| Year |
Citation |
Score |
| 2024 |
Berndt A, Lee J, Won W, Kimball K, Neiswanger C, Schattauer S, Wang Y, Yeboah F, Ruiz M, Evitts K, Rappleye M, Bremner S, Chun C, Smith N, Mack D, ... ... Chavkin C, et al. Ultra-fast genetically encoded sensor for precise real-time monitoring of physiological and pathophysiological peroxide dynamics. Research Square. PMID 38585715 DOI: 10.21203/rs.3.rs-4048855/v1 |
0.765 |
|
| 2024 |
Lee JD, Won W, Kimball K, Wang Y, Yeboah F, Evitts KM, Neiswanger C, Schattauer S, Rappleye M, Bremner SB, Chun C, Smith N, Mack DL, Young JE, Justin Lee C, ... Chavkin C, et al. Structure-guided engineering of a fast genetically encoded sensor for real-time H O monitoring. Biorxiv : the Preprint Server For Biology. PMID 38352381 DOI: 10.1101/2024.01.31.578117 |
0.764 |
|
| 2022 |
Abraham AD, Casello SM, Land BB, Chavkin C. Optogenetic stimulation of dynorphinergic neurons within the dorsal raphe activate kappa opioid receptors in the ventral tegmental area and ablation of dorsal raphe prodynorphin or kappa receptors in dopamine neurons blocks stress potentiation of cocaine reward. Addiction Neuroscience. 1. PMID 36176476 DOI: 10.1016/j.addicn.2022.100005 |
0.819 |
|
| 2021 |
Fontaine HM, Silva PR, Neiswanger C, Tran R, Abraham AD, Land BB, Neumaier JF, Chavkin C. Stress decreases serotonin tone in the nucleus accumbens in male mice to promote aversion and potentiate cocaine preference via decreased stimulation of 5-HT receptors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 34564712 DOI: 10.1038/s41386-021-01178-0 |
0.813 |
|
| 2021 |
Abraham AD, Casello SM, Schattauer SS, Wong BA, Mizuno GO, Mahe K, Tian L, Land BB, Chavkin C. Release of endogenous dynorphin opioids in the prefrontal cortex disrupts cognition. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 34545197 DOI: 10.1038/s41386-021-01168-2 |
0.816 |
|
| 2020 |
Steger JS, Land BB, Lemos JC, Chavkin C, Phillips PEM. Insidious Transmission of a Stress-Related Neuroadaptation. Frontiers in Behavioral Neuroscience. 14: 564054. PMID 33132859 DOI: 10.3389/fnbeh.2020.564054 |
0.789 |
|
| 2020 |
Reichard KL, Newton KA, Rivera ZMG, Sotero de Menezes PM, Schattauer SS, Land BB, Chavkin C. . Molecular Pharmacology. PMID 32913138 DOI: 10.1124/Molpharm.120.000124 |
0.847 |
|
| 2020 |
Ballantyne JC, Chavkin C. Will biased ligands be the opioids of the future? Pain. PMID 32379220 DOI: 10.1097/j.pain.0000000000001913 |
0.421 |
|
| 2020 |
Lesiak AJ, Coffey K, Cohen JH, Liang KJ, Chavkin C, Neumaier JF. Sequencing the serotonergic neuron translatome reveals a new role for Fkbp5 in stress. Molecular Psychiatry. PMID 32366949 DOI: 10.1038/S41380-020-0750-4 |
0.798 |
|
| 2019 |
Heymann G, Jo YS, Reichard KL, McFarland N, Chavkin C, Palmiter RD, Soden ME, Zweifel LS. Synergy of Distinct Dopamine Projection Populations in Behavioral Reinforcement. Neuron. PMID 31879163 DOI: 10.1016/J.Neuron.2019.11.024 |
0.318 |
|
| 2019 |
Schattauer SS, Bedini A, Summers F, Reilly-Treat A, Andrews MM, Land BB, Chavkin C. ROS generation is stimulated by kappa opioid receptor activation through phosphorylated c-Jun-N-terminal kinase and inhibited by p38 MAPK activation. The Journal of Biological Chemistry. PMID 31575661 DOI: 10.1074/Jbc.Ra119.009592 |
0.838 |
|
| 2019 |
Chavkin C, Cohen JH, Land BB. Repeated Administration of Norbinaltorphimine Produces Cumulative Kappa Opioid Receptor Inactivation. Frontiers in Pharmacology. 10: 88. PMID 30787880 DOI: 10.3389/Fphar.2019.00088 |
0.749 |
|
| 2019 |
Borsodi A, Bruchas M, Caló G, Chavkin C, Christie MJ, Civelli O, Connor M, Cox BM, Devi LA, Evans C, Höllt V, Henderson G, Husbands S, Kelly E, Kieffer B, et al. Opioid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f50/2019.4 |
0.827 |
|
| 2018 |
Abraham AD, Schattauer SS, Reichard KL, Cohen JH, Fontaine HM, Song AJ, Johnson SD, Land BB, Chavkin C. Estrogen regulation of GRK2 inactivates kappa opioid receptor signaling mediating analgesia, but not aversion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30076211 DOI: 10.1523/Jneurosci.0653-18.2018 |
0.829 |
|
| 2018 |
Chavkin C. Kappa-opioid antagonists as stress resilience medications for the treatment of alcohol use disorders. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29752444 DOI: 10.1038/s41386-018-0046-4 |
0.386 |
|
| 2018 |
Chavkin C. 6.1 Molecular Pharmacology of Opioids: Chronic Stress and Developmental Exposures Journal of the American Academy of Child & Adolescent Psychiatry. 57: S277-S278. DOI: 10.1016/j.jaac.2018.07.648 |
0.321 |
|
| 2017 |
Schattauer SS, Land BB, Reichard KL, Abraham AD, Burgeno LM, Kuhar JR, Phillips PEM, Ong SE, Chavkin C. Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase. Nature Communications. 8: 743. PMID 28963507 DOI: 10.1038/S41467-017-00791-2 |
0.838 |
|
| 2017 |
Abraham AD, Fontaine HM, Song AJ, Andrews MM, Baird MA, Kieffer BL, Land BB, Chavkin C. Kappa Opioid Receptor Activation in Dopamine Neurons Disrupts Behavioral Inhibition. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28649993 DOI: 10.1038/Npp.2017.133 |
0.84 |
|
| 2017 |
Schattauer SS, Kuhar JR, Song A, Chavkin C. Nalfurafine is a G-protein biased agonist having significantly greater bias at the human than rodent form of the kappa opioid receptor. Cellular Signalling. PMID 28088389 DOI: 10.1016/J.Cellsig.2017.01.016 |
0.847 |
|
| 2016 |
Chavkin C, Koob GF. Dynorphin, Dysphoria, and Dependence: the Stress of Addiction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 41: 373-4. PMID 26657953 DOI: 10.1038/npp.2015.258 |
0.495 |
|
| 2015 |
Ehrich JM, Messinger DI, Knakal CR, Kuhar JR, Schattauer SS, Bruchas MR, Zweifel LS, Kieffer BL, Phillips PE, Chavkin C. Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 12917-31. PMID 26377476 DOI: 10.1523/Jneurosci.2444-15.2015 |
0.828 |
|
| 2015 |
Chavkin C, Martinez D. Kappa Antagonist JDTic in Phase 1 Clinical Trial. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 2057-8. PMID 26174493 DOI: 10.1038/npp.2015.74 |
0.313 |
|
| 2015 |
Kuhar JR, Bedini A, Melief EJ, Chiu YC, Striegel HN, Chavkin C. Mu opioid receptor stimulation activates c-Jun N-terminal kinase 2 by distinct arrestin-dependent and independent mechanisms. Cellular Signalling. 27: 1799-806. PMID 26056051 DOI: 10.1016/J.Cellsig.2015.05.019 |
0.828 |
|
| 2015 |
Lowe JD, Sanderson HS, Cooke AE, Ostovar M, Tsisanova E, Withey SL, Chavkin C, Husbands SM, Kelly E, Henderson G, Bailey CP. Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization. Molecular Pharmacology. 88: 347-56. PMID 26013542 DOI: 10.1124/Mol.115.098293 |
0.658 |
|
| 2015 |
Oakley AE, Steiner RA, Chavkin C, Clifton DK, Ferrara LK, Reed SD. κ Agonists as a novel therapy for menopausal hot flashes. Menopause (New York, N.Y.). PMID 25988798 DOI: 10.1097/Gme.0000000000000476 |
0.516 |
|
| 2015 |
Groblewski PA, Zietz C, Willuhn I, Phillips PE, Chavkin C. Repeated stress exposure causes strain-dependent shifts in the behavioral economics of cocaine in rats. Addiction Biology. 20: 297-301. PMID 24919534 DOI: 10.1111/adb.12123 |
0.572 |
|
| 2015 |
Nwaneshiudu C, Emery M, Levin J, Chavkin C, Terman G. (331) Acute tolerance to opioid-induced respiratory depression after fentanyl and morphine administration The Journal of Pain. 16: S58. DOI: 10.1016/J.Jpain.2015.01.249 |
0.42 |
|
| 2014 |
Chavkin C, Ehrich JM. How does stress-induced activation of the kappa opioid system increase addiction risk? Biological Psychiatry. 76: 760-2. PMID 25442057 DOI: 10.1016/J.Biopsych.2014.08.015 |
0.828 |
|
| 2014 |
Ehrich JM, Phillips PE, Chavkin C. Kappa opioid receptor activation potentiates the cocaine-induced increase in evoked dopamine release recorded in vivo in the mouse nucleus accumbens. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 3036-48. PMID 24971603 DOI: 10.1038/Npp.2014.157 |
0.809 |
|
| 2014 |
Chavkin C, Schattauer SS, Levin JR. Arrestin-mediated activation of p38 MAPK: molecular mechanisms and behavioral consequences. Handbook of Experimental Pharmacology. 219: 281-92. PMID 24292835 DOI: 10.1007/978-3-642-41199-1_14 |
0.819 |
|
| 2013 |
Soden ME, Jones GL, Sanford CA, Chung AS, Güler AD, Chavkin C, Luján R, Zweifel LS. Disruption of dopamine neuron activity pattern regulation through selective expression of a human KCNN3 mutation. Neuron. 80: 997-1009. PMID 24206670 DOI: 10.1016/J.Neuron.2013.07.044 |
0.368 |
|
| 2013 |
Williams JT, Ingram SL, Henderson G, Chavkin C, von Zastrow M, Schulz S, Koch T, Evans CJ, Christie MJ. Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance. Pharmacological Reviews. 65: 223-54. PMID 23321159 DOI: 10.1124/Pr.112.005942 |
0.72 |
|
| 2013 |
Chavkin C. Dynorphin--still an extraordinarily potent opioid peptide. Molecular Pharmacology. 83: 729-36. PMID 23152558 DOI: 10.1124/mol.112.083337 |
0.465 |
|
| 2012 |
Schindler AG, Messinger DI, Smith JS, Shankar H, Gustin RM, Schattauer SS, Lemos JC, Chavkin NW, Hagan CE, Neumaier JF, Chavkin C. Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 17582-96. PMID 23223282 DOI: 10.1523/Jneurosci.3220-12.2012 |
0.814 |
|
| 2012 |
Schattauer SS, Miyatake M, Shankar H, Zietz C, Levin JR, Liu-Chen LY, Gurevich VV, Rieder MJ, Chavkin C. Ligand directed signaling differences between rodent and human κ-opioid receptors. The Journal of Biological Chemistry. 287: 41595-607. PMID 23086943 DOI: 10.1074/Jbc.M112.381368 |
0.827 |
|
| 2012 |
Lemos JC, Wanat MJ, Smith JS, Reyes BA, Hollon NG, Van Bockstaele EJ, Chavkin C, Phillips PE. Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive. Nature. 490: 402-6. PMID 22992525 DOI: 10.1038/nature11436 |
0.762 |
|
| 2012 |
Lemos JC, Roth CA, Messinger DI, Gill HK, Phillips PE, Chavkin C. Repeated stress dysregulates κ-opioid receptor signaling in the dorsal raphe through a p38α MAPK-dependent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 12325-36. PMID 22956823 DOI: 10.1523/JNEUROSCI.2053-12.2012 |
0.813 |
|
| 2012 |
Smith JS, Schindler AG, Martinelli E, Gustin RM, Bruchas MR, Chavkin C. Stress-induced activation of the dynorphin/κ-opioid receptor system in the amygdala potentiates nicotine conditioned place preference. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 1488-95. PMID 22279233 DOI: 10.1523/Jneurosci.2980-11.2012 |
0.76 |
|
| 2012 |
Hays SL, McPherson RJ, Juul SE, Wallace G, Schindler AG, Chavkin C, Gleason CA. Long-term effects of neonatal stress on adult conditioned place preference (CPP) and hippocampal neurogenesis. Behavioural Brain Research. 227: 7-11. PMID 22061798 DOI: 10.1016/J.Bbr.2011.10.033 |
0.653 |
|
| 2012 |
Lemos J, Wanat M, Smith J, Reyes B, Bockstaele EV, Chavkin C, Phillips P. Stress exposure produces a switch from appetitive to aversive signaling by corticotropin-releasing factor in the nucleus accumbens F1000research. 3. DOI: 10.7490/F1000Research.1089804.1 |
0.739 |
|
| 2011 |
Bruchas MR, Schindler AG, Shankar H, Messinger DI, Miyatake M, Land BB, Lemos JC, Hagan CE, Neumaier JF, Quintana A, Palmiter RD, Chavkin C. Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction. Neuron. 71: 498-511. PMID 21835346 DOI: 10.1016/J.Neuron.2011.06.011 |
0.799 |
|
| 2011 |
Melief EJ, Miyatake M, Carroll FI, Béguin C, Carlezon WA, Cohen BM, Grimwood S, Mitch CH, Rorick-Kehn L, Chavkin C. Duration of action of a broad range of selective κ-opioid receptor antagonists is positively correlated with c-Jun N-terminal kinase-1 activation. Molecular Pharmacology. 80: 920-9. PMID 21832171 DOI: 10.1124/Mol.111.074195 |
0.773 |
|
| 2011 |
Lemos JC, Roth CA, Chavkin C. Signaling events initiated by kappa opioid receptor activation: quantification and immunocolocalization using phospho-selective KOR, p38 MAPK, and K(IR) 3.1 antibodies. Methods in Molecular Biology (Clifton, N.J.). 717: 197-219. PMID 21370032 DOI: 10.1007/978-1-61779-024-9_11 |
0.762 |
|
| 2011 |
Chavkin C. The therapeutic potential of κ-opioids for treatment of pain and addiction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 369-70. PMID 21116263 DOI: 10.1038/npp.2010.137 |
0.472 |
|
| 2011 |
Chavkin C. Therapeutic potential of κ opioids Pharmacological Reports. 63: 205. DOI: 10.1016/S1734-1140(11)70417-0 |
0.445 |
|
| 2010 |
Lyssand JS, Whiting JL, Lee KS, Kastl R, Wacker JL, Bruchas MR, Miyatake M, Langeberg LK, Chavkin C, Scott JD, Gardner RG, Adams ME, Hague C. Alpha-dystrobrevin-1 recruits alpha-catulin to the alpha1D-adrenergic receptor/dystrophin-associated protein complex signalosome. Proceedings of the National Academy of Sciences of the United States of America. 107: 21854-9. PMID 21115837 DOI: 10.1073/Pnas.1010819107 |
0.59 |
|
| 2010 |
Reyes BA, Chavkin C, Van Bockstaele EJ. Agonist-induced internalization of κ-opioid receptors in noradrenergic neurons of the rat locus coeruleus. Journal of Chemical Neuroanatomy. 40: 301-9. PMID 20884346 DOI: 10.1016/j.jchemneu.2010.09.003 |
0.473 |
|
| 2010 |
Melief EJ, Miyatake M, Bruchas MR, Chavkin C. Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling. Proceedings of the National Academy of Sciences of the United States of America. 107: 11608-13. PMID 20534436 DOI: 10.1073/Pnas.1000751107 |
0.859 |
|
| 2010 |
Schindler AG, Li S, Chavkin C. Behavioral stress may increase the rewarding valence of cocaine-associated cues through a dynorphin/kappa-opioid receptor-mediated mechanism without affecting associative learning or memory retrieval mechanisms. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 1932-42. PMID 20445500 DOI: 10.1038/Npp.2010.67 |
0.646 |
|
| 2010 |
Bruchas MR, Chavkin C. Kinase cascades and ligand-directed signaling at the kappa opioid receptor. Psychopharmacology. 210: 137-47. PMID 20401607 DOI: 10.1007/S00213-010-1806-Y |
0.709 |
|
| 2010 |
Aita M, Byers MR, Chavkin C, Xu M. Trigeminal injury causes kappa opioid-dependent allodynic, glial and immune cell responses in mice. Molecular Pain. 6: 8. PMID 20109235 DOI: 10.1186/1744-8069-6-8 |
0.389 |
|
| 2010 |
Clayton CC, Bruchas MR, Lee ML, Chavkin C. Phosphorylation of the mu-opioid receptor at tyrosine 166 (Tyr3.51) in the DRY motif reduces agonist efficacy. Molecular Pharmacology. 77: 339-47. PMID 19959593 DOI: 10.1124/Mol.109.060558 |
0.702 |
|
| 2010 |
Bruchas MR, Land BB, Chavkin C. The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors. Brain Research. 1314: 44-55. PMID 19716811 DOI: 10.1016/J.Brainres.2009.08.062 |
0.803 |
|
| 2009 |
Bruchas MR, Land BB, Lemos JC, Chavkin C. CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior. Plos One. 4: e8528. PMID 20052275 DOI: 10.1371/Journal.Pone.0008528 |
0.821 |
|
| 2009 |
Land BB, Bruchas MR, Schattauer S, Giardino WJ, Aita M, Messinger D, Hnasko TS, Palmiter RD, Chavkin C. Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking. Proceedings of the National Academy of Sciences of the United States of America. 106: 19168-73. PMID 19864633 DOI: 10.1073/Pnas.0910705106 |
0.836 |
|
| 2009 |
Navarro VM, Gottsch ML, Chavkin C, Okamura H, Clifton DK, Steiner RA. Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 11859-66. PMID 19776272 DOI: 10.1523/Jneurosci.1569-09.2009 |
0.538 |
|
| 2009 |
Clayton CC, Xu M, Chavkin C. Tyrosine phosphorylation of Kir3 following kappa-opioid receptor activation of p38 MAPK causes heterologous desensitization. The Journal of Biological Chemistry. 284: 31872-81. PMID 19773548 DOI: 10.1074/jbc.M109.053793 |
0.413 |
|
| 2009 |
Vien TN, Gleason CA, Hays SL, McPherson RJ, Chavkin C, Juul SE. Effects of neonatal stress and morphine on kappa opioid receptor signaling. Neonatology. 96: 235-43. PMID 19478529 DOI: 10.1159/000220763 |
0.488 |
|
| 2009 |
Beaudry H, Proteau-Gagné A, Li S, Dory Y, Chavkin C, Gendron L. Differential noxious and motor tolerance of chronic delta opioid receptor agonists in rodents. Neuroscience. 161: 381-91. PMID 19328839 DOI: 10.1016/J.Neuroscience.2009.03.053 |
0.829 |
|
| 2009 |
Wang Y, Xu W, Huang P, Chavkin C, Van Bockstaele EJ, Liu-Chen LY. Effects of acute agonist treatment on subcellular distribution of kappa opioid receptor in rat spinal cord. Journal of Neuroscience Research. 87: 1695-702. PMID 19130621 DOI: 10.1002/jnr.21971 |
0.349 |
|
| 2009 |
Reyes BA, Chavkin C, van Bockstaele EJ. Subcellular targeting of kappa-opioid receptors in the rat nucleus locus coeruleus. The Journal of Comparative Neurology. 512: 419-31. PMID 19009591 DOI: 10.1002/cne.21880 |
0.377 |
|
| 2008 |
Bruchas MR, Xu M, Chavkin C. Repeated swim stress induces kappa opioid-mediated activation of extracellular signal-regulated kinase 1/2. Neuroreport. 19: 1417-22. PMID 18766023 DOI: 10.1097/Wnr.0B013E32830Dd655 |
0.706 |
|
| 2008 |
Redila VA, Chavkin C. Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system. Psychopharmacology. 200: 59-70. PMID 18575850 DOI: 10.1007/s00213-008-1122-y |
0.507 |
|
| 2008 |
Kreibich A, Reyes BA, Curtis AL, Ecke L, Chavkin C, Van Bockstaele EJ, Valentino RJ. Presynaptic inhibition of diverse afferents to the locus ceruleus by kappa-opiate receptors: a novel mechanism for regulating the central norepinephrine system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6516-25. PMID 18562623 DOI: 10.1523/Jneurosci.0390-08.2008 |
0.677 |
|
| 2008 |
Land BB, Bruchas MR, Lemos JC, Xu M, Melief EJ, Chavkin C. The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 407-14. PMID 18184783 DOI: 10.1523/Jneurosci.4458-07.2008 |
0.845 |
|
| 2008 |
Thomson LM, Terman GW, Zeng J, Lowe J, Chavkin C, Hermes SM, Hegarty DM, Aicher SA. Decreased substance P and NK1 receptor immunoreactivity and function in the spinal cord dorsal horn of morphine-treated neonatal rats. The Journal of Pain : Official Journal of the American Pain Society. 9: 11-9. PMID 17950674 DOI: 10.1016/J.Jpain.2007.07.008 |
0.398 |
|
| 2007 |
Gendron L, Pintar JE, Chavkin C. Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia. Neuroscience. 150: 807-17. PMID 17997230 DOI: 10.1016/J.Neuroscience.2007.09.060 |
0.748 |
|
| 2007 |
Bruchas MR, Land BB, Aita M, Xu M, Barot SK, Li S, Chavkin C. Stress-induced p38 mitogen-activated protein kinase activation mediates kappa-opioid-dependent dysphoria. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11614-23. PMID 17959804 DOI: 10.1523/Jneurosci.3769-07.2007 |
0.82 |
|
| 2007 |
Drake CT, Chavkin C, Milner TA. Opioid systems in the dentate gyrus. Progress in Brain Research. 163: 245-63. PMID 17765723 DOI: 10.1016/S0079-6123(07)63015-5 |
0.5 |
|
| 2007 |
Bruchas MR, Yang T, Schreiber S, Defino M, Kwan SC, Li S, Chavkin C. Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase. The Journal of Biological Chemistry. 282: 29803-11. PMID 17702750 DOI: 10.1074/Jbc.M705540200 |
0.714 |
|
| 2007 |
Petraschka M, Li S, Gilbert TL, Westenbroek RE, Bruchas MR, Schreiber S, Lowe J, Low MJ, Pintar JE, Chavkin C. The absence of endogenous beta-endorphin selectively blocks phosphorylation and desensitization of mu opioid receptors following partial sciatic nerve ligation. Neuroscience. 146: 1795-807. PMID 17467916 DOI: 10.1016/J.Neuroscience.2007.03.029 |
0.811 |
|
| 2007 |
Xu M, Bruchas MR, Ippolito DL, Gendron L, Chavkin C. Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2570-81. PMID 17344394 DOI: 10.1523/Jneurosci.3728-06.2007 |
0.807 |
|
| 2006 |
Macey TA, Lowe JD, Chavkin C. Mu opioid receptor activation of ERK1/2 is GRK3 and arrestin dependent in striatal neurons. The Journal of Biological Chemistry. 281: 34515-24. PMID 16982618 DOI: 10.1074/jbc.M604278200 |
0.516 |
|
| 2006 |
Li S, Lee ML, Bruchas MR, Chan GC, Storm DR, Chavkin C. Calmodulin-stimulated adenylyl cyclase gene deletion affects morphine responses. Molecular Pharmacology. 70: 1742-9. PMID 16914643 DOI: 10.1124/Mol.106.025783 |
0.65 |
|
| 2006 |
Bruchas MR, Macey TA, Lowe JD, Chavkin C. Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes. The Journal of Biological Chemistry. 281: 18081-9. PMID 16648139 DOI: 10.1074/Jbc.M513640200 |
0.689 |
|
| 2006 |
McLaughlin JP, Land BB, Li S, Pintar JE, Chavkin C. Prior activation of kappa opioid receptors by U50,488 mimics repeated forced swim stress to potentiate cocaine place preference conditioning. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 787-94. PMID 16123754 DOI: 10.1038/Sj.Npp.1300860 |
0.776 |
|
| 2006 |
McLaughlin JP, Li S, Valdez J, Chavkin TA, Chavkin C. Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 1241-8. PMID 16123746 DOI: 10.1038/Sj.Npp.1300872 |
0.677 |
|
| 2005 |
Ippolito DL, Xu M, Bruchas MR, Wickman K, Chavkin C. Tyrosine phosphorylation of K(ir)3.1 in spinal cord is induced by acute inflammation, chronic neuropathic pain, and behavioral stress. The Journal of Biological Chemistry. 280: 41683-93. PMID 16223722 DOI: 10.1074/Jbc.M507069200 |
0.756 |
|
| 2005 |
Petraschka M, Gilbert T, Westenbroek R, Li S, Chavkin C. Endogenous β-endorphin selectively activates and induces the phosphorylation of mu opioid receptors in striatum The Journal of Pain. 6: S8. DOI: 10.1016/J.JPAIN.2005.01.030 |
0.515 |
|
| 2004 |
Luk T, Jin W, Zvonok A, Lu D, Lin XZ, Chavkin C, Makriyannis A, Mackie K. Identification of a potent and highly efficacious, yet slowly desensitizing CB1 cannabinoid receptor agonist. British Journal of Pharmacology. 142: 495-500. PMID 15148260 DOI: 10.1038/Sj.Bjp.0705792 |
0.422 |
|
| 2004 |
Xu M, Petraschka M, McLaughlin JP, Westenbroek RE, Caron MG, Lefkowitz RJ, Czyzyk TA, Pintar JE, Terman GW, Chavkin C. Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4576-84. PMID 15140929 DOI: 10.1523/Jneurosci.5552-03.2004 |
0.675 |
|
| 2004 |
Celver J, Xu M, Jin W, Lowe J, Chavkin C. Distinct domains of the mu-opioid receptor control uncoupling and internalization. Molecular Pharmacology. 65: 528-37. PMID 14978231 DOI: 10.1124/Mol.65.3.528 |
0.803 |
|
| 2004 |
Chavkin C, Sud S, Jin W, Stewart J, Zjawiony JK, Siebert DJ, Toth BA, Hufeisen SJ, Roth BL. Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations. The Journal of Pharmacology and Experimental Therapeutics. 308: 1197-203. PMID 14718611 DOI: 10.1124/jpet.103.059394 |
0.538 |
|
| 2004 |
Terman GW, Jin W, Cheong YP, Lowe J, Caron MG, Lefkowitz RJ, Chavkin C. G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal. British Journal of Pharmacology. 141: 55-64. PMID 14662727 DOI: 10.1038/Sj.Bjp.0705595 |
0.552 |
|
| 2004 |
McLaughlin JP, Myers LC, Zarek PE, Caron MG, Lefkowitz RJ, Czyzyk TA, Pintar JE, Chavkin C. Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance. The Journal of Biological Chemistry. 279: 1810-8. PMID 14597630 DOI: 10.1074/Jbc.M305796200 |
0.679 |
|
| 2004 |
Petraschka M, Xu M, Westenbroek R, McLaughlin J, Chavkin C. Animal models of chronic pain The Journal of Pain. 5: S14. DOI: 10.1016/J.Jpain.2004.02.022 |
0.489 |
|
| 2003 |
McLaughlin JP, Marton-Popovici M, Chavkin C. Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5674-83. PMID 12843270 |
0.655 |
|
| 2003 |
McLaughlin JP, Xu M, Mackie K, Chavkin C. Phosphorylation of a carboxyl-terminal serine within the kappa-opioid receptor produces desensitization and internalization. The Journal of Biological Chemistry. 278: 34631-40. PMID 12815037 DOI: 10.1074/Jbc.M304022200 |
0.691 |
|
| 2003 |
McLaughlin JP, Marton-Popovici M, Chavkin C. κ Opioid Receptor Antagonism and Prodynorphin Gene Disruption Block Stress-Induced Behavioral Responses The Journal of Neuroscience. 23: 5674-5683. DOI: 10.1523/Jneurosci.23-13-05674.2003 |
0.688 |
|
| 2002 |
Ippolito DL, Temkin PA, Rogalski SL, Chavkin C. N-terminal tyrosine residues within the potassium channel Kir3 modulate GTPase activity of Galphai. The Journal of Biological Chemistry. 277: 32692-6. PMID 12082117 DOI: 10.1074/Jbc.M204407200 |
0.814 |
|
| 2002 |
Lowe JD, Celver JP, Gurevich VV, Chavkin C. mu-Opioid receptors desensitize less rapidly than delta-opioid receptors due to less efficient activation of arrestin. The Journal of Biological Chemistry. 277: 15729-35. PMID 11861651 DOI: 10.1074/Jbc.M200612200 |
0.82 |
|
| 2002 |
Celver J, Vishnivetskiy SA, Chavkin C, Gurevich VV. Conservation of the phosphate-sensitive elements in the arrestin family of proteins. The Journal of Biological Chemistry. 277: 9043-8. PMID 11782458 DOI: 10.1074/Jbc.M107400200 |
0.763 |
|
| 2001 |
Svingos AL, Chavkin C, Colago EE, Pickel VM. Major coexpression of kappa-opioid receptors and the dopamine transporter in nucleus accumbens axonal profiles. Synapse (New York, N.Y.). 42: 185-92. PMID 11746715 DOI: 10.1002/syn.10005 |
0.577 |
|
| 2001 |
Chavkin C, McLaughlin JP, Celver JP. Regulation of opioid receptor function by chronic agonist exposure: constitutive activity and desensitization. Molecular Pharmacology. 60: 20-5. PMID 11408596 DOI: 10.1124/Mol.60.1.20 |
0.832 |
|
| 2001 |
McLaughlin JP, Chavkin C. Tyrosine phosphorylation of the mu-opioid receptor regulates agonist intrinsic efficacy. Molecular Pharmacology. 59: 1360-8. PMID 11353794 DOI: 10.1124/Mol.59.6.1360 |
0.669 |
|
| 2001 |
Rogalski SL, Chavkin C. Eicosanoids inhibit the G-protein-gated inwardly rectifying potassium channel (Kir3) at the Na+/PIP2 gating site. The Journal of Biological Chemistry. 276: 14855-60. PMID 11278615 DOI: 10.1074/Jbc.M010097200 |
0.792 |
|
| 2001 |
Terman GW, Eastman CL, Chavkin C. Mu opiates inhibit long-term potentiation induction in the spinal cord slice. Journal of Neurophysiology. 85: 485-94. PMID 11160487 DOI: 10.1152/Jn.2001.85.2.485 |
0.392 |
|
| 2001 |
Celver JP, Lowe J, Kovoor A, Gurevich VV, Chavkin C. Threonine 180 is required for G-protein-coupled receptor kinase 3- and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in Xenopus oocytes. The Journal of Biological Chemistry. 276: 4894-900. PMID 11060299 DOI: 10.1074/Jbc.M007437200 |
0.807 |
|
| 2000 |
Chavkin C. Dynorphins are endogenous opioid peptides released from granule cells to act neurohumorly and inhibit excitatory neurotransmission in the hippocampus. Progress in Brain Research. 125: 363-7. PMID 11098672 DOI: 10.1016/S0079-6123(00)25025-5 |
0.404 |
|
| 2000 |
Appleyard SM, McLaughlin JP, Chavkin C. Tyrosine phosphorylation of the kappa -opioid receptor regulates agonist efficacy. The Journal of Biological Chemistry. 275: 38281-5. PMID 10995763 DOI: 10.1074/Jbc.M006756200 |
0.809 |
|
| 2000 |
Terman GW, Drake CT, Simmons ML, Milner TA, Chavkin C. Opioid modulation of recurrent excitation in the hippocampal dentate gyrus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 4379-88. PMID 10844006 DOI: 10.1523/Jneurosci.20-12-04379.2000 |
0.471 |
|
| 2000 |
Rogalski SL, Appleyard SM, Pattillo A, Terman GW, Chavkin C. TrkB activation by brain-derived neurotrophic factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel. The Journal of Biological Chemistry. 275: 25082-8. PMID 10833508 DOI: 10.1074/Jbc.M000183200 |
0.789 |
|
| 1999 |
Appleyard SM, Celver J, Pineda V, Kovoor A, Wayman GA, Chavkin C. Agonist-dependent desensitization of the kappa opioid receptor by G protein receptor kinase and beta-arrestin. The Journal of Biological Chemistry. 274: 23802-7. PMID 10446141 DOI: 10.1074/Jbc.274.34.23802 |
0.759 |
|
| 1999 |
Jin W, Brown S, Roche JP, Hsieh C, Celver JP, Kovoor A, Chavkin C, Mackie K. Distinct domains of the CB1 cannabinoid receptor mediate desensitization and internalization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 3773-80. PMID 10234009 DOI: 10.1523/Jneurosci.19-10-03773.1999 |
0.776 |
|
| 1999 |
Rogalski SL, Cyr C, Chavkin C. Activation of the endothelin receptor inhibits the G protein-coupled inwardly rectifying potassium channel by a phospholipase A2-mediated mechanism. Journal of Neurochemistry. 72: 1409-16. PMID 10098843 DOI: 10.1046/J.1471-4159.1999.721409.X |
0.832 |
|
| 1999 |
Kovoor A, Celver J, Abdryashitov RI, Chavkin C, Gurevich VV. Targeted construction of phosphorylation-independent beta-arrestin mutants with constitutive activity in cells. The Journal of Biological Chemistry. 274: 6831-4. PMID 10066734 DOI: 10.1074/Jbc.274.11.6831 |
0.77 |
|
| 1999 |
Jin W, Chavkin C. Mu opioids enhance mossy fiber synaptic transmission indirectly by reducing GABAB receptor activation. Brain Research. 821: 286-93. PMID 10064815 DOI: 10.1016/S0006-8993(99)01089-6 |
0.467 |
|
| 1998 |
Kovoor A, Celver JP, Wu A, Chavkin C. Agonist induced homologous desensitization of mu-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy. Molecular Pharmacology. 54: 704-11. PMID 9765514 |
0.795 |
|
| 1997 |
Appleyard SM, Patterson TA, Jin W, Chavkin C. Agonist-induced phosphorylation of the kappa-opioid receptor. Journal of Neurochemistry. 69: 2405-12. PMID 9375672 DOI: 10.1046/j.1471-4159.1997.69062405.x |
0.796 |
|
| 1997 |
Kovoor A, Nappey V, Kieffer BL, Chavkin C. Mu and delta opioid receptors are differentially desensitized by the coexpression of beta-adrenergic receptor kinase 2 and beta-arrestin 2 in xenopus oocytes. The Journal of Biological Chemistry. 272: 27605-11. PMID 9346897 DOI: 10.1074/Jbc.272.44.27605 |
0.405 |
|
| 1997 |
Simmons ML, Terman GW, Chavkin C. Spontaneous excitatory currents and kappa-opioid receptor inhibition in dentate gyrus are increased in the rat pilocarpine model of temporal lobe epilepsy. Journal of Neurophysiology. 78: 1860-8. PMID 9325355 DOI: 10.1152/Jn.1997.78.4.1860 |
0.428 |
|
| 1997 |
Drake CT, Chavkin C, Milner TA. Kappa opioid receptor-like immunoreactivity is present in substance P-containing subcortical afferents in guinea pig dentate gyrus. Hippocampus. 7: 36-47. PMID 9138667 DOI: 10.1002/(Sici)1098-1063(1997)7:1<36::Aid-Hipo4>3.0.Co;2-5 |
0.358 |
|
| 1997 |
Jin W, Terman GW, Chavkin C. Kappa opioid receptor tolerance in the guinea pig hippocampus. The Journal of Pharmacology and Experimental Therapeutics. 281: 123-8. PMID 9103488 |
0.441 |
|
| 1997 |
Coda B, Bausch S, Haas M, Chavkin C. The hypothesis that antagonism of fentanyl analgesia by 2-chloroprocaine is mediated by direct action on opioid receptors. Regional Anesthesia. 22: 43-52. PMID 9010946 DOI: 10.1016/S1098-7339(06)80055-6 |
0.536 |
|
| 1997 |
Bausch SB, Chavkin C. Changes in hippocampal circuitry after pilocarpine-induced seizures as revealed by opioid receptor distribution and activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 477-92. PMID 8987772 DOI: 10.1523/Jneurosci.17-01-00477.1997 |
0.454 |
|
| 1996 |
Bausch SB, Chavkin C. Vicia villosa agglutinin labels a subset of neurons coexpressing both the mu opioid receptor and parvalbumin in the developing rat subiculum. Brain Research. Developmental Brain Research. 97: 169-77. PMID 8997501 DOI: 10.1016/S0165-3806(96)00136-8 |
0.469 |
|
| 1996 |
Simmons ML, Chavkin C. Endogenous opioid regulation of hippocampal function. International Review of Neurobiology. 39: 145-96. PMID 8894847 DOI: 10.1016/S0074-7742(08)60666-2 |
0.5 |
|
| 1996 |
Drake CT, Patterson TA, Simmons ML, Chavkin C, Milner TA. Kappa opioid receptor-like immunoreactivity in guinea pig brain: ultrastructural localization in presynaptic terminals in hippocampal formation. The Journal of Comparative Neurology. 370: 377-95. PMID 8799863 DOI: 10.1002/(Sici)1096-9861(19960701)370:3<377::Aid-Cne8>3.0.Co;2-1 |
0.369 |
|
| 1996 |
Simmons ML, Chavkin C. k-Opioid receptor activation of a dendrotoxin-sensitive potassium channel mediates presynaptic inhibition of mossy fiber neurotransmitter release. Molecular Pharmacology. 50: 80-5. PMID 8700123 |
0.386 |
|
| 1996 |
Befort K, Tabbara L, Bausch S, Chavkin C, Evans C, Kieffer B. The conserved aspartate residue in the third putative transmembrane domain of the delta-opioid receptor is not the anionic counterpart for cationic opiate binding but is a constituent of the receptor binding site. Molecular Pharmacology. 49: 216-23. PMID 8632752 |
0.36 |
|
| 1996 |
Hell JW, Westenbroek RE, Breeze LJ, Wang KK, Chavkin C, Catterall WA. N-methyl-D-aspartate receptor-induced proteolytic conversion of postsynaptic class C L-type calcium channels in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. 93: 3362-7. PMID 8622942 DOI: 10.1073/pnas.93.8.3362 |
0.322 |
|
| 1995 |
Bausch SB, Patterson TA, Ehrengruber MU, Lester HA, Davidson N, Chavkin C. Colocalization of mu opioid receptors with GIRK1 potassium channels in the rat brain: an immunocytochemical study. Receptors & Channels. 3: 221-41. PMID 8821795 |
0.388 |
|
| 1995 |
Kovoor A, Henry DJ, Chavkin C. Agonist-induced desensitization of the mu opioid receptor-coupled potassium channel (GIRK1). The Journal of Biological Chemistry. 270: 589-95. PMID 7822283 DOI: 10.1074/Jbc.270.2.589 |
0.486 |
|
| 1995 |
Wu ZL, Thomas SA, Villacres EC, Xia Z, Simmons ML, Chavkin C, Palmiter RD, Storm DR. Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 92: 220-4. PMID 7816821 DOI: 10.1073/Pnas.92.1.220 |
0.303 |
|
| 1995 |
Henry DJ, Chavkin C. Activation of inwardly rectifying potassium channels (GIRK1) by co-expressed rat brain cannabinoid receptors in Xenopus oocytes. Neuroscience Letters. 186: 91-4. PMID 7777206 DOI: 10.1016/0304-3940(95)11289-9 |
0.4 |
|
| 1995 |
Henry DJ, Grandy DK, Lester HA, Davidson N, Chavkin C. Kappa-opioid receptors couple to inwardly rectifying potassium channels when coexpressed by Xenopus oocytes. Molecular Pharmacology. 47: 551-7. PMID 7700253 |
0.416 |
|
| 1995 |
Hell JW, Yokoyama CT, Breeze LJ, Chavkin C, Catterall WA. Phosphorylation of presynaptic and postsynaptic calcium channels by cAMP-dependent protein kinase in hippocampal neurons. The Embo Journal. 14: 3036-44. PMID 7621818 DOI: 10.1002/J.1460-2075.1995.Tb07306.X |
0.32 |
|
| 1995 |
Simmons ML, Terman GW, Gibbs SM, Chavkin C. L-type calcium channels mediate dynorphin neuropeptide release from dendrites but not axons of hippocampal granule cells. Neuron. 14: 1265-72. PMID 7605635 DOI: 10.1016/0896-6273(95)90273-2 |
0.352 |
|
| 1995 |
Bausch SB, Patterson TA, Appleyard SM, Chavkin C. Immunocytochemical localization of delta opioid receptors in mouse brain. Journal of Chemical Neuroanatomy. 8: 175-89. PMID 7598816 DOI: 10.1016/0891-0618(94)00044-T |
0.779 |
|
| 1995 |
Dascal N, Doupnik CA, Ivanina T, Bausch S, Wang W, Lin C, Garvey J, Chavkin C, Lester HA, Davidson N. Inhibition of function in Xenopus oocytes of the inwardly rectifying G-protein-activated atrial K channel (GIRK1) by overexpression of a membrane-attached form of the C-terminal tail. Proceedings of the National Academy of Sciences of the United States of America. 92: 6758-62. PMID 7542774 DOI: 10.1073/Pnas.92.15.6758 |
0.316 |
|
| 1995 |
Bausch SB, Chavkin C. COLOCALIZATION OF MU AND DELTA OPIOID RECEPTORS WITH GABA, PARVALBUMIN AND A G-PROTEIN-COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL (GIRK1) IN THE RODENT BRAIN Analgesia. 1: 282-285. DOI: 10.3727/107156995819563078 |
0.328 |
|
| 1994 |
Caudle RM, Chavkin C, Dubner R. Kappa 2 opioid receptors inhibit NMDA receptor-mediated synaptic currents in guinea pig CA3 pyramidal cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 5580-9. PMID 7916046 DOI: 10.1523/Jneurosci.14-09-05580.1994 |
0.667 |
|
| 1994 |
Terman GW, Wagner JJ, Chavkin C. Kappa opioids inhibit induction of long-term potentiation in the dentate gyrus of the guinea pig hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 4740-7. PMID 7913954 DOI: 10.1523/Jneurosci.14-08-04740.1994 |
0.627 |
|
| 1994 |
Drake CT, Terman GW, Simmons ML, Milner TA, Kunkel DD, Schwartzkroin PA, Chavkin C. Dynorphin opioids present in dentate granule cells may function as retrograde inhibitory neurotransmitters. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 3736-50. PMID 7911518 DOI: 10.1523/Jneurosci.14-06-03736.1994 |
0.397 |
|
| 1994 |
Simmons ML, Terman GW, Drake CT, Chavkin C. Inhibition of glutamate release by presynaptic kappa 1-opioid receptors in the guinea pig dentate gyrus. Journal of Neurophysiology. 72: 1697-705. PMID 7823095 DOI: 10.1152/Jn.1994.72.4.1697 |
0.439 |
|
| 1994 |
Patterson TA, Connor M, Appleyard SM, Chavkin C. Oocytes from Xenopus laevis contain an intrinsic sigma 2-like binding site. Neuroscience Letters. 180: 159-62. PMID 7700571 DOI: 10.1016/0304-3940(94)90511-8 |
0.711 |
|
| 1994 |
Henry D, Kovoor A, Chavkin C. Effects of treatment with kinase activators and inhibitors on mu and delta opioid receptor coupling to G-protein gated K+ channels in Xenopus oocytes Regulatory Peptides. 54: 157-158. DOI: 10.1016/0167-0115(94)90438-3 |
0.506 |
|
| 1994 |
Drake C, Patterson T, Simmons M, Milner T, Chavkin C. Distribution of kappa opioid receptor-like immunoreactivity in guinea pig hippocampal formation Regulatory Peptides. 54: 89-90. DOI: 10.1016/0167-0115(94)90403-0 |
0.474 |
|
| 1994 |
Bausch S, Patterson T, Chavkin C. Immunocytochemical localization of mu and delta opioid receptors in the rat dentate gyrus Regulatory Peptides. 54: 19-20. DOI: 10.1016/0167-0115(94)90368-9 |
0.495 |
|
| 1994 |
Chavkin C. The role of endogenous opioids in the guinea pig dentate gyrus: A brief review Regulatory Peptides. 53: S173-S174. DOI: 10.1016/0167-0115(94)90296-8 |
0.457 |
|
| 1993 |
Dascal N, Schreibmayer W, Lim NF, Wang W, Chavkin C, DiMagno L, Labarca C, Kieffer BL, Gaveriaux-Ruff C, Trollinger D. Atrial G protein-activated K+ channel: expression cloning and molecular properties. Proceedings of the National Academy of Sciences of the United States of America. 90: 10235-9. PMID 8234283 DOI: 10.1073/Pnas.90.21.10235 |
0.365 |
|
| 1993 |
Wagner JJ, Terman GW, Chavkin C. Endogenous dynorphins inhibit excitatory neurotransmission and block LTP induction in the hippocampus. Nature. 363: 451-4. PMID 8099201 DOI: 10.1038/363451A0 |
0.634 |
|
| 1993 |
Uezono Y, Bradley J, Min C, McCarty NA, Quick M, Riordan JR, Chavkin C, Zinn K, Lester HA, Davidson N. Receptors that couple to 2 classes of G proteins increase cAMP and activate CFTR expressed in Xenopus oocytes. Receptors & Channels. 1: 233-41. PMID 7522902 |
0.301 |
|
| 1992 |
Simmons ML, Wagner JJ, Caudle RM, Chavkin C. Endogenous opioid regulation of norepinephrine release in guinea pig hippocampus. Neuroscience Letters. 141: 84-8. PMID 1508405 DOI: 10.1016/0304-3940(92)90340-D |
0.77 |
|
| 1992 |
Connor MA, Chavkin C. Ionic zinc may function as an endogenous ligand for the haloperidol-sensitive sigma 2 receptor in rat brain. Molecular Pharmacology. 42: 471-9. PMID 1406599 |
0.438 |
|
| 1992 |
Wagner JJ, Caudle RM, Chavkin C. Kappa-opioids decrease excitatory transmission in the dentate gyrus of the guinea pig hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 132-41. PMID 1345943 DOI: 10.1523/Jneurosci.12-01-00132.1992 |
0.782 |
|
| 1992 |
Wagner JJ, Chavkin C. Endogenous opioids and LTP: another view. Neurochemistry International. 20: 457-60. PMID 1339017 DOI: 10.1016/0197-0186(92)90022-J |
0.623 |
|
| 1992 |
Wimpey TL, Chavkin C. 8-Bromo-cAMP blocks opioid activation of a voltage-gated potassium current in isolated hippocampal neurons. Neuroscience Letters. 137: 137-40. PMID 1320750 DOI: 10.1016/0304-3940(92)90316-Y |
0.476 |
|
| 1991 |
Caudle RM, Wagner JJ, Chavkin C. Endogenous opioids released from perforant path modulate norepinephrine actions and inhibitory postsynaptic potentials in guinea pig CA3 pyramidal cells. The Journal of Pharmacology and Experimental Therapeutics. 258: 18-26. PMID 2072294 |
0.738 |
|
| 1991 |
Wimpey TL, Chavkin C. Opioids activate both an inward rectifier and a novel voltage-gated potassium conductance in the hippocampal formation. Neuron. 6: 281-9. PMID 1993123 DOI: 10.1016/0896-6273(91)90363-5 |
0.457 |
|
| 1991 |
Connor MA, Chavkin C. Focal stimulation of specific pathways in the rat hippocampus causes a reduction in radioligand binding to the haloperidol-sensitive sigma receptor. Experimental Brain Research. 85: 528-36. PMID 1680737 DOI: 10.1007/BF00231736 |
0.511 |
|
| 1991 |
Wagner JJ, Evans CJ, Chavkin C. Focal stimulation of the mossy fibers releases endogenous dynorphins that bind kappa 1-opioid receptors in guinea pig hippocampus. Journal of Neurochemistry. 57: 333-43. PMID 1675664 DOI: 10.1111/J.1471-4159.1991.Tb02132.X |
0.651 |
|
| 1990 |
Wimpey TL, Caudle RM, Chavkin C. Chronic morphine exposure blocks opioid effects on both the early and late inhibitory postsynaptic potentials in hippocampal CA1 pyramidal cells. Neuroscience Letters. 110: 349-55. PMID 2158024 DOI: 10.1016/0304-3940(90)90872-7 |
0.691 |
|
| 1990 |
Caudle RM, Swearengen E, Chavkin C. Endogenously released opioids inhibit inhibitory post synaptic potentials in guinea pig CA3 pyramidal cells and rat dentate granule cells. Progress in Clinical and Biological Research. 328: 5-8. PMID 2154812 |
0.609 |
|
| 1990 |
Wagner JJ, Caudle RM, Neumaier JF, Chavkin C. Stimulation of endogenous opioid release displaces mu receptor binding in rat hippocampus. Neuroscience. 37: 45-53. PMID 1978741 DOI: 10.1016/0306-4522(90)90190-F |
0.828 |
|
| 1990 |
Caudle RM, Chavkin C. Mu opioid receptor activation reduces inhibitory postsynaptic potentials in hippocampal CA3 pyramidal cells of rat and guinea pig. The Journal of Pharmacology and Experimental Therapeutics. 252: 1361-9. PMID 1969476 |
0.599 |
|
| 1989 |
Neumaier JF, Chavkin C. Release of endogenous opioid peptides displaces [3H]diprenorphine binding in rat hippocampal slices. Brain Research. 493: 292-302. PMID 2765901 DOI: 10.1016/0006-8993(89)91164-5 |
0.675 |
|
| 1989 |
Swearengen E, Chavkin C. Comparison of opioid and GABA receptor control of excitability and membrane conductance in hippocampal CA1 pyramidal cells in rat. Neuropharmacology. 28: 689-97. PMID 2569690 DOI: 10.1016/0028-3908(89)90152-4 |
0.412 |
|
| 1989 |
Neumaier JF, Chavkin C. Calcium-dependent displacement of haloperidol-sensitive sigma receptor binding in rat hippocampal slices following tissue depolarization. Brain Research. 500: 215-22. PMID 2557959 DOI: 10.1016/0006-8993(89)90316-8 |
0.639 |
|
| 1989 |
Wimpey TL, Opheim KE, Chavkin C. Effects of chronic morphine administration on the mu and delta opioid responses in the CA1 region of the rat hippocampus. The Journal of Pharmacology and Experimental Therapeutics. 251: 405-11. PMID 2553917 |
0.378 |
|
| 1988 |
Chavkin C, Neumaier JF, Swearengen E. Opioid receptor mechanisms in the rat hippocampus. Nida Research Monograph. 82: 94-117. PMID 2899843 |
0.666 |
|
| 1988 |
Neumaier JF, Mailheau S, Chavkin C. Opioid receptor-mediated responses in the dentate gyrus and CA1 region of the rat hippocampus. The Journal of Pharmacology and Experimental Therapeutics. 244: 564-70. PMID 2894454 |
0.677 |
|
| 1987 |
Swearengen E, Chavkin C. NMDA receptor antagonist D-APV depresses excitatory activity produced by normorphine in rat hippocampal slices. Neuroscience Letters. 78: 80-4. PMID 2886961 DOI: 10.1016/0304-3940(87)90565-9 |
0.372 |
|
| 1986 |
Cox BM, Chavkin C. Properties of receptors mediating opioid effects: discrimination of receptor types. Nida Research Monograph. 71: 1-18. PMID 3025728 |
0.638 |
|
| 1986 |
Siggins GR, Henriksen SJ, Chavkin C, Gruol D. Opioid peptides and epileptogenesis in the limbic system: cellular mechanisms. Advances in Neurology. 44: 501-12. PMID 2939697 |
0.764 |
|
| 1986 |
Neumaier JF, Chavkin C. Opioid receptor activity in the dentate region of the rat hippocampus. Nida Research Monograph. 75: 101-4. PMID 2893261 |
0.674 |
|
| 1986 |
Chavkin C, Bloom FE. Opiate antagonists do not alter neuronal responses to stimulation of opioid-containing pathways in rat hippocampus. Neuropeptides. 7: 19-22. PMID 2869440 DOI: 10.1016/0143-4179(86)90074-0 |
0.582 |
|
| 1985 |
Chavkin C, Shoemaker WJ, McGinty JF, Bayon A, Bloom FE. Characterization of the prodynorphin and proenkephalin neuropeptide systems in rat hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 5: 808-16. PMID 3838345 |
0.563 |
|
| 1985 |
Chavkin C, Henriksen SJ, Siggins GR, Bloom FE. Selective inactivation of opioid receptors in rat hippocampus demonstrates that dynorphin-A and -B may act on mu-receptors in the CA1 region. Brain Research. 331: 366-70. PMID 2859095 DOI: 10.1016/0006-8993(85)91565-3 |
0.796 |
|
| 1985 |
Chavkin C, Shoemaker W, McGinty J, Bayon A, Bloom F. Characterization of the prodynorphin and proenkephalin neuropeptide systems in rat hippocampus The Journal of Neuroscience. 5: 808-816. DOI: 10.1523/JNEUROSCI.05-03-00808.1985 |
0.647 |
|
| 1984 |
Chavkin C, Goldstein A. Opioid receptor reserve in normal and morphine-tolerant guinea pig ileum myenteric plexus. Proceedings of the National Academy of Sciences of the United States of America. 81: 7253-7. PMID 6095280 DOI: 10.1073/Pnas.81.22.7253 |
0.682 |
|
| 1983 |
Chavkin C, Bakhit C, Weber E, Bloom FE. Relative contents and concomitant release of prodynorphin/neoendorphin-derived peptides in rat hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 80: 7669-73. PMID 6143317 DOI: 10.1073/PNAS.80.24.7669 |
0.461 |
|
| 1983 |
Gruol DL, Chavkin C, Valentino RJ, Siggins GR. Dynorphin-A alters the excitability of pyramidal neurons of the rat hippocampus in vitro. Life Sciences. 33: 533-6. PMID 6141499 DOI: 10.1016/0024-3205(83)90558-1 |
0.664 |
|
| 1983 |
Chavkin C, Bakhit C, Bloom FE. Evidence for dynorphin-A as a neurotransmitter in rat hippocampus. Life Sciences. 33: 13-6. PMID 6141483 DOI: 10.1016/0024-3205(83)90432-0 |
0.409 |
|
| 1983 |
Cox BM, Chavkin C. Comparison of dynorphin-selective Kappa receptors in mouse vas deferens and guinea pig ileum. Spare receptor fraction as a determinant of potency. Molecular Pharmacology. 23: 36-43. PMID 6135144 |
0.589 |
|
| 1982 |
Chavkin C, Goldstein A. Reduction in opiate receptor reserve in morphine tolerant guinea pig ilea. Life Sciences. 31: 1687-90. PMID 6296572 DOI: 10.1016/0024-3205(82)90186-2 |
0.643 |
|
| 1982 |
James IF, Chavkin C, Goldstein A. Preparation of brain membranes containing a single type of opioid receptor highly selective for dynorphin. Proceedings of the National Academy of Sciences of the United States of America. 79: 7570-4. PMID 6130527 DOI: 10.1073/Pnas.79.23.7570 |
0.61 |
|
| 1982 |
James IF, Chavkin C, Goldstein A. Selectivity of dynorphin for kappa opioid receptors. Life Sciences. 31: 1331-4. PMID 6128656 DOI: 10.1016/0024-3205(82)90374-5 |
0.631 |
|
| 1982 |
Chavkin C, James IF, Goldstein A. Dynorphin is a specific endogenous ligand of the kappa opioid receptor. Science (New York, N.Y.). 215: 413-5. PMID 6120570 DOI: 10.1126/Science.6120570 |
0.692 |
|
| 1982 |
Chavkin C, James IF, Goldstein A. Dynorphin is a specific endogenous ligand of the κ opioid receptor Pain. 14: 201. DOI: 10.1016/0304-3959(82)90120-8 |
0.68 |
|
| 1981 |
Chavkin C, Goldstein A. Demonstration of a specific dynorphin receptor in guinea pig ileum myenteric plexus. Nature. 291: 591-3. PMID 6264311 DOI: 10.1038/291591a0 |
0.64 |
|
| 1981 |
Chavkin C, Goldstein A. Specific receptor for the opioid peptide dynorphin: structure--activity relationships. Proceedings of the National Academy of Sciences of the United States of America. 78: 6543-7. PMID 6118865 DOI: 10.1073/Pnas.78.10.6543 |
0.669 |
|
| 1980 |
Cox BM, Leslie FM, Chavkin C. Characteristics of peptide and alkaloid opiate binding sites in brain and peripheral tissues. Advances in Biochemical Psychopharmacology. 22: 353-62. PMID 6249080 |
0.452 |
|
| 1980 |
Leslie FM, Chavkin C, Cox BM. Opioid binding properties of brain and peripheral tissues: evidence for heterogeneity in opioid ligand binding sites. The Journal of Pharmacology and Experimental Therapeutics. 214: 395-402. PMID 6248635 |
0.563 |
|
| 1980 |
Ghazarossian VE, Chavkin C, Goldstein A. A specific radioimmunoassay for the novel opioid peptide dynorphin. Life Sciences. 27: 75-86. PMID 6105608 DOI: 10.1016/0024-3205(80)90021-1 |
0.519 |
|
| 1980 |
Ho WKK, Cox BM, Chavkin C, Goldstein A. Opioid peptide dynorphin-(1-13): Adsorptive losses and potency estimates Neuropeptides. 1: 143-152. |
0.667 |
|
| 1979 |
Chavkin C, Cox BM, Goldstein A. Stereospecific opiate binding in bovine adrenal medulla. Molecular Pharmacology. 15: 751-3. PMID 226864 |
0.464 |
|
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