiology. 21: 1408-1409. PMID 20384646 DOI: 10.1111/J.1540-8167.2010.01768.X  0.431
2010 Dobrev D, Nattel S. New antiarrhythmic drugs for treatment of atrial fibrillation The Lancet. 375: 1212-1223. PMID 20334907 DOI: 10.1016/S0140-6736(10)60096-7  0.426
2010 Farkas AS, Nattel S. Minimizing Repolarization-Related Proarrhythmic Risk in Drug Development and Clinical Practice Drugs. 70: 573-603. PMID 20329805 DOI: 10.2165/11535230-000000000-00000  0.37
2010 Nishida K, Michael G, Dobrev D, Nattel S. Animal models for atrial fibrillation: Clinical insights and scientific opportunities Europace. 12: 160-172. PMID 19875395 DOI: 10.1093/Europace/Eup328  0.411
2010 Nattel S, Frelin Y, Gaborit N, Louault C, Demolombe S. Ion-channel mRNA-expression profiling: Insights into cardiac remodeling and arrhythmic substrates. Journal of Molecular and Cellular Cardiology. 48: 96-105. PMID 19631654 DOI: 10.1016/J.Yjmcc.2009.07.016  0.392
2010 Nattel S, Frelin Y, Gaborit N, Louault C, Demolombe S. Erratum to “Ion-channel mRNA-expression profiling: Insights into cardiac remodeling and arrhythmic substrates” [J. Mol. Cell. Cardiol. 48 (2010) 96–105] Journal of Molecular and Cellular Cardiology. 48: 1335-1339. DOI: 10.1016/J.Yjmcc.2010.03.012  0.367
2010 Xiao L, Ordog B, Marmabachi M, Maguy A, Nattel S. Unique Molecular Profile of Transient Outward Potassium Current (Ito) Subunits in Cardiac Purkinje Fibers Biophysical Journal. 98: 3-5. DOI: 10.1016/J.Bpj.2009.12.1819  0.333
2009 Nattel S. Frequency-domain versus time-domain analysis: optimizing complex fractionated atrial electrogram identification for atrial fibrillation ablation. Heart Rhythm. 6: 1483-1484. PMID 19968929 DOI: 10.1016/J.Hrthm.2009.08.013  0.332
2009 Katsouras G, Sakabe M, Comtois P, Maguy A, Burstein B, Guerra PG, Talajic M, Nattel S. Differences in atrial fibrillation properties under vagal nerve stimulation versus atrial tachycardia remodeling. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 6: 1465-72. PMID 19968926 DOI: 10.1016/J.Hrthm.2009.07.034  0.451
2009 Girmatsion Z, Biliczki P, Bonauer A, Wimmer-Greinecker G, Scherer M, Moritz A, Bukowska A, Goette A, Nattel S, Hohnloser SH, Ehrlich JR. Changes in microRNA-1 expression and IK1 up-regulation in human atrial fibrillation Heart Rhythm. 6: 1802-1809. PMID 19959133 DOI: 10.1016/J.Hrthm.2009.08.035  0.403
2009 Burstein B, Comtois P, Michael G, Nishida K, Villeneuve L, Yeh YH, Nattel S. Changes in connexin expression and the atrial fibrillation substrate in congestive heart failure. Circulation Research. 105: 1213-22. PMID 19875729 DOI: 10.1161/Circresaha.108.183400  0.397
2009 Qi X, Yeh Y, Chartier D, Xiao L, Tsuji Y, Brundel BJJM, Kodama I, Nattel S. The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndrome. Circulation-Arrhythmia and Electrophysiology. 2: 295-304. PMID 19808480 DOI: 10.1161/Circep.108.815654  0.3
2009 Del Duca D, Wong G, Trieu P, Rodaros D, Kouremenos A, Tadevosyan A, Vaniotis G, Villeneuve LR, Tchervenkov CI, Nattel S, Allen BG, Hébert TE, Rohlicek CV. Association of neonatal hypoxia with lasting changes in left ventricular gene expression: an animal model. The Journal of Thoracic and Cardiovascular Surgery. 138: 538-46, 546.e1. PMID 19698832 DOI: 10.1016/J.Jtcvs.2009.04.042  0.318
2009 Kirchhof P, Bax J, Blomstrom-Lundquist C, Calkins H, Camm AJ, Cappato R, Cosio F, Crijns H, Diener HC, Goette A, Israel CW, Kuck KH, Lip GY, Nattel S, Page RL, et al. Early and comprehensive management of atrial fibrillation: proceedings from the 2nd AFNET/EHRA consensus conference on atrial fibrillation entitled 'research perspectives in atrial fibrillation'. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 11: 860-85. PMID 19531542 DOI: 10.1093/Europace/Eup124  0.434
2009 Nattel S. Cell calcium, repolarization changes, and spontaneous postshock fibrillation in failing hearts: causes of refibrillation and electrical storm. Heart Rhythm. 6: 793-795. PMID 19467506 DOI: 10.1016/J.Hrthm.2009.03.019  0.368
2009 Chauvet C, Ménard A, Tremblay J, Xiao C, Shi Y, L'Heureux N, Cardin S, Tardif JC, Nattel S, Deng AY. Cardiac pathways distinguish two epistatic modules enacting BP quantitative trait loci and candidate gene analysis. Hypertension Research : Official Journal of the Japanese Society of Hypertension. 32: 631-7. PMID 19461651 DOI: 10.1038/Hr.2009.70  0.315
2009 Ehrlich JR, Nattel S. Novel Approaches for Pharmacological Management of Atrial Fibrillation Drugs. 69: 757-774. PMID 19441867 DOI: 10.2165/00003495-200969070-00001  0.416
2009 Maguy A, Le Bouter S, Comtois P, Chartier D, Villeneuve L, Wakili R, Nishida K, Nattel S. Ion channel subunit expression changes in cardiac Purkinje fibers: a potential role in conduction abnormalities associated with congestive heart failure. Circulation Research. 104: 1113-22. PMID 19359601 DOI: 10.1161/Circresaha.108.191809  0.39
2009 Ly HQ, Nattel S. Stem cells are not proarrhythmic: letting the genie out of the bottle. Circulation. 119: 1824-31. PMID 19349335 DOI: 10.1161/Circulationaha.108.812701  0.39
2009 Nattel S. Calcium‐activated potassium current: a novel ion channel candidate in atrial fibrillation The Journal of Physiology. 587: 1385-1386. PMID 19336611 DOI: 10.1113/Jphysiol.2009.170621  0.446
2009 Joyner MJ, Nattel S. Fast and furious: New ways to think about, study and treat cardiac arrhythmias Journal of Physiology. 587: 1383-1384. PMID 19336610 DOI: 10.1113/Jphysiol.2009.170936  0.342
2009 Yeh YH, Burstein B, Qi XY, Sakabe M, Chartier D, Comtois P, Wang Z, Kuo CT, Nattel S. Funny current downregulation and sinus node dysfunction associated with atrial tachyarrhythmia: a molecular basis for tachycardia-bradycardia syndrome. Circulation. 119: 1576-85. PMID 19289641 DOI: 10.1161/Circulationaha.108.789677  0.359
2009 Benjamin EJ, Chen PS, Bild DE, Mascette AM, Albert CM, Alonso A, Calkins H, Connolly SJ, Curtis AB, Darbar D, Ellinor PT, Go AS, Goldschlager NF, Heckbert SR, Jalife J, ... ... Nattel S, et al. Prevention of atrial fibrillation: report from a national heart, lung, and blood institute workshop. Circulation. 119: 606-18. PMID 19188521 DOI: 10.1161/Circulationaha.108.825380  0.453
2009 Lemola K, Khan R, Nattel S, Talajic M, Roy D, Guerra PG, Lemola S, Dubuc M, Thibault B, Macle L, Khairy P. Ventricular proarrhythmic effects of atrial fibrillation are modulated by depolarization and repolarization anomalies in patients with left ventricular dysfunction Pace - Pacing and Clinical Electrophysiology. 32: 99-105. PMID 19140919 DOI: 10.1111/J.1540-8159.2009.02182.X  0.438
2009 Nattel S. G-protein signaling and arrhythmogenic atrial remodeling: relevance to novel therapeutic targets in atrial fibrillation. Heart Rhythm. 6: 85-86. PMID 19121806 DOI: 10.1016/J.Hrthm.2008.11.028  0.385
2009 Greiser M, Neuberger HR, Harks E, El-Armouche A, Boknik P, de Haan S, Verheyen F, Verheule S, Schmitz W, Ravens U, Nattel S, Allessie MA, Dobrev D, Schotten U. Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation. Journal of Molecular and Cellular Cardiology. 46: 385-94. PMID 19100271 DOI: 10.1016/J.Yjmcc.2008.11.012  0.48
2009 Ehrlich JR, Nattel S. Atrial-selective pharmacological therapy for atrial fibrillation: hype or hope? Current Opinion in Cardiology. 24: 50-55. PMID 19077816 DOI: 10.1097/Hco.0B013E32831Bc336  0.435
2009 Gaborit N, Wichter T, Varro A, Szuts V, Lamirault G, Eckardt L, Paul M, Breithardt G, Schulze-Bahr E, Escande D, Nattel S, Demolombe S. Transcriptional profiling of ion channel genes in Brugada syndrome and other right ventricular arrhythmogenic diseases. European Heart Journal. 30: 487-496. PMID 19029124 DOI: 10.1093/Eurheartj/Ehn520  0.381
2009 Michael G, Xiao L, Qi XY, Dobrev D, Nattel S. Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis. Cardiovascular Research. 81: 491-9. PMID 18826964 DOI: 10.1093/Cvr/Cvn266  0.448
2009 Shiroshita-Takeshita A, Mitamura H, Ogawa S, Nattel S. Rate-dependence of atrial tachycardia effects on atrial refractoriness and atrial fibrillation maintenance. Cardiovascular Research. 81: 90-97. PMID 18801748 DOI: 10.1093/Cvr/Cvn249  0.42
2009 Demolombe S, Gaborit N, Wichter T, Paul M, Lamirault G, Varro A, Schulze-Bahr E, Escande D, Nattel S. G004 Transcriptional profiling of ion channel genes in right-ventricular myocardial diseases: particular signature for brugada syndrome Archives of Cardiovascular Diseases. 102. DOI: 10.1016/S1875-2136(09)72279-X  0.379
2008 Yeh YH, Wakili R, Qi XY, Chartier D, Boknik P, Kääb S, Ravens U, Coutu P, Dobrev D, Nattel S. Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure. Circulation. Arrhythmia and Electrophysiology. 1: 93-102. PMID 19808399 DOI: 10.1161/Circep.107.754788  0.435
2008 Nattel S, Burstein B, Dobrev D. Atrial remodeling and atrial fibrillation: mechanisms and implications Circulation. Arrhythmia and Electrophysiology. 1: 62-73. PMID 19808395 DOI: 10.1161/Circep.107.754564  0.474
2008 Nattel S, Duker G, Carlsson L. Model systems for the discovery and development of antiarrhythmic drugs. Progress in Biophysics & Molecular Biology. 98: 328-339. PMID 19038282 DOI: 10.1016/J.Pbiomolbio.2008.10.009  0.46
2008 Nattel S. Delayed-rectifier potassium currents and the control of cardiac repolarization: Noble and Tsien 40 years after. The Journal of Physiology. 586: 5849-5852. PMID 18955376 DOI: 10.1113/Jphysiol.2008.163089  0.413
2008 Ke L, Qi XY, Dijkhuis AJ, Chartier D, Nattel S, Henning RH, Kampinga HH, Brundel BJ. Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation. Journal of Molecular and Cellular Cardiology. 45: 685-93. PMID 18823990 DOI: 10.1016/J.Yjmcc.2008.08.012  0.451
2008 Van Wagoner DR, Nattel S. Insights into mechanisms linking cardiac hypertrophy and atrial fibrosis: evidence for a role of histone deacetylase in atrial fibrillation pathophysiology and therapy. Journal of Molecular and Cellular Cardiology. 45: 707-8. PMID 18817781 DOI: 10.1016/J.Yjmcc.2008.09.001  0.452
2008 Deng AY, Nattel S, Shi Y, L'heureux N, Cardin S, Ménard A, Roy J, Tardif JC. Distinct genomic replacements from Lewis correct diastolic dysfunction, attenuate hypertension, and reduce left ventricular hypertrophy in Dahl salt-sensitive rats. Journal of Hypertension. 26: 1935-43. PMID 18806617 DOI: 10.1097/Hjh.0B013E32830A9A5E  0.315
2008 Cardin S, Pelletier P, Libby E, Le Bouter S, Xiao L, Kääb S, Demolombe S, Glass L, Nattel S. Marked differences between atrial and ventricular gene-expression remodeling in dogs with experimental heart failure Journal of Molecular and Cellular Cardiology. 45: 821-831. PMID 18805423 DOI: 10.1016/J.Yjmcc.2008.08.007  0.375
2008 Dobrev D, Nattel S. Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics Journal of Cardiovascular Pharmacology. 52: 293-299. PMID 18791467 DOI: 10.1097/Fjc.0B013E318171924D  0.432
2008 Palardy M, Ducharme A, Nattel S, Tardif JC, White M, Racine N, Tétreault K, Dabouz F, Talajic M, Roy D. Absence of protective effect of renin-angiotensin system inhibitors on atrial fibrillation development: Insights from the Canadian Trail of Atrial Fibrillation (CTAF) Canadian Journal of Cardiology. 24: 709-713. PMID 18787722 DOI: 10.1016/S0828-282X(08)70670-6  0.397
2008 Nattel S. Inward rectifier–funny current balance and spontaneous automaticity: Cautionary notes for biologic pacemaker development Heart Rhythm. 5: 1318-1319. PMID 18774109 DOI: 10.1016/J.Hrthm.2008.06.014  0.326
2008 Xiao L, Coutu P, Villeneuve LR, Tadevosyan A, Maguy A, Le Bouter S, Allen BG, Nattel S. Mechanisms underlying rate-dependent remodeling of transient outward potassium current in canine ventricular myocytes. Circulation Research. 103: 733-42. PMID 18723449 DOI: 10.1161/Circresaha.108.171157  0.362
2008 Qi XY, Yeh Y, Xiao L, Burstein B, Maguy A, Chartier D, Villeneuve LR, Brundel BJJM, Dobrev D, Nattel S. Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current Circulation Research. 103: 845-854. PMID 18723446 DOI: 10.1161/Circresaha.108.175463  0.364
2008 Xiao L, Xiao J, Luo X, Lin H, Wang Z, Nattel S. Feedback Remodeling of Cardiac Potassium Current Expression A Novel Potential Mechanism for Control of Repolarization Reserve Circulation. 118: 983-992. PMID 18711016 DOI: 10.1161/Circulationaha.107.758672  0.389
2008 Comtois P, Sakabe M, Vigmond EJ, Munoz M, Texier A, Shiroshita-Takeshita A, Nattel S. Mechanisms of atrial fibrillation termination by rapidly unbinding Na+ channel blockers: insights from mathematical models and experimental correlates. American Journal of Physiology. Heart and Circulatory Physiology. 295: H1489-504. PMID 18676686 DOI: 10.1152/Ajpheart.01054.2007  0.466
2008 Burstein B, Nattel S. Atrial structural remodeling as an antiarrhythmic target. Journal of Cardiovascular Pharmacology. 52: 4-10. PMID 18594481 DOI: 10.1097/Fjc.0B013E3181668057  0.411
2008 Nattel S. Evolving developments in the therapeutics of atrial fibrillation: addressing an unmet need. Journal of Cardiovascular Pharmacology. 52: 1-3. PMID 18594478 DOI: 10.1097/Fjc.0B013E31817B87A1  0.424
2008 Sun H, Varela D, Chartier D, Ruben PC, Nattel S, Zamponi GW, Leblanc N. Differential interactions of Na+ channel toxins with T-type Ca2+ channels. The Journal of General Physiology. 132: 101-13. PMID 18591418 DOI: 10.1085/Jgp.200709883  0.316
2008 Roy D, Talajic M, Nattel S, Wyse DG, Dorian P, Lee KL, Bourassa MG, Arnold JM, Buxton AE, Camm AJ, Connolly SJ, Dubuc M, Ducharme A, Guerra PG, Hohnloser SH, et al. Rhythm control versus rate control for atrial fibrillation and heart failure. The New England Journal of Medicine. 358: 2667-77. PMID 18565859 DOI: 10.1056/Nejmoa0708789  0.43
2008 Stillitano F, Lonardo G, Zicha S, Varro A, Cerbai E, Mugelli A, Nattel S. Molecular basis of funny current (If) in normal and failing human heart. Journal of Molecular and Cellular Cardiology. 45: 289-299. PMID 18556018 DOI: 10.1016/J.Yjmcc.2008.04.013  0.395
2008 Nattel S. Effects of Heart Disease on Cardiac Ion Current Density Versus Current Amplitude Important Conceptual Subtleties in the Language of Arrhythmogenic Ion Channel Remodeling Circulation Research. 102: 1298-1300. PMID 18535265 DOI: 10.1161/Circresaha.108.178087  0.414
2008 Nattel S. Complex fractionated atrial electrograms: can they be made simple? Heart Rhythm. 5: 855-856. PMID 18534370 DOI: 10.1016/J.Hrthm.2008.04.011  0.393
2008 Andalib A, Brugada R, Nattel S. Atrial fibrillation: evidence for genetically determined disease. Current Opinion in Cardiology. 23: 176-83. PMID 18382204 DOI: 10.1097/Hco.0B013E3282Fa7142  0.389
2008 Diness TG, Yeh YH, Qi XY, Chartier D, Tsuji Y, Hansen RS, Olesen SP, Grunnet M, Nattel S. Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome. Cardiovascular Research. 79: 61-9. PMID 18367457 DOI: 10.1093/Cvr/Cvn075  0.408
2008 Burstein B, Libby E, Calderone A, Nattel S. Differential behaviors of atrial versus ventricular fibroblasts: a potential role for platelet-derived growth factor in atrial-ventricular remodeling differences. Circulation. 117: 1630-41. PMID 18347210 DOI: 10.1161/Circulationaha.107.748053  0.406
2008 Brundel BJ, Ke L, Dijkhuis AJ, Qi X, Shiroshita-Takeshita A, Nattel S, Henning RH, Kampinga HH. Heat shock proteins as molecular targets for intervention in atrial fibrillation. Cardiovascular Research. 78: 422-8. PMID 18326558 DOI: 10.1093/Cvr/Cvn060  0.44
2008 Shimano M, Tsuji Y, Inden Y, Kitamura K, Uchikawa T, Harata S, Nattel S, Murohara T. Pioglitazone, a peroxisome proliferator-activated receptor-gamma activator, attenuates atrial fibrosis and atrial fibrillation promotion in rabbits with congestive heart failure Heart Rhythm. 5: 451-459. PMID 18313605 DOI: 10.1016/J.Hrthm.2007.12.010  0.474
2008 Burstein B, Nattel S. Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation. Journal of the American College of Cardiology. 51: 802-809. PMID 18294563 DOI: 10.1016/J.Jacc.2007.09.064  0.449
2008 Ehrlich JR, Biliczki P, Hohnloser SH, Nattel S. Atrial-selective approaches for the treatment of atrial fibrillation. Journal of the American College of Cardiology. 51: 787-792. PMID 18294561 DOI: 10.1016/J.Jacc.2007.08.067  0.45
2008 Sakabe M, Shiroshita-Takeshita A, Maguy A, Brundel BJJM, Fujiki A, Inoue H, Nattel S. Effects of a heat shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischaemia. Cardiovascular Research. 78: 63-70. PMID 18238941 DOI: 10.1093/Cvr/Cvn019  0.358
2008 Lemola K, Chartier D, Yeh YH, Dubuc M, Cartier R, Armour A, Ting M, Sakabe M, Shiroshita-Takeshita A, Comtois P, Nattel S. Pulmonary vein region ablation in experimental vagal atrial fibrillation: role of pulmonary veins versus autonomic ganglia. Circulation. 117: 470-7. PMID 18195170 DOI: 10.1161/Circulationaha.107.737023  0.414
2008 Burstein B, Nishida K, Comtois P, Villenuve L, Yeh Y, Leung T, Nattel S. RELATIVE CONTRIBUTIONS OF FIBROSIS AND CONNEXIN CHANGES TOTHE ATRIAL FIBRILLATION SUBSTRATE DURING THE DEVELOPMENT AND REVERSAL OF CONGESTIVEHEART FAILURE Clinical & Investigative Medicine. 31: 5. DOI: 10.25011/Cim.V31I4.4793  0.399
2007 Cherry EM, Ehrlich JR, Nattel S, Fenton FH. Pulmonary vein reentry--properties and size matter: insights from a computational analysis. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 4: 1553-62. PMID 18068635 DOI: 10.1016/J.Hrthm.2007.08.017  0.379
2007 Voigt N, Maguy A, Yeh Y, Qi X, Ravens U, Dobrev D, Nattel S. Changes in I K, ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes. Cardiovascular Research. 77: 35-43. PMID 18006448 DOI: 10.1093/Cvr/Cvm051  0.437
2007 Sakabe M, Shiroshita-Takeshita A, Maguy A, Dumesnil C, Nigam A, Leung TK, Nattel S. Omega-3 polyunsaturated fatty acids prevent atrial fibrillation associated with heart failure but not atrial tachycardia remodeling. Circulation. 116: 2101-9. PMID 17967774 DOI: 10.1161/Circulationaha.107.704759  0.476
2007 Burstein B, Maguy A, Clément R, Gosselin H, Poulin F, Ethier N, Tardif JC, Hébert TE, Calderone A, Nattel S. Effects of resveratrol (trans-3,5,4'-trihydroxystilbene) treatment on cardiac remodeling following myocardial infarction. The Journal of Pharmacology and Experimental Therapeutics. 323: 916-23. PMID 17875610 DOI: 10.1124/Jpet.107.127548  0.373
2007 Burstein B, Qi XY, Yeh YH, Calderone A, Nattel S. Atrial cardiomyocyte tachycardia alters cardiac fibroblast function: a novel consideration in atrial remodeling. Cardiovascular Research. 76: 442-52. PMID 17720149 DOI: 10.1016/J.Cardiores.2007.07.013  0.487
2007 Ehrlich JR, Nattel S, Hohnloser SH. Novel anti-arrhythmic drugs for atrial fibrillation management. Current Vascular Pharmacology. 5: 185-194. PMID 17627562 DOI: 10.2174/157016107781024073  0.441
2007 Yeh YH, Qi X, Shiroshita-Takeshita A, Liu J, Maguy A, Chartier D, Hebert T, Wang Z, Nattel S. Atrial tachycardia induces remodelling of muscarinic receptors and their coupled potassium currents in canine left atrial and pulmonary vein cardiomyocytes. British Journal of Pharmacology. 152: 1021-32. PMID 17618308 DOI: 10.1038/sj.bjp.0707376  0.342
2007 El-Armouche A, Pohlmann L, Schlossarek S, Starbatty J, Yeh Y, Nattel S, Dobrev D, Eschenhagen T, Carrier L. Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure Journal of Molecular and Cellular Cardiology. 43: 223-229. PMID 17560599 DOI: 10.1016/J.Yjmcc.2007.05.003  0.347
2007 Shimano M, Tsuji Y, Yoshida Y, Inden Y, Tsuboi N, Itoh T, Suzuki H, Muramatsu T, Okada T, Harata S, Yamada T, Hirayama H, Nattel S, Murohara T. Acute and chronic effects of cardiac resynchronization in patients developing heart failure with long-term pacemaker therapy for acquired complete atrioventricular block. Europace. 9: 869-874. PMID 17557768 DOI: 10.1093/Europace/Eum119  0.397
2007 Nattel S. The heart on a chip: the role of realistic mathematical models of cardiac electrical activity in understanding and treating cardiac arrhythmias. Heart Rhythm. 4: 779-780. PMID 17556202 DOI: 10.1016/J.Hrthm.2007.03.038  0.412
2007 Abi-Char J, Maguy A, Coulombe A, Balse E, Ratajczak P, Samuel J, Nattel S, Hatem SN. Membrane cholesterol modulates Kv1.5 potassium channel distribution and function in rat cardiomyocytes The Journal of Physiology. 582: 1205-1217. PMID 17525113 DOI: 10.1113/Jphysiol.2007.134809  0.301
2007 Gaborit N, Bouter SL, Szuts V, Varro A, Escande D, Nattel S, Demolombe S. Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart The Journal of Physiology. 582: 675-693. PMID 17478540 DOI: 10.1113/Jphysiol.2006.126714  0.366
2007 Li D, Nattel S. Pharmacological elimination of motion artifacts during optical imaging of cardiac tissues: Is blebbistatin the answer? Heart Rhythm. 4: 627-628. PMID 17467632 DOI: 10.1016/J.Hrthm.2007.01.013  0.317
2007 Nattel S, Maguy A, Bouter SL, Yeh Y. Arrhythmogenic Ion-Channel Remodeling in the Heart: Heart Failure, Myocardial Infarction, and Atrial Fibrillation Physical Review. 87: 425-456. PMID 17429037 DOI: 10.1152/Physrev.00014.2006  0.449
2007 Yeh YH, Ehrlich JR, Qi X, Hébert TE, Chartier D, Nattel S. Adrenergic control of a constitutively active acetylcholine-regulated potassium current in canine atrial cardiomyocytes. Cardiovascular Research. 74: 406-15. PMID 17343836 DOI: 10.1016/J.Cardiores.2007.01.020  0.482
2007 Nattel S, Comtois P. Teasing out circadian variability in heart rate turbulence: A new approach to detecting biorhythms underlying cardiac function. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 4: 301-3. PMID 17341392 DOI: 10.1016/J.Hrthm.2006.12.024  0.344
2007 Rivard L, Sinno H, Shiroshita-Takeshita A, Schram G, Leung TK, Nattel S. The pharmacological response of ischemia-related atrial fibrillation in dogs: evidence for substrate-specific efficacy. Cardiovascular Research. 74: 104-13. PMID 17316585 DOI: 10.1016/J.Cardiores.2007.01.018  0.417
2007 Shiroshita-Takeshita A, Brundel BJ, Burstein B, Leung TK, Mitamura H, Ogawa S, Nattel S. Effects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failure. Cardiovascular Research. 74: 75-84. PMID 17270161 DOI: 10.1016/J.Cardiores.2007.01.002  0.354
2007 Cardin S, Libby E, Pelletier P, Le Bouter S, Shiroshita-Takeshita A, Le Meur N, Léger J, Demolombe S, Ponton A, Glass L, Nattel S. Contrasting gene expression profiles in two canine models of atrial fibrillation. Circulation Research. 100: 425-33. PMID 17234964 DOI: 10.1161/01.Res.0000258428.09589.1A  0.392
2007 Shiroshita-Takeshita A, Sakabe M, Haugan K, Hennan JK, Nattel S. Model-Dependent Effects of the Gap Junction Conduction–Enhancing Antiarrhythmic Peptide Rotigaptide (ZP123) on Experimental Atrial Fibrillation in Dogs Circulation. 115: 310-318. PMID 17224477 DOI: 10.1161/Circulationaha.106.665547  0.459
2007 Burstein B, Qi X, Calderone A, Nattel S. Rapid electrical pacing of cardiomyocytes alters the behavior of cardiac fibroblasts: Implications for atrial fibrillations Clinical and Investigative Medicine. 30: 75-76. DOI: 10.25011/Cim.V30I4.2843  0.388
2007 Nattel S. S2-1 Electrophysiologic Mechanism Of Atrial Fibrillation: From Bench To Bedside International Journal of Cardiology. 122. DOI: 10.1016/S0167-5273(08)70303-6  0.416
2006 Nattel S, Carlsson L. Innovative approaches to anti-arrhythmic drug therapy. Nature Reviews Drug Discovery. 5: 1034-1049. PMID 17139288 DOI: 10.1038/Nrd2112  0.436
2006 Brundel BJJM, Shiroshita-Takeshita A, Qi X, Yeh Y, Chartier D, Gelder ICv, Henning RH, Kampinga HH, Nattel S. Induction of Heat Shock Response Protects the Heart Against Atrial Fibrillation Circulation Research. 99: 1394-1402. PMID 17110598 DOI: 10.1161/01.Res.0000252323.83137.Fe  0.407
2006 Nattel S. Inappropriate sinus tachycardia and beta-receptor autoantibodies: A mechanistic breakthrough? Heart Rhythm. 3: 1187-1188. PMID 17018349 DOI: 10.1016/J.Hrthm.2006.07.019  0.304
2006 Nattel S. Preoperative atrial cardiomyocyte ionic currents and postoperative AF: important insights into what is not the mechanism. Journal of Cardiovascular Electrophysiology. 17: 1239-41. PMID 16995887 DOI: 10.1111/j.1540-8167.2006.00625.x  0.337
2006 White DE, Coutu P, Shi YF, Tardif JC, Nattel S, St Arnaud R, Dedhar S, Muller WJ. Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure. Genes & Development. 20: 2355-60. PMID 16951252 DOI: 10.1101/Gad.1458906  0.36
2006 Ehrlich JR, Hoche C, Coutu P, Metz-Weidmann C, Dittrich W, Hohnloser SH, Nattel S, Gögelein H. Properties of a time-dependent potassium current in pig atrium: evidence for a role of kv1.5 in repolarization. The Journal of Pharmacology and Experimental Therapeutics. 319: 898-906. PMID 16916995 DOI: 10.1124/Jpet.106.110080  0.312
2006 Coutu P, Chartier D, Nattel S. Comparison of Ca2+-handling properties of canine pulmonary vein and left atrial cardiomyocytes. American Journal of Physiology. Heart and Circulatory Physiology. 291: H2290-300. PMID 16798822 DOI: 10.1152/Ajpheart.00730.2005  0.374
2006 Nattel S. Ventricular tachyarrhythmia induction by strong cardiac shocks: can understanding underlying mechanisms lead to improved prevention of defibrillator failure? Heart Rhythm. 3: 596-597. PMID 16648067 DOI: 10.1016/J.Hrthm.2006.03.024  0.399
2006 Cha T, Ehrlich JR, Chartier D, Qi X, Xiao L, Nattel S. Kir3-Based Inward Rectifier Potassium Current Potential Role in Atrial Tachycardia Remodeling Effects on Atrial Repolarization and Arrhythmias Circulation. 113: 1730-1737. PMID 16585394 DOI: 10.1161/Circulationaha.105.561738  0.445
2006 Xiao L, Zhang L, Han W, Wang Z, Nattel S. Sex-based transmural differences in cardiac repolarization and ionic-current properties in canine left ventricles. American Journal of Physiology-Heart and Circulatory Physiology. 291. PMID 16501015 DOI: 10.1152/Ajpheart.01288.2005  0.348
2006 Tsuji Y, Zicha S, Qi X, Kodama I, Nattel S. Potassium Channel Subunit Remodeling in Rabbits Exposed to Long-Term Bradycardia or Tachycardia Discrete Arrhythmogenic Consequences Related to Differential Delayed-Rectifier Changes Circulation. 113: 345-355. PMID 16432066 DOI: 10.1161/Circulationaha.105.552968  0.439
2006 Nattel S, Opie LH. Controversies in atrial fibrillation. Lancet (London, England). 367: 262-72. PMID 16427496 DOI: 10.1016/S0140-6736(06)68037-9  0.443
2006 Carlsson L, Chartier D, Nattel S. Characterization of the in vivo and in vitro electrophysiological effects of the novel antiarrhythmic agent AZD7009 in atrial and ventricular tissue of the dog. Journal of Cardiovascular Pharmacology. 47: 123-132. PMID 16424796 DOI: 10.1097/01.Fjc.0000196242.04384.C3  0.391
2006 Maguy A, Hebert TE, Nattel S. Involvement of lipid rafts and caveolae in cardiac ion channel function. Cardiovascular Research. 69: 798-807. PMID 16405931 DOI: 10.1016/J.Cardiores.2005.11.013  0.347
2006 Shiroshita-Takeshita A, Brundel BJJM, Lavoie J, Nattel S. Prednisone prevents atrial fibrillation promotion by atrial tachycardia remodeling in dogs Cardiovascular Research. 69: 865-875. PMID 16405878 DOI: 10.1016/J.Cardiores.2005.11.028  0.402
2006 Ehrlich JR, Hohnloser SH, Nattel S. Role of angiotensin system and effects of its inhibition in atrial fibrillation: clinical and experimental evidence. European Heart Journal. 27: 512-518. PMID 16311236 DOI: 10.1093/Eurheartj/Ehi668  0.464
2006 Lamirault G, Gaborit N, Le Meur N, Chevalier C, Lande G, Demolombe S, Escande D, Nattel S, Léger JJ, Steenman M. Gene expression profile associated with chronic atrial fibrillation and underlying valvular heart disease in man. Journal of Molecular and Cellular Cardiology. 40: 173-84. PMID 16242148 DOI: 10.1016/J.Yjmcc.2005.09.004  0.407
2006 Brundel BJJM, Melnyk P, Rivard L, Nattel S. Corrigendum to "The pathology of atrial fibrillation in dogs" [J Vet Cardiol 7 (2005) 121-129] (DOI:10.1016/j.jvc.2005.07.001) Journal of Veterinary Cardiology. 8: 167. DOI: 10.1016/J.Jvc.2006.08.001  0.401
2006 Shiroshita-Takeshita A, Maltais C, Ford J, Madge D, Pinnock R, Nattel S. P3-17: Electrophysiological and atrial antiarrhythmic effects of a novel IKUR/Kv1.5 blocker in dogs with atrial tachycardia remodeling Heart Rhythm. 3. DOI: 10.1016/J.Hrthm.2006.02.549  0.462
2006 Shiroshita-Takeshita A, Sakabe M, Haugan K, Hennan JK, Nattel S. AB46-4: Model-dependent effects of a gap junction conduction enhancing antiarrhythmic peptide (rotigaptide) on experimental atrial fibrillation Heart Rhythm. 3. DOI: 10.1016/J.Hrthm.2006.02.291  0.356
2005 Brundel BJ, Melnyk P, Rivard L, Nattel S. The pathology of atrial fibrillation in dogs. Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology. 7: 121-9. PMID 19083327 DOI: 10.1016/J.Jvc.2005.07.001  0.445
2005 Syed Z, Vigmond E, Nattel S, Leon LJ. Atrial cell action potential parameter fitting using genetic algorithms. Medical & Biological Engineering & Computing. 43: 561-71. PMID 16411628 DOI: 10.1007/Bf02351029  0.324
2005 Nattel S. Pulmonary vein cellular electrophysiology and atrial fibrillation: Does basic research help us understand clinical pulmonary-vein arrhythmogenesis? Heart Rhythm. 2: 1346. PMID 16360088 DOI: 10.1016/J.Hrthm.2005.10.020  0.335
2005 Nattel S. Can losartan prevent new-onset atrial fibrillation in hypertensive patients more effectively than atenolol? Nature Reviews Cardiology. 2: 332-333. PMID 16265553 DOI: 10.1038/Ncpcardio0247  0.392
2005 Roy D, Talajic M, Dubuc M, Thibault B, Guerra PG, Macle L, Gagné P, Khairy P, Nattel S. Atrial fibrillation: Basic and clinical research at the Montreal Heart Institute Canadian Journal of Cardiology. 21: 1091-1096. PMID 16234895  0.342
2005 Nattel S, Shiroshita-Takeshita A, Brundel BJJM, Rivard L. Mechanisms of atrial fibrillation: lessons from animal models. Progress in Cardiovascular Diseases. 48: 9-28. PMID 16194689 DOI: 10.1016/J.Pcad.2005.06.002  0.415
2005 Shiroshita-Takeshita A, Brundel BJJM, Nattel S. Atrial fibrillation: basic mechanisms, remodeling and triggers. Journal of Interventional Cardiac Electrophysiology. 13: 181-193. PMID 16177845 DOI: 10.1007/S10840-005-2362-Y  0.451
2005 Nattel S. Aldosterone antagonism and atrial fibrillation: time for clinical assessment? European Heart Journal. 26: 2079-2080. PMID 16141259 DOI: 10.1093/Eurheartj/Ehi477  0.489
2005 Comtois P, Kneller J, Nattel S. Of circles and spirals: bridging the gap between the leading circle and spiral wave concepts of cardiac reentry. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 10-20. PMID 16102499 DOI: 10.1016/J.Eupc.2005.05.011  0.312
2005 Ehrlich JR, Zicha S, Coutu P, Hébert TE, Nattel S. Atrial fibrillation-associated minK38G/S polymorphism modulates delayed rectifier current and membrane localization. Cardiovascular Research. 67: 520-8. PMID 16039273 DOI: 10.1016/J.Cardiores.2005.03.007  0.371
2005 Gaborit N, Steenman M, Lamirault G, Meur NL, Bouter SL, Lande G, Léger J, Charpentier F, Christ T, Dobrev D, Escande D, Nattel S, Demolombe S. Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation. Circulation. 112: 471-481. PMID 16027256 DOI: 10.1161/Circulationaha.104.506857  0.44
2005 Nattel S. Specific potassium channel blockade for arrhythmia prevention in the ionically remodeled failing heart: peril or panacea? Heart Rhythm. 2: 739-740. PMID 15992731 DOI: 10.1016/J.Hrthm.2005.04.026  0.406
2005 Hesketh JC, Herrera D, Zicha S, Nattel S. Novel Targets for Cardiac Antiarrhythmic Drug Development Current Pharmaceutical Design. 11: 1959-1974. PMID 15974970 DOI: 10.2174/1381612054021051  0.411
2005 Fang Y, Schram G, Romanenko VG, Shi C, Conti L, Vandenberg CA, Davies PF, Nattel S, Levitan I. Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2. American Journal of Physiology. Cell Physiology. 289: C1134-44. PMID 15958527 DOI: 10.1152/Ajpcell.00077.2005  0.316
2005 Nattel S. Combined parasympathetic-sympathetic nerve discharge and pulmonary vein afterdepolarizations: a new unifying concept with basic and clinical relevance. Heart Rhythm. 2: 632-633. PMID 15922272 DOI: 10.1016/J.Hrthm.2005.03.001  0.465
2005 Zicha S, Fernández-Velasco M, Lonardo G, L'Heureux N, Nattel S. Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model Cardiovascular Research. 66: 472-481. PMID 15914112 DOI: 10.1016/J.Cardiores.2005.02.011  0.351
2005 Nattel S. Regional discrepancies in ionic currents and arrhythmia susceptibility: clinical relevance. Heart Rhythm. 2: 177-178. PMID 15851293 DOI: 10.1016/J.Hrthm.2004.11.007  0.364
2005 Zou R, Kneller J, Leon LJ, Nattel S. Substrate size as a determinant of fibrillatory activity maintenance in a mathematical model of canine atrium American Journal of Physiology-Heart and Circulatory Physiology. 289. PMID 15849234 DOI: 10.1152/Ajpheart.00252.2005  0.343
2005 Pandit SV, Berenfeld O, Anumonwo JM, Zaritski RM, Kneller J, Nattel S, Jalife J. Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillation. Biophysical Journal. 88: 3806-21. PMID 15792974 DOI: 10.1529/Biophysj.105.060459  0.41
2005 Kneller J, Kalifa J, Zou R, Zaitsev AV, Warren M, Berenfeld O, Vigmond EJ, Leon LJ, Nattel S, Jalife J. Mechanisms of atrial fibrillation termination by pure sodium channel blockade in an ionically-realistic mathematical model. Circulation Research. 96: e35-47. PMID 15731458 DOI: 10.1161/01.Res.0000160709.49633.2B  0.449
2005 Cha TJ, Ehrlich JR, Zhang L, Chartier D, Leung TK, Nattel S. Atrial tachycardia remodeling of pulmonary vein cardiomyocytes: comparison with left atrium and potential relation to arrhythmogenesis. Circulation. 111: 728-35. PMID 15699259 DOI: 10.1161/01.Cir.0000155240.05251.D0  0.458
2005 Nattel S, Schott J. Arrhythmogenic right ventricular dysplasia type 1 and mutations in transforming growth factor β3 gene regulatory regions: a breakthrough? Cardiovascular Research. 65: 302-304. PMID 15639468 DOI: 10.1016/J.Cardiores.2004.11.023  0.314
2005 Melnyk P, Ehrlich JR, Pourrier M, Villeneuve L, Cha TJ, Nattel S. Comparison of ion channel distribution and expression in cardiomyocytes of canine pulmonary veins versus left atrium. Cardiovascular Research. 65: 104-16. PMID 15621038 DOI: 10.1016/J.Cardiores.2004.08.014  0.395
2005 Nattel S, Shiroshita-Takeshita A, Cardin S, Pelletier P. Mechanisms of atrial remodeling and clinical relevance. Current Opinion in Cardiology. 20: 21-5. PMID 15596955  0.381
2005 Rivard L, Shiroshita-Takeshita A, Maltais C, Ford J, Pinnock R, Madge D, Nattel S. Electrophysiological and atrial antiarrhythmic effects of a novel IKur/Kv1.5 blocker in dogs Heart Rhythm. 2. DOI: 10.1016/J.Hrthm.2005.02.561  0.458
2005 Shiroshita-Takeshita A, Cardin S, Mitamura H, Ogawa S, Nattel S. The beneficial effects of a novel specific chymase inhibitor, SUNC8257, on congestive heart failure-related atrial remodeling in dogs Heart Rhythm. 2. DOI: 10.1016/J.Hrthm.2005.02.296  0.383
2004 Li GR, Lau CP, Leung TK, Nattel S. Ionic current abnormalities associated with prolonged action potentials in cardiomyocytes from diseased human right ventricles. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 1: 460-8. PMID 15851200 DOI: 10.1016/J.Hrthm.2004.06.003  0.404
2004 Nattel S. Age, gender, and supraventricular arrhythmias: roles of ion channels, connexins, and tissue architecture? Heart Rhythm. 1: 397-398. PMID 15851190 DOI: 10.1016/J.Hrthm.2004.06.012  0.413
2004 Vigmond EJ, Tsoi V, Kuo S, Arevalo H, Kneller J, Nattel S, Trayanova N. The effect of vagally induced dispersion of action potential duration on atrial arrhythmogenesis. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 1: 334-44. PMID 15851180 DOI: 10.1016/J.Hrthm.2004.03.077  0.316
2004 Zicha S, Xiao L, Stafford S, Cha TJ, Han W, Varro A, Nattel S. Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts. The Journal of Physiology. 561: 735-48. PMID 15498806 DOI: 10.1113/Jphysiol.2004.075861  0.374
2004 Shiroshita-Takeshita A, Schram G, Lavoie J, Nattel S. Effect of Simvastatin and Antioxidant Vitamins on Atrial Fibrillation Promotion by Atrial-Tachycardia Remodeling in Dogs Circulation. 110: 2313-2319. PMID 15477401 DOI: 10.1161/01.Cir.0000145163.56529.D1  0.402
2004 Nattel S. Antiarrhythmic drugs for atrial fibrillation: Do we need better use, better drugs or a randomized trial of ablation as primary therapy? Canadian Medical Association Journal. 171: 752-753. PMID 15451839 DOI: 10.1503/Cmaj.1040853  0.422
2004 Cha T, Ehrlich JR, Zhang L, Nattel S. Atrial Ionic Remodeling Induced by Atrial Tachycardia in the Presence of Congestive Heart Failure Circulation. 110: 1520-1526. PMID 15381657 DOI: 10.1161/01.Cir.0000142052.03565.87  0.48
2004 Nattel S. Is atrial remodeling a viable target for prevention of atrial fibrillation recurrence? Journal of Cardiovascular Electrophysiology. 15: 885-6. PMID 15333079 DOI: 10.1046/j.1540-8167.2004.04325.x  0.313
2004 Schram G, Zhang L, Derakhchan K, Ehrlich JR, Belardinelli L, Nattel S. Ranolazine: ion-channel-blocking actions and in vivo electrophysiological effects. British Journal of Pharmacology. 142: 1300-1308. PMID 15277312 DOI: 10.1038/Sj.Bjp.0705879  0.357
2004 Hanna N, Cardin S, Leung TK, Nattel S. Differences in atrial versus ventricular remodeling in dogs with ventricular tachypacing-induced congestive heart failure. Cardiovascular Research. 63: 236-44. PMID 15249181 DOI: 10.1016/J.Cardiores.2004.03.026  0.425
2004 Zicha S, Maltsev VA, Nattel S, Sabbah HN, Undrovinas AI. Post-transcriptional alterations in the expression of cardiac Na+ channel subunits in chronic heart failure Journal of Molecular and Cellular Cardiology. 37: 91-100. PMID 15242739 DOI: 10.1016/J.Yjmcc.2004.04.003  0.404
2004 Nattel S. Defining “Culprit Mechanisms” in Arrhythmogenic Cardiac Remodeling Circulation Research. 94: 1403-1405. PMID 15192034 DOI: 10.1161/01.Res.0000133229.19586.Bb  0.463
2004 Pourrier M, Nattel S. [Anchoring proteins and cardiac sudden death: how and why?]. M S-Medecine Sciences. 20: 437. PMID 15124116 DOI: 10.1051/Medsci/2004204437  0.372
2004 Ehrlich JR, Cha TJ, Zhang L, Chartier D, Villeneuve L, Hébert TE, Nattel S. Characterization of a hyperpolarization-activated time-dependent potassium current in canine cardiomyocytes from pulmonary vein myocardial sleeves and left atrium. The Journal of Physiology. 557: 583-97. PMID 15020696 DOI: 10.1113/Jphysiol.2004.061119  0.389
2004 Nakashima H, Gerlach U, Schmidt D, Nattel S. In vivo electrophysiological effects of a selective slow delayed-rectifier potassium channel blocker in anesthetized dogs: potential insights into class III actions Cardiovascular Research. 61: 705-714. PMID 14985067 DOI: 10.1016/J.Cardiores.2003.12.016  0.407
2004 Shi H, Wang H, Li D, Nattel S, Wang Z. Differential alterations of receptor densities of three muscarinic acetylcholine receptor subtypes and current densities of the corresponding K+ channels in canine atria with atrial fibrillation induced by experimental congestive heart failure. Cellular Physiology and Biochemistry. 14: 31-40. PMID 14976404 DOI: 10.1159/000076924  0.43
2004 Nattel S, Kneller J, Zou R, Leon LJ. Mechanisms of termination of atrial fibrillation by Class I antiarrhythmic drugs: evidence from clinical, experimental, and mathematical modeling studies. Journal of Cardiovascular Electrophysiology. 14: S133-9. PMID 14760915 DOI: 10.1046/j.1540.8167.90302.x  0.376
2004 Wang J, Zhang Y, Wang H, Han H, Nattel S, Yang B, Wang Z. Potential mechanisms for the enhancement of HERG K+ channel function by phospholipid metabolites. British Journal of Pharmacology. 141: 586-99. PMID 14744814 DOI: 10.1038/Sj.Bjp.0705646  0.304
2004 Liu GX, Zhou J, Nattel S, Koren G. Single-channel recordings of a rapid delayed rectifier current in adult mouse ventricular myocytes: basic properties and effects of divalent cations. The Journal of Physiology. 556: 401-13. PMID 14742731 DOI: 10.1113/Jphysiol.2003.059303  0.363
2004 Cha TJ, Ehrlich JR, Zhang L, Shi YF, Tardif JC, Leung TK, Nattel S. Dissociation between ionic remodeling and ability to sustain atrial fibrillation during recovery from experimental congestive heart failure. Circulation. 109: 412-8. PMID 14718405 DOI: 10.1161/01.Cir.0000109501.47603.0C  0.447
2004 Ehrlich JR, Pourrier M, Weerapura M, Ethier N, Marmabachi AM, Hébert TE, Nattel S. KvLQT1 modulates the distribution and biophysical properties of HERG. A novel alpha-subunit interaction between delayed rectifier currents. The Journal of Biological Chemistry. 279: 1233-41. PMID 14585842 DOI: 10.1074/Jbc.M309087200  0.331
2004 Caballero R, Pourrier M, Schram G, Delpón E, Tamargo J, Nattel S. Effects of flecainide and quinidine on Kv4.2 currents: voltage dependence and role of S6 valines. British Journal of Pharmacology. 138: 1475-84. PMID 12721103 DOI: 10.1038/Sj.Bjp.0705199  0.308
2004 Nakashima H, Gerlach U, Nattel S. 1059-18 The role of slow delayed rectifier potassium current (IKs) in cardiac electrophysiology and atrial fibrillation Journal of the American College of Cardiology. 43. DOI: 10.1016/S0735-1097(04)90057-5  0.478
2003 Nattel S, Lumer G, Talajic M, Roy D. Cost evaluation of rhythm control methods for atrial fibrillation: evidence from CTAF. Cardiac Electrophysiology Review. 7: 211-214. PMID 14739715 DOI: 10.1023/B:Cepr.0000012384.57261.71  0.352
2003 Nattel S. Remodeling of cardiac inward-rectifier currents: an often-overlooked contributor to arrhythmogenic states. Journal of Molecular and Cellular Cardiology. 35: 1395-1398. PMID 14654365 DOI: 10.1016/J.Yjmcc.2003.09.004  0.374
2003 Cardin S, Li D, Thorin-Trescases N, Leung TK, Thorin E, Nattel S. Evolution of the atrial fibrillation substrate in experimental congestive heart failure: angiotensin-dependent and -independent pathways. Cardiovascular Research. 60: 315-25. PMID 14613861 DOI: 10.1016/J.Cardiores.2003.08.014  0.355
2003 Pourrier M, Schram G, Nattel S. Properties, expression and potential roles of cardiac K+ channel accessory subunits: MinK, MiRPs, KChIP, and KChAP. The Journal of Membrane Biology. 194: 141-152. PMID 14502427 DOI: 10.1007/S00232-003-2034-8  0.358
2003 Guerra PG, Thibault B, Dubuc M, Talajic M, Roy D, Crépeau J, Nattel S, Tardif J. Identification of atrial tissue in pulmonary veins using intravascular ultrasound Journal of the American Society of Echocardiography. 16: 982-987. PMID 12931111 DOI: 10.1016/S0894-7317(03)00421-8  0.389
2003 Nattel S. Drugs to promote sinus rhythm reversion and maintenance in atrial fibrillation--why amiodarone is better. Cardiovascular Drugs and Therapy. 17: 5-6. PMID 12916518 DOI: 10.1023/A:1024295422944  0.404
2003 Schram G, Pourrier M, Wang Z, White M, Nattel S. Barium block of Kir2 and human cardiac inward rectifier currents: evidence for subunit-heteromeric contribution to native currents. Cardiovascular Research. 59: 328-338. PMID 12909316 DOI: 10.1016/S0008-6363(03)00366-3  0.347
2003 Kalifa J, Jalife J, Zaitsev AV, Bagwe S, Warren M, Moreno J, Berenfeld O, Nattel S. Intra-atrial pressure increases rate and organization of waves emanating from the superior pulmonary veins during atrial fibrillation. Circulation. 108: 668-71. PMID 12900337 DOI: 10.1161/01.Cir.0000086979.39843.7B  0.387
2003 Pourrier M, Zicha S, Ehrlich J, Han W, Nattel S. Canine Ventricular KCNE2 Expression Resides Predominantly in Purkinje Fibers Circulation Research. 93: 189-191. PMID 12842918 DOI: 10.1161/01.Res.0000084851.60947.B5  0.397
2003 Pang L, Koren G, Wang Z, Nattel S. Tissue-specific expression of two human Ca(v)1.2 isoforms under the control of distinct 5' flanking regulatory elements. Febs Letters. 546: 349-54. PMID 12832067 DOI: 10.1016/S0014-5793(03)00629-X  0.323
2003 Zicha S, Moss I, Allen B, Varro A, Papp J, Dumaine R, Antzelevich C, Nattel S. Molecular basis of species-specific expression of repolarizing K+ currents in the heart. American Journal of Physiology. Heart and Circulatory Physiology. 285: H1641-9. PMID 12816752 DOI: 10.1152/Ajpheart.00346.2003  0.336
2003 Nattel S. Atrial electrophysiology and mechanisms of atrial fibrillation. Journal of Cardiovascular Pharmacology and Therapeutics. 8. PMID 12746747 DOI: 10.1177/107424840300800102  0.472
2003 Shinagawa K, Derakhchan K, Nattel S. Pharmacological prevention of atrial tachycardia induced atrial remodeling as a potential therapeutic strategy. Pacing and Clinical Electrophysiology. 26: 752-764. PMID 12698678 DOI: 10.1046/J.1460-9592.2003.00128.X  0.476
2003 Sinno H, Derakhchan K, Libersan D, Merhi Y, Leung TK, Nattel S. Atrial ischemia promotes atrial fibrillation in dogs. Circulation. 107: 1930-6. PMID 12668526 DOI: 10.1161/01.Cir.0000058743.15215.03  0.433
2003 Shinagawa K, Shiroshita-Takeshita A, Schram G, Nattel S. Effects of Antiarrhythmic Drugs on Fibrillation in the Remodeled Atrium Insights Into the Mechanism of the Superior Efficacy of Amiodarone Circulation. 107: 1440-1446. PMID 12642367 DOI: 10.1161/01.Cir.0000055316.35552.74  0.479
2003 Ehrlich JR, Cha T, Zhang L, Chartier D, Melnyk P, Hohnloser SH, Nattel S. Cellular electrophysiology of canine pulmonary vein cardiomyocytes: action potential and ionic current properties The Journal of Physiology. 551: 801-813. DOI: 10.1111/J.1469-7793.2003.00801.X  0.367
2003 Xiao L, Chartier D, Han W, Wang Z, Nattel S. Gender-based transmural differences in canine cardiac repolarization Journal of the American College of Cardiology. 41: 112. DOI: 10.1016/S0735-1097(03)80699-X  0.376
2002 Zou R, Kneller J, Leon LJ, Nattel S. Development of a computer algorithm for the detection of phase singularities and initial application to analyze simulations of atrial fibrillation Chaos. 12: 764-778. PMID 12779605 DOI: 10.1063/1.1497505  0.386
2002 Jørgensen P, Schäfer C, Guerra PG, Talajic M, Nattel S, Glass L. A mathematical model of human atrioventricular nodal function incorporating concealed conduction. Bulletin of Mathematical Biology. 64: 1083-99. PMID 12508532 DOI: 10.1006/Bulm.2002.0313  0.44
2002 Han W, Bao W, Wang Z, Nattel S. Comparison of Ion-Channel Subunit Expression in Canine Cardiac Purkinje Fibers and Ventricular Muscle Circulation Research. 91: 790-797. PMID 12411393 DOI: 10.1161/01.Res.0000039534.18114.D9  0.328
2002 Khairy P, Nattel S. New insights into the mechanisms and management of atrial fibrillation Cmaj. 167: 1012-1020. PMID 12403742  0.344
2002 Nattel S, Khairy P, Roy D, Thibault B, Guerra P, Talajic M, Dubuc M. New approaches to atrial fibrillation management: A critical review of a rapidly evolving field Drugs. 62: 2377-2397. PMID 12396229 DOI: 10.2165/00003495-200262160-00005  0.486
2002 Han W, Zhang L, Schram G, Nattel S. Properties of potassium currents in Purkinje cells of failing human hearts. American Journal of Physiology-Heart and Circulatory Physiology. 283. PMID 12388306 DOI: 10.1152/Ajpheart.00389.2002  0.404
2002 Schram G, Melnyk P, Pourrier M, Wang Z, Nattel S. Kir2.4 and Kir2.1 K(+) channel subunits co-assemble: a potential new contributor to inward rectifier current heterogeneity. The Journal of Physiology. 544: 337-49. PMID 12381809 DOI: 10.1113/Jphysiol.2002.026047  0.301
2002 Shi H, Wang H, Han H, Xu D, Yang B, Nattel S, Wang Z. Ultrarapid delayed rectifier K(+) current in H9c2 rat ventricular cell line: biophysical property and molecular identity. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 12: 215-26. PMID 12297727 DOI: 10.1159/000066281  0.335
2002 Melnyk P, Zhang L, Shrier A, Nattel S. Differential distribution of Kir2.1 and Kir2.3 subunits in canine atrium and ventricle. American Journal of Physiology. Heart and Circulatory Physiology. 283: H1123-33. PMID 12181143 DOI: 10.1152/Ajpheart.00934.2001  0.354
2002 Li G, Lau C, Ducharme A, Tardif J, Nattel S. Transmural action potential and ionic current remodeling in ventricles of failing canine hearts. American Journal of Physiology-Heart and Circulatory Physiology. 283. PMID 12181133 DOI: 10.1152/Ajpheart.00105.2002  0.39
2002 Lumer GB, Roy D, Talajic M, Couturier A, Lambert J, Frasure-Smith N, Thibault B, Dubuc M, Gagné P, Nattel S. Amiodarone reduces procedures and costs related to atrial fibrillation in a controlled clinical trial European Heart Journal. 23: 1050-1056. PMID 12093058 DOI: 10.1053/Euhj.2001.2986  0.365
2002 Shi Y, Li D, Tardif J, Nattel S. Enalapril effects on atrial remodeling and atrial fibrillation in experimental congestive heart failure. Cardiovascular Research. 54: 456-461. PMID 12062350 DOI: 10.1016/S0008-6363(02)00243-2  0.46
2002 Shinagawa K, Mitamura H, Ogawa S, Nattel S. Effects of inhibiting Na+/H+-exchange or angiotensin converting enzyme on atrial tachycardia-induced remodeling Cardiovascular Research. 54: 438-446. PMID 12062348 DOI: 10.1016/S0008-6363(01)00515-6  0.343
2002 Kneller J, Sun H, Leblanc N, Nattel S. Remodeling of Ca(2+)-handling by atrial tachycardia: evidence for a role in loss of rate-adaptation. Cardiovascular Research. 54: 416-26. PMID 12062346 DOI: 10.1016/S0008-6363(02)00274-2  0.33
2002 Nattel S. Therapeutic implications of atrial fibrillation mechanisms: can mechanistic insights be used to improve AF management? Cardiovascular Research. 54: 347-360. PMID 12062340 DOI: 10.1016/S0008-6363(01)00562-4  0.442
2002 Bosch RF, Nattel S. Cellular electrophysiology of atrial fibrillation Cardiovascular Research. 54: 259-269. PMID 12062331 DOI: 10.1016/S0008-6363(01)00529-6  0.507
2002 Nattel S, Allessie M, Haissaguerre M. Spotlight on atrial fibrillation-the 'complete arrhythmia'. Cardiovascular Research. 54: 197-203. PMID 12062326 DOI: 10.1016/S0008-6363(02)00324-3  0.436
2002 Shinagawa K, Shi YF, Tardif JC, Leung TK, Nattel S. Dynamic nature of atrial fibrillation substrate during development and reversal of heart failure in dogs. Circulation. 105: 2672-8. PMID 12045175 DOI: 10.1161/01.Cir.0000016826.62813.F5  0.45
2002 Ehrlich JR, Nattel S, Hohnloser SH. Atrial fibrillation and congestive heart failure: specific considerations at the intersection of two common and important cardiac disease sets. Journal of Cardiovascular Electrophysiology. 13: 399-405. PMID 12033360 DOI: 10.1046/j.1540-8167.2002.00399.x  0.362
2002 Kneller J, Zou R, Vigmond EJ, Wang Z, Leon LJ, Nattel S. Cholinergic atrial fibrillation in a computer model of a two-dimensional sheet of canine atrial cells with realistic ionic properties. Circulation Research. 90: E73-87. PMID 12016272 DOI: 10.1161/01.Res.0000019783.88094.Ba  0.437
2002 Schram G, Pourrier M, Melnyk P, Nattel S. Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function. Circulation Research. 90: 939-50. PMID 12016259 DOI: 10.1161/01.Res.0000018627.89528.6F  0.408
2002 Weerapura M, Nattel S, Chartier D, Caballero R, Hébert TE. A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link? The Journal of Physiology. 540: 15-27. PMID 11927665 DOI: 10.1113/Jphysiol.2001.013296  0.338
2002 Weerapura M, Hébert TE, Nattel S. Dofetilide block involves interactions with open and inactivated states of HERG channels. PflüGers Archiv : European Journal of Physiology. 443: 520-31. PMID 11907818 DOI: 10.1007/S004240100720  0.316
2002 Kneller J, Ramirez RJ, Chartier D, Courtemanche M, Nattel S. Time-dependent transients in an ionically based mathematical model of the canine atrial action potential American Journal of Physiology - Heart and Circulatory Physiology. 282. PMID 11893581 DOI: 10.1152/Ajpheart.00489.2001  0.343
2002 Glass L, Nagai Y, Hall K, Talajic M, Nattel S. Predicting the entrainment of reentrant cardiac waves using phase resetting curves. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. 65: 021908. PMID 11863564 DOI: 10.1103/Physreve.65.021908  0.359
2002 Zhang L, Wang Z, Nattel S. Effects of sustained β-adrenergic stimulation on ionic currents of cultured adult guinea pig cardiomyocytes American Journal of Physiology-Heart and Circulatory Physiology. 282: 880-889. PMID 11834482 DOI: 10.1152/Ajpheart.01138.2000  0.324
2002 Nattel S. New ideas about atrial fibrillation 50 years on Nature. 415: 219-226. PMID 11805846 DOI: 10.1038/415219A  0.469
2002 Shinagawa K, Li D, Leung TK, Nattel S. Consequences of atrial tachycardia-induced remodeling depend on the preexisting atrial substrate. Circulation. 105: 251-7. PMID 11790709 DOI: 10.1161/Hc0202.102014  0.446
2002 Wang J, Wang H, Han H, Zhang Y, Yang B, Nattel S, Wang Z. Phospholipid metabolite 1-palmitoyl-lysophosphatidylcholine enhances human ether-a-go-go-related gene (HERG) K(+) channel function. Circulation. 104: 2645-8. PMID 11723012 DOI: 10.1161/Hc4701.100513  0.4
2001 Li D, Shinagawa K, Pang L, Leung TK, Cardin S, Wang Z, Nattel S. Effects of angiotensin-converting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacing-induced congestive heart failure. Circulation. 104: 2608-14. PMID 11714658 DOI: 10.1161/Hc4601.099402  0.442
2001 Nattel S, Khairy P, Schram G. Arrhythmogenic ionic remodeling: Adaptive responses with maladaptive consequences Trends in Cardiovascular Medicine. 11: 295-301. PMID 11709284 DOI: 10.1016/S1050-1738(01)00134-7  0.436
2001 Nattel S. Effects of ionic remodeling on cardiac antiarrhythmic drug actions. Journal of Cardiovascular Pharmacology. 38: 809-811. PMID 11707683 DOI: 10.1097/00005344-200112000-00001  0.367
2001 Shi Y, Ducharme A, Li D, Gaspo R, Nattel S, Tardif J. Remodeling of atrial dimensions and emptying function in canine models of atrial fibrillation Cardiovascular Research. 52: 217-225. PMID 11684069 DOI: 10.1016/S0008-6363(01)00377-7  0.441
2001 Han W, Chartier D, Li D, Nattel S. Ionic Remodeling of Cardiac Purkinje Cells by Congestive Heart Failure Circulation. 104: 2095-2100. PMID 11673352 DOI: 10.1161/Hc4201.097134  0.415
2001 Li D, Zhang L, Kneller J, Nattel S. Potential Ionic Mechanism for Repolarization Differences Between Canine Right and Left Atrium Circulation Research. 88: 1168-1175. PMID 11397783 DOI: 10.1161/Hh1101.091266  0.417
2001 Derakhchan K, Li D, Courtemanche M, Smith B, Brouillette J, Pagé PL, Nattel S. Method for simultaneous epicardial and endocardial mapping of in vivo canine heart: Application to atrial conduction properties and arrhythmia mechanisms Journal of Cardiovascular Electrophysiology. 12: 548-555. PMID 11386516 DOI: 10.1046/j.1540-8167.2001.00548.x  0.351
2001 Bénardeau A, Fareh S, Nattel S. Effects of verapamil on atrial fibrillation and its electrophysiological determinants in dogs Cardiovascular Research. 50: 85-96. PMID 11282081 DOI: 10.1016/S0008-6363(01)00201-2  0.434
2001 Derakhchan K, Villemaire C, Talajic M, Nattel S. The class III antiarrhythmic drugs dofetilide and sotalol prevent AF induction by atrial premature complexes at doses that fail to terminate AF. Cardiovascular Research. 50: 75-84. PMID 11282080 DOI: 10.1016/S0008-6363(00)00320-5  0.447
2001 Fareh S, Bénardeau A, Nattel S. Differential efficacy of L- and T-type calcium channel blockers in preventing tachycardia-induced atrial remodeling in dogs. Cardiovascular Research. 49: 762-770. PMID 11230975 DOI: 10.1016/S0008-6363(00)00288-1  0.437
2001 Sun H, Chartier D, Leblanc N, Nattel S. Intracellular calcium changes and tachycardia-induced contractile dysfunction in canine atrial myocytes Cardiovascular Research. 49: 751-761. PMID 11230974 DOI: 10.1016/S0008-6363(00)00294-7  0.312
2001 Han W, Wang Z, Nattel S. Slow delayed rectifier current and repolarization in canine cardiac Purkinje cells. American Journal of Physiology-Heart and Circulatory Physiology. 280. PMID 11179049 DOI: 10.1152/Ajpheart.2001.280.3.H1075  0.381
2000 Nattel S. Acquired delayed rectifier channelopathies: how heart disease and antiarrhythmic drugs mimic potentially-lethal congenital cardiac disorders Cardiovascular Research. 48: 188-190. PMID 11054465 DOI: 10.1016/S0008-6363(00)00181-4  0.424
2000 Ramirez RJ, Nattel S, Courtemanche M. Mathematical analysis of canine atrial action potentials: Rate, regional factors, and electrical remodeling American Journal of Physiology - Heart and Circulatory Physiology. 279. PMID 11009464 DOI: 10.1152/Ajpheart.2000.279.4.H1767  0.429
2000 Yue L, Wang Z, Rindt H, Nattel S. Molecular evidence for a role of Shaw (Kv3) potassium channel subunits in potassium currents of dog atrium Journal of Physiology. 527: 467-478. PMID 10990534 DOI: 10.1111/J.1469-7793.2000.00467.X  0.376
2000 Nattel S, Li D. Ionic remodeling in the heart: pathophysiological significance and new therapeutic opportunities for atrial fibrillation. Circulation Research. 87: 440-447. PMID 10988234 DOI: 10.1161/01.Res.87.6.440  0.503
2000 Wang H, Shi H, Zhang L, Pourrier M, Yang B, Nattel S, Wang Z. Nicotine is a potent blocker of the cardiac A-type K(+) channels. Effects on cloned Kv4.3 channels and native transient outward current. Circulation. 102: 1165-71. PMID 10973847 DOI: 10.1161/01.Cir.102.10.1165  0.345
2000 Han W, Wang Z, Nattel S. A comparison of transient outward currents in canine cardiac Purkinje cells and ventricular myocytes. American Journal of Physiology-Heart and Circulatory Physiology. 279. PMID 10924043 DOI: 10.1152/Ajpheart.2000.279.2.H466  0.413
2000 Weerapura M, Nattel S, Courtemanche M, Doern D, Ethier N, Hébert TE. State-dependent barium block of wild-type and inactivation-deficient HERG channels in Xenopus oocytes Journal of Physiology. 526: 265-278. PMID 10896755 DOI: 10.1111/J.1469-7793.2000.T01-1-00265.X  0.326
2000 Li D, Bénardeau A, Nattel S. Contrasting Efficacy of Dofetilide in Differing Experimental Models of Atrial Fibrillation Circulation. 102: 104-112. PMID 10880422 DOI: 10.1161/01.Cir.102.1.104  0.457
2000 Nattel S, Li D, Yue L. Basic mechanisms of atrial fibrillation - Very new insights into very old ideas Annual Review of Physiology. 62: 51-77. PMID 10845084 DOI: 10.1146/Annurev.Physiol.62.1.51  0.478
2000 Li D, Melnyk P, Feng J, Wang Z, Petrecca K, Shrier A, Nattel S. Effects of experimental heart failure on atrial cellular and ionic electrophysiology. Circulation. 101: 2631-8. PMID 10840016 DOI: 10.1161/01.Cir.101.22.2631  0.441
2000 Roy D, Talajic M, Dorian P, Connolly S, Eisenberg MJ, Green M, Kus T, Lambert J, Dubuc M, Gagné P, Nattel S, Thibault B. Amiodarone to prevent recurrence of atrial fibrillation New England Journal of Medicine. 342: 913-920. PMID 10738049 DOI: 10.1056/NEJM200003303421302  0.401
2000 Yue L, Feng JL, Wang Z, Nattel S. Effects of ambasilide, quinidine, flecainide and verapamil on ultra- rapid delayed rectifier potassium currents in canine atrial myocytes Cardiovascular Research. 46: 151-161. PMID 10727663 DOI: 10.1016/S0008-6363(99)00430-7  0.38
2000 Nattel S, Matthews C, De Blasio E, Han W, Li D, Yue L. Dose-dependence of 4-aminopyridine plasma concentrations and electrophysiological effects in dogs: Potential relevance to ionic mechanisms in vivo Circulation. 101: 1179-1184. PMID 10715266 DOI: 10.1161/01.Cir.101.10.1179  0.36
2000 ROY D, TALAJIC M, DORIAN P, CONNOLLY S, EISENIBERG MJ, GREEN M, KUS T, LAMBERT J, DUBUC M, GAGNE P, NATTEL S, THIBAULT B. Amiodarone to Prevent Recurrence of Atrial Fibrillation Survey of Anesthesiology. 44: 358. DOI: 10.1097/00132586-200012000-00040  0.301
1999 Nattel S, Yue L, Wang Z. Cardiac ultrarapid delayed rectifiers: A novel potassium current family of functional similarity and molecular diversity Cellular Physiology and Biochemistry. 9: 217-226. PMID 10575199 DOI: 10.1159/000016318  0.383
1999 Fareh S, Bénardeau A, Thibault B, Nattel S. The T-Type Ca2+ Channel Blocker Mibefradil Prevents the Development of a Substrate for Atrial Fibrillation by Tachycardia-Induced Atrial Remodeling in Dogs Circulation. 100: 2191-2197. PMID 10571979 DOI: 10.1161/01.Cir.100.21.2191  0.437
1999 Nattel S. Electrophysiologic remodeling: are ion channels static players or dynamic movers? Journal of Cardiovascular Electrophysiology. 10: 1553-1556. PMID 10571375 DOI: 10.1111/J.1540-8167.1999.Tb00214.X  0.419
1999 Nattel S, Singh BN. Evolution, mechanisms, and classification of antiarrhythmic drugs: focus on class III actions. American Journal of Cardiology. 84: 11-19. PMID 10568655 DOI: 10.1016/S0002-9149(99)00697-9  0.33
1999 Courtemanche M, Ramirez RJ, Nattel S. Ionic targets for drug therapy and atrial fibrillation-induced electrical remodeling: Insights from a mathematical model Cardiovascular Research. 42: 477-489. PMID 10533583 DOI: 10.1016/S0008-6363(99)00034-6  0.467
1999 Gaspo R, Sun H, Fareh S, Levi M, Yue L, Allen BG, Hebert TE, Nattel S. Dihydropyridine and beta adrenergic receptor binding in dogs with tachycardia-induced atrial fibrillation Cardiovascular Research. 42: 434-442. PMID 10533579 DOI: 10.1016/S0008-6363(99)00036-X  0.369
1999 Nattel S. Atrial electrophysiological remodeling caused by rapid atrial activation: underlying mechanisms and clinical relevance to atrial fibrillation. Cardiovascular Research. 42: 298-308. PMID 10533568 DOI: 10.1016/S0008-6363(99)00022-X  0.501
1999 Nattel S, Roden DM, Escande D. A spotlight on electrophysiological remodeling and the molecular biology of ion channels Cardiovascular Research. 42: 267-269. PMID 10533565 DOI: 10.1016/S0008-6363(99)00072-3  0.435
1999 Nattel S. Ionic determinants of atrial fibrillation and Ca2+ channel abnormalities : cause, consequence, or innocent bystander? Circulation Research. 85: 473-476. PMID 10473677 DOI: 10.1161/01.Res.85.5.473  0.481
1999 Bosch RF, Wang Z, Li G, Nattel S. Electrophysiological mechanisms by which hypothyroidism delays repolarization in guinea pig hearts American Journal of Physiology-Heart and Circulatory Physiology. 277. PMID 10409199 DOI: 10.1152/Ajpheart.1999.277.1.H211  0.381
1999 Li D, Fareh S, Leung TK, Nattel S. Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort. Circulation. 100: 87-95. PMID 10393686 DOI: 10.1161/01.Cir.100.1.87  0.487
1999 Yue L, Melnyk P, Gaspo R, Wang Z, Nattel S. Molecular mechanisms underlying ionic remodeling in a dog model of atrial fibrillation Circulation Research. 84: 776-784. PMID 10205145 DOI: 10.1161/01.Res.84.7.776  0.432
1999 Nattel S. The molecular and ionic specificity of antiarrhythmic drug actions. Journal of Cardiovascular Electrophysiology. 10: 272-82. PMID 10090234 DOI: 10.1111/j.1540-8167.1999.tb00673.x  0.306
1999 Yue L, Feng J, Wang Z, Nattel S. Adrenergic control of the ultrarapid delayed rectifier current in canine atrial myocytes Journal of Physiology. 516: 385-398. PMID 10087339 DOI: 10.1111/J.1469-7793.1999.0385V.X  0.351
1999 Wang Z, Feng J, Shi H, Pond A, Nerbonne JM, Nattel S. Potential molecular basis of different physiological properties of the transient outward K+ current in rabbit and human atrial myocytes Circulation Research. 84: 551-561. PMID 10082477 DOI: 10.1161/01.Res.84.5.551  0.432
1999 Li GR, Yang B, Feng J, Bosch RF, Carrier M, Nattel S. Transmembrane ICa contributes to rate-dependent changes of action potentials in human ventricular myocytes. The American Journal of Physiology. 276: H98-H106. PMID 9887022 DOI: 10.1152/Ajpheart.1999.276.1.H98  0.359
1999 Fareh S, Nattel S. The mechanisms of enhanced vulnerability to atrial fibrillation caused by atrial tachycardia-induced electrical remodeling: Insights from combined activation and refractoriness mapping Journal of Electrocardiology. 32: 139. DOI: 10.1016/S0022-0736(99)90063-8  0.432
1998 Feng J, Xu D, Wang Z, Nattel S. Ultrarapid delayed rectifier current inactivation in human atrial myocytes: properties and consequences. American Journal of Physiology. Heart and Circulatory Physiology. 275: H1717-H1725. PMID 29592254 DOI: 10.1152/Ajpheart.1998.275.5.H1717  0.337
1998 Li GR, Sun H, Nattel S. Characterization of a transient outward Kcurrent with inward rectification in canine ventricular myocytes. American Journal of Physiology. Cell Physiology. 274: C577-C585. PMID 29591139 DOI: 10.1152/Ajpcell.1998.274.3.C577  0.335
1998 Wang Z, Yue L, White M, Pelletier G, Nattel S. Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle Circulation. 98: 2422-2428. PMID 9832487 DOI: 10.1161/01.Cir.98.22.2422  0.365
1998 Guerra PG, Talajic M, Roy D, Dubuc M, Thibault B, Nattel S. Is There a Future for Antiarrhythmic Drug Therapy Drugs. 56: 767-781. PMID 9829152 DOI: 10.2165/00003495-199856050-00003  0.407
1998 Fareh S, Villemaire C, Nattel S. Importance of Refractoriness Heterogeneity in the Enhanced Vulnerability to Atrial Fibrillation Induction Caused by Tachycardia-Induced Atrial Electrical Remodeling Circulation. 98: 2202-2209. PMID 9815876 DOI: 10.1161/01.Cir.98.20.2202  0.374
1998 Feng J, Yue L, Wang Z, Nattel S. Ionic mechanisms of regional action potential heterogeneity in the canine right atrium Circulation Research. 83: 541-551. PMID 9734477 DOI: 10.1161/01.Res.83.5.541  0.363
1998 Sun H, Gaspo R, Leblanc N, Nattel S. Cellular mechanisms of atrial contractile dysfunction caused by sustained atrial tachycardia Circulation. 98: 719-727. PMID 9715865 DOI: 10.1161/01.Cir.98.7.719  0.403
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