| Year |
Citation |
Score |
| 2024 |
Junk L, Schmiedel VM, Guha S, Fischel K, Greb P, Vill K, Krisilia V, van Geelen L, Rumpel K, Kaur P, Krishnamurthy RV, Narayanan S, Shandil RK, Singh M, Kofink C, ... ... Clausen T, et al. Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria. Nature Communications. 15: 2005. PMID 38443338 DOI: 10.1038/s41467-024-46218-7 |
0.762 |
|
| 2023 |
Hoi DM, Junker S, Junk L, Schwechel K, Fischel K, Podlesainski D, Hawkins PME, van Geelen L, Kaschani F, Leodolter J, Morreale FE, Kleine S, Guha S, Rumpel K, Schmiedel VM, ... ... Clausen T, et al. Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival. Cell. 186: 2176-2192.e22. PMID 37137307 DOI: 10.1016/j.cell.2023.04.009 |
0.803 |
|
| 2023 |
Scinicariello S, Soderholm A, Schäfer M, Shulkina A, Schwartz I, Hacker K, Gogova R, Kalis R, Froussios K, Budroni V, Bestehorn A, Clausen T, Kovarik P, Zuber J, Versteeg GA. HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation. Elife. 12. PMID 36961408 DOI: 10.7554/eLife.83159 |
0.801 |
|
| 2023 |
Picchianti L, Sánchez de Medina Hernández V, Zhan N, Irwin NA, Groh R, Stephani M, Hornegger H, Beveridge R, Sawa-Makarska J, Lendl T, Grujic N, Naumann C, Martens S, Richards TA, Clausen T, et al. Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy. The Embo Journal. e112053. PMID 36762703 DOI: 10.15252/embj.2022112053 |
0.798 |
|
| 2023 |
Ehrmann JF, Grabarczyk DB, Heinke M, Deszcz L, Kurzbauer R, Hudecz O, Shulkina A, Gogova R, Meinhart A, Versteeg GA, Clausen T. Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex. Science (New York, N.Y.). 379: 1117-1123. PMID 36758105 DOI: 10.1126/science.ade8873 |
0.797 |
|
| 2022 |
Morreale FE, Kleine S, Leodolter J, Junker S, Hoi DM, Ovchinnikov S, Okun A, Kley J, Kurzbauer R, Junk L, Guha S, Podlesainski D, Kazmaier U, Boehmelt G, Weinstabl H, ... ... Clausen T, et al. BacPROTACs mediate targeted protein degradation in bacteria. Cell. PMID 35662409 DOI: 10.1016/j.cell.2022.05.009 |
0.811 |
|
| 2022 |
Rey J, Breiden M, Lux V, Bluemke A, Steindel M, Ripkens K, Möllers B, Bravo Rodriguez K, Boisguerin P, Volkmer R, Mieres-Perez J, Clausen T, Sanchez-Garcia E, Ehrmann M. An allosteric HTRA1-calpain 2 complex with restricted activation profile. Proceedings of the National Academy of Sciences of the United States of America. 119: e2113520119. PMID 35349341 DOI: 10.1073/pnas.2113520119 |
0.687 |
|
| 2022 |
Hawkins PME, Hoi DM, Cheung CY, Wang T, Quan D, Sasi VM, Liu DY, Linington RG, Jackson CJ, Oehlers SH, Cook GM, Britton WJ, Clausen T, Payne RJ. Potent Bactericidal Antimycobacterials Targeting the Chaperone ClpC1 Based on the Depsipeptide Natural Products Ecumicin and Ohmyungsamycin A. Journal of Medicinal Chemistry. PMID 35293761 DOI: 10.1021/acs.jmedchem.1c02122 |
0.788 |
|
| 2022 |
Cable J, Weber-Ban E, Clausen T, Walters KJ, Sharon M, Finley DJ, Gu Y, Hanna J, Feng Y, Martens S, Simonsen A, Hansen M, Zhang H, Goodwin JM, Reggio A, et al. Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report. Annals of the New York Academy of Sciences. PMID 35000205 DOI: 10.1111/nyas.14745 |
0.722 |
|
| 2021 |
Hajdusits B, Suskiewicz MJ, Hundt N, Meinhart A, Kurzbauer R, Leodolter J, Kukura P, Clausen T. McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation. Elife. 10. PMID 34328418 DOI: 10.7554/eLife.63505 |
0.822 |
|
| 2021 |
Grabarczyk DB, Petrova OA, Deszcz L, Kurzbauer R, Murphy P, Ahel J, Vogel A, Gogova R, Faas V, Kordic D, Schleiffer A, Meinhart A, Imre R, Lehner A, Neuhold J, ... ... Clausen T, et al. HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain. Nature Chemical Biology. PMID 34294896 DOI: 10.1038/s41589-021-00831-5 |
0.765 |
|
| 2021 |
Rodriguez Carvajal A, Grishkovskaya I, Gomez Diaz C, Vogel A, Sonn-Segev A, Kushwah MS, Schodl K, Deszcz L, Orban-Nemeth Z, Sakamoto S, Mechtler K, Kukura P, Clausen T, Haselbach D, Ikeda F. The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains. Elife. 10. PMID 34142657 DOI: 10.7554/eLife.60660 |
0.796 |
|
| 2021 |
Asanović I, Strandback E, Kroupova A, Pasajlic D, Meinhart A, Tsung-Pin P, Djokovic N, Anrather D, Schuetz T, Suskiewicz MJ, Sillamaa S, Köcher T, Beveridge R, Nikolic K, Schleiffer A, ... ... Clausen T, et al. The oxidoreductase PYROXD1 uses NAD(P) as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response. Molecular Cell. PMID 33930333 DOI: 10.1016/j.molcel.2021.04.007 |
0.79 |
|
| 2020 |
Stephani M, Picchianti L, Gajic A, Beveridge R, Skarwan E, Sanchez de Medina Hernandez V, Mohseni A, Clavel M, Zeng Y, Naumann C, Matuszkiewicz M, Turco E, Loefke C, Li B, Dürnberger G, ... ... Clausen T, et al. A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress. Elife. 9. PMID 32851973 DOI: 10.7554/eLife.58396 |
0.795 |
|
| 2020 |
Beveridge R, Kessler D, Rumpel K, Ettmayer P, Meinhart A, Clausen T. Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy. Acs Central Science. 6: 1223-1230. PMID 32724856 DOI: 10.1021/acscentsci.0c00049 |
0.83 |
|
| 2020 |
Ahel J, Lehner A, Vogel A, Schleiffer A, Meinhart A, Haselbach D, Clausen T. Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism. Elife. 9. PMID 32573437 DOI: 10.7554/eLife.56185 |
0.799 |
|
| 2020 |
Merdanovic M, Burston SG, Schmitz AL, Köcher S, Knapp S, Clausen T, Kaiser M, Huber R, Ehrmann M. Activation by substoichiometric inhibition. Proceedings of the National Academy of Sciences of the United States of America. PMID 31907318 DOI: 10.1073/Pnas.1918721117 |
0.695 |
|
| 2019 |
Hellerschmied D, Lehner A, Franicevic N, Arnese R, Johnson C, Vogel A, Meinhart A, Kurzbauer R, Deszcz L, Gazda L, Geeves M, Clausen T. Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin. Nature Communications. 10: 4781. PMID 31636255 DOI: 10.1038/S41467-019-12667-8 |
0.788 |
|
| 2019 |
Suskiewicz MJ, Hajdusits B, Beveridge R, Heuck A, Vu LD, Kurzbauer R, Hauer K, Thoeny V, Rumpel K, Mechtler K, Meinhart A, Clausen T. Structure of McsB, a protein kinase for regulated arginine phosphorylation. Nature Chemical Biology. 15: 510-518. PMID 30962626 DOI: 10.1038/s41589-019-0265-y |
0.827 |
|
| 2019 |
Vogel A, Gudino R, Arnese R, Clausen T. Keeping muscle proteins in shape – UCS proteins acting as myosin-specific quality control factors Acta Crystallographica Section a Foundations and Advances. 75: e77-e77. DOI: 10.1107/s2053273319094798 |
0.805 |
|
| 2019 |
Hajdusits B, Suskiewicz MJ, Hundt N, Meinhart A, Kukura P, Clausen T. How the pArg protein mark keeps the stress response kinase MCSB under control Acta Crystallographica Section A. 75. DOI: 10.1107/S2053273319094786 |
0.806 |
|
| 2018 |
Hellerschmied D, Roessler M, Lehner A, Gazda L, Stejskal K, Imre R, Mechtler K, Dammermann A, Clausen T. UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins. Nature Communications. 9: 484. PMID 29396393 DOI: 10.1038/s41467-018-02924-7 |
0.844 |
|
| 2017 |
Ouyang M, Li X, Zhao S, Pu H, Shen J, Adam Z, Clausen T, Zhang L. The crystal structure of Deg9 reveals a novel octameric-type HtrA protease. Nature Plants. 3: 973-982. PMID 29180814 DOI: 10.1038/S41477-017-0060-2 |
0.349 |
|
| 2016 |
Heuck A, Schitter-Sollner S, Suskiewicz MJ, Kurzbauer R, Kley J, Schleiffer A, Rombaut P, Herzog F, Clausen T. Structural basis for the disaggregase activity and regulation of Hsp104. Elife. 5. PMID 27901467 DOI: 10.7554/eLife.21516 |
0.81 |
|
| 2016 |
Trentini DB, Suskiewicz MJ, Heuck A, Kurzbauer R, Deszcz L, Mechtler K, Clausen T. Arginine phosphorylation marks proteins for degradation by a Clp protease. Nature. 539: 48-53. PMID 27749819 DOI: 10.1038/nature20122 |
0.852 |
|
| 2016 |
Suskiewicz MJ, Clausen T. Chemical Biology Interrogates Protein Arginine Phosphorylation. Cell Chemical Biology. 23: 888-90. PMID 27541193 DOI: 10.1016/j.chembiol.2016.08.003 |
0.777 |
|
| 2015 |
Poepsel S, Sprengel A, Sacca B, Kaschani F, Kaiser M, Gatsogiannis C, Raunser S, Clausen T, Ehrmann M. Determinants of amyloid fibril degradation by the PDZ protease HTRA1. Nature Chemical Biology. 11: 862-9. PMID 26436840 DOI: 10.1038/nchembio.1931 |
0.664 |
|
| 2015 |
Schneider M, Hellerschmied D, Schubert T, Amlacher S, Vinayachandran V, Reja R, Pugh BF, Clausen T, Köhler A. The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression. Cell. 162: 1016-28. PMID 26317468 DOI: 10.1016/J.Cell.2015.07.059 |
0.787 |
|
| 2015 |
Schneider M, Hellerschmied D, Schubert T, Amlacher S, Vinayachandran V, Reja R, Pugh BF, Clausen T, Köhler A. The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression Cell. 162: 1016-1028. DOI: 10.1016/j.cell.2015.07.059 |
0.766 |
|
| 2014 |
Schmidt A, Trentini DB, Spiess S, Fuhrmann J, Ammerer G, Mechtler K, Clausen T. Quantitative Phosphoproteomics Reveals the Role of Protein Arginine Phosphorylation in the Bacterial Stress Response. Molecular & Cellular Proteomics : McP. 13: 537-550. PMID 33498137 DOI: 10.1074/mcp.M113.032292 |
0.795 |
|
| 2014 |
Norell D, Heuck A, Tran-Thi TA, Götzke H, Jacob-Dubuisson F, Clausen T, Daley DO, Braun V, Müller M, Fan E. Versatile in vitro system to study translocation and functional integration of bacterial outer membrane proteins. Nature Communications. 5: 5396. PMID 25369922 DOI: 10.1038/ncomms6396 |
0.625 |
|
| 2014 |
Trentini DB, Fuhrmann J, Mechtler K, Clausen T. Chasing Phosphoarginine Proteins: Development of a Selective Enrichment Method Using a Phosphatase Trap. Molecular & Cellular Proteomics : McP. 13: 1953-64. PMID 24825175 DOI: 10.1074/Mcp.O113.035790 |
0.832 |
|
| 2014 |
Dikfidan A, Loll B, Zeymer C, Magler I, Clausen T, Meinhart A. RNA specificity and regulation of catalysis in the eukaryotic polynucleotide kinase Clp1. Molecular Cell. 54: 975-86. PMID 24813946 DOI: 10.1016/j.molcel.2014.04.005 |
0.663 |
|
| 2014 |
Hellerschmied D, Clausen T. Myosin chaperones. Current Opinion in Structural Biology. 25: 9-15. PMID 24440450 DOI: 10.1016/j.sbi.2013.11.002 |
0.819 |
|
| 2014 |
Schmidt A, Trentini DB, Spiess S, Fuhrmann J, Ammerer G, Mechtler K, Clausen T. Quantitative phosphoproteomics reveals the role of protein arginine phosphorylation in the bacterial stress response. Molecular & Cellular Proteomics : McP. 13: 537-50. PMID 24263382 DOI: 10.1074/Mcp.M113.032292 |
0.813 |
|
| 2013 |
Mastny M, Heuck A, Kurzbauer R, Heiduk A, Boisguerin P, Volkmer R, Ehrmann M, Rodrigues CD, Rudner DZ, Clausen T. CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis. Cell. 155: 647-58. PMID 24243021 DOI: 10.1016/j.cell.2013.09.050 |
0.754 |
|
| 2013 |
Fuhrmann J, Mierzwa B, Trentini DB, Spiess S, Lehner A, Charpentier E, Clausen T. Structural basis for recognizing phosphoarginine and evolving residue-specific protein phosphatases in gram-positive bacteria. Cell Reports. 3: 1832-9. PMID 23770242 DOI: 10.1016/J.Celrep.2013.05.023 |
0.84 |
|
| 2013 |
Malvezzi F, Litos G, Schleiffer A, Heuck A, Mechtler K, Clausen T, Westermann S. A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors. The Embo Journal. 32: 409-23. PMID 23334295 DOI: 10.1038/emboj.2012.356 |
0.617 |
|
| 2013 |
Gazda L, Pokrzywa W, Hellerschmied D, Löwe T, Forné I, Mueller-Planitz F, Hoppe T, Clausen T. The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans. Cell. 152: 183-95. PMID 23332754 DOI: 10.1016/j.cell.2012.12.025 |
0.836 |
|
| 2012 |
Dal Santo S, Stampfl H, Krasensky J, Kempa S, Gibon Y, Petutschnig E, Rozhon W, Heuck A, Clausen T, Jonak C. Stress-induced GSK3 regulates the redox stress response by phosphorylating glucose-6-phosphate dehydrogenase in Arabidopsis. The Plant Cell. 24: 3380-92. PMID 22885737 DOI: 10.1105/tpc.112.101279 |
0.585 |
|
| 2012 |
Tennstaedt A, Pöpsel S, Truebestein L, Hauske P, Brockmann A, Schmidt N, Irle I, Sacca B, Niemeyer CM, Brandt R, Ksiezak-Reding H, Tirniceriu AL, Egensperger R, Baldi A, Dehmelt L, ... ... Clausen T, et al. Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates. The Journal of Biological Chemistry. 287: 20931-41. PMID 22535953 DOI: 10.1074/Jbc.M111.316232 |
0.721 |
|
| 2012 |
Malet H, Canellas F, Sawa J, Yan J, Thalassinos K, Ehrmann M, Clausen T, Saibil HR. Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ. Nature Structural & Molecular Biology. 19: 152-7. PMID 22245966 DOI: 10.1038/nsmb.2210 |
0.841 |
|
| 2011 |
Sawa J, Malet H, Krojer T, Canellas F, Ehrmann M, Clausen T. Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope. The Journal of Biological Chemistry. 286: 30680-30690. PMID 21685389 DOI: 10.1074/jbc.M111.243832 |
0.831 |
|
| 2011 |
Merdanovic M, Clausen T, Kaiser M, Huber R, Ehrmann M. Protein quality control in the bacterial periplasm. Annual Review of Microbiology. 65: 149-68. PMID 21639788 DOI: 10.1146/Annurev-Micro-090110-102925 |
0.726 |
|
| 2011 |
Kley J, Schmidt B, Boyanov B, Stolt-Bergner PC, Kirk R, Ehrmann M, Knopf RR, Naveh L, Adam Z, Clausen T. Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure. Nature Structural & Molecular Biology. 18: 728-31. PMID 21532594 DOI: 10.1038/nsmb.2055 |
0.598 |
|
| 2011 |
Clausen T, Kaiser M, Huber R, Ehrmann M. HTRA proteases: regulated proteolysis in protein quality control. Nature Reviews. Molecular Cell Biology. 12: 152-62. PMID 21326199 DOI: 10.1038/Nrm3065 |
0.725 |
|
| 2011 |
Truebestein L, Tennstaedt A, Mönig T, Krojer T, Canellas F, Kaiser M, Clausen T, Ehrmann M. Substrate-induced remodeling of the active site regulates human HTRA1 activity. Nature Structural & Molecular Biology. 18: 386-8. PMID 21297635 DOI: 10.1038/nsmb.2013 |
0.812 |
|
| 2011 |
Heuck A, Schleiffer A, Clausen T. Augmenting β-augmentation: structural basis of how BamB binds BamA and may support folding of outer membrane proteins. Journal of Molecular Biology. 406: 659-66. PMID 21236263 DOI: 10.1016/j.jmb.2011.01.002 |
0.618 |
|
| 2010 |
Krojer T, Sawa J, Huber R, Clausen T. HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues. Nature Structural & Molecular Biology. 17: 844-52. PMID 20581825 DOI: 10.1038/Nsmb.1840 |
0.75 |
|
| 2010 |
Sawa J, Heuck A, Ehrmann M, Clausen T. Molecular transformers in the cell: lessons learned from the DegP protease-chaperone. Current Opinion in Structural Biology. 20: 253-8. PMID 20188538 DOI: 10.1016/j.sbi.2010.01.014 |
0.792 |
|
| 2010 |
Hasenbein S, Meltzer M, Hauske P, Kaiser M, Huber R, Clausen T, Ehrmann M. Conversion of a regulatory into a degradative protease. Journal of Molecular Biology. 397: 957-66. PMID 20184896 DOI: 10.1016/J.Jmb.2010.02.027 |
0.712 |
|
| 2009 |
Meltzer M, Hasenbein S, Mamant N, Merdanovic M, Poepsel S, Hauske P, Kaiser M, Huber R, Krojer T, Clausen T, Ehrmann M. Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli. Research in Microbiology. 160: 660-6. PMID 19695325 DOI: 10.1016/J.Resmic.2009.07.012 |
0.816 |
|
| 2009 |
Hauske P, Mamant N, Hasenbein S, Nickel S, Ottmann C, Clausen T, Ehrmann M, Kaiser M. Peptidic small molecule activators of the stress sensor DegS. Molecular Biosystems. 5: 980-5. PMID 19668863 DOI: 10.1039/b902089f |
0.652 |
|
| 2009 |
Breithaupt C, Kurzbauer R, Schaller F, Stintzi A, Schaller A, Huber R, Macheroux P, Clausen T. Structural basis of substrate specificity of plant 12-oxophytodienoate reductases. Journal of Molecular Biology. 392: 1266-77. PMID 19660473 DOI: 10.1016/J.Jmb.2009.07.087 |
0.398 |
|
| 2009 |
Fuhrmann J, Schmidt A, Spiess S, Lehner A, Turgay K, Mechtler K, Charpentier E, Clausen T. McsB is a protein arginine kinase that phosphorylates and inhibits the heat-shock regulator CtsR. Science (New York, N.Y.). 324: 1323-7. PMID 19498169 DOI: 10.1126/Science.1170088 |
0.822 |
|
| 2009 |
Hauske P, Meltzer M, Ottmann C, Krojer T, Clausen T, Ehrmann M, Kaiser M. Selectivity profiling of DegP substrates and inhibitors. Bioorganic & Medicinal Chemistry. 17: 2920-4. PMID 19233659 DOI: 10.1016/j.bmc.2009.01.073 |
0.774 |
|
| 2008 |
Krojer T, Pangerl K, Kurt J, Sawa J, Stingl C, Mechtler K, Huber R, Ehrmann M, Clausen T. Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins Proceedings of the National Academy of Sciences of the United States of America. 105: 7702-7707. PMID 18505836 DOI: 10.1073/Pnas.0803392105 |
0.835 |
|
| 2008 |
Krojer T, Sawa J, Schäfer E, Saibil HR, Ehrmann M, Clausen T. Structural basis for the regulated protease and chaperone function of DegP. Nature. 453: 885-90. PMID 18496527 DOI: 10.1038/nature07004 |
0.819 |
|
| 2008 |
Meltzer M, Hasenbein S, Hauske P, Kucz N, Merdanovic M, Grau S, Beil A, Jones D, Krojer T, Clausen T, Ehrmann M, Kaiser M. Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control. Angewandte Chemie (International Ed. in English). 47: 1332-4. PMID 18175296 DOI: 10.1002/anie.200703273 |
0.769 |
|
| 2007 |
Hasselblatt H, Kurzbauer R, Wilken C, Krojer T, Sawa J, Kurt J, Kirk R, Hasenbein S, Ehrmann M, Clausen T. Regulation of the σE stress response by DegS: How the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress Genes and Development. 21: 2659-2670. PMID 17938245 DOI: 10.1101/gad.445307 |
0.771 |
|
| 2007 |
Krojer T, Sawa J, Fuhrmann J, Gazda L, Kirk R, Kurt J, Nussbaumer B, Schmidt B, Clausen T. The protease state of the heat-shock protein DegP fromEscherichia coli Acta Crystallographica Section a Foundations of Crystallography. 63: s120-s120. DOI: 10.1107/S0108767307097413 |
0.796 |
|
| 2006 |
Breithaupt C, Kurzbauer R, Lilie H, Schaller A, Strassner J, Huber R, Macheroux P, Clausen T. Crystal structure of 12-oxophytodienoate reductase 3 from tomato: Self-inhibition by dimerization Proceedings of the National Academy of Sciences of the United States of America. 103: 14337-14342. PMID 16983071 DOI: 10.1073/Pnas.0606603103 |
0.399 |
|
| 2006 |
Grau S, Richards PJ, Kerr B, Hughes C, Caterson B, Williams AS, Junker U, Jones SA, Clausen T, Ehrmann M. The role of human HtrA1 in arthritic disease. The Journal of Biological Chemistry. 281: 6124-9. PMID 16377621 DOI: 10.1074/jbc.M500361200 |
0.6 |
|
| 2005 |
Kitzing K, Fitzpatrick TB, Wilken C, Sawa J, Bourenkov GP, Macheroux P, Clausen T. The 1.3 A crystal structure of the flavoprotein YqjM reveals a novel class of Old Yellow Enzymes. The Journal of Biological Chemistry. 280: 27904-13. PMID 15890652 DOI: 10.1074/jbc.M502587200 |
0.32 |
|
| 2005 |
Grau S, Baldi A, Bussani R, Tian X, Stefanescu R, Przybylski M, Richards P, Jones SA, Shridhar V, Clausen T, Ehrmann M. Implications of the serine protease HtrA1 in amyloid precursor protein processing Proceedings of the National Academy of Sciences of the United States of America. 102: 6021-6026. PMID 15855271 DOI: 10.1073/pnas.0501823102 |
0.633 |
|
| 2005 |
Groll M, Bochtler M, Brandstetter H, Clausen T, Huber R. Molecular machines for protein degradation. Chembiochem : a European Journal of Chemical Biology. 6: 222-56. PMID 15678420 DOI: 10.1002/Cbic.200400313 |
0.7 |
|
| 2004 |
Ehrmann M, Clausen T. Proteolysis as a regulatory mechanism. Annual Review of Genetics. 38: 709-24. PMID 15568990 DOI: 10.1146/annurev.genet.38.072902.093416 |
0.626 |
|
| 2004 |
Kurzbauer R, Teis D, de Araujo ME, Maurer-Stroh S, Eisenhaber F, Bourenkov GP, Bartunik HD, Hekman M, Rapp UR, Huber LA, Clausen T. Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes. Proceedings of the National Academy of Sciences of the United States of America. 101: 10984-9. PMID 15263099 DOI: 10.1073/Pnas.0403435101 |
0.353 |
|
| 2004 |
Fitzpatrick TB, Auweter S, Kitzing K, Clausen T, Amrhein N, Macheroux P. Structural and functional impairment of an Old Yellow Enzyme homologue upon affinity tag incorporation. Protein Expression and Purification. 36: 280-91. PMID 15249051 DOI: 10.1016/j.pep.2004.04.012 |
0.425 |
|
| 2004 |
Wilken C, Kitzing K, Kurzbauer R, Ehrmann M, Clausen T. Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease. Cell. 117: 483-94. PMID 15137941 DOI: 10.1016/s0092-8674(04)00454-4 |
0.691 |
|
| 2003 |
Groll M, Clausen T. Molecular shredders: how proteasomes fulfill their role. Current Opinion in Structural Biology. 13: 665-73. PMID 14675543 DOI: 10.1016/j.sbi.2003.10.005 |
0.406 |
|
| 2003 |
Messerschmidt A, Worbs M, Steegborn C, Wahl MC, Huber R, Laber B, Clausen T. Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine gamma-lyase from yeast and intrafamiliar structure comparison. Biological Chemistry. 384: 373-86. PMID 12715888 DOI: 10.1515/BC.2003.043 |
0.415 |
|
| 2002 |
Clausen T, Southan C, Ehrmann M. The HtrA family of proteases: implications for protein composition and cell fate. Molecular Cell. 10: 443-55. PMID 12408815 DOI: 10.1016/S1097-2765(02)00658-5 |
0.687 |
|
| 2002 |
Kaiser JT, Bruno S, Clausen T, Huber R, Schiaretti F, Mozzarelli A, Kessler D. Snapshots of the cystine lyase C-DES during catalysis. Studies in solution and in the crystalline state. The Journal of Biological Chemistry. 278: 357-65. PMID 12386155 DOI: 10.1074/Jbc.M209862200 |
0.406 |
|
| 2002 |
Garrido-Franco M, Laber B, Huber R, Clausen T. Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis. Journal of Molecular Biology. 321: 601-12. PMID 12206776 DOI: 10.1016/S0022-2836(02)00695-2 |
0.429 |
|
| 2002 |
Krojer T, Garrido-Franco M, Huber R, Ehrmann M, Clausen T. Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine Nature. 416: 455-459. PMID 11919638 DOI: 10.1038/416455A |
0.811 |
|
| 2002 |
Steegborn C, Danot O, Huber R, Clausen T. Crystal structure of transcription factor MalT domain III: a novel helix repeat fold implicated in regulated oligomerization. Structure (London, England : 1993). 9: 1051-60. PMID 11709169 DOI: 10.1016/S0969-2126(01)00665-7 |
0.485 |
|
| 2002 |
Breithaupt C, Macheroux P, Schaller A, Huber R, Clausen T. Crystallographic studies of 12-oxophytodienoate reductases from tomato Acta Crystallographica Section a Foundations of Crystallography. 58: c96-c96. DOI: 10.1107/S0108767302088876 |
0.333 |
|
| 2002 |
Krojer T, Garrido-Franco M, Huber R, Ehrmann M, Clausen T. Erratum: corrigendum: Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine Nature. 417: 102-102. DOI: 10.1038/417102c |
0.742 |
|
| 2001 |
Garrido-Franco M, Ehlert S, Messerschmidt A, Marinkovic' S, Huber R, Laber B, Bourenkov GP, Clausen T. Structure and function of threonine synthase from yeast. The Journal of Biological Chemistry. 277: 12396-405. PMID 11756443 DOI: 10.1074/Jbc.M108734200 |
0.483 |
|
| 2001 |
Steegborn C, Laber B, Messerschmidt A, Huber R, Clausen T. Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor. Journal of Molecular Biology. 311: 789-801. PMID 11518531 DOI: 10.1006/jmbi.2001.4880 |
0.438 |
|
| 2001 |
Breitinger U, Clausen T, Ehlert S, Huber R, Laber B, Schmidt F, Pohl E, Messerschmidt A. The three-dimensional structure of cystathionine beta-lyase from Arabidopsis and its substrate specificity. Plant Physiology. 126: 631-42. PMID 11402193 DOI: 10.1104/pp.126.2.631 |
0.426 |
|
| 2001 |
Breithaupt C, Strassner J, Breitinger U, Huber R, Macheroux P, Schaller A, Clausen T. X-ray structure of 12-oxophytodienoate reductase 1 provides structural insight into substrate binding and specificity within the family of OYE. Structure (London, England : 1993). 9: 419-29. PMID 11377202 DOI: 10.1016/S0969-2126(01)00602-5 |
0.339 |
|
| 2001 |
Franco MG, Laber B, Huber R, Clausen T. Structural basis for the function of pyridoxine 5'-phosphate synthase. Structure (London, England : 1993). 9: 245-53. PMID 11286891 DOI: 10.1016/S0969-2126(01)00584-6 |
0.34 |
|
| 2000 |
Garrido Franco M, Huber R, Schmidt FS, Laber B, Clausen T. Crystallization and preliminary X-ray crystallographic analysis of PdxJ, the pyridoxine 5'-phosphate synthesizing enzyme. Acta Crystallographica. Section D, Biological Crystallography. 56: 1045-8. PMID 10944349 DOI: 10.1107/S0907444900007368 |
0.36 |
|
| 2000 |
Krupka HI, Huber R, Holt SC, Clausen T. Crystal structure of cystalysin from Treponema denticola: A pyridoxal 5'-phosphate-dependent protein acting as a haemolytic enzyme Embo Journal. 19: 3168-3178. PMID 10880431 DOI: 10.1093/Emboj/19.13.3168 |
0.445 |
|
| 2000 |
Clausen T, Kaiser JT, Steegborn C, Huber R, Kessler D. Crystal structure of the cystine C-S lyase from Synechocystis: stabilization of cysteine persulfide for FeS cluster biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 97: 3856-61. PMID 10760256 DOI: 10.1073/Pnas.97.8.3856 |
0.377 |
|
| 2000 |
Kaiser JT, Clausen T, Bourenkow GP, Bartunik HD, Steinbacher S, Huber R. Crystal structure of a NifS-like protein from Thermotoga maritima: implications for iron sulphur cluster assembly. Journal of Molecular Biology. 297: 451-64. PMID 10715213 DOI: 10.1006/Jmbi.2000.3581 |
0.525 |
|
| 2000 |
Clausen T, Schlegel A, Peist R, Schneider E, Steegborn C, Chang YS, Haase A, Bourenkov GP, Bartunik HD, Boos W. X-ray structure of MalY from Escherichia coli: a pyridoxal 5'-phosphate-dependent enzyme acting as a modulator in mal gene expression. The Embo Journal. 19: 831-42. PMID 10698925 DOI: 10.1093/Emboj/19.5.831 |
0.353 |
|
| 1999 |
Steegborn C, Messerschmidt A, Laber B, Streber W, Huber R, Clausen T. The crystal structure of cystathionine gamma-synthase from Nicotiana tabacum reveals its substrate and reaction specificity. Journal of Molecular Biology. 290: 983-96. PMID 10438597 DOI: 10.1006/jmbi.1999.2935 |
0.414 |
|
| 1999 |
Steegborn C, Clausen T, Sondermann P, Jacob U, Worbs M, Marinkovic S, Huber R, Wahl MC. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration. The Journal of Biological Chemistry. 274: 12675-84. PMID 10212249 DOI: 10.1074/jbc.274.18.12675 |
0.355 |
|
| 1999 |
Clausen T, Huber R, Prade L, Wahl MC, Messerschmidt A. Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution. The Embo Journal. 17: 6827-38. PMID 9843488 DOI: 10.1093/emboj/17.23.6827 |
0.435 |
|
| 1997 |
Clausen T, Huber R, Messerschmidt A, Pohlenz HD, Laber B. Slow-binding inhibition of Escherichia coli cystathionine beta-lyase by L-aminoethoxyvinylglycine: a kinetic and X-ray study. Biochemistry. 36: 12633-43. PMID 9376370 DOI: 10.1021/bi970630m |
0.397 |
|
| 1997 |
Wahl MC, Huber R, Prade L, Marinkovic S, Messerschmidt A, Clausen T. Cloning, purification, crystallization, and preliminary X-ray diffraction analysis of cystathionine gamma-synthase from E. coli. Febs Letters. 414: 492-6. PMID 9323022 DOI: 10.1016/S0014-5793(97)01057-0 |
0.351 |
|
| 1997 |
Jacob U, Mack M, Clausen T, Huber R, Buckel W, Messerschmidt A. Glutaconate CoA-transferase from Acidaminococcus fermentans: The crystal structure reveals homology with other CoA-transferases Structure. 5: 415-426. PMID 9083111 DOI: 10.1016/S0969-2126(97)00198-6 |
0.393 |
|
| 1996 |
Clausen T, Huber R, Laber B, Pohlenz HD, Messerschmidt A. Crystal structure of the pyridoxal-5'-phosphate dependent cystathionine beta-lyase from Escherichia coli at 1.83 A. Journal of Molecular Biology. 262: 202-24. PMID 8831789 DOI: 10.1006/jmbi.1996.0508 |
0.393 |
|
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