Year |
Citation |
Score |
2024 |
Ferguson CM, Godinho BMDC, Echeverria D, Hassler M, Vangjeli L, Sousa J, McHugh N, Alterman J, Hariharan V, Krishnamurthy PM, Watts J, Rogaev E, Khvorova A. A combinatorial approach for achieving CNS-selective RNAi. Nucleic Acids Research. PMID 38348876 DOI: 10.1093/nar/gkae100 |
0.32 |
|
2023 |
Zhang H, Kelly K, Lee J, Echeverria D, Cooper D, Panwala R, Amrani N, Chen Z, Gaston N, Wagh A, Newby GA, Xie J, Liu DR, Gao G, Wolfe SA, ... ... Watts JK, et al. Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo. Nucleic Acids Research. PMID 38033325 DOI: 10.1093/nar/gkad1125 |
0.359 |
|
2023 |
Shah S, Sharp KJ, Raju Ponny S, Lee J, Watts JK, Berry-Kravis E, Richter JD. Antisense oligonucleotide rescue of CGG expansion-dependent mis-splicing in fragile X syndrome restores FMRP. Proceedings of the National Academy of Sciences of the United States of America. 120: e2302534120. PMID 37364131 DOI: 10.1073/pnas.2302534120 |
0.366 |
|
2023 |
Zhang H, Kelly K, Lee J, Echeverria D, Cooper D, Panwala R, Chen Z, Gaston N, Newby GA, Xie J, Liu DR, Gao G, Wolfe SA, Khvorova A, Watts JK, et al. Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing . Biorxiv : the Preprint Server For Biology. PMID 36993169 DOI: 10.1101/2023.03.20.533459 |
0.354 |
|
2023 |
Hariharan VN, Shin M, Chang CW, O'Reilly D, Biscans A, Yamada K, Guo Z, Somasundaran M, Tang Q, Monopoli K, Krishnamurthy PM, Devi G, McHugh N, Cooper DA, Echeverria D, ... ... Watts JK, et al. Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection. Proceedings of the National Academy of Sciences of the United States of America. 120: e2219523120. PMID 36893269 DOI: 10.1073/pnas.2219523120 |
0.64 |
|
2022 |
Wang F, Calvo-Roitberg E, Rembetsy-Brown JM, Fang M, Sousa J, Kartje ZJ, Krishnamurthy PM, Lee J, Green MR, Pai AA, Watts JK. G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects. Nucleic Acids Research. PMID 36511872 DOI: 10.1093/nar/gkac1108 |
0.411 |
|
2021 |
Goddard LR, Mardle CE, Gneid H, Ball CG, Gowers DM, Atkins HS, Butt LE, Watts JK, Vincent HA, Callaghan AJ. An Investigation into the Potential of Targeting mRNA with Locked Nucleic Acid (LNA) Gapmers as an Antibacterial Strategy. Molecules (Basel, Switzerland). 26. PMID 34200016 DOI: 10.3390/molecules26113414 |
0.322 |
|
2020 |
Price DA, Kartje ZJ, Hughes JA, Hill TD, Loth TM, Watts JK, Gagnon KT, Moran SD. Infrared Spectroscopy Reveals the Preferred Motif Size and Local Disorder in Parallel Stranded DNA G-quadruplexes. Chembiochem : a European Journal of Chemical Biology. PMID 32372560 DOI: 10.1002/cbic.202000136 |
0.593 |
|
2020 |
Wang F, Zuroske T, Watts JK. RNA therapeutics on the rise. Nature Reviews. Drug Discovery. PMID 32341501 DOI: 10.1038/d41573-020-00078-0 |
0.339 |
|
2020 |
Watts JK, Ockene IS. RNA Interference for the Masses? siRNA Targeting PCSK9 Promises Prevention of Cardiovascular Disease. Nucleic Acid Therapeutics. PMID 31928497 DOI: 10.1089/nat.2019.0835 |
0.309 |
|
2018 |
Debacker AJ, Sharma VK, Meda Krishnamurthy P, O'Reilly D, Greenhill R, Watts J. Next-generation PNA chimeras exhibit high affinity and potent gene silencing. Biochemistry. PMID 30520300 DOI: 10.1021/acs.biochem.8b00827 |
0.692 |
|
2018 |
Mir A, Alterman JF, Hassler MR, Debacker AJ, Hudgens E, Echeverria D, Brodsky MH, Khvorova A, Watts JK, Sontheimer EJ. Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing. Nature Communications. 9: 2641. PMID 29980686 DOI: 10.1038/S41467-018-05073-Z |
0.41 |
|
2018 |
Li L, Shen X, Liu Z, Norrbom M, Prakash TP, O'Reilly D, Sharma VK, Damha MJ, Watts JK, Rigo F, Corey DR. Activation of Frataxin Protein Expression by Antisense Oligonucleotides Targeting the Mutant Expanded Repeat. Nucleic Acid Therapeutics. PMID 29341839 DOI: 10.1089/Nat.2017.0703 |
0.72 |
|
2018 |
Hu J, Rong Z, Gong X, Zhou Z, Sharma VK, Xing C, Watts JK, Corey DR, Mootha VV. Oligonucleotides Targeting TCF4 Triplet Repeat Expansion Inhibit RNA Foci and Mis-splicing in Fuchs' Dystrophy. Human Molecular Genetics. PMID 29325021 DOI: 10.1093/Hmg/Ddy018 |
0.607 |
|
2017 |
Pendergraff HM, Krishnamurthy PM, Debacker AJ, Moazami MP, Sharma VK, Niitsoo L, Yu Y, Tan YN, Haitchi HM, Watts JK. Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA. Molecular Therapy. Nucleic Acids. 8: 158-168. PMID 28918018 DOI: 10.1016/j.omtn.2017.06.012 |
0.421 |
|
2016 |
Pendergraff HM, Debacker AJ, Watts JK. Single-Stranded Silencing RNAs: Hit Rate and Chemical Modification. Nucleic Acid Therapeutics. PMID 27123752 DOI: 10.1089/nat.2015.0557 |
0.412 |
|
2014 |
Schaukowitch K, Joo JY, Liu X, Watts JK, Martinez C, Kim TK. Enhancer RNA facilitates NELF release from immediate early genes. Molecular Cell. 56: 29-42. PMID 25263592 DOI: 10.1016/j.molcel.2014.08.023 |
0.349 |
|
2012 |
Watts JK, Corey DR. Silencing disease genes in the laboratory and the clinic. The Journal of Pathology. 226: 365-79. PMID 22069063 DOI: 10.1002/Path.2993 |
0.556 |
|
2011 |
Gagnon KT, Watts JK, Pendergraff HM, Montaillier C, Thai D, Potier P, Corey DR. Antisense and antigene inhibition of gene expression by cell-permeable oligonucleotide-oligospermine conjugates. Journal of the American Chemical Society. 133: 8404-7. PMID 21539318 DOI: 10.1021/Ja200312Y |
0.711 |
|
2011 |
Hu J, Gagnon KT, Liu J, Watts JK, Syeda-Nawaz J, Bennett CF, Swayze EE, Randolph J, Chattopadhyaya J, Corey DR. Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs. Biological Chemistry. 392: 315-25. PMID 21294677 DOI: 10.1515/Bc.2011.045 |
0.708 |
|
2011 |
Anzahaee MY, Watts JK, Alla NR, Nicholson AW, Damha MJ. Energetically important C-H···F-C pseudohydrogen bonding in water: evidence and application to rational design of oligonucleotides with high binding affinity. Journal of the American Chemical Society. 133: 728-31. PMID 21171597 DOI: 10.1021/Ja109817P |
0.466 |
|
2010 |
Deleavey GF, Watts JK, Alain T, Robert F, Kalota A, Aishwarya V, Pelletier J, Gewirtz AM, Sonenberg N, Damha MJ. Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing. Nucleic Acids Research. 38: 4547-57. PMID 20413581 DOI: 10.1093/Nar/Gkq181 |
0.645 |
|
2010 |
Watts JK, Yu D, Charisse K, Montaillier C, Potier P, Manoharan M, Corey DR. Effect of chemical modifications on modulation of gene expression by duplex antigene RNAs that are complementary to non-coding transcripts at gene promoters. Nucleic Acids Research. 38: 5242-59. PMID 20403811 DOI: 10.1093/Nar/Gkq258 |
0.628 |
|
2010 |
Watts JK, Corey DR. Clinical status of duplex RNA. Bioorganic & Medicinal Chemistry Letters. 20: 3203-7. PMID 20399650 DOI: 10.1016/J.Bmcl.2010.03.109 |
0.599 |
|
2010 |
Watts JK, Martín-Pintado N, Gómez-Pinto I, Schwartzentruber J, Portella G, Orozco M, González C, Damha MJ. Differential stability of 2'F-ANA*RNA and ANA*RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility. Nucleic Acids Research. 38: 2498-511. PMID 20071751 DOI: 10.1093/Nar/Gkp1225 |
0.557 |
|
2009 |
Deleavey GF, Watts JK, Damha MJ. Chemical modification of siRNA. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 16.3. PMID 20013783 DOI: 10.1002/0471142700.Nc1603S39 |
0.633 |
|
2009 |
Watts JK, Katolik A, Viladoms J, Damha MJ. Studies on the hydrolytic stability of 2'-fluoroarabinonucleic acid (2'F-ANA). Organic & Biomolecular Chemistry. 7: 1904-10. PMID 19590787 DOI: 10.1039/B900443B |
0.579 |
|
2008 |
Watts JK, Deleavey GF, Damha MJ. Chemically modified siRNA: tools and applications. Drug Discovery Today. 13: 842-55. PMID 18614389 DOI: 10.1016/J.Drudis.2008.05.007 |
0.57 |
|
2008 |
Watts JK, Johnston BD, Jayakanthan K, Wahba AS, Pinto BM, Damha MJ. Synthesis and biophysical characterization of oligonucleotides containing a 4'-selenonucleotide. Journal of the American Chemical Society. 130: 8578-9. PMID 18543920 DOI: 10.1021/Ja802205U |
0.577 |
|
2007 |
Watts JK, Choubdar N, Sadalapure K, Robert F, Wahba AS, Pelletier J, Mario Pinto B, Damha MJ. 2'-Fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity. Nucleic Acids Research. 35: 1441-1451. PMID 28383739 DOI: 10.1093/nar/gkl1153 |
0.607 |
|
2007 |
Watts JK, Choubdar N, Sadalapure K, Robert F, Wahba AS, Pelletier J, Pinto BM, Damha MJ. 2'-fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity. Nucleic Acids Research. 35: 1441-51. PMID 17284457 DOI: 10.1093/Nar/Gkl1153 |
0.607 |
|
2006 |
Watts JK, Sadalapure K, Choubdar N, Pinto BM, Damha MJ. Synthesis and conformational analysis of 2'-fluoro-5-methyl-4'-thioarabinouridine (4'S-FMAU). The Journal of Organic Chemistry. 71: 921-5. PMID 16438502 DOI: 10.1021/Jo051844+ |
0.459 |
|
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